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The map label for this gene is zraS [C]

Identifier: 21674513

GI number: 21674513

Start: 1604950

End: 1606587

Strand: Direct

Name: zraS [C]

Synonym: CT1695

Alternate gene names: 21674513

Gene position: 1604950-1606587 (Clockwise)

Preceding gene: 21674512

Following gene: 21674521

Centisome position: 74.48

GC content: 55.01

Gene sequence:

>1638_bases
ATGCCAACCCCTTTATTCGATACCTGTCTCTCTTCAGATGACCTGAACGCTTTTGATGCCAGCCAGAAACCCGGAACAAC
AACGTTCAACACCCTGGCGTCGCTCACTGAACTTTATGACGCTATTCCAGCCTCAATCATCATCATCGATGAACGGATGC
GCCTGATCGGCTGGAACCGCTTTTCGCGCGACACCATCAACGGGCTGAGTGACAACGAAATGCCGGGTATCAACCCGATG
AAGCGTGTGCACCCCGATGACCTCCCCGAAATGATCCGGAAAATGCGTAACGTCATCGACCTCGACATCGAACTGAGCGC
CGAGTTCAGAATGTATCACAAAAGCGGGCCGCCCTACAAATGGGCGATGTGCCGGGGTAAACGGACCATCATTGAGGGGA
AAACCTGCGTGGTGGCAGTCGTGACTGAAATCACCGATCTCAAGGAGGCTGAAGAGCAGCGCAAAAAGCTTCAGGAACAG
CTCTTGCAGCTTCAGAAAATGGAGCTCGTCGGCCAGCTTGCCAGCGGCATCGCACACGATTTCAACAACGCGCTTGCAGC
CATCATTGGCAACACGGAACTGGCGCTCAAAAAGCTCGACCCGGCCAACCCGGCCGTATCGAATATCACGGATATTCACA
CGCTTGCGACACGCTCGGCGAATCTTACCCGCCAGTTGCTCGCCTTTGCGCGCAAGCAGATGGCAATGCCTCGGGTGCTC
AACCTGACCGAAGAGGTTTCGGACTGCCTTCGCCTGTACCAGCGGCTCATCGACAAGAACATCCATCTCGAATGGCATCT
ATGCGACGAGCCGATCCAGGTAAAGCTCGACCCCACGCAGCTCGAACAGATTCTCTCCAACCTGCTCGTCAACGCACGTG
ACGCCATCGATGGCAGTGGATGCATCACGGTCAGATGCGAAGGCGCACGATTCGAGCCGACCGACGGCAAAACCTGCAAT
CCCAGGCTCTCACCAGGGGATTATGCAAGACTGTCGATCACCGATAGCGGCTGCGGCATTGAAGCCTCCGTCTTGCCCCA
CATCTACGAACCGTTCTTCACCACCAAGGAGATCGGCAAAGGCATCGGACTCGGCCTTTCGTCGGTCTATGGCATCGTGA
GGCAGAACAACGGTCATATCGAGTGCCATTCCGAACCCGGCAAGGGGACGACCTTCGATATCTGGCTCCCCCTGCATCAG
GAATCGCAACAGAAAACGGACGTCCATGCTGACAAACCGCAAACTGAACTAAAGACAAAAGCGAAGATCATGGTGGTCGA
GGACGAGCCCTACATCCTCAAACTGGTGCAGGATATTCTCGAAAGCCATGAATTCACGGTCTTCACGGCAACTGACGCTG
ACCAGTGCCTGCTCGCCGCCAAAACCCACGAGTACCGGATCGATCTGCTTGTAACCGACGTGGTACTGCCGACGATGAAC
GGCATCGAGCAGAGCCGGGTGCTCCAAAAGAAAAATCCGGCCATGAAATGCCTGTTCATGTCAGCCCACGCTCCGGATAA
CGTCGATGGTCAGAAAAAGCTCAGGGTTGGAGTGGATTTTATCGAGAAGCCGTTCGGCATCGACGAGTTTCTCCGTGCGA
TCGACCAGGTGCTGAACAGTGAGGTCGAAAAAATTTGA

Upstream 100 bases:

>100_bases
GATCGGAAAACAAGCGCCATCGGTAATCACAATGCAATGAAAACCATTTATCAACAAGTGGCATCAATCTATCTCAATAT
CTGAAAATCTGCGCATATCG

Downstream 100 bases:

>100_bases
GGAGAACCGGACTCAGCGTGCCAGACGCTTGGTGGCGTTGACATGCTTCAGCACACCTGAAACATCCGCTTCCACCGCAT
GAGCACGGTCAAAGCGCTGC

Product: sensor histidine kinase/response regulator

Products: NA

Alternate protein names: Blue-light-activated histidine kinase; Response regulator [H]

Number of amino acids: Translated: 545; Mature: 544

Protein sequence:

>545_residues
MPTPLFDTCLSSDDLNAFDASQKPGTTTFNTLASLTELYDAIPASIIIIDERMRLIGWNRFSRDTINGLSDNEMPGINPM
KRVHPDDLPEMIRKMRNVIDLDIELSAEFRMYHKSGPPYKWAMCRGKRTIIEGKTCVVAVVTEITDLKEAEEQRKKLQEQ
LLQLQKMELVGQLASGIAHDFNNALAAIIGNTELALKKLDPANPAVSNITDIHTLATRSANLTRQLLAFARKQMAMPRVL
NLTEEVSDCLRLYQRLIDKNIHLEWHLCDEPIQVKLDPTQLEQILSNLLVNARDAIDGSGCITVRCEGARFEPTDGKTCN
PRLSPGDYARLSITDSGCGIEASVLPHIYEPFFTTKEIGKGIGLGLSSVYGIVRQNNGHIECHSEPGKGTTFDIWLPLHQ
ESQQKTDVHADKPQTELKTKAKIMVVEDEPYILKLVQDILESHEFTVFTATDADQCLLAAKTHEYRIDLLVTDVVLPTMN
GIEQSRVLQKKNPAMKCLFMSAHAPDNVDGQKKLRVGVDFIEKPFGIDEFLRAIDQVLNSEVEKI

Sequences:

>Translated_545_residues
MPTPLFDTCLSSDDLNAFDASQKPGTTTFNTLASLTELYDAIPASIIIIDERMRLIGWNRFSRDTINGLSDNEMPGINPM
KRVHPDDLPEMIRKMRNVIDLDIELSAEFRMYHKSGPPYKWAMCRGKRTIIEGKTCVVAVVTEITDLKEAEEQRKKLQEQ
LLQLQKMELVGQLASGIAHDFNNALAAIIGNTELALKKLDPANPAVSNITDIHTLATRSANLTRQLLAFARKQMAMPRVL
NLTEEVSDCLRLYQRLIDKNIHLEWHLCDEPIQVKLDPTQLEQILSNLLVNARDAIDGSGCITVRCEGARFEPTDGKTCN
PRLSPGDYARLSITDSGCGIEASVLPHIYEPFFTTKEIGKGIGLGLSSVYGIVRQNNGHIECHSEPGKGTTFDIWLPLHQ
ESQQKTDVHADKPQTELKTKAKIMVVEDEPYILKLVQDILESHEFTVFTATDADQCLLAAKTHEYRIDLLVTDVVLPTMN
GIEQSRVLQKKNPAMKCLFMSAHAPDNVDGQKKLRVGVDFIEKPFGIDEFLRAIDQVLNSEVEKI
>Mature_544_residues
PTPLFDTCLSSDDLNAFDASQKPGTTTFNTLASLTELYDAIPASIIIIDERMRLIGWNRFSRDTINGLSDNEMPGINPMK
RVHPDDLPEMIRKMRNVIDLDIELSAEFRMYHKSGPPYKWAMCRGKRTIIEGKTCVVAVVTEITDLKEAEEQRKKLQEQL
LQLQKMELVGQLASGIAHDFNNALAAIIGNTELALKKLDPANPAVSNITDIHTLATRSANLTRQLLAFARKQMAMPRVLN
LTEEVSDCLRLYQRLIDKNIHLEWHLCDEPIQVKLDPTQLEQILSNLLVNARDAIDGSGCITVRCEGARFEPTDGKTCNP
RLSPGDYARLSITDSGCGIEASVLPHIYEPFFTTKEIGKGIGLGLSSVYGIVRQNNGHIECHSEPGKGTTFDIWLPLHQE
SQQKTDVHADKPQTELKTKAKIMVVEDEPYILKLVQDILESHEFTVFTATDADQCLLAAKTHEYRIDLLVTDVVLPTMNG
IEQSRVLQKKNPAMKCLFMSAHAPDNVDGQKKLRVGVDFIEKPFGIDEFLRAIDQVLNSEVEKI

Specific function: Photosensitive kinase and response regulator that is involved in increased bacterial virulence upon exposure to light [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=267, Percent_Identity=29.9625468164794, Blast_Score=115, Evalue=8e-27,
Organism=Escherichia coli, GI1788549, Length=253, Percent_Identity=29.6442687747036, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI1788713, Length=269, Percent_Identity=28.6245353159851, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI145693157, Length=285, Percent_Identity=26.3157894736842, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI87081816, Length=260, Percent_Identity=26.5384615384615, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI48994928, Length=522, Percent_Identity=24.7126436781609, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1790300, Length=281, Percent_Identity=27.7580071174377, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1790861, Length=263, Percent_Identity=27.3764258555133, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786783, Length=238, Percent_Identity=26.0504201680672, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 61041; Mature: 60910

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS50112 PAS ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTPLFDTCLSSDDLNAFDASQKPGTTTFNTLASLTELYDAIPASIIIIDERMRLIGWNR
CCCCHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCHHHHCCCC
FSRDTINGLSDNEMPGINPMKRVHPDDLPEMIRKMRNVIDLDIELSAEFRMYHKSGPPYK
CCHHHCCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHEECEEEECCEEEEEECCCCCEE
WAMCRGKRTIIEGKTCVVAVVTEITDLKEAEEQRKKLQEQLLQLQKMELVGQLASGIAHD
EEEECCCEEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FNNALAAIIGNTELALKKLDPANPAVSNITDIHTLATRSANLTRQLLAFARKQMAMPRVL
HHHHHHHHCCCCHHEEEECCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHH
NLTEEVSDCLRLYQRLIDKNIHLEWHLCDEPIQVKLDPTQLEQILSNLLVNARDAIDGSG
HHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEECHHHHHHHHHHHHHHHHHCCCCCC
CITVRCEGARFEPTDGKTCNPRLSPGDYARLSITDSGCGIEASVLPHIYEPFFTTKEIGK
EEEEEECCCEECCCCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHCCCCCHHHHCC
GIGLGLSSVYGIVRQNNGHIECHSEPGKGTTFDIWLPLHQESQQKTDVHADKPQTELKTK
CCCCCHHHHHHHHCCCCCEEEEECCCCCCCEEEEEEECCCCCCHHCCCCCCCCHHHHCCC
AKIMVVEDEPYILKLVQDILESHEFTVFTATDADQCLLAAKTHEYRIDLLVTDVVLPTMN
EEEEEECCCCHHHHHHHHHHHCCCEEEEEECCCCCEEEEECCCCEEEEEEEEHHHHHCCC
GIEQSRVLQKKNPAMKCLFMSAHAPDNVDGQKKLRVGVDFIEKPFGIDEFLRAIDQVLNS
CHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHEECHHHHHCCCCHHHHHHHHHHHHHH
EVEKI
HHHCC
>Mature Secondary Structure 
PTPLFDTCLSSDDLNAFDASQKPGTTTFNTLASLTELYDAIPASIIIIDERMRLIGWNR
CCCHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCHHHHCCCC
FSRDTINGLSDNEMPGINPMKRVHPDDLPEMIRKMRNVIDLDIELSAEFRMYHKSGPPYK
CCHHHCCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHEECEEEECCEEEEEECCCCCEE
WAMCRGKRTIIEGKTCVVAVVTEITDLKEAEEQRKKLQEQLLQLQKMELVGQLASGIAHD
EEEECCCEEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FNNALAAIIGNTELALKKLDPANPAVSNITDIHTLATRSANLTRQLLAFARKQMAMPRVL
HHHHHHHHCCCCHHEEEECCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHH
NLTEEVSDCLRLYQRLIDKNIHLEWHLCDEPIQVKLDPTQLEQILSNLLVNARDAIDGSG
HHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEECHHHHHHHHHHHHHHHHHCCCCCC
CITVRCEGARFEPTDGKTCNPRLSPGDYARLSITDSGCGIEASVLPHIYEPFFTTKEIGK
EEEEEECCCEECCCCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHCCCCCHHHHCC
GIGLGLSSVYGIVRQNNGHIECHSEPGKGTTFDIWLPLHQESQQKTDVHADKPQTELKTK
CCCCCHHHHHHHHCCCCCEEEEECCCCCCCEEEEEEECCCCCCHHCCCCCCCCHHHHCCC
AKIMVVEDEPYILKLVQDILESHEFTVFTATDADQCLLAAKTHEYRIDLLVTDVVLPTMN
EEEEEECCCCHHHHHHHHHHHCCCEEEEEECCCCCEEEEECCCCEEEEEEEEHHHHHCCC
GIEQSRVLQKKNPAMKCLFMSAHAPDNVDGQKKLRVGVDFIEKPFGIDEFLRAIDQVLNS
CHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHEECHHHHHCCCCHHHHHHHHHHHHHH
EVEKI
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA