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The map label for this gene is lpxK [H]

Identifier: 21674494

GI number: 21674494

Start: 1586755

End: 1587831

Strand: Direct

Name: lpxK [H]

Synonym: CT1676

Alternate gene names: 21674494

Gene position: 1586755-1587831 (Clockwise)

Preceding gene: 21674493

Following gene: 21674496

Centisome position: 73.63

GC content: 60.17

Gene sequence:

>1077_bases
ATGAACTCTCAACAGGATTTGACGATGCATAACCGCAGCGCCGCCATCCTCCTGCGCCCCGCCGCCGCACTCTACGGCAT
GGTGATGAGCCTGCGCAACTGCCTCTACGACCAGGGGATTTTCAAGAGCTGGCATTCGCCGATTCCTGTGGTTTCTGTCG
GCAACATCACCACCGGTGGCACCGGCAAAACCCCGCTCGTGGACTGGATCGTCAAGTTCTACGAAGCTTCCGGGATTGCA
ACAGCAATCGTATCGCGGGGTTACGGACGCCGGACAAAAGGCGTACAGCTCGTCTCGGATGGCGGCCGCCTGCTGCTCGG
CAGCCGCGACGCGGGCGACGAAACCGCGATGCTCGCCGCGCGAAATCCCCGCACCATCGTGGTGGTCGCCGAAAAGCGCG
TCGAAGGCGTGCAATTCCTGATGCACCAGTTCGCCGACCGCCTGCCCGGTGTGATCGTACTCGACGACGCATTCCAGCAC
CGCAAGATCGCGCGAGACCTCGACATCGTGGTGGTCAACGCCGGAGCGCCGGAGGAGATCGACGCAATGCTGCCCGCCGG
ACGTTTGCGCGAACCACTGCGAGGATTACGTCGCGCACACCTCATCATCCTCGGCAAAATCACCGACGACGCCAACTCCG
CGACGCTGCTCCAGACATTGCGTGAGACCGGCAAACCGGTGATCCGCTCGAAGATCAAACCAGGTAAACTGATACATGTG
GATGGATCGGAAAACGAAACGAATGAATCCGTCAAGACCCTCGCCTTCGCCGGAATCGGCGCACCGGAAGGGTTCCTGCA
CAGCCTCAAAACGGCAGGAATAAAGATTGCTGCAACAAAGTTTTTCCGGGACCACGAGCCTTATACAGAATCGGCGATCC
GCTCGATCATCGGCGAAGCGAAGCGGCAAGGCCTCGTACCGGTCACAACTGAGAAAGACTGGTTCCGCATCGCGGATGAG
CCGGAGCTTGCCGAAATGCTCCGGCAGGTAGGCTGCCGCTATCTGACGATTACCCCCGAATTCCCGGACGGGACGCAGGA
GTTGGAGAGGCAGTTGCTGGATGTGTTGAAGCGCTGA

Upstream 100 bases:

>100_bases
AGGTTTGAAATCCCGCTTCCCTTCAGCCGCGTCAGGGTCACGCTGCACGTCGTCCAGGTACCGGAGTTCCCGACCGAGGA
GGCCTTCCGCGCCTGGGCCG

Downstream 100 bases:

>100_bases
ACTAACTAAAAATCTATTTCGAAAAGAAGGATCCTCAGTCTTCCTTGACGATTTTCGATATGGCTTTAAAGGTATCACCT
TCAGCAACACGCAAGAGTTC

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase [H]

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MNSQQDLTMHNRSAAILLRPAAALYGMVMSLRNCLYDQGIFKSWHSPIPVVSVGNITTGGTGKTPLVDWIVKFYEASGIA
TAIVSRGYGRRTKGVQLVSDGGRLLLGSRDAGDETAMLAARNPRTIVVVAEKRVEGVQFLMHQFADRLPGVIVLDDAFQH
RKIARDLDIVVVNAGAPEEIDAMLPAGRLREPLRGLRRAHLIILGKITDDANSATLLQTLRETGKPVIRSKIKPGKLIHV
DGSENETNESVKTLAFAGIGAPEGFLHSLKTAGIKIAATKFFRDHEPYTESAIRSIIGEAKRQGLVPVTTEKDWFRIADE
PELAEMLRQVGCRYLTITPEFPDGTQELERQLLDVLKR

Sequences:

>Translated_358_residues
MNSQQDLTMHNRSAAILLRPAAALYGMVMSLRNCLYDQGIFKSWHSPIPVVSVGNITTGGTGKTPLVDWIVKFYEASGIA
TAIVSRGYGRRTKGVQLVSDGGRLLLGSRDAGDETAMLAARNPRTIVVVAEKRVEGVQFLMHQFADRLPGVIVLDDAFQH
RKIARDLDIVVVNAGAPEEIDAMLPAGRLREPLRGLRRAHLIILGKITDDANSATLLQTLRETGKPVIRSKIKPGKLIHV
DGSENETNESVKTLAFAGIGAPEGFLHSLKTAGIKIAATKFFRDHEPYTESAIRSIIGEAKRQGLVPVTTEKDWFRIADE
PELAEMLRQVGCRYLTITPEFPDGTQELERQLLDVLKR
>Mature_358_residues
MNSQQDLTMHNRSAAILLRPAAALYGMVMSLRNCLYDQGIFKSWHSPIPVVSVGNITTGGTGKTPLVDWIVKFYEASGIA
TAIVSRGYGRRTKGVQLVSDGGRLLLGSRDAGDETAMLAARNPRTIVVVAEKRVEGVQFLMHQFADRLPGVIVLDDAFQH
RKIARDLDIVVVNAGAPEEIDAMLPAGRLREPLRGLRRAHLIILGKITDDANSATLLQTLRETGKPVIRSKIKPGKLIHV
DGSENETNESVKTLAFAGIGAPEGFLHSLKTAGIKIAATKFFRDHEPYTESAIRSIIGEAKRQGLVPVTTEKDWFRIADE
PELAEMLRQVGCRYLTITPEFPDGTQELERQLLDVLKR

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) [H]

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family [H]

Homologues:

Organism=Escherichia coli, GI1787144, Length=298, Percent_Identity=29.8657718120805, Blast_Score=124, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003758 [H]

Pfam domain/function: PF02606 LpxK [H]

EC number: =2.7.1.130 [H]

Molecular weight: Translated: 39349; Mature: 39349

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSQQDLTMHNRSAAILLRPAAALYGMVMSLRNCLYDQGIFKSWHSPIPVVSVGNITTGG
CCCCCCCEECCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCEECCC
TGKTPLVDWIVKFYEASGIATAIVSRGYGRRTKGVQLVSDGGRLLLGSRDAGDETAMLAA
CCCCHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCEEEEECCCEEEEECCCCCCCEEEEEE
RNPRTIVVVAEKRVEGVQFLMHQFADRLPGVIVLDDAFQHRKIARDLDIVVVNAGAPEEI
CCCCEEEEEECCHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHCCCCEEEECCCCCHHH
DAMLPAGRLREPLRGLRRAHLIILGKITDDANSATLLQTLRETGKPVIRSKIKPGKLIHV
HHHCCCHHHHHHHHHHHHEEEEEEEEECCCCCHHHHHHHHHHHCCHHHHHCCCCCCEEEE
DGSENETNESVKTLAFAGIGAPEGFLHSLKTAGIKIAATKFFRDHEPYTESAIRSIIGEA
CCCCCCCHHHHHHHHEECCCCCHHHHHHHHHCCEEEEEHHHHHCCCCHHHHHHHHHHHHH
KRQGLVPVTTEKDWFRIADEPELAEMLRQVGCRYLTITPEFPDGTQELERQLLDVLKR
HHCCCCEEECCCCCEEECCCHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MNSQQDLTMHNRSAAILLRPAAALYGMVMSLRNCLYDQGIFKSWHSPIPVVSVGNITTGG
CCCCCCCEECCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCEECCC
TGKTPLVDWIVKFYEASGIATAIVSRGYGRRTKGVQLVSDGGRLLLGSRDAGDETAMLAA
CCCCHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCEEEEECCCEEEEECCCCCCCEEEEEE
RNPRTIVVVAEKRVEGVQFLMHQFADRLPGVIVLDDAFQHRKIARDLDIVVVNAGAPEEI
CCCCEEEEEECCHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHCCCCEEEECCCCCHHH
DAMLPAGRLREPLRGLRRAHLIILGKITDDANSATLLQTLRETGKPVIRSKIKPGKLIHV
HHHCCCHHHHHHHHHHHHEEEEEEEEECCCCCHHHHHHHHHHHCCHHHHHCCCCCCEEEE
DGSENETNESVKTLAFAGIGAPEGFLHSLKTAGIKIAATKFFRDHEPYTESAIRSIIGEA
CCCCCCCHHHHHHHHEECCCCCHHHHHHHHHCCEEEEEHHHHHCCCCHHHHHHHHHHHHH
KRQGLVPVTTEKDWFRIADEPELAEMLRQVGCRYLTITPEFPDGTQELERQLLDVLKR
HHCCCCEEECCCCCEEECCCHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]