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The map label for this gene is trpC

Identifier: 21674489

GI number: 21674489

Start: 1581845

End: 1582615

Strand: Reverse

Name: trpC

Synonym: CT1671

Alternate gene names: 21674489

Gene position: 1582615-1581845 (Counterclockwise)

Preceding gene: 21674490

Following gene: 21674483

Centisome position: 73.44

GC content: 59.53

Gene sequence:

>771_bases
ATGACCTATCTTACCCGGATTCTCGAGACCAAGGCAAGAGAGGTTGCCGAACTGAAAAAGCTGAAACCGGAGCGCCGCTA
TCGTGAGGCGTGCGGCGATCTTCCGGCGACGCGCGATTTCCGCTCGGCCATTACGAGCCGTGACGGCGGCATCAATCTCA
TCGCTGAAGTAAAAAAGGCATCGCCCTCGCGCGGCGTGCTCGTCGAGGATTTTCGTCCGCTTGACATCGCTGCGCGCTAC
GCCGAACTTGGCGCGTCGGCCTTCTCCGTCCTTACCGACTCCCACTACTTTCAGGGGTCGCCAGACTACTTGAAGGCGAT
CACGCAGCAGTTCTCCATTCCTGTGCTCCGCAAGGAGTTCATTATCGACGAGAGCCAGATTTACGAAACCCGCCTCATGG
GCGCGGATGCGGCGCTCCTCATCGTGGCGGCGCTCGAACCGTCGCAACTCCGCGACTACCTCCAGCTTTTCGCTGAACTT
GGCCTGCACGCGCTGGTCGAAGTGCACGATCGCCGTGAACTTGATATTGCCATCGAGCAGGGTTCTACGATTGTCGGGGT
CAACAACCGCGATCTGCGCGACTTCACCGTCGATCTCATGACCTCGGTTAACCTGAAGCGGGAGTATCCTGAAGGCGTGC
TCTCCGTCGCTGAAAGCGGCCTGAAACGCCGCGACGATGTGCTGCTCATGCAGGACGCCGGCTTTGACGCTGTGCTCATC
GGCGAGGGTTTGCTGGCAAGCGAGGAGTTGAGGCAGTTCTCGTGGGGTTAG

Upstream 100 bases:

>100_bases
TTCATCAGGCGACCGGCATCGACCCGTGGTTCCTTGACAACATCCGACAGATCGTCGAATTCGAGGACGAACTTCGACAG
ATGGCAGCTGGAAGCGCGGC

Downstream 100 bases:

>100_bases
GGGGAGTGGTGGACAGATAACTTCCGGAAATCTTCTCTTTTCATAGAAGACTTATAGGCCCTGTGAGACCTATAAGTCTT
TTTCTTTTCTTACTCCAGCC

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 256; Mature: 255

Protein sequence:

>256_residues
MTYLTRILETKAREVAELKKLKPERRYREACGDLPATRDFRSAITSRDGGINLIAEVKKASPSRGVLVEDFRPLDIAARY
AELGASAFSVLTDSHYFQGSPDYLKAITQQFSIPVLRKEFIIDESQIYETRLMGADAALLIVAALEPSQLRDYLQLFAEL
GLHALVEVHDRRELDIAIEQGSTIVGVNNRDLRDFTVDLMTSVNLKREYPEGVLSVAESGLKRRDDVLLMQDAGFDAVLI
GEGLLASEELRQFSWG

Sequences:

>Translated_256_residues
MTYLTRILETKAREVAELKKLKPERRYREACGDLPATRDFRSAITSRDGGINLIAEVKKASPSRGVLVEDFRPLDIAARY
AELGASAFSVLTDSHYFQGSPDYLKAITQQFSIPVLRKEFIIDESQIYETRLMGADAALLIVAALEPSQLRDYLQLFAEL
GLHALVEVHDRRELDIAIEQGSTIVGVNNRDLRDFTVDLMTSVNLKREYPEGVLSVAESGLKRRDDVLLMQDAGFDAVLI
GEGLLASEELRQFSWG
>Mature_255_residues
TYLTRILETKAREVAELKKLKPERRYREACGDLPATRDFRSAITSRDGGINLIAEVKKASPSRGVLVEDFRPLDIAARYA
ELGASAFSVLTDSHYFQGSPDYLKAITQQFSIPVLRKEFIIDESQIYETRLMGADAALLIVAALEPSQLRDYLQLFAELG
LHALVEVHDRRELDIAIEQGSTIVGVNNRDLRDFTVDLMTSVNLKREYPEGVLSVAESGLKRRDDVLLMQDAGFDAVLIG
EGLLASEELRQFSWG

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=250, Percent_Identity=38, Blast_Score=144, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6322638, Length=230, Percent_Identity=40.4347826086956, Blast_Score=158, Evalue=8e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_CHLTE (Q8KBW1)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_662554.1
- ProteinModelPortal:   Q8KBW1
- SMR:   Q8KBW1
- GeneID:   1006764
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT1671
- NMPDR:   fig|194439.1.peg.1648
- TIGR:   CT1671
- HOGENOM:   HBG540956
- OMA:   VDLPLLC
- ProtClustDB:   PRK00278
- BioCyc:   CTEP194439:CT_1671-MONOMER
- BRENDA:   4.1.1.48
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 28665; Mature: 28534

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYLTRILETKAREVAELKKLKPERRYREACGDLPATRDFRSAITSRDGGINLIAEVKKA
CHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHC
SPSRGVLVEDFRPLDIAARYAELGASAFSVLTDSHYFQGSPDYLKAITQQFSIPVLRKEF
CCCCCEEECCCCCHHHHHHHHHHCHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHH
IIDESQIYETRLMGADAALLIVAALEPSQLRDYLQLFAELGLHALVEVHDRRELDIAIEQ
HCCHHHHHHHHHCCCCHHEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEC
GSTIVGVNNRDLRDFTVDLMTSVNLKREYPEGVLSVAESGLKRRDDVLLMQDAGFDAVLI
CCEEEECCCCCHHHHHHHHHHHCCCCHHCHHHHHHHHHHHHCCCCCEEEEECCCCCEEEE
GEGLLASEELRQFSWG
CCCCHHHHHHHHCCCC
>Mature Secondary Structure 
TYLTRILETKAREVAELKKLKPERRYREACGDLPATRDFRSAITSRDGGINLIAEVKKA
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHC
SPSRGVLVEDFRPLDIAARYAELGASAFSVLTDSHYFQGSPDYLKAITQQFSIPVLRKEF
CCCCCEEECCCCCHHHHHHHHHHCHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHH
IIDESQIYETRLMGADAALLIVAALEPSQLRDYLQLFAELGLHALVEVHDRRELDIAIEQ
HCCHHHHHHHHHCCCCHHEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEC
GSTIVGVNNRDLRDFTVDLMTSVNLKREYPEGVLSVAESGLKRRDDVLLMQDAGFDAVLI
CCEEEECCCCCHHHHHHHHHHHCCCCHHCHHHHHHHHHHHHCCCCCEEEEECCCCCEEEE
GEGLLASEELRQFSWG
CCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901