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The map label for this gene is leuS [H]

Identifier: 21674468

GI number: 21674468

Start: 1561714

End: 1564137

Strand: Direct

Name: leuS [H]

Synonym: CT1650

Alternate gene names: 21674468

Gene position: 1561714-1564137 (Clockwise)

Preceding gene: 21674467

Following gene: 229026532

Centisome position: 72.47

GC content: 59.69

Gene sequence:

>2424_bases
ATGAAATACGACTTTTCAGCTTTAGAGAAAAAGTGGCAGTCCCGTTGGGCAGATGAGCAGACCTTTGCCTCCTCCGCCGA
CCAAGAGAAGCCAAAATATTACGTGCTCGACATGTTCCCCTATCCGAGCGGTTCGGGACTGCACGTCGGCCACCTCGAAG
GCTATACGGCCACCGACATCATGGCGCGCTACAAGCGCTGCCAAGGCCACAACGTGCTGCACCCGATGGGCTGGGACGCC
TTCGGCCTGCCCGCCGAGCAGTTCGCCATCAAGACCGGCACCCACCCGCGCCTGACAACCGAAAAGAACGTCGCCAGCTT
CCGGGAGACCCTCAAGAGCATGGGCTTCTCCTACGACTGGAGCCGCGAGATCAACACCACCGACCCGAACTACTTCAAGT
GGACGCAGTGGATTTTCCTCAAGCTCTACGAAAAAGGGCTAGCCTACATCTCGGAGGTGGACGTCAACTGGTGCGAAGAG
CTGAAAGTGGTGCTGGCCAACGAAGAGGTGGACGAGAAAATCGCTGACGGCTACACTGTGGTGCGCCGCCCACTGCGCCA
GTGGGTGCTGAAGATCACCGCCTACGCCGAGCGGCTGCTGAAGGATCTGGACGAGGTTGACTGGCCGGAGAACGTCAAGC
AGATGCAGCGCAACTGGATCGGGCGCTCTGAGGGCATGGAGATCGACTTCGAGCTGCGGTGCCACCGCACCAACCTGCGG
GTCTATACCACCCGTCCGGACACGCTTTTTGGCGCGACGTATCTCGTCATTTCGCCGGAGCACCCGATGGCCGAAAAGCT
CGCCATCGCCCAGCAGCTCGTCGCGGTCAAAAAATATATCGAACAGGCGAAGCTCAAAACCGAGCTGGAGCGTACCGGTT
TGCAGAAAGAAAAAACCGGCGTCTTCACCGGCTCCTACGCGATCAATCCGGCCAACGGCGAGGCGCTGCCGGTCTGGATT
TCGGACTTCGTGCTCACCAGCTACGGCACCGGCGCGATCATGTCCGTCCCGGCGCACGACAGCCGCGACTGGGAGTTCGC
AAAAAAATTCGGCCTGCCGATCCGCGAAGTCATCAAAAGCCCGCATGACGTGCAGGAGAGGGTGTTTGACGGCAAGGAGA
GCGTTTGCGTGAACTCCGCGAACGACGAAATCAGCATCAACGGCCTCGACTTCAAAACCGCCTTCGACCGCATGGCCGCC
TGGCTGGAGTCGAAAGGCAAGGGCAAACGCAAGGTCAACTACAAGTTGCGCGACTGGGTCTTCAGCCGCCAGCGCTACTG
GGGCGAGCCAATCCCGATCAAGCATTACGAAGACGGCACGATGCGCCCCGAAACCAACCTGCCGCTTACGCTTCCGGAGG
TCGAAGCTTACCAGCCCACCTCGACTGGCGAGTCGCCGCTGGCCAACATCGAGAGCTGGCTCTACGGCGAGGACGAACAT
GGAAAGTTCCGCCGCGAGACCAACACCATGCCGCAGTGGGCTGGAAGCTGCTGGTACTACCTACGCTTCATCGATCCGCA
GAACAGCGACGCGCTGGTCGATCCGTCGCTCGAACAGTACTGGATGAACGTCGATCTCTACATCGGCGGCGCGGAGCACG
CAGTGCTGCACCTGCTCTACTCACGCTTCTGGCACAAGGTGCTCTACGACCTCGGCGTGGTGAGCACCAAAGAGCCGTTC
CAGCGCCTCTTCAACCAGGGCATGATTCTCGGCGAAGACAACGAAAAGATGTCCAAATCGCGCGGCAACGTCATCCCCGC
CGACCACGTGCTGAGCACCTACGGCGCGGACGCACTGAGGCTCTACGAAATGTTCCTCGGCCCGCTTGACCAGGTCAAGC
CCTGGAACACCCACGGCATCGAAGGCATCAGCCGCTTTTTGAACAAGGTGTGGCGACTGGTCTGGGACGAAAACACCGAG
ACGCAGAAAACCACCGAGGACAAACCGTCGGAAGCCATCCTCAAACGGATGCACAAAGCGATCAAAAAGGTGACCGAAGA
TACCGAGCAGCTCAAATTCAACACCGCCATTTCGGAGATGATGGTACTGGTCAACGAGCTGCACAAGGCGGGCTGCTACA
GCCGCGAGACGACTGAAACCCTGCTGGTGCTGCTCTCACCTTTCGCACCGCACATCACCGAGGAGCTGTGGCAGGCGCTC
GGCCACGCCGAATCGATCAGCGGAGCTGTATGGCCGGTCTTCGACGCGAAGCTTGCAACGGACGACGTGCTCACCATCGC
CGTGCAGGTCAACGGCAAGCTCCGCGGTACGTTTGAAGCTCCCGCGGGCTGCACGAAAGAGGAGATGATCGAGTCGGCCA
AAAAGGTCGAAAGCGTTGCGAAGTTCCTCGACGGGCAGCAGATCGTCAAGGAGATCGCCGTGCCCGGCAAGCTAGTGAAC
TTCGCCGTAAAACCGCAACAATGA

Upstream 100 bases:

>100_bases
GAAACCAAGGCAGTGCGGGGGAAATAACCCTGCACTGCCTTTTTTCATTACCGGCGCGGGATTATCTTCCCGGCAACATT
TTCGAACAGACCAACGACTC

Downstream 100 bases:

>100_bases
CAACGAAGCGATGAGATGAGGTTCTTAGTGTGATCAATTTTTTTCTGTAACTTCTTAATCACGATAATACAAGGGGTTCG
GCAGGCCCCTTACCAAGCTC

Product: leucyl-tRNA synthetase

Products: NA

Alternate protein names: Leucine--tRNA ligase; LeuRS [H]

Number of amino acids: Translated: 807; Mature: 807

Protein sequence:

>807_residues
MKYDFSALEKKWQSRWADEQTFASSADQEKPKYYVLDMFPYPSGSGLHVGHLEGYTATDIMARYKRCQGHNVLHPMGWDA
FGLPAEQFAIKTGTHPRLTTEKNVASFRETLKSMGFSYDWSREINTTDPNYFKWTQWIFLKLYEKGLAYISEVDVNWCEE
LKVVLANEEVDEKIADGYTVVRRPLRQWVLKITAYAERLLKDLDEVDWPENVKQMQRNWIGRSEGMEIDFELRCHRTNLR
VYTTRPDTLFGATYLVISPEHPMAEKLAIAQQLVAVKKYIEQAKLKTELERTGLQKEKTGVFTGSYAINPANGEALPVWI
SDFVLTSYGTGAIMSVPAHDSRDWEFAKKFGLPIREVIKSPHDVQERVFDGKESVCVNSANDEISINGLDFKTAFDRMAA
WLESKGKGKRKVNYKLRDWVFSRQRYWGEPIPIKHYEDGTMRPETNLPLTLPEVEAYQPTSTGESPLANIESWLYGEDEH
GKFRRETNTMPQWAGSCWYYLRFIDPQNSDALVDPSLEQYWMNVDLYIGGAEHAVLHLLYSRFWHKVLYDLGVVSTKEPF
QRLFNQGMILGEDNEKMSKSRGNVIPADHVLSTYGADALRLYEMFLGPLDQVKPWNTHGIEGISRFLNKVWRLVWDENTE
TQKTTEDKPSEAILKRMHKAIKKVTEDTEQLKFNTAISEMMVLVNELHKAGCYSRETTETLLVLLSPFAPHITEELWQAL
GHAESISGAVWPVFDAKLATDDVLTIAVQVNGKLRGTFEAPAGCTKEEMIESAKKVESVAKFLDGQQIVKEIAVPGKLVN
FAVKPQQ

Sequences:

>Translated_807_residues
MKYDFSALEKKWQSRWADEQTFASSADQEKPKYYVLDMFPYPSGSGLHVGHLEGYTATDIMARYKRCQGHNVLHPMGWDA
FGLPAEQFAIKTGTHPRLTTEKNVASFRETLKSMGFSYDWSREINTTDPNYFKWTQWIFLKLYEKGLAYISEVDVNWCEE
LKVVLANEEVDEKIADGYTVVRRPLRQWVLKITAYAERLLKDLDEVDWPENVKQMQRNWIGRSEGMEIDFELRCHRTNLR
VYTTRPDTLFGATYLVISPEHPMAEKLAIAQQLVAVKKYIEQAKLKTELERTGLQKEKTGVFTGSYAINPANGEALPVWI
SDFVLTSYGTGAIMSVPAHDSRDWEFAKKFGLPIREVIKSPHDVQERVFDGKESVCVNSANDEISINGLDFKTAFDRMAA
WLESKGKGKRKVNYKLRDWVFSRQRYWGEPIPIKHYEDGTMRPETNLPLTLPEVEAYQPTSTGESPLANIESWLYGEDEH
GKFRRETNTMPQWAGSCWYYLRFIDPQNSDALVDPSLEQYWMNVDLYIGGAEHAVLHLLYSRFWHKVLYDLGVVSTKEPF
QRLFNQGMILGEDNEKMSKSRGNVIPADHVLSTYGADALRLYEMFLGPLDQVKPWNTHGIEGISRFLNKVWRLVWDENTE
TQKTTEDKPSEAILKRMHKAIKKVTEDTEQLKFNTAISEMMVLVNELHKAGCYSRETTETLLVLLSPFAPHITEELWQAL
GHAESISGAVWPVFDAKLATDDVLTIAVQVNGKLRGTFEAPAGCTKEEMIESAKKVESVAKFLDGQQIVKEIAVPGKLVN
FAVKPQQ
>Mature_807_residues
MKYDFSALEKKWQSRWADEQTFASSADQEKPKYYVLDMFPYPSGSGLHVGHLEGYTATDIMARYKRCQGHNVLHPMGWDA
FGLPAEQFAIKTGTHPRLTTEKNVASFRETLKSMGFSYDWSREINTTDPNYFKWTQWIFLKLYEKGLAYISEVDVNWCEE
LKVVLANEEVDEKIADGYTVVRRPLRQWVLKITAYAERLLKDLDEVDWPENVKQMQRNWIGRSEGMEIDFELRCHRTNLR
VYTTRPDTLFGATYLVISPEHPMAEKLAIAQQLVAVKKYIEQAKLKTELERTGLQKEKTGVFTGSYAINPANGEALPVWI
SDFVLTSYGTGAIMSVPAHDSRDWEFAKKFGLPIREVIKSPHDVQERVFDGKESVCVNSANDEISINGLDFKTAFDRMAA
WLESKGKGKRKVNYKLRDWVFSRQRYWGEPIPIKHYEDGTMRPETNLPLTLPEVEAYQPTSTGESPLANIESWLYGEDEH
GKFRRETNTMPQWAGSCWYYLRFIDPQNSDALVDPSLEQYWMNVDLYIGGAEHAVLHLLYSRFWHKVLYDLGVVSTKEPF
QRLFNQGMILGEDNEKMSKSRGNVIPADHVLSTYGADALRLYEMFLGPLDQVKPWNTHGIEGISRFLNKVWRLVWDENTE
TQKTTEDKPSEAILKRMHKAIKKVTEDTEQLKFNTAISEMMVLVNELHKAGCYSRETTETLLVLLSPFAPHITEELWQAL
GHAESISGAVWPVFDAKLATDDVLTIAVQVNGKLRGTFEAPAGCTKEEMIESAKKVESVAKFLDGQQIVKEIAVPGKLVN
FAVKPQQ

Specific function: Unknown

COG id: COG0495

COG function: function code J; Leucyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI7661872, Length=880, Percent_Identity=33.5227272727273, Blast_Score=443, Evalue=1e-124,
Organism=Homo sapiens, GI94721239, Length=165, Percent_Identity=28.4848484848485, Blast_Score=67, Evalue=6e-11,
Organism=Homo sapiens, GI94721241, Length=165, Percent_Identity=28.4848484848485, Blast_Score=67, Evalue=6e-11,
Organism=Escherichia coli, GI1786861, Length=869, Percent_Identity=42.0023014959724, Blast_Score=644, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71997517, Length=802, Percent_Identity=28.6783042394015, Blast_Score=280, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI71997510, Length=802, Percent_Identity=28.6783042394015, Blast_Score=280, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI17510661, Length=869, Percent_Identity=21.6340621403913, Blast_Score=120, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI212645227, Length=316, Percent_Identity=26.5822784810127, Blast_Score=105, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17541896, Length=213, Percent_Identity=25.8215962441315, Blast_Score=67, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323414, Length=811, Percent_Identity=34.2786683107275, Blast_Score=431, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6321531, Length=497, Percent_Identity=21.7303822937626, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6325217, Length=357, Percent_Identity=24.0896358543417, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319395, Length=193, Percent_Identity=26.9430051813472, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21355409, Length=856, Percent_Identity=31.3084112149533, Blast_Score=358, Evalue=9e-99,
Organism=Drosophila melanogaster, GI17864482, Length=877, Percent_Identity=23.1470923603193, Blast_Score=120, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24653289, Length=877, Percent_Identity=23.1470923603193, Blast_Score=120, Evalue=5e-27,
Organism=Drosophila melanogaster, GI28574730, Length=166, Percent_Identity=29.5180722891566, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24668547, Length=166, Percent_Identity=29.5180722891566, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24668543, Length=166, Percent_Identity=29.5180722891566, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002300
- InterPro:   IPR002302
- InterPro:   IPR014729
- InterPro:   IPR009080
- InterPro:   IPR013155
- InterPro:   IPR009008 [H]

Pfam domain/function: PF08264 Anticodon_1; PF00133 tRNA-synt_1 [H]

EC number: =6.1.1.4 [H]

Molecular weight: Translated: 92479; Mature: 92479

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYDFSALEKKWQSRWADEQTFASSADQEKPKYYVLDMFPYPSGSGLHVGHLEGYTATDI
CCCCHHHHHHHHHHHCCCHHHHHCCCCCCCCCEEEEEECCCCCCCCEEEECCCCCHHHHH
MARYKRCQGHNVLHPMGWDAFGLPAEQFAIKTGTHPRLTTEKNVASFRETLKSMGFSYDW
HHHHHHHCCCCCCCCCCCCCCCCCHHHHEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCC
SREINTTDPNYFKWTQWIFLKLYEKGLAYISEVDVNWCEELKVVLANEEVDEKIADGYTV
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHCCHHH
VRRPLRQWVLKITAYAERLLKDLDEVDWPENVKQMQRNWIGRSEGMEIDFELRCHRTNLR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEEEEEEEEECCEE
VYTTRPDTLFGATYLVISPEHPMAEKLAIAQQLVAVKKYIEQAKLKTELERTGLQKEKTG
EEECCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCC
VFTGSYAINPANGEALPVWISDFVLTSYGTGAIMSVPAHDSRDWEFAKKFGLPIREVIKS
EEECCEEECCCCCCEEEEEHHHHHHHCCCCCCEEECCCCCCCCHHHHHHHCCCHHHHHCC
PHDVQERVFDGKESVCVNSANDEISINGLDFKTAFDRMAAWLESKGKGKRKVNYKLRDWV
CHHHHHHHHCCCCCEEEECCCCEEEECCCCHHHHHHHHHHHHHHCCCCCEEECHHHHHHH
FSRQRYWGEPIPIKHYEDGTMRPETNLPLTLPEVEAYQPTSTGESPLANIESWLYGEDEH
HHHHHHCCCCCCCEECCCCCCCCCCCCCEECCCCCCCCCCCCCCCHHHHHHHHHCCCCCC
GKFRRETNTMPQWAGSCWYYLRFIDPQNSDALVDPSLEQYWMNVDLYIGGAEHAVLHLLY
CCHHHHCCCCCCCCCCEEEEEEEECCCCCCCEECCCHHHHEEEEEEEECCHHHHHHHHHH
SRFWHKVLYDLGVVSTKEPFQRLFNQGMILGEDNEKMSKSRGNVIPADHVLSTYGADALR
HHHHHHHHHHHCCCCCHHHHHHHHHCCEEECCCCHHHHHHCCCCCCHHHHHHHHCHHHHH
LYEMFLGPLDQVKPWNTHGIEGISRFLNKVWRLVWDENTETQKTTEDKPSEAILKRMHKA
HHHHHHCCHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHH
IKKVTEDTEQLKFNTAISEMMVLVNELHKAGCYSRETTETLLVLLSPFAPHITEELWQAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHH
GHAESISGAVWPVFDAKLATDDVLTIAVQVNGKLRGTFEAPAGCTKEEMIESAKKVESVA
CCHHHCCCCCCCHHCCHHCCCCEEEEEEEECCEEEEEECCCCCCCHHHHHHHHHHHHHHH
KFLDGQQIVKEIAVPGKLVNFAVKPQQ
HHHCHHHHHHHHCCCCCEEEEEECCCC
>Mature Secondary Structure
MKYDFSALEKKWQSRWADEQTFASSADQEKPKYYVLDMFPYPSGSGLHVGHLEGYTATDI
CCCCHHHHHHHHHHHCCCHHHHHCCCCCCCCCEEEEEECCCCCCCCEEEECCCCCHHHHH
MARYKRCQGHNVLHPMGWDAFGLPAEQFAIKTGTHPRLTTEKNVASFRETLKSMGFSYDW
HHHHHHHCCCCCCCCCCCCCCCCCHHHHEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCC
SREINTTDPNYFKWTQWIFLKLYEKGLAYISEVDVNWCEELKVVLANEEVDEKIADGYTV
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHCCHHH
VRRPLRQWVLKITAYAERLLKDLDEVDWPENVKQMQRNWIGRSEGMEIDFELRCHRTNLR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEEEEEEEEECCEE
VYTTRPDTLFGATYLVISPEHPMAEKLAIAQQLVAVKKYIEQAKLKTELERTGLQKEKTG
EEECCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCC
VFTGSYAINPANGEALPVWISDFVLTSYGTGAIMSVPAHDSRDWEFAKKFGLPIREVIKS
EEECCEEECCCCCCEEEEEHHHHHHHCCCCCCEEECCCCCCCCHHHHHHHCCCHHHHHCC
PHDVQERVFDGKESVCVNSANDEISINGLDFKTAFDRMAAWLESKGKGKRKVNYKLRDWV
CHHHHHHHHCCCCCEEEECCCCEEEECCCCHHHHHHHHHHHHHHCCCCCEEECHHHHHHH
FSRQRYWGEPIPIKHYEDGTMRPETNLPLTLPEVEAYQPTSTGESPLANIESWLYGEDEH
HHHHHHCCCCCCCEECCCCCCCCCCCCCEECCCCCCCCCCCCCCCHHHHHHHHHCCCCCC
GKFRRETNTMPQWAGSCWYYLRFIDPQNSDALVDPSLEQYWMNVDLYIGGAEHAVLHLLY
CCHHHHCCCCCCCCCCEEEEEEEECCCCCCCEECCCHHHHEEEEEEEECCHHHHHHHHHH
SRFWHKVLYDLGVVSTKEPFQRLFNQGMILGEDNEKMSKSRGNVIPADHVLSTYGADALR
HHHHHHHHHHHCCCCCHHHHHHHHHCCEEECCCCHHHHHHCCCCCCHHHHHHHHCHHHHH
LYEMFLGPLDQVKPWNTHGIEGISRFLNKVWRLVWDENTETQKTTEDKPSEAILKRMHKA
HHHHHHCCHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHH
IKKVTEDTEQLKFNTAISEMMVLVNELHKAGCYSRETTETLLVLLSPFAPHITEELWQAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHH
GHAESISGAVWPVFDAKLATDDVLTIAVQVNGKLRGTFEAPAGCTKEEMIESAKKVESVA
CCHHHCCCCCCCHHCCHHCCCCEEEEEEEECCEEEEEECCCCCCCHHHHHHHHHHHHHHH
KFLDGQQIVKEIAVPGKLVNFAVKPQQ
HHHCHHHHHHHHCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA