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The map label for this gene is panC

Identifier: 21674465

GI number: 21674465

Start: 1558348

End: 1559202

Strand: Direct

Name: panC

Synonym: CT1647

Alternate gene names: 21674465

Gene position: 1558348-1559202 (Clockwise)

Preceding gene: 21674464

Following gene: 21674466

Centisome position: 72.31

GC content: 60.0

Gene sequence:

>855_bases
ATGCAGATCATCAATGACCCCGCCGAGATGCAGAAGATCGCCGAAAAACTGCGTCTCCAGCACCAGTATATCGGCGTCGT
CATGACGATGGGCGCGCTGCACGAGGGGCACCTGAGTCTGGTAAAACTTGCGAAAGCGCATGCCGGAACGGTCATTATGA
CCATCTTCGTCAACCCGACGCAATTCGGCCCGAACGAAGATTTTTACCGTTATCCAAGACCCTTCGAACAGGACGCCGCG
CTGGCGCGTTCGGCAGGCGTTGACTACCTGTTTGCGCCTTCGACGGAAGCGATGTACCCGGATGGATACTCGACCAGCAT
CGATCCCGGCCCCATCGCCACGCGCTTCGAGGGCGCTTCCCGACCCGGCCACTTCGGCGGCATGGTTACGGTAGTGGTCA
AACTGCTCGGCATCACGCGACCGCACCTGGCCGTCTTTGGCGAGAAGGACGCCCAGCAGCTCGCCATCATCCGGCGCGTG
GTGACCGATCTGAACATCGGCACCACGATTCTCGGGGCTCCGATCGTGCGCGAAAGCGACGGGCTGGCCACCAGTTCGCG
GAACATCTATCTCTCGTCGAACGAACGCCAGCAGGCAACGGTGCTTTACCGCGCCATCCGGTACGCGAAGATGGAGATCG
ACAAAGACCGCACCGATCTAGAGGCGATTGCTGGCGAAGCTGAAGCGCTGGTGCGTTCCGAGCCTGATGCCGAACCCGAT
TATCTCTGCTTTGTCGATGACGCCACTTTCGAGCCGGTCACGCAGGCGGTTACCGGCAAAGCCTACCGGCTCATCATGGC
TGTGCGCATCGGTTCGACCAGGCTGATCGACAACTGGCGGTTTGACTATCAGTAA

Upstream 100 bases:

>100_bases
CCCGATGAACTGGCGAACCACTTCACCGGCCAGAAGCAGCGGGGCGAATTCGTCGTGGTCGTCCATCCGCCAGACAAACA
TTCAAAAAAGAGACAGGAAC

Downstream 100 bases:

>100_bases
TGCACAAAAGCGGAACCGCATGAAAGCGCTGCCGATACTGAAAGGCAACAAATTTATAGTATATTATTTGACTTTGTAAT
TTTTTGAATTGGCTTCGACC

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MQIINDPAEMQKIAEKLRLQHQYIGVVMTMGALHEGHLSLVKLAKAHAGTVIMTIFVNPTQFGPNEDFYRYPRPFEQDAA
LARSAGVDYLFAPSTEAMYPDGYSTSIDPGPIATRFEGASRPGHFGGMVTVVVKLLGITRPHLAVFGEKDAQQLAIIRRV
VTDLNIGTTILGAPIVRESDGLATSSRNIYLSSNERQQATVLYRAIRYAKMEIDKDRTDLEAIAGEAEALVRSEPDAEPD
YLCFVDDATFEPVTQAVTGKAYRLIMAVRIGSTRLIDNWRFDYQ

Sequences:

>Translated_284_residues
MQIINDPAEMQKIAEKLRLQHQYIGVVMTMGALHEGHLSLVKLAKAHAGTVIMTIFVNPTQFGPNEDFYRYPRPFEQDAA
LARSAGVDYLFAPSTEAMYPDGYSTSIDPGPIATRFEGASRPGHFGGMVTVVVKLLGITRPHLAVFGEKDAQQLAIIRRV
VTDLNIGTTILGAPIVRESDGLATSSRNIYLSSNERQQATVLYRAIRYAKMEIDKDRTDLEAIAGEAEALVRSEPDAEPD
YLCFVDDATFEPVTQAVTGKAYRLIMAVRIGSTRLIDNWRFDYQ
>Mature_284_residues
MQIINDPAEMQKIAEKLRLQHQYIGVVMTMGALHEGHLSLVKLAKAHAGTVIMTIFVNPTQFGPNEDFYRYPRPFEQDAA
LARSAGVDYLFAPSTEAMYPDGYSTSIDPGPIATRFEGASRPGHFGGMVTVVVKLLGITRPHLAVFGEKDAQQLAIIRRV
VTDLNIGTTILGAPIVRESDGLATSSRNIYLSSNERQQATVLYRAIRYAKMEIDKDRTDLEAIAGEAEALVRSEPDAEPD
YLCFVDDATFEPVTQAVTGKAYRLIMAVRIGSTRLIDNWRFDYQ

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=283, Percent_Identity=39.9293286219081, Blast_Score=199, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6322046, Length=280, Percent_Identity=33.9285714285714, Blast_Score=153, Evalue=3e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_CHLTE (Q8KBY5)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_662530.1
- ProteinModelPortal:   Q8KBY5
- SMR:   Q8KBY5
- GeneID:   1006779
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT1647
- NMPDR:   fig|194439.1.peg.1624
- TIGR:   CT1647
- HOGENOM:   HBG428839
- OMA:   EDFGSYP
- ProtClustDB:   PRK00380
- BioCyc:   CTEP194439:CT_1647-MONOMER
- BRENDA:   6.3.2.1
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 31471; Mature: 31471

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: NA

Important sites: ACT_SITE 37-37 BINDING 61-61 BINDING 61-61 BINDING 153-153 BINDING 176-176

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIINDPAEMQKIAEKLRLQHQYIGVVMTMGALHEGHLSLVKLAKAHAGTVIMTIFVNPT
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEEEEECCC
QFGPNEDFYRYPRPFEQDAALARSAGVDYLFAPSTEAMYPDGYSTSIDPGPIATRFEGAS
CCCCCCCCCCCCCCCCHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCC
RPGHFGGMVTVVVKLLGITRPHLAVFGEKDAQQLAIIRRVVTDLNIGTTILGAPIVRESD
CCCCCCHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHCCCCHHHHCCCCEECCC
GLATSSRNIYLSSNERQQATVLYRAIRYAKMEIDKDRTDLEAIAGEAEALVRSEPDAEPD
CCEECCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCC
YLCFVDDATFEPVTQAVTGKAYRLIMAVRIGSTRLIDNWRFDYQ
EEEEECCCCCCHHHHHHCCHHEEEEEEEEECCEEEEECCCCCCC
>Mature Secondary Structure
MQIINDPAEMQKIAEKLRLQHQYIGVVMTMGALHEGHLSLVKLAKAHAGTVIMTIFVNPT
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEEEEECCC
QFGPNEDFYRYPRPFEQDAALARSAGVDYLFAPSTEAMYPDGYSTSIDPGPIATRFEGAS
CCCCCCCCCCCCCCCCHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCC
RPGHFGGMVTVVVKLLGITRPHLAVFGEKDAQQLAIIRRVVTDLNIGTTILGAPIVRESD
CCCCCCHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHCCCCHHHHCCCCEECCC
GLATSSRNIYLSSNERQQATVLYRAIRYAKMEIDKDRTDLEAIAGEAEALVRSEPDAEPD
CCEECCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCC
YLCFVDDATFEPVTQAVTGKAYRLIMAVRIGSTRLIDNWRFDYQ
EEEEECCCCCCHHHHHHCCHHEEEEEEEEECCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901