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The map label for this gene is adk

Identifier: 21674011

GI number: 21674011

Start: 1114446

End: 1115102

Strand: Direct

Name: adk

Synonym: CT1185

Alternate gene names: 21674011

Gene position: 1114446-1115102 (Clockwise)

Preceding gene: 21674010

Following gene: 21674013

Centisome position: 51.72

GC content: 57.23

Gene sequence:

>657_bases
ATGAGAATAATCCTGTTGGGCGCGCCGGGCGCCGGCAAAGGAACACAGGCACAATATATTTCTGAAGCTTTTGGCATACC
CCAGATATCGACCGGCGACATGCTGCGTGCCGCTGTCAAGGCAGCCACTCCTCTTGGACTCGCAGCCAAAAAGATCATGG
ATGAGGGTGGACTCGTCCCGGACGACCTCATCATCAGCCTTGTCAAAGAGCGCATAGCGCAACCAGACTGCGCCAATGGC
TGCCTTTTTGACGGCTTCCCGCGCACCCTGGCCCAAGCCGAAGCCCTGAGAGCTGGGGGTATTCGAATCGACCATATCAT
TGAAATGAACGTCCCTGACGAAGAGATCATCAAACGCATGAGCGGACGCCGCGTCCATCTCGCCTCTGGCCGCACCTACC
ACGTCACATTCAACCCACCAGCTGTACCGGACAAGGACGACCTCACTGGTGAACCGCTGGTGCAGCGCAACGACGACTGC
GAAGAGACCGTTCGCAAGCGACTGAAAGCCTACCACGAGCTGACCGAACCGCTGGTCGGCTACTATCGCAACCTCTCGAT
GAACGGCTCCGCTGACGCTCCGAAATACTCCAGAATCGCAGGAATCGGCACCGTCGAACAGATCAAAGATGAGATCATCG
CCACCCTCAACGGCTAA

Upstream 100 bases:

>100_bases
CACTGCCCCGGATTCGGATGTCGAAGAGGTGAAAAAACCGGCCAAACCGAAAATTACCGTCATCTCCCTGAAAAAAAATT
CATAAAAAGACTATCGTTTC

Downstream 100 bases:

>100_bases
CTGCCGGGTGCATATCGTGAAAAAAAAAGCCAGTTTGAACCACTGGCTTTTTTTCATTATGAATGATGAACTTTGAATGA
GCAATCTTTTTCCTGCCCTT

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MRIILLGAPGAGKGTQAQYISEAFGIPQISTGDMLRAAVKAATPLGLAAKKIMDEGGLVPDDLIISLVKERIAQPDCANG
CLFDGFPRTLAQAEALRAGGIRIDHIIEMNVPDEEIIKRMSGRRVHLASGRTYHVTFNPPAVPDKDDLTGEPLVQRNDDC
EETVRKRLKAYHELTEPLVGYYRNLSMNGSADAPKYSRIAGIGTVEQIKDEIIATLNG

Sequences:

>Translated_218_residues
MRIILLGAPGAGKGTQAQYISEAFGIPQISTGDMLRAAVKAATPLGLAAKKIMDEGGLVPDDLIISLVKERIAQPDCANG
CLFDGFPRTLAQAEALRAGGIRIDHIIEMNVPDEEIIKRMSGRRVHLASGRTYHVTFNPPAVPDKDDLTGEPLVQRNDDC
EETVRKRLKAYHELTEPLVGYYRNLSMNGSADAPKYSRIAGIGTVEQIKDEIIATLNG
>Mature_218_residues
MRIILLGAPGAGKGTQAQYISEAFGIPQISTGDMLRAAVKAATPLGLAAKKIMDEGGLVPDDLIISLVKERIAQPDCANG
CLFDGFPRTLAQAEALRAGGIRIDHIIEMNVPDEEIIKRMSGRRVHLASGRTYHVTFNPPAVPDKDDLTGEPLVQRNDDC
EETVRKRLKAYHELTEPLVGYYRNLSMNGSADAPKYSRIAGIGTVEQIKDEIIATLNG

Specific function: This small ubiquitous enzyme is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI4502013, Length=197, Percent_Identity=47.2081218274112, Blast_Score=196, Evalue=9e-51,
Organism=Homo sapiens, GI7524346, Length=197, Percent_Identity=47.2081218274112, Blast_Score=196, Evalue=9e-51,
Organism=Homo sapiens, GI19923437, Length=185, Percent_Identity=47.027027027027, Blast_Score=169, Evalue=1e-42,
Organism=Homo sapiens, GI310110345, Length=184, Percent_Identity=42.3913043478261, Blast_Score=152, Evalue=2e-37,
Organism=Homo sapiens, GI53832003, Length=184, Percent_Identity=42.3913043478261, Blast_Score=152, Evalue=2e-37,
Organism=Homo sapiens, GI8051579, Length=184, Percent_Identity=42.3913043478261, Blast_Score=152, Evalue=2e-37,
Organism=Homo sapiens, GI53832001, Length=184, Percent_Identity=42.3913043478261, Blast_Score=152, Evalue=2e-37,
Organism=Homo sapiens, GI22749187, Length=193, Percent_Identity=28.4974093264249, Blast_Score=98, Evalue=6e-21,
Organism=Homo sapiens, GI4502011, Length=198, Percent_Identity=28.7878787878788, Blast_Score=95, Evalue=4e-20,
Organism=Homo sapiens, GI28144899, Length=183, Percent_Identity=28.4153005464481, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI28144897, Length=183, Percent_Identity=28.4153005464481, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI21450759, Length=139, Percent_Identity=29.4964028776978, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI237858799, Length=138, Percent_Identity=29.7101449275362, Blast_Score=73, Evalue=2e-13,
Organism=Escherichia coli, GI1786680, Length=212, Percent_Identity=60.8490566037736, Blast_Score=267, Evalue=5e-73,
Organism=Caenorhabditis elegans, GI17552384, Length=199, Percent_Identity=45.2261306532663, Blast_Score=194, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17537943, Length=208, Percent_Identity=30.7692307692308, Blast_Score=115, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17567503, Length=217, Percent_Identity=29.9539170506912, Blast_Score=97, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17550688, Length=189, Percent_Identity=25.9259259259259, Blast_Score=70, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6320432, Length=198, Percent_Identity=48.4848484848485, Blast_Score=199, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6321018, Length=196, Percent_Identity=41.8367346938776, Blast_Score=152, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6322828, Length=187, Percent_Identity=28.3422459893048, Blast_Score=81, Evalue=2e-16,
Organism=Drosophila melanogaster, GI22026816, Length=198, Percent_Identity=47.4747474747475, Blast_Score=196, Evalue=1e-50,
Organism=Drosophila melanogaster, GI17737899, Length=182, Percent_Identity=44.5054945054945, Blast_Score=155, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24645822, Length=182, Percent_Identity=44.5054945054945, Blast_Score=155, Evalue=2e-38,
Organism=Drosophila melanogaster, GI17647141, Length=193, Percent_Identity=28.4974093264249, Blast_Score=84, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24663208, Length=193, Percent_Identity=28.4974093264249, Blast_Score=84, Evalue=9e-17,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_CHLTE (Q8KD69)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_662076.1
- ProteinModelPortal:   Q8KD69
- SMR:   Q8KD69
- GeneID:   1006547
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT1185
- NMPDR:   fig|194439.1.peg.1170
- TIGR:   CT1185
- HOGENOM:   HBG630208
- OMA:   RTYHVKY
- ProtClustDB:   PRK00279
- BioCyc:   CTEP194439:CT_1185-MONOMER
- BRENDA:   2.7.4.3
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid

EC number: =2.7.4.3

Molecular weight: Translated: 23621; Mature: 23621

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIILLGAPGAGKGTQAQYISEAFGIPQISTGDMLRAAVKAATPLGLAAKKIMDEGGLVP
CEEEEEECCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCH
DDLIISLVKERIAQPDCANGCLFDGFPRTLAQAEALRAGGIRIDHIIEMNVPDEEIIKRM
HHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEEEECCCCHHHHHHHH
SGRRVHLASGRTYHVTFNPPAVPDKDDLTGEPLVQRNDDCEETVRKRLKAYHELTEPLVG
CCCEEEEECCCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
YYRNLSMNGSADAPKYSRIAGIGTVEQIKDEIIATLNG
HHHCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MRIILLGAPGAGKGTQAQYISEAFGIPQISTGDMLRAAVKAATPLGLAAKKIMDEGGLVP
CEEEEEECCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCH
DDLIISLVKERIAQPDCANGCLFDGFPRTLAQAEALRAGGIRIDHIIEMNVPDEEIIKRM
HHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEEEECCCCHHHHHHHH
SGRRVHLASGRTYHVTFNPPAVPDKDDLTGEPLVQRNDDCEETVRKRLKAYHELTEPLVG
CCCEEEEECCCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
YYRNLSMNGSADAPKYSRIAGIGTVEQIKDEIIATLNG
HHHCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901