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The map label for this gene is argB

Identifier: 21673937

GI number: 21673937

Start: 1044791

End: 1045648

Strand: Direct

Name: argB

Synonym: CT1111

Alternate gene names: 21673937

Gene position: 1044791-1045648 (Clockwise)

Preceding gene: 21673936

Following gene: 21673938

Centisome position: 48.48

GC content: 58.51

Gene sequence:

>858_bases
ATGCTCGTCGAGGCGCTGCCCTACATCAGGAAATTCGAGGGCAAGACCTTCGTCATCAAGTATGGCGGCGCGGCCATGAA
GGACGAGGTGCTCAAGAACATCTTCGCAGAAAACGTCACACTCCTGCGCAAAGTGGGCATCAAGGTAGTGATCGTCCACG
GCGGAGGTGATGCCATCACCAAAACCTCCGCGAAACTTGGACTGGAAACAACCTTTGTTCACGGCAAGCGTGTGACGGAC
CGCCAGACCGTCGACGTGATCCAGATGACGCTCGCCGGAAAGGTGAACCAGGACATCGTGCAGCTCATCAACAAGGATGG
CGGCAACGCCGTTGGCGTCAGCGGTCTCGATGCCGACACGATCCTGGCCAAGCCATCCCCGAACGCCTCGACCCTCGGCC
TGGTCGGCGAGGTGGCGGAGATCAACACCCGCTACATCGACCTGCTCTGCGACGCAGGACTGATTCCGGTCATCGCGCCC
ATCGGCTACGACATGGAGGGCAACATCTACAACATCAACGCCGACGATGCGGCGGCGGCCATCGCCGTGGCGCTCAAGGC
TGAAAAACTGATCTACGTCAGCGACGTGGAGGGCGTGCGGGTCGGGAACCGGATTCTGAAAACGATCTGCAAGGCGGATG
CGGCTGAGCTCATCGAAAAAGGAATCATCACTGGCGGCATGATTCCCAAGGTCGTTTCGGCCTACCAGACGCTCGACGGC
GGCGTCGGTAAGGTGCACCTCATCGATGGTCAGATCACCCATTCGCTGCTGCTTGAAGTCTTCACCAACGAAGGCGTCGG
CACGCAGTTTGTCAACGAACTTGAACAAGAACCAACTGCTGAAGAAGGAGCATCATGA

Upstream 100 bases:

>100_bases
CTGACCGGTTTTGCCCATCTTTTCACAAGGACTATTCATGGAAAAAATGTGCAGTGAGTTCCGCCCCGAGGGAAAAAGAC
CTGAGCCGGCCATCGGCTAC

Downstream 100 bases:

>100_bases
GCCAGGACAACAAAGGCAACGGATCAAAAAAACGCGACTTTCTCGGATTCACCGGCCTCGATGCAGCCAAAATCATTGAA
CTGTTCGACTACTCGCTTTT

Product: acetylglutamate kinase

Products: NA

Alternate protein names: N-acetyl-L-glutamate 5-phosphotransferase; NAG kinase; AGK

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MLVEALPYIRKFEGKTFVIKYGGAAMKDEVLKNIFAENVTLLRKVGIKVVIVHGGGDAITKTSAKLGLETTFVHGKRVTD
RQTVDVIQMTLAGKVNQDIVQLINKDGGNAVGVSGLDADTILAKPSPNASTLGLVGEVAEINTRYIDLLCDAGLIPVIAP
IGYDMEGNIYNINADDAAAAIAVALKAEKLIYVSDVEGVRVGNRILKTICKADAAELIEKGIITGGMIPKVVSAYQTLDG
GVGKVHLIDGQITHSLLLEVFTNEGVGTQFVNELEQEPTAEEGAS

Sequences:

>Translated_285_residues
MLVEALPYIRKFEGKTFVIKYGGAAMKDEVLKNIFAENVTLLRKVGIKVVIVHGGGDAITKTSAKLGLETTFVHGKRVTD
RQTVDVIQMTLAGKVNQDIVQLINKDGGNAVGVSGLDADTILAKPSPNASTLGLVGEVAEINTRYIDLLCDAGLIPVIAP
IGYDMEGNIYNINADDAAAAIAVALKAEKLIYVSDVEGVRVGNRILKTICKADAAELIEKGIITGGMIPKVVSAYQTLDG
GVGKVHLIDGQITHSLLLEVFTNEGVGTQFVNELEQEPTAEEGAS
>Mature_285_residues
MLVEALPYIRKFEGKTFVIKYGGAAMKDEVLKNIFAENVTLLRKVGIKVVIVHGGGDAITKTSAKLGLETTFVHGKRVTD
RQTVDVIQMTLAGKVNQDIVQLINKDGGNAVGVSGLDADTILAKPSPNASTLGLVGEVAEINTRYIDLLCDAGLIPVIAP
IGYDMEGNIYNINADDAAAAIAVALKAEKLIYVSDVEGVRVGNRILKTICKADAAELIEKGIITGGMIPKVVSAYQTLDG
GVGKVHLIDGQITHSLLLEVFTNEGVGTQFVNELEQEPTAEEGAS

Specific function: Arginine biosynthesis; first step. [C]

COG id: COG0548

COG function: function code E; Acetylglutamate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acetylglutamate kinase family

Homologues:

Organism=Escherichia coli, GI1789181, Length=281, Percent_Identity=27.7580071174377, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI145693208, Length=221, Percent_Identity=36.6515837104072, Blast_Score=91, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320913, Length=273, Percent_Identity=24.1758241758242, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): ARGB_CHLTE (P59297)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_662002.1
- ProteinModelPortal:   P59297
- SMR:   P59297
- GeneID:   1006897
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT1111
- NMPDR:   fig|194439.1.peg.1096
- TIGR:   CT1111
- HOGENOM:   HBG497643
- OMA:   MDIVEMV
- ProtClustDB:   PRK00942
- BioCyc:   CTEP194439:CT_1111-MONOMER
- BRENDA:   2.7.2.8
- GO:   GO:0005737
- HAMAP:   MF_00082_B
- InterPro:   IPR004662
- InterPro:   IPR001048
- InterPro:   IPR001057
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF000728
- PRINTS:   PR00474
- TIGRFAMs:   TIGR00761

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.2.8

Molecular weight: Translated: 30156; Mature: 30156

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: NA

Important sites: BINDING 77-77 BINDING 171-171

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVEALPYIRKFEGKTFVIKYGGAAMKDEVLKNIFAENVTLLRKVGIKVVIVHGGGDAIT
CCCCHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCEE
KTSAKLGLETTFVHGKRVTDRQTVDVIQMTLAGKVNQDIVQLINKDGGNAVGVSGLDADT
HHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEECCCCCCE
ILAKPSPNASTLGLVGEVAEINTRYIDLLCDAGLIPVIAPIGYDMEGNIYNINADDAAAA
EEECCCCCCCHHHHHHHHHHHHHHHEEEHHCCCCHHHHHCCCCCCCCCEEEECCCHHHHH
IAVALKAEKLIYVSDVEGVRVGNRILKTICKADAAELIEKGIITGGMIPKVVSAYQTLDG
HHHHEECCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCC
GVGKVHLIDGQITHSLLLEVFTNEGVGTQFVNELEQEPTAEEGAS
CCCEEEEECCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MLVEALPYIRKFEGKTFVIKYGGAAMKDEVLKNIFAENVTLLRKVGIKVVIVHGGGDAIT
CCCCHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCEE
KTSAKLGLETTFVHGKRVTDRQTVDVIQMTLAGKVNQDIVQLINKDGGNAVGVSGLDADT
HHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEECCCCCCE
ILAKPSPNASTLGLVGEVAEINTRYIDLLCDAGLIPVIAPIGYDMEGNIYNINADDAAAA
EEECCCCCCCHHHHHHHHHHHHHHHEEEHHCCCCHHHHHCCCCCCCCCEEEECCCHHHHH
IAVALKAEKLIYVSDVEGVRVGNRILKTICKADAAELIEKGIITGGMIPKVVSAYQTLDG
HHHHEECCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCC
GVGKVHLIDGQITHSLLLEVFTNEGVGTQFVNELEQEPTAEEGAS
CCCEEEEECCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901