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The map label for this gene is argH [H]

Identifier: 21673881

GI number: 21673881

Start: 992791

End: 994182

Strand: Reverse

Name: argH [H]

Synonym: CT1055

Alternate gene names: 21673881

Gene position: 994182-992791 (Counterclockwise)

Preceding gene: 21673882

Following gene: 21673879

Centisome position: 46.13

GC content: 60.7

Gene sequence:

>1392_bases
ATGTCCGATCAATCCAATCAGAAGGAGCTCTTGTGGCAGAGCCGTTTTTCGGAACCGTTTGACCGGGAGGCGCTGAAGTT
CTCCTCGTCGGTGCATGTGGACGGGCTGCTCTATCGCGAAGACATTCAAGGCTCTATTGCCCATGCCACCATGCTTGGCG
AGCAGGGAATTATCTCGAAAGAGGAGGCCGGGCAAATTGTCACCGGGCTGAAGGCGGTCGAAAAGGAGATTGAGTCGGGC
GAGCTAACCCCGGTGTGGGAGGATGAGGATATTCACACGGTGATCGAGAACCGGCTGAAGGAGCTGATCGGCCCGACGGC
GGGCAAGCTGCACTCCGGGCGCAGCCGCAACGACCAGGTGGCGACCGACACGCGCCTCTATCTGCGCCGCAACATCGACC
GCATCGGCGAGTTGCTCAAGGCGATGCAATCGACGCTGCTCGACAAGGCGGAGCAGTACAAGCACACCATCATGTTCGGC
TACACCCACCTGCAGCGCGCCCAGCCGATCTCCGCAGGCCACTACTACATGGCGTGGCACTCGATGTTCGGGCGCGACGC
CCAGCGCCTCGCCGATCTGCGCAAGCGGGCCAACATTTCGCCGCTCGGCGCGGCGGCTTTCGCGGGCAGCACCCTGCCGC
TCGATCCGGCGCGCTCGGCGGAACTGCTGGAGTTCGACGGTGTCTTCACCAACAGCATCGATGCGGTGAGTGACCGCGAC
CTGGTGATCGAGTTCGTTTCGGCCTGCTCGATGATCATGATGCACTTGTCGCGTTTTTCGGAGGATGTAATTCTCTGGAG
CTCGGCGGAGTTCAACTACCTGTCGATCAGCGACGCCTTCGCGACCGGTTCGTCGATCATGCCGCAGAAAAAGAACGCCG
ATATCGCCGAGCTGGTGCGCGGCAAGACGGGCCGTGTCTATGGCAACCTGATGAACCTTCTCACCATTATGAAAGGGCTG
CCGCTCTCCTACAACCGCGACATGCAGGAGGACAAGCCGCCTCTGTTCGATACCGCCGAAACCACTGCATCGAGTCTCTC
GGTCTTCCGCCGGATGATCGAAAAGACCTGGCTGAACGAGGAGCGCCTCGCCCGACTCACCGCCGAAGACCTGAGCCTCG
CCACCGAGATCGCCGAGTACCTCGTCAAGAAGCAGATTCCTTTCCGCGACGCCCACCGCATCACCGGCAAGATCGTGGCG
TATGCCATCGAACAGGGCAAAACCCTGCCGACCATCTCGCTCGACGAGTACCGCACTTTCTCTGAAGCCTTCGACGAAGG
GATCTACGACGACCTCAAACCCGACGCCAGCGTCAACTCCAAGAAAACCGCTGGCAGCTGCTCGTTCAAATCGGTCGAAG
AGCAGATCGCGCGAGCGAAAGCGGCGCGTTGA

Upstream 100 bases:

>100_bases
CCCATTCTGCTATTATCAATTATCAATTGTCTTCCGTATTTTCCCCCACCGAACCATTTTATGGGCGCTCTGCCCTGCAA
CCTCTTAGCGATACTTCATC

Downstream 100 bases:

>100_bases
CGGAACAATCTCTTGTAGGGACGGGTTTTATGCCCGCCCTGTTTCGGCAAACCCGGAACCAAAAAAGGCGCTCCATCACC
GAGCGCCTTTTTTATTGGAA

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MSDQSNQKELLWQSRFSEPFDREALKFSSSVHVDGLLYREDIQGSIAHATMLGEQGIISKEEAGQIVTGLKAVEKEIESG
ELTPVWEDEDIHTVIENRLKELIGPTAGKLHSGRSRNDQVATDTRLYLRRNIDRIGELLKAMQSTLLDKAEQYKHTIMFG
YTHLQRAQPISAGHYYMAWHSMFGRDAQRLADLRKRANISPLGAAAFAGSTLPLDPARSAELLEFDGVFTNSIDAVSDRD
LVIEFVSACSMIMMHLSRFSEDVILWSSAEFNYLSISDAFATGSSIMPQKKNADIAELVRGKTGRVYGNLMNLLTIMKGL
PLSYNRDMQEDKPPLFDTAETTASSLSVFRRMIEKTWLNEERLARLTAEDLSLATEIAEYLVKKQIPFRDAHRITGKIVA
YAIEQGKTLPTISLDEYRTFSEAFDEGIYDDLKPDASVNSKKTAGSCSFKSVEEQIARAKAAR

Sequences:

>Translated_463_residues
MSDQSNQKELLWQSRFSEPFDREALKFSSSVHVDGLLYREDIQGSIAHATMLGEQGIISKEEAGQIVTGLKAVEKEIESG
ELTPVWEDEDIHTVIENRLKELIGPTAGKLHSGRSRNDQVATDTRLYLRRNIDRIGELLKAMQSTLLDKAEQYKHTIMFG
YTHLQRAQPISAGHYYMAWHSMFGRDAQRLADLRKRANISPLGAAAFAGSTLPLDPARSAELLEFDGVFTNSIDAVSDRD
LVIEFVSACSMIMMHLSRFSEDVILWSSAEFNYLSISDAFATGSSIMPQKKNADIAELVRGKTGRVYGNLMNLLTIMKGL
PLSYNRDMQEDKPPLFDTAETTASSLSVFRRMIEKTWLNEERLARLTAEDLSLATEIAEYLVKKQIPFRDAHRITGKIVA
YAIEQGKTLPTISLDEYRTFSEAFDEGIYDDLKPDASVNSKKTAGSCSFKSVEEQIARAKAAR
>Mature_462_residues
SDQSNQKELLWQSRFSEPFDREALKFSSSVHVDGLLYREDIQGSIAHATMLGEQGIISKEEAGQIVTGLKAVEKEIESGE
LTPVWEDEDIHTVIENRLKELIGPTAGKLHSGRSRNDQVATDTRLYLRRNIDRIGELLKAMQSTLLDKAEQYKHTIMFGY
THLQRAQPISAGHYYMAWHSMFGRDAQRLADLRKRANISPLGAAAFAGSTLPLDPARSAELLEFDGVFTNSIDAVSDRDL
VIEFVSACSMIMMHLSRFSEDVILWSSAEFNYLSISDAFATGSSIMPQKKNADIAELVRGKTGRVYGNLMNLLTIMKGLP
LSYNRDMQEDKPPLFDTAETTASSLSVFRRMIEKTWLNEERLARLTAEDLSLATEIAEYLVKKQIPFRDAHRITGKIVAY
AIEQGKTLPTISLDEYRTFSEAFDEGIYDDLKPDASVNSKKTAGSCSFKSVEEQIARAKAAR

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=451, Percent_Identity=42.5720620842572, Blast_Score=358, Evalue=7e-99,
Organism=Homo sapiens, GI68303542, Length=451, Percent_Identity=42.5720620842572, Blast_Score=358, Evalue=7e-99,
Organism=Homo sapiens, GI68303547, Length=451, Percent_Identity=40.3547671840355, Blast_Score=323, Evalue=2e-88,
Organism=Homo sapiens, GI68303549, Length=451, Percent_Identity=40.1330376940133, Blast_Score=322, Evalue=4e-88,
Organism=Escherichia coli, GI1790398, Length=455, Percent_Identity=40.4395604395604, Blast_Score=348, Evalue=4e-97,
Organism=Saccharomyces cerevisiae, GI6321806, Length=464, Percent_Identity=39.4396551724138, Blast_Score=339, Evalue=6e-94,
Organism=Drosophila melanogaster, GI221473854, Length=446, Percent_Identity=37.4439461883408, Blast_Score=310, Evalue=1e-84,
Organism=Drosophila melanogaster, GI78706858, Length=446, Percent_Identity=37.4439461883408, Blast_Score=310, Evalue=1e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 51897; Mature: 51766

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDQSNQKELLWQSRFSEPFDREALKFSSSVHVDGLLYREDIQGSIAHATMLGEQGIISK
CCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCEEEHHHCCCHHHHHHHHCCCCCCCH
EEAGQIVTGLKAVEKEIESGELTPVWEDEDIHTVIENRLKELIGPTAGKLHSGRSRNDQV
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCH
ATDTRLYLRRNIDRIGELLKAMQSTLLDKAEQYKHTIMFGYTHLQRAQPISAGHYYMAWH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
SMFGRDAQRLADLRKRANISPLGAAAFAGSTLPLDPARSAELLEFDGVFTNSIDAVSDRD
HHHCHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCHH
LVIEFVSACSMIMMHLSRFSEDVILWSSAEFNYLSISDAFATGSSIMPQKKNADIAELVR
HHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEHHHHHCCCCCCCCCCCCCHHHHHC
GKTGRVYGNLMNLLTIMKGLPLSYNRDMQEDKPPLFDTAETTASSLSVFRRMIEKTWLNE
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCH
ERLARLTAEDLSLATEIAEYLVKKQIPFRDAHRITGKIVAYAIEQGKTLPTISLDEYRTF
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
SEAFDEGIYDDLKPDASVNSKKTAGSCSFKSVEEQIARAKAAR
HHHHHCCCHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SDQSNQKELLWQSRFSEPFDREALKFSSSVHVDGLLYREDIQGSIAHATMLGEQGIISK
CCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCEEEHHHCCCHHHHHHHHCCCCCCCH
EEAGQIVTGLKAVEKEIESGELTPVWEDEDIHTVIENRLKELIGPTAGKLHSGRSRNDQV
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCH
ATDTRLYLRRNIDRIGELLKAMQSTLLDKAEQYKHTIMFGYTHLQRAQPISAGHYYMAWH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
SMFGRDAQRLADLRKRANISPLGAAAFAGSTLPLDPARSAELLEFDGVFTNSIDAVSDRD
HHHCHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCHH
LVIEFVSACSMIMMHLSRFSEDVILWSSAEFNYLSISDAFATGSSIMPQKKNADIAELVR
HHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEHHHHHCCCCCCCCCCCCCHHHHHC
GKTGRVYGNLMNLLTIMKGLPLSYNRDMQEDKPPLFDTAETTASSLSVFRRMIEKTWLNE
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCH
ERLARLTAEDLSLATEIAEYLVKKQIPFRDAHRITGKIVAYAIEQGKTLPTISLDEYRTF
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
SEAFDEGIYDDLKPDASVNSKKTAGSCSFKSVEEQIARAKAAR
HHHHHCCCHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA