Click here to switch to the map view.

The map label for this gene is fbaA [H]

Identifier: 21673879

GI number: 21673879

Start: 989414

End: 990385

Strand: Reverse

Name: fbaA [H]

Synonym: CT1053

Alternate gene names: 21673879

Gene position: 990385-989414 (Counterclockwise)

Preceding gene: 21673881

Following gene: 21673873

Centisome position: 45.96

GC content: 58.44

Gene sequence:

>972_bases
ATGAAGAAAATCACCGGGTATAAAGAGTTGGGTCTCGTCAACAGTCGTGAACTTTTCGCCAAAGCCATCAGCGGCGGATA
CGCCATTCCTGCGTATAACTTCAACAATCTCGAACAGCTCCAGGCAATTATCATGGCTTGCGTCGAGACCGCTTCACCGG
TCATCCTCCAGGTTTCCAAAGGTGCGCGCAGCTACGCCAACCAGACCCTGTTACGCCATCTGGCCGCAGGTGCGGTCGAG
TACGCCGCTGAACTCGGTCGCGAGATTCCGATTGTGCTGCACCTCGATCACGGCGACAGCTTCGAGCTGTGCAAGGATTG
TATCGAGACCGGCTTCTCGTCGGTAATGATCGACGGCTCGCATCTGAGCTATGAGGACAATGTGTCGCTGACCCGCAAGG
TCGTTGAATTTGCGCACCAGCATGACGTCACGGTCGAAGGCGAGCTGGGTGTACTGGCAGGCATCGAAGATGAAGTTCAC
GCCACAAAGCACACCTACACCGAGCCGGATCAGGTCGAGGATTTCGTCGGCAAAACCGGCGTGGACAGTCTGGCCATCGC
CATCGGCACTTCACACGGCGCGTTCAAGTTCAAGCCGGGTGAAGATCACAAAATCAGGCTCGACATCCTCGCCGAGATCG
AGAAGCGCATTCCCGGCTTCCCCATCGTGCTGCACGGCGCGTCGTCCGTTCCGCAGGATCTGGTACAGATGATCAACGCC
CACGGCGGCAAGCTCAAGGACGCGGTCGGCATCGGCGAAGACCAGCTTCGGGAAGCCGCACGCTCTGCGGTCTGCAAGAT
CAACATCGACTCCGACGGACGCCTCGCCATGACCGCCGCCGTCCGCAAGGTGCTCGACGAAAAGCCGGAAGAGTTCGATC
CGCGCAAATACCTCGGCCCGGCACGCGACGCGCTCAAGCAGCTCTACATGCACAAAATCATCAACGTCCTCGGTTCGAAC
GGCAAGGCGTAA

Upstream 100 bases:

>100_bases
ACATAGTATCTACATAACAGGTTTCTGCACGATCAGGAAATTCTTTCAAAAATTCTCATTCTCTACTGAAAACCATAAAA
TCTCAAATGGAGAGCACTCT

Downstream 100 bases:

>100_bases
AAAAAGCTTTACCCACAAATCAAAAGAGGCTGGCTCGGTTCATCCCGGCCAGCCTTTTTCTTTTTTCTCCCTTGTTCACC
TCGTCCACGCCCTCCTTTTT

Product: fructose-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MKKITGYKELGLVNSRELFAKAISGGYAIPAYNFNNLEQLQAIIMACVETASPVILQVSKGARSYANQTLLRHLAAGAVE
YAAELGREIPIVLHLDHGDSFELCKDCIETGFSSVMIDGSHLSYEDNVSLTRKVVEFAHQHDVTVEGELGVLAGIEDEVH
ATKHTYTEPDQVEDFVGKTGVDSLAIAIGTSHGAFKFKPGEDHKIRLDILAEIEKRIPGFPIVLHGASSVPQDLVQMINA
HGGKLKDAVGIGEDQLREAARSAVCKINIDSDGRLAMTAAVRKVLDEKPEEFDPRKYLGPARDALKQLYMHKIINVLGSN
GKA

Sequences:

>Translated_323_residues
MKKITGYKELGLVNSRELFAKAISGGYAIPAYNFNNLEQLQAIIMACVETASPVILQVSKGARSYANQTLLRHLAAGAVE
YAAELGREIPIVLHLDHGDSFELCKDCIETGFSSVMIDGSHLSYEDNVSLTRKVVEFAHQHDVTVEGELGVLAGIEDEVH
ATKHTYTEPDQVEDFVGKTGVDSLAIAIGTSHGAFKFKPGEDHKIRLDILAEIEKRIPGFPIVLHGASSVPQDLVQMINA
HGGKLKDAVGIGEDQLREAARSAVCKINIDSDGRLAMTAAVRKVLDEKPEEFDPRKYLGPARDALKQLYMHKIINVLGSN
GKA
>Mature_323_residues
MKKITGYKELGLVNSRELFAKAISGGYAIPAYNFNNLEQLQAIIMACVETASPVILQVSKGARSYANQTLLRHLAAGAVE
YAAELGREIPIVLHLDHGDSFELCKDCIETGFSSVMIDGSHLSYEDNVSLTRKVVEFAHQHDVTVEGELGVLAGIEDEVH
ATKHTYTEPDQVEDFVGKTGVDSLAIAIGTSHGAFKFKPGEDHKIRLDILAEIEKRIPGFPIVLHGASSVPQDLVQMINA
HGGKLKDAVGIGEDQLREAARSAVCKINIDSDGRLAMTAAVRKVLDEKPEEFDPRKYLGPARDALKQLYMHKIINVLGSN
GKA

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789526, Length=318, Percent_Identity=36.1635220125786, Blast_Score=187, Evalue=7e-49,
Organism=Escherichia coli, GI87082041, Length=315, Percent_Identity=33.968253968254, Blast_Score=185, Evalue=4e-48,
Organism=Escherichia coli, GI1788072, Length=315, Percent_Identity=30.4761904761905, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1789293, Length=318, Percent_Identity=24.8427672955975, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322790, Length=340, Percent_Identity=26.4705882352941, Blast_Score=69, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011289
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 35125; Mature: 35125

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKITGYKELGLVNSRELFAKAISGGYAIPAYNFNNLEQLQAIIMACVETASPVILQVSK
CCCCCCHHHHCCCCHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEECC
GARSYANQTLLRHLAAGAVEYAAELGREIPIVLHLDHGDSFELCKDCIETGFSSVMIDGS
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHCCCCEEEECCC
HLSYEDNVSLTRKVVEFAHQHDVTVEGELGVLAGIEDEVHATKHTYTEPDQVEDFVGKTG
CCCCCCCHHHHHHHHHHHHHCCCEECCCCCEEECCCHHHHHHHCCCCCHHHHHHHHCCCC
VDSLAIAIGTSHGAFKFKPGEDHKIRLDILAEIEKRIPGFPIVLHGASSVPQDLVQMINA
CCCEEEEEECCCCEEEECCCCCCEEEHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHC
HGGKLKDAVGIGEDQLREAARSAVCKINIDSDGRLAMTAAVRKVLDEKPEEFDPRKYLGP
CCCCCHHHHCCCHHHHHHHHHHCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCHHHCCH
ARDALKQLYMHKIINVLGSNGKA
HHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKKITGYKELGLVNSRELFAKAISGGYAIPAYNFNNLEQLQAIIMACVETASPVILQVSK
CCCCCCHHHHCCCCHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEECC
GARSYANQTLLRHLAAGAVEYAAELGREIPIVLHLDHGDSFELCKDCIETGFSSVMIDGS
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHCCCCEEEECCC
HLSYEDNVSLTRKVVEFAHQHDVTVEGELGVLAGIEDEVHATKHTYTEPDQVEDFVGKTG
CCCCCCCHHHHHHHHHHHHHCCCEECCCCCEEECCCHHHHHHHCCCCCHHHHHHHHCCCC
VDSLAIAIGTSHGAFKFKPGEDHKIRLDILAEIEKRIPGFPIVLHGASSVPQDLVQMINA
CCCEEEEEECCCCEEEECCCCCCEEEHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHC
HGGKLKDAVGIGEDQLREAARSAVCKINIDSDGRLAMTAAVRKVLDEKPEEFDPRKYLGP
CCCCCHHHHCCCHHHHHHHHHHCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCHHHCCH
ARDALKQLYMHKIINVLGSNGKA
HHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9665876 [H]