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The map label for this gene is purC [H]

Identifier: 21673788

GI number: 21673788

Start: 906586

End: 907293

Strand: Direct

Name: purC [H]

Synonym: CT0960

Alternate gene names: 21673788

Gene position: 906586-907293 (Clockwise)

Preceding gene: 21673787

Following gene: 21673789

Centisome position: 42.07

GC content: 54.66

Gene sequence:

>708_bases
ATGAACAAAGTTACACTGCTTCACGAGGGCAAGGCCAAGAAGGTTTGGCAGACCGATAACCCGGACCTCATCATACAGGA
GTTCAAAGACGACGCGACCGCGTTTAATAACAAGAAAAAGGGTTCCATCGCCGATAAGGGTGTGACCAACAACGCTATCG
CCAGTCGCCTTTTCACTATGCTCGGCGAAAACGGTATTCCGACTCACTTCGTCGGCAAGCTGAACGACCGTGACATGCTG
TGCAAGAAACTCGACATTCTTCTGATCGAGGTGGTCACGCGCAACATCGCCGCCGGTTCGCTGGTCAGGCGCTACGGCTT
CAAGGAAGGAACCGTTCTGTCGAAGCCGATTGTTGAACTCTATCTCAAGAACGACGAGCTCGACGATCCGCTGATGAACG
AGGATCACGCCGTCGCGCTTGGCCTTGGAACCTGCGAAGAGGTTGCGCACCTCAAGGCGATGGCCAAGAAAATCAATAGC
CTTCTCGTGCCGTGGTTTGCTGAACGGAAGCTCAGACTCGTGGATTTCAAGCTCGAATTTGGTCGTCACAAAGGCGAGAT
TCTGCTGGGTGACGAGATCAGCCCCGATACCTGCCGGTTCTGGGATGCCGAGTCGGGTGAGAAGCTTGACAAGGATCGTT
TCCGCCTCGACCTTGGCGGCGTTGAGGATGCATACTCCGAGGTCAAGCGCCGCGTGCTGGAACAGTAA

Upstream 100 bases:

>100_bases
CAGGCAACCGGTCAGCAGGGGGAGTGAGCTTTTACCGGTATCGGGGCGCGGGAACCGGTACTTATCCATGCAAAAACAAG
ACAGAAGTAATTCTACATCG

Downstream 100 bases:

>100_bases
GCCATCGATGCCGGAAACCTCTTCAATGCTTGAATCCGTTGTTGCCTACCTGCAACAGGCCGAACCTTCTTCGGTCTATG
CAGTATTGTTTCTGTCGGCA

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 235; Mature: 235

Protein sequence:

>235_residues
MNKVTLLHEGKAKKVWQTDNPDLIIQEFKDDATAFNNKKKGSIADKGVTNNAIASRLFTMLGENGIPTHFVGKLNDRDML
CKKLDILLIEVVTRNIAAGSLVRRYGFKEGTVLSKPIVELYLKNDELDDPLMNEDHAVALGLGTCEEVAHLKAMAKKINS
LLVPWFAERKLRLVDFKLEFGRHKGEILLGDEISPDTCRFWDAESGEKLDKDRFRLDLGGVEDAYSEVKRRVLEQ

Sequences:

>Translated_235_residues
MNKVTLLHEGKAKKVWQTDNPDLIIQEFKDDATAFNNKKKGSIADKGVTNNAIASRLFTMLGENGIPTHFVGKLNDRDML
CKKLDILLIEVVTRNIAAGSLVRRYGFKEGTVLSKPIVELYLKNDELDDPLMNEDHAVALGLGTCEEVAHLKAMAKKINS
LLVPWFAERKLRLVDFKLEFGRHKGEILLGDEISPDTCRFWDAESGEKLDKDRFRLDLGGVEDAYSEVKRRVLEQ
>Mature_235_residues
MNKVTLLHEGKAKKVWQTDNPDLIIQEFKDDATAFNNKKKGSIADKGVTNNAIASRLFTMLGENGIPTHFVGKLNDRDML
CKKLDILLIEVVTRNIAAGSLVRRYGFKEGTVLSKPIVELYLKNDELDDPLMNEDHAVALGLGTCEEVAHLKAMAKKINS
LLVPWFAERKLRLVDFKLEFGRHKGEILLGDEISPDTCRFWDAESGEKLDKDRFRLDLGGVEDAYSEVKRRVLEQ

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Homo sapiens, GI119220557, Length=221, Percent_Identity=33.0316742081448, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI5453539, Length=221, Percent_Identity=33.0316742081448, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI119220559, Length=228, Percent_Identity=32.0175438596491, Blast_Score=96, Evalue=2e-20,
Organism=Escherichia coli, GI1788820, Length=232, Percent_Identity=46.1206896551724, Blast_Score=209, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17531275, Length=220, Percent_Identity=32.7272727272727, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24583917, Length=244, Percent_Identity=30.7377049180328, Blast_Score=87, Evalue=7e-18,
Organism=Drosophila melanogaster, GI18860083, Length=223, Percent_Identity=30.9417040358744, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 26541; Mature: 26541

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS01057 SAICAR_SYNTHETASE_1 ; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKVTLLHEGKAKKVWQTDNPDLIIQEFKDDATAFNNKKKGSIADKGVTNNAIASRLFTM
CCCEEEEECCCCCCCCCCCCCCEEHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHH
LGENGIPTHFVGKLNDRDMLCKKLDILLIEVVTRNIAAGSLVRRYGFKEGTVLSKPIVEL
HCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCHHHHE
YLKNDELDDPLMNEDHAVALGLGTCEEVAHLKAMAKKINSLLVPWFAERKLRLVDFKLEF
EECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCHHHCCCEEEEEEEEEC
GRHKGEILLGDEISPDTCRFWDAESGEKLDKDRFRLDLGGVEDAYSEVKRRVLEQ
CCCCCCEEECCCCCCCCEEECCCCCCCCCCCHHEEEECCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNKVTLLHEGKAKKVWQTDNPDLIIQEFKDDATAFNNKKKGSIADKGVTNNAIASRLFTM
CCCEEEEECCCCCCCCCCCCCCEEHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHH
LGENGIPTHFVGKLNDRDMLCKKLDILLIEVVTRNIAAGSLVRRYGFKEGTVLSKPIVEL
HCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCHHHHE
YLKNDELDDPLMNEDHAVALGLGTCEEVAHLKAMAKKINSLLVPWFAERKLRLVDFKLEF
EECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCHHHCCCEEEEEEEEEC
GRHKGEILLGDEISPDTCRFWDAESGEKLDKDRFRLDLGGVEDAYSEVKRRVLEQ
CCCCCCEEECCCCCCCCEEECCCCCCCCCCCHHEEEECCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA