Definition Chlorobium tepidum TLS, complete genome.
Accession NC_002932
Length 2,154,946

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The map label for this gene is hdhA [H]

Identifier: 21673748

GI number: 21673748

Start: 871454

End: 872212

Strand: Direct

Name: hdhA [H]

Synonym: CT0920

Alternate gene names: 21673748

Gene position: 871454-872212 (Clockwise)

Preceding gene: 21673747

Following gene: 21673750

Centisome position: 40.44

GC content: 61.79

Gene sequence:

>759_bases
ATGAGATTGCAGGGAAAAATTGCCCTGGTTACCGGGGCGGCGGGAGGCATCGGCAGCGCGACCGCACGCTGTTTTGCCCG
CGAAGGGGCGACGGTTGTTCTGGTGGATATCGATCTGGAGGCGTGCAGCCGGGTGTGTGATGACATTGCGCAAAGCATCG
GACAGGCTTCGTGCTCGGGGGTCGATCTTACCTCCGAAAAGCAGGTTGTCGAGCTGTTTACCAATATTCGCCGTGACTAC
GGGCGGCTCGATATCGTGGTCAACATCGCGGGCGGCGATTGCGAACCGGCGGCTTCGGTTGAGACAATTGACATGGAAAT
GGCGATGAAGAATCTCGACATGAACCTCAAATCGTGCATGTTGTGCTGCCGCGAGGCCGCGAAAATCATGAAACCGCAAG
CGTATGGCCGGATCGTGAACATGAGTTCGCTGGTCTGGCGCGGCAGCCCGAACCAGTTCAGCTATTCGGCCTCCAAGGGC
GGCATCTTCGCCTTCACCCGCTCGCTCGCCCTGGCGCTTGGCGCGTTCAACATCACGGCCAATGCCCTTGCGCCTGCGCT
GGTCGAGGTCGAGGCGTTCACGCGAGCGCTCGGCCCGGAGCGCTGGCAGGCGCTCGCGAAAGCCTCCGCCGAACGTTACC
CCCTCGGACGCATCGCCACGCCGGACGACGTCGCCAAAGCCGCGCTTTTCCTTGCCTCGGACGATGCCTCTTTCATCACC
GGGCAGATCCTCGAAATCTCCGGCGGCGCGAGGCTTTGA

Upstream 100 bases:

>100_bases
TTCAAGTTGTTCGCCGGATCGGCGGCGGAAAAGCGGGTGATTGCGGTGCAGTAAAAGGCTTGGCGCTCTGAACAAGGATC
AACCAAAACTGTGGCATACG

Downstream 100 bases:

>100_bases
GCAATTGCTGATGCATTGATGGCGCTTCCAGTGAGTTGCCGCCACCGGTGCGGGAGTTGCTGCAAGCCGGAGTGCTCTGC
AATGACGCGGCGATCGGCAA

Product: 7-alpha-hydroxysteroid dehydrogenase

Products: NA

Alternate protein names: 3-ketoacyl-acyl carrier protein reductase [H]

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MRLQGKIALVTGAAGGIGSATARCFAREGATVVLVDIDLEACSRVCDDIAQSIGQASCSGVDLTSEKQVVELFTNIRRDY
GRLDIVVNIAGGDCEPAASVETIDMEMAMKNLDMNLKSCMLCCREAAKIMKPQAYGRIVNMSSLVWRGSPNQFSYSASKG
GIFAFTRSLALALGAFNITANALAPALVEVEAFTRALGPERWQALAKASAERYPLGRIATPDDVAKAALFLASDDASFIT
GQILEISGGARL

Sequences:

>Translated_252_residues
MRLQGKIALVTGAAGGIGSATARCFAREGATVVLVDIDLEACSRVCDDIAQSIGQASCSGVDLTSEKQVVELFTNIRRDY
GRLDIVVNIAGGDCEPAASVETIDMEMAMKNLDMNLKSCMLCCREAAKIMKPQAYGRIVNMSSLVWRGSPNQFSYSASKG
GIFAFTRSLALALGAFNITANALAPALVEVEAFTRALGPERWQALAKASAERYPLGRIATPDDVAKAALFLASDDASFIT
GQILEISGGARL
>Mature_252_residues
MRLQGKIALVTGAAGGIGSATARCFAREGATVVLVDIDLEACSRVCDDIAQSIGQASCSGVDLTSEKQVVELFTNIRRDY
GRLDIVVNIAGGDCEPAASVETIDMEMAMKNLDMNLKSCMLCCREAAKIMKPQAYGRIVNMSSLVWRGSPNQFSYSASKG
GIFAFTRSLALALGAFNITANALAPALVEVEAFTRALGPERWQALAKASAERYPLGRIATPDDVAKAALFLASDDASFIT
GQILEISGGARL

Specific function: 7-Alpha-Dehydroxylation Of Cholic Acid, Yielding Deoxycholic Acid And Lithocholic Acid, Respectively. Highest Affinity With Taurochenodeoxycholic Acid. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI40254992, Length=249, Percent_Identity=32.5301204819277, Blast_Score=114, Evalue=8e-26,
Organism=Homo sapiens, GI19923817, Length=257, Percent_Identity=28.7937743190661, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI32483357, Length=258, Percent_Identity=31.0077519379845, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI15277342, Length=262, Percent_Identity=29.0076335877863, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI59889578, Length=233, Percent_Identity=33.0472103004292, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI31542939, Length=261, Percent_Identity=32.5670498084291, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI10190704, Length=255, Percent_Identity=29.4117647058824, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI66933014, Length=266, Percent_Identity=30.4511278195489, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI109715829, Length=270, Percent_Identity=28.8888888888889, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI7705925, Length=257, Percent_Identity=30.7392996108949, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI4504505, Length=218, Percent_Identity=31.651376146789, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI224922801, Length=179, Percent_Identity=37.4301675977654, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI4758504, Length=263, Percent_Identity=29.277566539924, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI126723750, Length=261, Percent_Identity=27.2030651340996, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI225579078, Length=206, Percent_Identity=29.126213592233, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI5031737, Length=250, Percent_Identity=27.2, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI210032110, Length=242, Percent_Identity=26.8595041322314, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI83715985, Length=263, Percent_Identity=28.1368821292776, Blast_Score=68, Evalue=9e-12,
Organism=Escherichia coli, GI1787905, Length=252, Percent_Identity=35.7142857142857, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI2367175, Length=252, Percent_Identity=36.5079365079365, Blast_Score=120, Evalue=6e-29,
Organism=Escherichia coli, GI1787335, Length=259, Percent_Identity=32.4324324324324, Blast_Score=120, Evalue=8e-29,
Organism=Escherichia coli, GI87082100, Length=256, Percent_Identity=32.03125, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1789057, Length=255, Percent_Identity=30.1960784313725, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1790717, Length=248, Percent_Identity=27.0161290322581, Blast_Score=94, Evalue=8e-21,
Organism=Escherichia coli, GI87082160, Length=254, Percent_Identity=29.9212598425197, Blast_Score=92, Evalue=2e-20,
Organism=Escherichia coli, GI1789208, Length=254, Percent_Identity=29.5275590551181, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1789378, Length=265, Percent_Identity=26.0377358490566, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1786812, Length=260, Percent_Identity=27.3076923076923, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1788459, Length=255, Percent_Identity=26.2745098039216, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI2367365, Length=249, Percent_Identity=28.9156626506024, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17562904, Length=267, Percent_Identity=29.9625468164794, Blast_Score=109, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17531453, Length=264, Percent_Identity=31.8181818181818, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17562906, Length=271, Percent_Identity=30.2583025830258, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17560220, Length=264, Percent_Identity=29.5454545454545, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17559104, Length=269, Percent_Identity=31.2267657992565, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17562908, Length=264, Percent_Identity=31.4393939393939, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17555706, Length=252, Percent_Identity=30.1587301587302, Blast_Score=100, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI17544670, Length=266, Percent_Identity=30.0751879699248, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI25147288, Length=252, Percent_Identity=30.1587301587302, Blast_Score=97, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI193204405, Length=264, Percent_Identity=29.9242424242424, Blast_Score=97, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17562910, Length=268, Percent_Identity=29.4776119402985, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17536025, Length=254, Percent_Identity=28.3464566929134, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17561402, Length=262, Percent_Identity=28.2442748091603, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17560332, Length=266, Percent_Identity=30.8270676691729, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17560676, Length=260, Percent_Identity=28.4615384615385, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71994600, Length=254, Percent_Identity=29.5275590551181, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71994604, Length=252, Percent_Identity=29.7619047619048, Blast_Score=87, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17551412, Length=270, Percent_Identity=28.5185185185185, Blast_Score=87, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17536651, Length=254, Percent_Identity=27.1653543307087, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17538182, Length=261, Percent_Identity=26.8199233716475, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI72000259, Length=265, Percent_Identity=27.5471698113208, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17563726, Length=264, Percent_Identity=26.5151515151515, Blast_Score=81, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17560150, Length=272, Percent_Identity=26.1029411764706, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17562990, Length=269, Percent_Identity=26.0223048327138, Blast_Score=80, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17538480, Length=268, Percent_Identity=29.1044776119403, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17568967, Length=197, Percent_Identity=31.9796954314721, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17565030, Length=269, Percent_Identity=28.6245353159851, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI115534694, Length=251, Percent_Identity=30.6772908366534, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17561272, Length=255, Percent_Identity=28.6274509803922, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17538486, Length=272, Percent_Identity=26.8382352941176, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17508895, Length=168, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6324126, Length=261, Percent_Identity=26.8199233716475, Blast_Score=79, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6322861, Length=261, Percent_Identity=26.4367816091954, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323882, Length=210, Percent_Identity=29.5238095238095, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24644339, Length=258, Percent_Identity=33.3333333333333, Blast_Score=116, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24639444, Length=257, Percent_Identity=31.5175097276265, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI23397609, Length=258, Percent_Identity=31.3953488372093, Blast_Score=100, Evalue=9e-22,
Organism=Drosophila melanogaster, GI28571526, Length=254, Percent_Identity=30.3149606299213, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI21357041, Length=251, Percent_Identity=29.8804780876494, Blast_Score=98, Evalue=5e-21,
Organism=Drosophila melanogaster, GI21355319, Length=258, Percent_Identity=30.2325581395349, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24644337, Length=256, Percent_Identity=31.640625, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24586328, Length=257, Percent_Identity=27.6264591439689, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17737361, Length=266, Percent_Identity=28.5714285714286, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI18859837, Length=195, Percent_Identity=31.7948717948718, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24643142, Length=255, Percent_Identity=29.0196078431373, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI28573296, Length=205, Percent_Identity=27.3170731707317, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19921754, Length=252, Percent_Identity=26.1904761904762, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24647946, Length=205, Percent_Identity=26.3414634146341, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI22024069, Length=203, Percent_Identity=29.064039408867, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI45553409, Length=204, Percent_Identity=26.4705882352941, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24647948, Length=204, Percent_Identity=26.4705882352941, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011284
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.100 [H]

Molecular weight: Translated: 26652; Mature: 26652

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLQGKIALVTGAAGGIGSATARCFAREGATVVLVDIDLEACSRVCDDIAQSIGQASCSG
CCCCCEEEEEEECCCCCCHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCC
VDLTSEKQVVELFTNIRRDYGRLDIVVNIAGGDCEPAASVETIDMEMAMKNLDMNLKSCM
CCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCHHHHH
LCCREAAKIMKPQAYGRIVNMSSLVWRGSPNQFSYSASKGGIFAFTRSLALALGAFNITA
HHHHHHHHHHCCHHHHEEECHHHEEECCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHH
NALAPALVEVEAFTRALGPERWQALAKASAERYPLGRIATPDDVAKAALFLASDDASFIT
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHEEEEECCCCCCCE
GQILEISGGARL
EEEEEECCCCCC
>Mature Secondary Structure
MRLQGKIALVTGAAGGIGSATARCFAREGATVVLVDIDLEACSRVCDDIAQSIGQASCSG
CCCCCEEEEEEECCCCCCHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCC
VDLTSEKQVVELFTNIRRDYGRLDIVVNIAGGDCEPAASVETIDMEMAMKNLDMNLKSCM
CCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCHHHHH
LCCREAAKIMKPQAYGRIVNMSSLVWRGSPNQFSYSASKGGIFAFTRSLALALGAFNITA
HHHHHHHHHHCCHHHHEEECHHHEEECCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHH
NALAPALVEVEAFTRALGPERWQALAKASAERYPLGRIATPDDVAKAALFLASDDASFIT
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHEEEEECCCCCCCE
GQILEISGGARL
EEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]