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The map label for this gene is bioF-2 [C]

Identifier: 21672892

GI number: 21672892

Start: 48892

End: 50112

Strand: Reverse

Name: bioF-2 [C]

Synonym: CT0051

Alternate gene names: 21672892

Gene position: 50112-48892 (Counterclockwise)

Preceding gene: 21672893

Following gene: 21672891

Centisome position: 2.33

GC content: 65.19

Gene sequence:

>1221_bases
ATGAGCGGCGGATTTACGAATGCGGGCCAGGTCGAGCCGCCGATTGTGGCCGACATCGCGGTGGAGCTTGCGAAGCTCAA
GGCGAAGCAGCGCTTCCGCTCGATTCCCGCCACCGGCGAGCGGAGCGGGCGCTTCGTCACTGTTGGCGGTCGCAAGCTGC
TGAACCTCTCCTCGAACGACTATCTCGGCCTCGGCGCTGACCGCGAGCTGTTCAGCTCGTTCATCGCACAGATTCGAGAT
GATCGGTTCGACGACGGACGCTTCGCCATGACCAGCTCCTCGTCGCGCCTGCTGACGGGCCACCACCCGGTCTGCGACCA
GCTCGAATCGGCGATTGCCGCCGCCTACGGCAGCGAAACGGCGCTCGTTTTCAACAGCGGCTACCACGCCAACACCGGCA
TTCTGCCCGCACTCGCCACCCGCCACGACCTGATCCTCAGCGACCGCCTCAACCACGCCAGCATCATCGACGGCCTGCGG
ATCGCCGACGCCGATTATCGCCGCTTCCGCCACGCCGATTATGACCACCTCGAAGAGCAGCTCGAAACCGCCGCCAGAGA
GTGCTACCGGCAGATTTTCATCGTCACCGAATCGGTCTTCAGCATGGACGGCGACCTTGCCGACTTGCGTCGTCTGGTCA
AGCTGAAGCGTCGTTTCAAGGCGGTGCTGATCGTGGACGAAGCGCACGGCGCAGGCGTCTTCGGCGAGCGGGGCCTCGGC
CTCTGCGAAGCGCTCGGCGTGACGAATGAGATCGACATCATCGTCGGCACTTTCGGCAAGTCACTCGCCTCCGCCGGGGC
CTACGCTGTCATGCGCGGCCTCTTTCGCGAGTACCTCGTCAACACGATGCGCACCCTGATCTTCACCACCGCCCTCCCGC
CAATGACGCTCGCTTGGAGCCTCGCCACCTTCACGAAACAACTCACGATGCAGCGGGAGCGCGACCATCTGCTCGGTCTC
GCGGCGACCTTGCGCGGCAGCCTCCGCGAGGCGGGATTCGACGTACCCGGCGAGAGCCACATCGTACCGGTGGTGCTGGG
CGAAGATCGCACAGCGGTCGAGATGGCCGGAGCGCTGCGCGAAGCGGGTTTCCACGCGCTGCCGGTACGCCCGCCGACGG
TACCCGAAAACAGCTCGCGTCTCCGCTTTTCACTCCGCGCCGACCTGACGAGCGGCGACATCGCCGCCCTTGCCGAAACC
ATGAAAAGAGGCGCGGCATGA

Upstream 100 bases:

>100_bases
TGGCGGGAGCGGATGGCTTCCTCACCGGCGGTTACCTGACGACGCGGGGACGTGACATTTCCACCGACCGGCAGCTCGCC
CGGCAACTCTCGAAGTTCTC

Downstream 100 bases:

>100_bases
AGGCAGAGTGGATCGTGCGCAAGGGCAACACGGATTTGCTGCTCTTTTTCAACGGCTGGGGGATGGATCGCCGCGTGGCC
GACTGGCTCGTTTCGGCGTG

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MSGGFTNAGQVEPPIVADIAVELAKLKAKQRFRSIPATGERSGRFVTVGGRKLLNLSSNDYLGLGADRELFSSFIAQIRD
DRFDDGRFAMTSSSSRLLTGHHPVCDQLESAIAAAYGSETALVFNSGYHANTGILPALATRHDLILSDRLNHASIIDGLR
IADADYRRFRHADYDHLEEQLETAARECYRQIFIVTESVFSMDGDLADLRRLVKLKRRFKAVLIVDEAHGAGVFGERGLG
LCEALGVTNEIDIIVGTFGKSLASAGAYAVMRGLFREYLVNTMRTLIFTTALPPMTLAWSLATFTKQLTMQRERDHLLGL
AATLRGSLREAGFDVPGESHIVPVVLGEDRTAVEMAGALREAGFHALPVRPPTVPENSSRLRFSLRADLTSGDIAALAET
MKRGAA

Sequences:

>Translated_406_residues
MSGGFTNAGQVEPPIVADIAVELAKLKAKQRFRSIPATGERSGRFVTVGGRKLLNLSSNDYLGLGADRELFSSFIAQIRD
DRFDDGRFAMTSSSSRLLTGHHPVCDQLESAIAAAYGSETALVFNSGYHANTGILPALATRHDLILSDRLNHASIIDGLR
IADADYRRFRHADYDHLEEQLETAARECYRQIFIVTESVFSMDGDLADLRRLVKLKRRFKAVLIVDEAHGAGVFGERGLG
LCEALGVTNEIDIIVGTFGKSLASAGAYAVMRGLFREYLVNTMRTLIFTTALPPMTLAWSLATFTKQLTMQRERDHLLGL
AATLRGSLREAGFDVPGESHIVPVVLGEDRTAVEMAGALREAGFHALPVRPPTVPENSSRLRFSLRADLTSGDIAALAET
MKRGAA
>Mature_405_residues
SGGFTNAGQVEPPIVADIAVELAKLKAKQRFRSIPATGERSGRFVTVGGRKLLNLSSNDYLGLGADRELFSSFIAQIRDD
RFDDGRFAMTSSSSRLLTGHHPVCDQLESAIAAAYGSETALVFNSGYHANTGILPALATRHDLILSDRLNHASIIDGLRI
ADADYRRFRHADYDHLEEQLETAARECYRQIFIVTESVFSMDGDLADLRRLVKLKRRFKAVLIVDEAHGAGVFGERGLGL
CEALGVTNEIDIIVGTFGKSLASAGAYAVMRGLFREYLVNTMRTLIFTTALPPMTLAWSLATFTKQLTMQRERDHLLGLA
ATLRGSLREAGFDVPGESHIVPVVLGEDRTAVEMAGALREAGFHALPVRPPTVPENSSRLRFSLRADLTSGDIAALAETM
KRGAA

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=382, Percent_Identity=32.1989528795811, Blast_Score=191, Evalue=2e-48,
Organism=Homo sapiens, GI284448556, Length=349, Percent_Identity=33.2378223495702, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI4758668, Length=357, Percent_Identity=28.5714285714286, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI119220554, Length=356, Percent_Identity=28.9325842696629, Blast_Score=139, Evalue=7e-33,
Organism=Homo sapiens, GI83977444, Length=354, Percent_Identity=30.225988700565, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI83977440, Length=356, Percent_Identity=30.3370786516854, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI83977442, Length=354, Percent_Identity=30.225988700565, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI4502025, Length=342, Percent_Identity=30.7017543859649, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI40316939, Length=342, Percent_Identity=30.7017543859649, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI5454084, Length=257, Percent_Identity=26.4591439688716, Blast_Score=101, Evalue=1e-21,
Organism=Escherichia coli, GI1790046, Length=356, Percent_Identity=33.7078651685393, Blast_Score=188, Evalue=5e-49,
Organism=Escherichia coli, GI1786993, Length=364, Percent_Identity=34.8901098901099, Blast_Score=187, Evalue=8e-49,
Organism=Caenorhabditis elegans, GI71994529, Length=389, Percent_Identity=31.8766066838046, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI32566772, Length=377, Percent_Identity=29.7082228116711, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17560914, Length=314, Percent_Identity=28.6624203821656, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17560912, Length=313, Percent_Identity=28.7539936102236, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI71982617, Length=266, Percent_Identity=28.5714285714286, Blast_Score=101, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI71982625, Length=266, Percent_Identity=28.5714285714286, Blast_Score=101, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6320267, Length=361, Percent_Identity=31.3019390581717, Blast_Score=159, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6320438, Length=359, Percent_Identity=29.5264623955432, Blast_Score=147, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6323954, Length=289, Percent_Identity=25.6055363321799, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24662918, Length=380, Percent_Identity=34.2105263157895, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI17136286, Length=364, Percent_Identity=30.4945054945055, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI17137420, Length=375, Percent_Identity=29.0666666666667, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24653280, Length=264, Percent_Identity=28.7878787878788, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24653276, Length=264, Percent_Identity=28.7878787878788, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24653278, Length=264, Percent_Identity=28.7878787878788, Blast_Score=106, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 44236; Mature: 44105

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGGFTNAGQVEPPIVADIAVELAKLKAKQRFRSIPATGERSGRFVTVGGRKLLNLSSND
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCEEEECCCCC
YLGLGADRELFSSFIAQIRDDRFDDGRFAMTSSSSRLLTGHHPVCDQLESAIAAAYGSET
CEECCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCCEEECCCHHHHHHHHHHHHHCCCCE
ALVFNSGYHANTGILPALATRHDLILSDRLNHASIIDGLRIADADYRRFRHADYDHLEEQ
EEEEECCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHCCCCCCCHHHHHHHCCCHHHHHHH
LETAARECYRQIFIVTESVFSMDGDLADLRRLVKLKRRFKAVLIVDEAHGAGVFGERGLG
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCEEEEEEECCCCCCCCCCCCCC
LCEALGVTNEIDIIVGTFGKSLASAGAYAVMRGLFREYLVNTMRTLIFTTALPPMTLAWS
HHHHHCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LATFTKQLTMQRERDHLLGLAATLRGSLREAGFDVPGESHIVPVVLGEDRTAVEMAGALR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHH
EAGFHALPVRPPTVPENSSRLRFSLRADLTSGDIAALAETMKRGAA
HCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
SGGFTNAGQVEPPIVADIAVELAKLKAKQRFRSIPATGERSGRFVTVGGRKLLNLSSND
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCEEEECCCCC
YLGLGADRELFSSFIAQIRDDRFDDGRFAMTSSSSRLLTGHHPVCDQLESAIAAAYGSET
CEECCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCCEEECCCHHHHHHHHHHHHHCCCCE
ALVFNSGYHANTGILPALATRHDLILSDRLNHASIIDGLRIADADYRRFRHADYDHLEEQ
EEEEECCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHCCCCCCCHHHHHHHCCCHHHHHHH
LETAARECYRQIFIVTESVFSMDGDLADLRRLVKLKRRFKAVLIVDEAHGAGVFGERGLG
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCEEEEEEECCCCCCCCCCCCCC
LCEALGVTNEIDIIVGTFGKSLASAGAYAVMRGLFREYLVNTMRTLIFTTALPPMTLAWS
HHHHHCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LATFTKQLTMQRERDHLLGLAATLRGSLREAGFDVPGESHIVPVVLGEDRTAVEMAGALR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHH
EAGFHALPVRPPTVPENSSRLRFSLRADLTSGDIAALAETMKRGAA
HCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA