Click here to switch to the map view.

The map label for this gene is rsmH

Identifier: 21672883

GI number: 21672883

Start: 40793

End: 41749

Strand: Reverse

Name: rsmH

Synonym: CT0042

Alternate gene names: 21672883

Gene position: 41749-40793 (Counterclockwise)

Preceding gene: 21672884

Following gene: 21672882

Centisome position: 1.94

GC content: 58.93

Gene sequence:

>957_bases
ATGGATTACCAGGACTATCATGAGCCGGTGCTGGCCAGGGAATCCGTATCGCTGCTGGTCACCCTCCCGGGGATATACAT
CGACGGCACCCTTGGCGGAGGTGGCCATTCTCTGCAACTGCTTCGGCATCTTCAAACGCTTAACGGTGATTCGCTCCTTG
TCGGCATCGATCAGGATACTCATGCCCTCGAAGCTGCGGGGAAGAAACTCGGGGAGTTTGGTGACCGGCGCCGCCTGGTC
AGGGGCAATTTCGGCATGGTGAAAGAGCTCGTGGAGCCAATGATGCGGGGCGCGGGGAACGGTCTTCCGGTCATGGGTTT
TCTGCTCGATCTCGGGGTGTCATCGTTTCAGATCGATACGCCAGAGCGCGGATTCAGCTATCTCAAGGACGGCCCTCTCG
ATATGCGAATGGACCCGGACGGGCCGCTGACCGCCGCCGATATTGTCAACGGGTATGAAGAGGCTGCGCTGGCAAAGCTG
TTCTTCCGGTATGGCGAGGAGCCGCTTGGCGGCAGAATCGCCAGGGCGATTGTCTCGGCGAGAAGTTCCGCGCCACTGAC
GACGACCGGCGAGCTGGCCGAAGTGATCAGGGCGGCCTGCCCCAGAAAAGACCTGGCGATCAAGACACTGTCGAGAATTT
ATCAGGCATTGCGCATTGAGGTCAACGATGAACTCGGCGTTCTTGAACAGGCTTTAGAGGATGGCTTCGAGCTGCTTTCA
TCGGGCGGGCGGTTCGCGGTCATCAGCTACCATTCGCTGGAGGATAGGATCGTCAAACGCTTTTTTGCAGCCAAAACGTC
GGCGGACTGGGGCCCAAAGGGGCTCGCGCTCCGCGAACCGCTGAAGCCTGCCGAAGCGGTGCTGGTGGTCAGAAAGCCGC
TCGAAGCCACGGCTGAAGAAATCAGCCGCAATCCGAGATCGAGAAGTGCGCGTCTCAGAGTCATTCAGAAACTGTAA

Upstream 100 bases:

>100_bases
AACGCGAAAATGACGGTCTGGGAGCCGCTCCGTCTGGAACGGCTGCTAAGCGATAACGCGAGCCGGTTCGCACCACTTGC
AAACCGGTACATCTGAGCCC

Downstream 100 bases:

>100_bases
CCTTCAGAGGAGGTAAGTCGTGAACGTTTTGAAATCCGCTGAAAAGCCGTTTGCCGGTTTCGTTGGCAGGCCGGGCAAAA
TTTTGGGGAAGGAGGACGGG

Product: hypothetical protein

Products: NA

Alternate protein names: 16S rRNA m(4)C1402 methyltransferase; rRNA (cytosine-N(4)-)-methyltransferase RsmH

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MDYQDYHEPVLARESVSLLVTLPGIYIDGTLGGGGHSLQLLRHLQTLNGDSLLVGIDQDTHALEAAGKKLGEFGDRRRLV
RGNFGMVKELVEPMMRGAGNGLPVMGFLLDLGVSSFQIDTPERGFSYLKDGPLDMRMDPDGPLTAADIVNGYEEAALAKL
FFRYGEEPLGGRIARAIVSARSSAPLTTTGELAEVIRAACPRKDLAIKTLSRIYQALRIEVNDELGVLEQALEDGFELLS
SGGRFAVISYHSLEDRIVKRFFAAKTSADWGPKGLALREPLKPAEAVLVVRKPLEATAEEISRNPRSRSARLRVIQKL

Sequences:

>Translated_318_residues
MDYQDYHEPVLARESVSLLVTLPGIYIDGTLGGGGHSLQLLRHLQTLNGDSLLVGIDQDTHALEAAGKKLGEFGDRRRLV
RGNFGMVKELVEPMMRGAGNGLPVMGFLLDLGVSSFQIDTPERGFSYLKDGPLDMRMDPDGPLTAADIVNGYEEAALAKL
FFRYGEEPLGGRIARAIVSARSSAPLTTTGELAEVIRAACPRKDLAIKTLSRIYQALRIEVNDELGVLEQALEDGFELLS
SGGRFAVISYHSLEDRIVKRFFAAKTSADWGPKGLALREPLKPAEAVLVVRKPLEATAEEISRNPRSRSARLRVIQKL
>Mature_318_residues
MDYQDYHEPVLARESVSLLVTLPGIYIDGTLGGGGHSLQLLRHLQTLNGDSLLVGIDQDTHALEAAGKKLGEFGDRRRLV
RGNFGMVKELVEPMMRGAGNGLPVMGFLLDLGVSSFQIDTPERGFSYLKDGPLDMRMDPDGPLTAADIVNGYEEAALAKL
FFRYGEEPLGGRIARAIVSARSSAPLTTTGELAEVIRAACPRKDLAIKTLSRIYQALRIEVNDELGVLEQALEDGFELLS
SGGRFAVISYHSLEDRIVKRFFAAKTSADWGPKGLALREPLKPAEAVLVVRKPLEATAEEISRNPRSRSARLRVIQKL

Specific function: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA

COG id: COG0275

COG function: function code M; Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. RsmH family

Homologues:

Organism=Homo sapiens, GI165377209, Length=346, Percent_Identity=38.150289017341, Blast_Score=186, Evalue=2e-47,
Organism=Homo sapiens, GI165377202, Length=196, Percent_Identity=43.3673469387755, Blast_Score=128, Evalue=7e-30,
Organism=Escherichia coli, GI1786270, Length=315, Percent_Identity=43.4920634920635, Blast_Score=206, Evalue=2e-54,
Organism=Drosophila melanogaster, GI62472493, Length=342, Percent_Identity=34.2105263157895, Blast_Score=148, Evalue=5e-36,
Organism=Drosophila melanogaster, GI28571637, Length=342, Percent_Identity=34.2105263157895, Blast_Score=148, Evalue=5e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RSMH_CHLTE (Q8KGC6)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_660948.1
- ProteinModelPortal:   Q8KGC6
- SMR:   Q8KGC6
- GeneID:   1006460
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT0042
- NMPDR:   fig|194439.1.peg.42
- TIGR:   CT0042
- HOGENOM:   HBG302779
- OMA:   PQLDDPE
- ProtClustDB:   CLSK637125
- BioCyc:   CTEP194439:CT_0042-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01007
- InterPro:   IPR002903
- PANTHER:   PTHR11265
- PIRSF:   PIRSF004486
- TIGRFAMs:   TIGR00006

Pfam domain/function: PF01795 Methyltransf_5

EC number: NA

Molecular weight: Translated: 34753; Mature: 34753

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: NA

Important sites: BINDING 57-57 BINDING 84-84 BINDING 110-110 BINDING 117-117

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYQDYHEPVLARESVSLLVTLPGIYIDGTLGGGGHSLQLLRHLQTLNGDSLLVGIDQDT
CCCCHHHHHHHHHCCCEEEEEECCEEEECCCCCCHHHHHHHHHHHHCCCCEEEEECCCCH
HALEAAGKKLGEFGDRRRLVRGNFGMVKELVEPMMRGAGNGLPVMGFLLDLGVSSFQIDT
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCEECCC
PERGFSYLKDGPLDMRMDPDGPLTAADIVNGYEEAALAKLFFRYGEEPLGGRIARAIVSA
CHHHHHHHCCCCCCEEECCCCCCHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
RSSAPLTTTGELAEVIRAACPRKDLAIKTLSRIYQALRIEVNDELGVLEQALEDGFELLS
CCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
SGGRFAVISYHSLEDRIVKRFFAAKTSADWGPKGLALREPLKPAEAVLVVRKPLEATAEE
CCCCEEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHH
ISRNPRSRSARLRVIQKL
HHCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MDYQDYHEPVLARESVSLLVTLPGIYIDGTLGGGGHSLQLLRHLQTLNGDSLLVGIDQDT
CCCCHHHHHHHHHCCCEEEEEECCEEEECCCCCCHHHHHHHHHHHHCCCCEEEEECCCCH
HALEAAGKKLGEFGDRRRLVRGNFGMVKELVEPMMRGAGNGLPVMGFLLDLGVSSFQIDT
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCEECCC
PERGFSYLKDGPLDMRMDPDGPLTAADIVNGYEEAALAKLFFRYGEEPLGGRIARAIVSA
CHHHHHHHCCCCCCEEECCCCCCHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
RSSAPLTTTGELAEVIRAACPRKDLAIKTLSRIYQALRIEVNDELGVLEQALEDGFELLS
CCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
SGGRFAVISYHSLEDRIVKRFFAAKTSADWGPKGLALREPLKPAEAVLVVRKPLEATAEE
CCCCEEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHH
ISRNPRSRSARLRVIQKL
HHCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901