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The map label for this gene is ftsI [H]

Identifier: 21672881

GI number: 21672881

Start: 38323

End: 40278

Strand: Reverse

Name: ftsI [H]

Synonym: CT0040

Alternate gene names: 21672881

Gene position: 40278-38323 (Counterclockwise)

Preceding gene: 21672882

Following gene: 21672880

Centisome position: 1.87

GC content: 59.92

Gene sequence:

>1956_bases
ATGAACCAGGCGAGAACAACACCGGAGAACCACCGCGGCACCAGCGACCATGAATTCAGCCTGCGCCTTGGCATTATGGT
TGCGCTCATGCTGCTGTTTTGCCTGGCGATCGTCTCGAAGCTGCTGGGCATCCAGGTGTTCGATGTCAAAAAATACCGAG
CGAAAGCGAGCCGGCAATACGAGACGATCGTAACCGAAAAAGCCCGGCGGGGGCGCATTCTCGACCGTTACGGTCGTCCG
CTTGCCGAGAGCGTCGAGAGCATCTCTTTCTACGCCGATCCGGAGCAGGTGAACGATGCCGGCGCTACAGCAAAACTGTT
TGCGAACACCTTCGGCAAGAGCCGCGACTACTATCTCGATCTGCTTCGCAAGAACAAGCGTTTTGTCTGGCTGGAGCGCA
ACGTGCCGGTATCGCAGGCCGCGAAACTGATGAGTCTCAAAATCAAGGGTGTAGGGTTCCGGCGCGAGCAGCATCGCTAC
TACCTGAACGTGGCCGCCCAGCTCATCGGCCTGACCGATCGCGACAACAAGGGGATCAGCGGACTCGAAAAGAGCTTCGA
AAGCCAGCTCAGCGGACGCGACGGCGTGCGGATTTTTCAGCGCTCGGCAACCGGCGAACGCTATCCGGCTCCCGACGCCG
ATCAGGTGCAGCCCCTTGCAGGCAATGATGTGACGCTGACCATCGACGCCGATGTGCAGGGGATCCTTGAAGAGGAGATT
GCACAGGCGGTCAAGGAGTTCAAGGCCAGTGGCGCGATGGGCATCATCATGGATGTCCGGACGGGTGAAATCATCGCGAT
GGCCAACTACCCCACTTTCGATCTGAACCGCAGGAGCGGGCTGACCGCCGATCAAATGCGCAATCGTGCCGTTACCGATA
TGTTTGAGCCGGGCTCGACCTTCAAGATCGTCATGGCCTCGGCGGCCACCGAGGCGCTCGGCTGGAGGGCGGAAACACCG
GTGGACGGCCACGGCGGGTCGATCACCATCTACGGCAAGCAGGTGCGGGATCACGAACCGTTCGGAGCGATGAACTTCCA
GAAGGCGATCACCGAGTCGAGCAACGTCGTCGCGGCGAGCACCGCCATGCGGGTCGGAGCCACGACCTTTTACCGCTACG
CCCACGCCCTCGGCTTTGGCCAGAAAACCGGCGTCGGCCTCATCGGCGAATCGGGCGGATTTCTCAAGCCGGTTTCGCGC
TGGGGCAAAATGACGCTGCCGTGGATGGGATACGGCTATCAGGTGATGGCCACGCCACTCCAGGTGCTTCAGGCCTACGC
AACGCTCGCCAACGACGGCGTGCGCATGAGACCCTTCATCATCAAAAGAGTGAGCGGGCCTGACGGCAAGACCATCGAAG
AGACCAGGCCGCTGAAGGTGGTGCAGGCGCTGAAGCCGGAAACGGCCCATTACATGGCGCGGGAATATTTCCGCGCGGTG
GTCGAAAAGGGCACCGGCATGTCGGCGAAAATCGAGGGAATTCCGGTCGCCGGAAAGACCGGCACGGCCCAGAAGCTGCA
CAACGGCAGCTATCAAGGGTGGCGCTACTACGTAGCGTCGTTCGTTGGATTTTTCCCTTACGACAATCCTCAGTATGCTG
CGATTATCGTTGTCGATGAGCCGCAGACAGCGTATTATGCGTCAGCCGTGGCGGCTCCGGTTTTTTCGAGGGTCTGCGGC
CGCGCGGTAGCCTGCTCTCTGGAGATGCAGAAACGGCTGAGCATGAAATCCCCCGAAAAGGAGCTGCTTGACCGCGTTTC
GACAGTGGTTGTTCCAGAGCTGAAAGGATTGCGTGAGAGCGAAGCCGCCAAGCTACTTGAATGGAACGGCTTGAAGCTGG
AACCATCGGGGAGCAGCGGCGGCAGCGTGACCTCGCAGAGCATCGCGCCCGGCACGAAGGTACAGAAAGAAACAACGGTC
AGGGTTCGCCTGGCGAAAAGGGTTCAGAACAAGTAA

Upstream 100 bases:

>100_bases
GTACATCTCCGGTTATGCCAAAAATCTCGGACTCGACTCCTCATTCATTCCTCCGGTCGAGATTGAACCCTGACAGCACC
CCTCTTTTATCGAAGAATGC

Downstream 100 bases:

>100_bases
TGAAGGAAATCCGCGAAGGAGCGCCGGGTGCGCAGCTCGACGACCTGGTCGCCGCTCTCGGCGCGCTGGCTGAACGCCGG
GGCGGCGACGGAGCGCGAGC

Product: penicillin-binding protein 3

Products: NA

Alternate protein names: Penicillin-binding protein 3; PBP-3; Peptidoglycan glycosyltransferase 3 [H]

Number of amino acids: Translated: 651; Mature: 651

Protein sequence:

>651_residues
MNQARTTPENHRGTSDHEFSLRLGIMVALMLLFCLAIVSKLLGIQVFDVKKYRAKASRQYETIVTEKARRGRILDRYGRP
LAESVESISFYADPEQVNDAGATAKLFANTFGKSRDYYLDLLRKNKRFVWLERNVPVSQAAKLMSLKIKGVGFRREQHRY
YLNVAAQLIGLTDRDNKGISGLEKSFESQLSGRDGVRIFQRSATGERYPAPDADQVQPLAGNDVTLTIDADVQGILEEEI
AQAVKEFKASGAMGIIMDVRTGEIIAMANYPTFDLNRRSGLTADQMRNRAVTDMFEPGSTFKIVMASAATEALGWRAETP
VDGHGGSITIYGKQVRDHEPFGAMNFQKAITESSNVVAASTAMRVGATTFYRYAHALGFGQKTGVGLIGESGGFLKPVSR
WGKMTLPWMGYGYQVMATPLQVLQAYATLANDGVRMRPFIIKRVSGPDGKTIEETRPLKVVQALKPETAHYMAREYFRAV
VEKGTGMSAKIEGIPVAGKTGTAQKLHNGSYQGWRYYVASFVGFFPYDNPQYAAIIVVDEPQTAYYASAVAAPVFSRVCG
RAVACSLEMQKRLSMKSPEKELLDRVSTVVVPELKGLRESEAAKLLEWNGLKLEPSGSSGGSVTSQSIAPGTKVQKETTV
RVRLAKRVQNK

Sequences:

>Translated_651_residues
MNQARTTPENHRGTSDHEFSLRLGIMVALMLLFCLAIVSKLLGIQVFDVKKYRAKASRQYETIVTEKARRGRILDRYGRP
LAESVESISFYADPEQVNDAGATAKLFANTFGKSRDYYLDLLRKNKRFVWLERNVPVSQAAKLMSLKIKGVGFRREQHRY
YLNVAAQLIGLTDRDNKGISGLEKSFESQLSGRDGVRIFQRSATGERYPAPDADQVQPLAGNDVTLTIDADVQGILEEEI
AQAVKEFKASGAMGIIMDVRTGEIIAMANYPTFDLNRRSGLTADQMRNRAVTDMFEPGSTFKIVMASAATEALGWRAETP
VDGHGGSITIYGKQVRDHEPFGAMNFQKAITESSNVVAASTAMRVGATTFYRYAHALGFGQKTGVGLIGESGGFLKPVSR
WGKMTLPWMGYGYQVMATPLQVLQAYATLANDGVRMRPFIIKRVSGPDGKTIEETRPLKVVQALKPETAHYMAREYFRAV
VEKGTGMSAKIEGIPVAGKTGTAQKLHNGSYQGWRYYVASFVGFFPYDNPQYAAIIVVDEPQTAYYASAVAAPVFSRVCG
RAVACSLEMQKRLSMKSPEKELLDRVSTVVVPELKGLRESEAAKLLEWNGLKLEPSGSSGGSVTSQSIAPGTKVQKETTV
RVRLAKRVQNK
>Mature_651_residues
MNQARTTPENHRGTSDHEFSLRLGIMVALMLLFCLAIVSKLLGIQVFDVKKYRAKASRQYETIVTEKARRGRILDRYGRP
LAESVESISFYADPEQVNDAGATAKLFANTFGKSRDYYLDLLRKNKRFVWLERNVPVSQAAKLMSLKIKGVGFRREQHRY
YLNVAAQLIGLTDRDNKGISGLEKSFESQLSGRDGVRIFQRSATGERYPAPDADQVQPLAGNDVTLTIDADVQGILEEEI
AQAVKEFKASGAMGIIMDVRTGEIIAMANYPTFDLNRRSGLTADQMRNRAVTDMFEPGSTFKIVMASAATEALGWRAETP
VDGHGGSITIYGKQVRDHEPFGAMNFQKAITESSNVVAASTAMRVGATTFYRYAHALGFGQKTGVGLIGESGGFLKPVSR
WGKMTLPWMGYGYQVMATPLQVLQAYATLANDGVRMRPFIIKRVSGPDGKTIEETRPLKVVQALKPETAHYMAREYFRAV
VEKGTGMSAKIEGIPVAGKTGTAQKLHNGSYQGWRYYVASFVGFFPYDNPQYAAIIVVDEPQTAYYASAVAAPVFSRVCG
RAVACSLEMQKRLSMKSPEKELLDRVSTVVVPELKGLRESEAAKLLEWNGLKLEPSGSSGGSVTSQSIAPGTKVQKETTV
RVRLAKRVQNK

Specific function: Cell wall formation. Essential for the formation of a septum of the murein sacculus. Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=568, Percent_Identity=32.2183098591549, Blast_Score=258, Evalue=7e-70,
Organism=Escherichia coli, GI1786854, Length=581, Percent_Identity=23.7521514629948, Blast_Score=109, Evalue=7e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: =2.4.1.129 [H]

Molecular weight: Translated: 71735; Mature: 71735

Theoretical pI: Translated: 10.05; Mature: 10.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQARTTPENHRGTSDHEFSLRLGIMVALMLLFCLAIVSKLLGIQVFDVKKYRAKASRQY
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEHHHHHHHHHHHH
ETIVTEKARRGRILDRYGRPLAESVESISFYADPEQVNDAGATAKLFANTFGKSRDYYLD
HHHHHHHHHCCCHHHHHCCHHHHHHHHHEEECCHHHHCCCCCHHHHHHHHHCCCHHHHHH
LLRKNKRFVWLERNVPVSQAAKLMSLKIKGVGFRREQHRYYLNVAAQLIGLTDRDNKGIS
HHHCCCCEEEEECCCCHHHHHHHHEEEEECCCCCHHHHHHHHEEHHHHHCCCCCCCCCCH
GLEKSFESQLSGRDGVRIFQRSATGERYPAPDADQVQPLAGNDVTLTIDADVQGILEEEI
HHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHH
AQAVKEFKASGAMGIIMDVRTGEIIAMANYPTFDLNRRSGLTADQMRNRAVTDMFEPGST
HHHHHHHHCCCCEEEEEEECCCCEEEEECCCCCCCCCCCCCCHHHHHCCHHHHHCCCCCC
FKIVMASAATEALGWRAETPVDGHGGSITIYGKQVRDHEPFGAMNFQKAITESSNVVAAS
EEEEEEHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHCCCCCEEEEH
TAMRVGATTFYRYAHALGFGQKTGVGLIGESGGFLKPVSRWGKMTLPWMGYGYQVMATPL
HHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHCCCEECCCCCCCHHHHHHHH
QVLQAYATLANDGVRMRPFIIKRVSGPDGKTIEETRPLKVVQALKPETAHYMAREYFRAV
HHHHHHHHHHCCCCEECCEEEEEECCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHH
VEKGTGMSAKIEGIPVAGKTGTAQKLHNGSYQGWRYYVASFVGFFPYDNPQYAAIIVVDE
HHCCCCCEEEECCEECCCCCCCHHHHCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEEEC
PQTAYYASAVAAPVFSRVCGRAVACSLEMQKRLSMKSPEKELLDRVSTVVVPELKGLRES
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHH
EAAKLLEWNGLKLEPSGSSGGSVTSQSIAPGTKVQKETTVRVRLAKRVQNK
HHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNQARTTPENHRGTSDHEFSLRLGIMVALMLLFCLAIVSKLLGIQVFDVKKYRAKASRQY
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEHHHHHHHHHHHH
ETIVTEKARRGRILDRYGRPLAESVESISFYADPEQVNDAGATAKLFANTFGKSRDYYLD
HHHHHHHHHCCCHHHHHCCHHHHHHHHHEEECCHHHHCCCCCHHHHHHHHHCCCHHHHHH
LLRKNKRFVWLERNVPVSQAAKLMSLKIKGVGFRREQHRYYLNVAAQLIGLTDRDNKGIS
HHHCCCCEEEEECCCCHHHHHHHHEEEEECCCCCHHHHHHHHEEHHHHHCCCCCCCCCCH
GLEKSFESQLSGRDGVRIFQRSATGERYPAPDADQVQPLAGNDVTLTIDADVQGILEEEI
HHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHH
AQAVKEFKASGAMGIIMDVRTGEIIAMANYPTFDLNRRSGLTADQMRNRAVTDMFEPGST
HHHHHHHHCCCCEEEEEEECCCCEEEEECCCCCCCCCCCCCCHHHHHCCHHHHHCCCCCC
FKIVMASAATEALGWRAETPVDGHGGSITIYGKQVRDHEPFGAMNFQKAITESSNVVAAS
EEEEEEHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHCCCCCEEEEH
TAMRVGATTFYRYAHALGFGQKTGVGLIGESGGFLKPVSRWGKMTLPWMGYGYQVMATPL
HHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHCCCEECCCCCCCHHHHHHHH
QVLQAYATLANDGVRMRPFIIKRVSGPDGKTIEETRPLKVVQALKPETAHYMAREYFRAV
HHHHHHHHHHCCCCEECCEEEEEECCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHH
VEKGTGMSAKIEGIPVAGKTGTAQKLHNGSYQGWRYYVASFVGFFPYDNPQYAAIIVVDE
HHCCCCCEEEECCEECCCCCCCHHHHCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEEEC
PQTAYYASAVAAPVFSRVCGRAVACSLEMQKRLSMKSPEKELLDRVSTVVVPELKGLRES
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHH
EAAKLLEWNGLKLEPSGSSGGSVTSQSIAPGTKVQKETTVRVRLAKRVQNK
HHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]