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The map label for this gene is hbpA [H]

Identifier: 13488275

GI number: 13488275

Start: 245811

End: 247373

Strand: Direct

Name: hbpA [H]

Synonym: mlr9269

Alternate gene names: 13488275

Gene position: 245811-247373 (Clockwise)

Preceding gene: 13488360

Following gene: 13488276

Centisome position: 69.85

GC content: 60.78

Gene sequence:

>1563_bases
ATGCAGACAACACGTCGATCATTTCTCAGCATGACTGCCATGGTTGCTGGCGCCCTGGCTTTGCCGCGTTCGCTTCTGGC
CGCAGCCGGCCAGCGGCCAAGCCTCAACATCGCCGTCCAGGACCTGCGCACGATCCTCGAGCCTGTGGCCAGCTCTTCCA
TCGCCAACGTCTCCTGGCGGGTGCAATACAGTATCTTTGATCAGCTGCTGCGGACCGACTACAACGACAATTTCCGCCTC
AACTTCGCGCTCGCGACATCATTGAAGCAGATCGACGCGAAGACCCATGAGATCGTCCTGCGCGACAATGTGAAATTCCA
CGACGGCTCGACGATGACCGCTGACGACGTGGCGTTCTCGCTTGGCGTCGAGCGGTTGCGCGGCGACAAGGCGCCGGGTG
CCGCGGTGGTTGCCAACTTCCTCTCTTCGCTCGCCGATGTGCAGAAGGTCGACGATCGCACGGTCCGCCTGTTCACCAAA
ACTGAGGATCCGGTCTTCACCGATCGTCTCGGCGCATGGGGTACTCAGATTATCAGCGCGAACGCTTGGAAAGCCGCCGC
CAGCTACGACGCATGGGCGGCAAAGCCGATTGGTACCGGCCCCTACAAGATCGGTGATGTGCGCAGCGGCGATGAGATGA
CCCTGATCGCCCATGACGAATATTGGGGTGGTAAGCCGCCGTTCGCCTCCATCCGCTTCAAGCGCTTGCCCGAGATTGCC
GCGCGCATCGCCGGCCTCAAAGCCGGAGACTACGATATCGTCACCGACATTACGCCTGACCATATCTCGGAGATTGAAGG
CGTCAGCGGGCTTTCCGTCACCGGTGGCGAGGCCATGTGGTTCCGGTTCCTGACCTTTGCCCCGCTCAAGACGCCTGTTC
TCAAAGATGTCAATCTTCGCCGCGCGCTCGCCTTCGCGATCGACCGGGACGCGCTGGCTGACGGTCTCTGGAACGGCCGC
GCAAAGGCGCTGACCAGCTGGCAGTTGCCGATCTTCGGCGAGATCAACGATCCCGAGCGCAAGGGCGTGTCCTACGACCC
GGCCCTGGTCAAGGAACTGCTCGCCAAGTCGTCGTACAAGGGCGAGGAAATTCCTTATCCGACCGTCGGGACCTATTACC
CCATGCAGCTTCCGGACAACCAGGCTCTGGTGGAGATGTGGAAAGCCGCGGGCATCAATGTCAAGCTGATCATGTGCGAG
AACTGGGACCAGGTCGGCAATATCGGCGGTATCAACGACACGTCTGGTGGCGCCTTCTACGCCGACCCTGTCTCCATGCT
CTGGCAGATCATCGGTCCGACAAACGACCTCCAGGCCTCGGGCGGCTGGACCAATGCCGAATTCAATGCGCTCGGCAATC
AGCTTGAGACGACGCTGGACCTCGCCAAGCGCAAGGAAGCGTTCAAGCGCATGCAGGACATTGTCGAAATCGATGACCCC
TGCATCACGCCGCTGCACTCCATGCCGTTTATCTACGGGCAAAAGACGGGCCTGGAGTTCACGCCCAATCCGTTGCCGCA
GATGTGGCTTGGCCCGAAGTTGCCGTCCGAACCTGTGGCTTGA

Upstream 100 bases:

>100_bases
CTCATAAAACCGTCATACAGCTGCGCTATGTGTCTCCCGGCTTCGGGACGCACCTGACTCTTCAGCTTGCTCTCCCGGTT
GACAACGAGAGGGTTAGATT

Downstream 100 bases:

>100_bases
GCCCGATGCTGAACGCATTCAGCACGAACAGCGCGGACGCCGCGCTGTTCGCCAGTCAGGACGTCGTCGATCACCGCAAA
CGACCCGTTCTCACGGTCAA

Product: extracellular solute-binding protein

Products: ADP; phosphate; dipeptides [Cytoplasm] [C]

Alternate protein names: Hemin-binding lipoprotein [H]

Number of amino acids: Translated: 520; Mature: 520

Protein sequence:

>520_residues
MQTTRRSFLSMTAMVAGALALPRSLLAAAGQRPSLNIAVQDLRTILEPVASSSIANVSWRVQYSIFDQLLRTDYNDNFRL
NFALATSLKQIDAKTHEIVLRDNVKFHDGSTMTADDVAFSLGVERLRGDKAPGAAVVANFLSSLADVQKVDDRTVRLFTK
TEDPVFTDRLGAWGTQIISANAWKAAASYDAWAAKPIGTGPYKIGDVRSGDEMTLIAHDEYWGGKPPFASIRFKRLPEIA
ARIAGLKAGDYDIVTDITPDHISEIEGVSGLSVTGGEAMWFRFLTFAPLKTPVLKDVNLRRALAFAIDRDALADGLWNGR
AKALTSWQLPIFGEINDPERKGVSYDPALVKELLAKSSYKGEEIPYPTVGTYYPMQLPDNQALVEMWKAAGINVKLIMCE
NWDQVGNIGGINDTSGGAFYADPVSMLWQIIGPTNDLQASGGWTNAEFNALGNQLETTLDLAKRKEAFKRMQDIVEIDDP
CITPLHSMPFIYGQKTGLEFTPNPLPQMWLGPKLPSEPVA

Sequences:

>Translated_520_residues
MQTTRRSFLSMTAMVAGALALPRSLLAAAGQRPSLNIAVQDLRTILEPVASSSIANVSWRVQYSIFDQLLRTDYNDNFRL
NFALATSLKQIDAKTHEIVLRDNVKFHDGSTMTADDVAFSLGVERLRGDKAPGAAVVANFLSSLADVQKVDDRTVRLFTK
TEDPVFTDRLGAWGTQIISANAWKAAASYDAWAAKPIGTGPYKIGDVRSGDEMTLIAHDEYWGGKPPFASIRFKRLPEIA
ARIAGLKAGDYDIVTDITPDHISEIEGVSGLSVTGGEAMWFRFLTFAPLKTPVLKDVNLRRALAFAIDRDALADGLWNGR
AKALTSWQLPIFGEINDPERKGVSYDPALVKELLAKSSYKGEEIPYPTVGTYYPMQLPDNQALVEMWKAAGINVKLIMCE
NWDQVGNIGGINDTSGGAFYADPVSMLWQIIGPTNDLQASGGWTNAEFNALGNQLETTLDLAKRKEAFKRMQDIVEIDDP
CITPLHSMPFIYGQKTGLEFTPNPLPQMWLGPKLPSEPVA
>Mature_520_residues
MQTTRRSFLSMTAMVAGALALPRSLLAAAGQRPSLNIAVQDLRTILEPVASSSIANVSWRVQYSIFDQLLRTDYNDNFRL
NFALATSLKQIDAKTHEIVLRDNVKFHDGSTMTADDVAFSLGVERLRGDKAPGAAVVANFLSSLADVQKVDDRTVRLFTK
TEDPVFTDRLGAWGTQIISANAWKAAASYDAWAAKPIGTGPYKIGDVRSGDEMTLIAHDEYWGGKPPFASIRFKRLPEIA
ARIAGLKAGDYDIVTDITPDHISEIEGVSGLSVTGGEAMWFRFLTFAPLKTPVLKDVNLRRALAFAIDRDALADGLWNGR
AKALTSWQLPIFGEINDPERKGVSYDPALVKELLAKSSYKGEEIPYPTVGTYYPMQLPDNQALVEMWKAAGINVKLIMCE
NWDQVGNIGGINDTSGGAFYADPVSMLWQIIGPTNDLQASGGWTNAEFNALGNQLETTLDLAKRKEAFKRMQDIVEIDDP
CITPLHSMPFIYGQKTGLEFTPNPLPQMWLGPKLPSEPVA

Specific function: Important role in heme acquisition or metabolism [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 5 family [H]

Homologues:

Organism=Escherichia coli, GI1789966, Length=451, Percent_Identity=25.0554323725055, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1787551, Length=374, Percent_Identity=26.4705882352941, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1787762, Length=328, Percent_Identity=26.5243902439024, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1787052, Length=345, Percent_Identity=24.3478260869565, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: 660 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2980 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000914 [H]

Pfam domain/function: PF00496 SBP_bac_5 [H]

EC number: NA

Molecular weight: Translated: 57076; Mature: 57076

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTTRRSFLSMTAMVAGALALPRSLLAAAGQRPSLNIAVQDLRTILEPVASSSIANVSWR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHCCCCCCEEEE
VQYSIFDQLLRTDYNDNFRLNFALATSLKQIDAKTHEIVLRDNVKFHDGSTMTADDVAFS
EEHHHHHHHHHCCCCCCEEEEEHHHHHHHHHCCCCEEEEEECCEEECCCCCCCHHHHHHH
LGVERLRGDKAPGAAVVANFLSSLADVQKVDDRTVRLFTKTEDPVFTDRLGAWGTQIISA
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHCCCHHHEEEC
NAWKAAASYDAWAAKPIGTGPYKIGDVRSGDEMTLIAHDEYWGGKPPFASIRFKRLPEIA
CCHHHHCCCCCCCCCCCCCCCEEECCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHH
ARIAGLKAGDYDIVTDITPDHISEIEGVSGLSVTGGEAMWFRFLTFAPLKTPVLKDVNLR
HHHHCCCCCCCEEEECCCHHHHHHHCCCCCCEECCCHHHHHHHHHHCCCCCCHHHCCHHH
RALAFAIDRDALADGLWNGRAKALTSWQLPIFGEINDPERKGVSYDPALVKELLAKSSYK
HHHHHHHCHHHHHHHHCCCCHHEEEEECCEEECCCCCHHHCCCCCCHHHHHHHHHHCCCC
GEEIPYPTVGTYYPMQLPDNQALVEMWKAAGINVKLIMCENWDQVGNIGGINDTSGGAFY
CCCCCCCCCCCEEECCCCCCHHHHHHHHHCCCEEEEEEECCCHHHCCCCCCCCCCCCEEE
ADPVSMLWQIIGPTNDLQASGGWTNAEFNALGNQLETTLDLAKRKEAFKRMQDIVEIDDP
ECHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
CITPLHSMPFIYGQKTGLEFTPNPLPQMWLGPKLPSEPVA
CCCCHHHCCEEEECCCCCCCCCCCCCHHHCCCCCCCCCCC
>Mature Secondary Structure
MQTTRRSFLSMTAMVAGALALPRSLLAAAGQRPSLNIAVQDLRTILEPVASSSIANVSWR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHCCCCCCEEEE
VQYSIFDQLLRTDYNDNFRLNFALATSLKQIDAKTHEIVLRDNVKFHDGSTMTADDVAFS
EEHHHHHHHHHCCCCCCEEEEEHHHHHHHHHCCCCEEEEEECCEEECCCCCCCHHHHHHH
LGVERLRGDKAPGAAVVANFLSSLADVQKVDDRTVRLFTKTEDPVFTDRLGAWGTQIISA
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHCCCHHHEEEC
NAWKAAASYDAWAAKPIGTGPYKIGDVRSGDEMTLIAHDEYWGGKPPFASIRFKRLPEIA
CCHHHHCCCCCCCCCCCCCCCEEECCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHH
ARIAGLKAGDYDIVTDITPDHISEIEGVSGLSVTGGEAMWFRFLTFAPLKTPVLKDVNLR
HHHHCCCCCCCEEEECCCHHHHHHHCCCCCCEECCCHHHHHHHHHHCCCCCCHHHCCHHH
RALAFAIDRDALADGLWNGRAKALTSWQLPIFGEINDPERKGVSYDPALVKELLAKSSYK
HHHHHHHCHHHHHHHHCCCCHHEEEEECCEEECCCCCHHHCCCCCCHHHHHHHHHHCCCC
GEEIPYPTVGTYYPMQLPDNQALVEMWKAAGINVKLIMCENWDQVGNIGGINDTSGGAFY
CCCCCCCCCCCEEECCCCCCHHHHHHHHHCCCEEEEEEECCCHHHCCCCCCCCCCCCEEE
ADPVSMLWQIIGPTNDLQASGGWTNAEFNALGNQLETTLDLAKRKEAFKRMQDIVEIDDP
ECHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
CITPLHSMPFIYGQKTGLEFTPNPLPQMWLGPKLPSEPVA
CCCCHHHCCEEEECCCCCCCCCCCCCHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; dipeptides [Periplasm]; H2O [C]

Specific reaction: ATP + dipeptides [Periplasm] + H2O = ADP + phosphate + dipeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1339409; 7542800; 2041470 [H]