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The map label for this gene is virB11 [H]

Identifier: 13488269

GI number: 13488269

Start: 237941

End: 238987

Strand: Direct

Name: virB11 [H]

Synonym: mlr9260

Alternate gene names: 13488269

Gene position: 237941-238987 (Clockwise)

Preceding gene: 13488268

Following gene: 13488270

Centisome position: 67.61

GC content: 60.94

Gene sequence:

>1047_bases
GTGAGCGGGCAGCAAAGAACCGTCTTTCTAAATAAGGCGCTGGAGCCGGTGCGGCGCTGGCTCGACGACGATCGCGTGGT
CGAAATCTGCGCAAACGGGCCTGGACTTGTGTGGGTCGAAATTGTTGGCTCGACACATATGGAGCCCTTCGACGTGCCCG
AGCTCGACCGCGCCGCGATCACTTACCTCATGGAACGTATAGCGGCATCATCCTCGCAATCGATCAGCGAGGAAAATCCC
TTGCTTTCGGCCGCCCTCCCCGGCGGCGAACGCTTCCAGGGCGTGCTTGCGCCGGCGACGCCGACAGGAGGCGCCTTCGC
GATCCGCAAGCAGGTCGTGAAGGATATGCGCCTTGATGATTACCGGAAGCGGGGGTCGTTCGATACGATCTCCGTCCAGG
ATCCCGGCGAATTGAGCGAGACCGACAGCGCCCTTTGCGAATATCTCGACGCCGGCAAGATCGAGGATTTCCTCCGCTTG
GCCGTGCGGGAACGGTATTCGATCTTACTTTCAGGAGGCACATCGTCGGGCAAAACGACGTTCCTGAACGCGATTTTGCA
CGAGGTGCCCTCGGATGAGCGGATCCTCACCATTGAGGATACGAGAGAAGTCAAACCACGCCAGCCCAACTATCTGCCCC
TCGTCGTGTCAAAGGGCGACCAGGGCCTGGCGCACGTGACCGTTGAAACGCTGCTGCAGGCGGCCATGCGCTTGCGGCCG
GATCGAATCTTCCTGGGCGAGATCCGGGGAGCGGAAGCCTATTCGTTCTTGCGCGCCGTCAACACGGGCCATCCAGGATC
GATCACGACGATCCATGCCGACAGCCCCACCGGTGCGTTCGAGCAGTTAGCCTTGATGGTCATGCAGGCTGGGCTCGGGC
TGAGGAAGGCAGAGATCATCGATTACGTGCGGGCGGTCCTGCCGATTGTCATCCAACAGACGCGCCGGGGCGGCTGGCGT
GGAACTTCGGCGATCTGGTTCAGCCGCATGACCGAATGGAGAGCCGCCAGAAAGGTTTCCCAGAATGTCGCGCGTATTGG
CTTATAG

Upstream 100 bases:

>100_bases
GTCGATCAGGGATCGCGAATAATGGTGTTCGTGCGCCGCGACCTCGATTTTTCGGAGTTCTATCCGGACCCGGTACGCGA
GGCGTTGACGGAGATACGAC

Downstream 100 bases:

>100_bases
GCTTTTCCTCGGCCTCATGGGCCTCGCCGCCTTCTTCGCCCTTTGGAGCCTGGCCTACGAGCTGGTGGCGACATGGCGGT
GGAACCCCGCCCTCCCTTCC

Product: type IV secretion system protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 348; Mature: 347

Protein sequence:

>348_residues
MSGQQRTVFLNKALEPVRRWLDDDRVVEICANGPGLVWVEIVGSTHMEPFDVPELDRAAITYLMERIAASSSQSISEENP
LLSAALPGGERFQGVLAPATPTGGAFAIRKQVVKDMRLDDYRKRGSFDTISVQDPGELSETDSALCEYLDAGKIEDFLRL
AVRERYSILLSGGTSSGKTTFLNAILHEVPSDERILTIEDTREVKPRQPNYLPLVVSKGDQGLAHVTVETLLQAAMRLRP
DRIFLGEIRGAEAYSFLRAVNTGHPGSITTIHADSPTGAFEQLALMVMQAGLGLRKAEIIDYVRAVLPIVIQQTRRGGWR
GTSAIWFSRMTEWRAARKVSQNVARIGL

Sequences:

>Translated_348_residues
MSGQQRTVFLNKALEPVRRWLDDDRVVEICANGPGLVWVEIVGSTHMEPFDVPELDRAAITYLMERIAASSSQSISEENP
LLSAALPGGERFQGVLAPATPTGGAFAIRKQVVKDMRLDDYRKRGSFDTISVQDPGELSETDSALCEYLDAGKIEDFLRL
AVRERYSILLSGGTSSGKTTFLNAILHEVPSDERILTIEDTREVKPRQPNYLPLVVSKGDQGLAHVTVETLLQAAMRLRP
DRIFLGEIRGAEAYSFLRAVNTGHPGSITTIHADSPTGAFEQLALMVMQAGLGLRKAEIIDYVRAVLPIVIQQTRRGGWR
GTSAIWFSRMTEWRAARKVSQNVARIGL
>Mature_347_residues
SGQQRTVFLNKALEPVRRWLDDDRVVEICANGPGLVWVEIVGSTHMEPFDVPELDRAAITYLMERIAASSSQSISEENPL
LSAALPGGERFQGVLAPATPTGGAFAIRKQVVKDMRLDDYRKRGSFDTISVQDPGELSETDSALCEYLDAGKIEDFLRLA
VRERYSILLSGGTSSGKTTFLNAILHEVPSDERILTIEDTREVKPRQPNYLPLVVSKGDQGLAHVTVETLLQAAMRLRPD
RIFLGEIRGAEAYSFLRAVNTGHPGSITTIHADSPTGAFEQLALMVMQAGLGLRKAEIIDYVRAVLPIVIQQTRRGGWRG
TSAIWFSRMTEWRAARKVSQNVARIGL

Specific function: The type IV secretion system VirB/VirD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-

COG id: COG0630

COG function: function code NU; Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis

Gene ontology:

Cell location: Cell inner membrane (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GSP E family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR014155
- InterPro:   IPR001482 [H]

Pfam domain/function: PF00437 GSPII_E [H]

EC number: NA

Molecular weight: Translated: 38417; Mature: 38286

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGQQRTVFLNKALEPVRRWLDDDRVVEICANGPGLVWVEIVGSTHMEPFDVPELDRAAI
CCCCCEEHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEEEECCCCCCCCCCCCHHHHHH
TYLMERIAASSSQSISEENPLLSAALPGGERFQGVLAPATPTGGAFAIRKQVVKDMRLDD
HHHHHHHHCCCCCCCCCCCCEEEEECCCCHHCCEEECCCCCCCCHHHHHHHHHHHCCHHH
YRKRGSFDTISVQDPGELSETDSALCEYLDAGKIEDFLRLAVRERYSILLSGGTSSGKTT
HHHCCCCCEEECCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHEEEEECCCCCCHHH
FLNAILHEVPSDERILTIEDTREVKPRQPNYLPLVVSKGDQGLAHVTVETLLQAAMRLRP
HHHHHHHHCCCCCEEEEEECCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCC
DRIFLGEIRGAEAYSFLRAVNTGHPGSITTIHADSPTGAFEQLALMVMQAGLGLRKAEII
CEEEEECCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCHHHHHH
DYVRAVLPIVIQQTRRGGWRGTSAIWFSRMTEWRAARKVSQNVARIGL
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SGQQRTVFLNKALEPVRRWLDDDRVVEICANGPGLVWVEIVGSTHMEPFDVPELDRAAI
CCCCEEHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEEEECCCCCCCCCCCCHHHHHH
TYLMERIAASSSQSISEENPLLSAALPGGERFQGVLAPATPTGGAFAIRKQVVKDMRLDD
HHHHHHHHCCCCCCCCCCCCEEEEECCCCHHCCEEECCCCCCCCHHHHHHHHHHHCCHHH
YRKRGSFDTISVQDPGELSETDSALCEYLDAGKIEDFLRLAVRERYSILLSGGTSSGKTT
HHHCCCCCEEECCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHEEEEECCCCCCHHH
FLNAILHEVPSDERILTIEDTREVKPRQPNYLPLVVSKGDQGLAHVTVETLLQAAMRLRP
HHHHHHHHCCCCCEEEEEECCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCC
DRIFLGEIRGAEAYSFLRAVNTGHPGSITTIHADSPTGAFEQLALMVMQAGLGLRKAEII
CEEEEECCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCHHHHHH
DYVRAVLPIVIQQTRRGGWRGTSAIWFSRMTEWRAARKVSQNVARIGL
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10882236 [H]