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The map label for this gene is comC [H]

Identifier: 13488244

GI number: 13488244

Start: 196365

End: 197465

Strand: Direct

Name: comC [H]

Synonym: mlr9216

Alternate gene names: 13488244

Gene position: 196365-197465 (Clockwise)

Preceding gene: 13488243

Following gene: 13488245

Centisome position: 55.8

GC content: 60.76

Gene sequence:

>1101_bases
ATGAGTTCAACCGAAGACCTACGGCTGGGTGAACCGCACGAAGGGCGCTTTTTGGTGGTGAAGTCCGACCGTCTCACGCG
CATATGCGCGGCGCTGTTGAAAGCAGCCGGCGCTTCAGAGGACGAAGCGCAAGCAGTCGCCACCGGCTGCGTCAACGCCA
ACCTGGCTGGCCATGATTCTCATGGGGTCATCGCCATTCCAGGCTACATCGACAGCCTGAAGGCAGGGGATATCGTGCCG
GGTGCAGAGTGGACAATTGTGCGAGAATCCCCCACCACGGCTGTTATCGATGGCAATTGGGGTTTTGGTTTTCATGTCAA
CGCTAAGGCCATGGCGCTCGTGATCGAAAAAGCAAAGATCGCGAACGTCGCGGCGTGCACAGTCTTCAGGCAGAGCCATG
TCGGACGGCTAGCCGCGTATCCTTTGATGGCGGTAAGCGCCGGCATGATCGGGTTTGCGGTCGCTGGTTCCGGTAGCTTT
CCCGATTGTGTCGCGCCCTTCGGTGGACGTGAGGCGCGGCTTGGCACCAACCCCATCTCGATCGGGGTGCCCTCCAATCT
CCAAGCCCCATTTCTGCTCGACATGGCAACCTCAGCCGCTGCCGCCGGCAAGCTCGAAGTGGCGATCGCGCGTCGTGAGA
AAATTCCCGAGGGCTGGTTGATCGATGCCGAGGGACGCCCCACGACCAACCCCCACGACTACCTCAAGGGCGGGGTGCTA
CTGCCGCTCGGCGGTCCCGAGGGCTACAAGGGCAGCGGCCTCGCCGCAATCGTGGAACTGTTGTGCGGACTGCTGCCAGA
TCCTGGTTTCGGGCCCCAGCCGAGCGGCCGGGAGAATTTAGGCTGCTTTATGGCTGTCTTCAATGTGGCAGCGTTCTGCC
CGCTTAACAAATTCAAACAAGAGGTCGCCGAGTTCGCGCGGTACCTTAAATCGGCGACGCCGTCGGAAGGCTCGCCCGGC
GTGTTCTACCCCGGAGAGATCGGATATTTGCGCGCACAGGAGCGCATGGCAAACGGCATTGAGATAGAGAAAGCGACCTG
GGACAAGCTGCGCACGCTGGCGCGTAATTACAGGCTTGCCGGAGAACTTGATCTCGCCTGA

Upstream 100 bases:

>100_bases
GCCTTACTCACGAGTTCGACCCACGCGGGTGGCAAGAAATTTGCACGGGGTGTTACGCCGCCTGATGGTCGGTGATGGGC
CTGAATCGAGGAAACGTTCA

Downstream 100 bases:

>100_bases
AATGTATGACGGATGAAGGTCGGGTTTGACGCATATTGGCGTAATACCGCGGAGCGTTCGCCTGCCACTGCCCCAGGAAG
TCGGCGACGCGGCGTTTGAC

Product: malate dehydrogenase

Products: NA

Alternate protein names: (R)-2-hydroxyacid dehydrogenase; (R)-sulfolactate dehydrogenase [H]

Number of amino acids: Translated: 366; Mature: 365

Protein sequence:

>366_residues
MSSTEDLRLGEPHEGRFLVVKSDRLTRICAALLKAAGASEDEAQAVATGCVNANLAGHDSHGVIAIPGYIDSLKAGDIVP
GAEWTIVRESPTTAVIDGNWGFGFHVNAKAMALVIEKAKIANVAACTVFRQSHVGRLAAYPLMAVSAGMIGFAVAGSGSF
PDCVAPFGGREARLGTNPISIGVPSNLQAPFLLDMATSAAAAGKLEVAIARREKIPEGWLIDAEGRPTTNPHDYLKGGVL
LPLGGPEGYKGSGLAAIVELLCGLLPDPGFGPQPSGRENLGCFMAVFNVAAFCPLNKFKQEVAEFARYLKSATPSEGSPG
VFYPGEIGYLRAQERMANGIEIEKATWDKLRTLARNYRLAGELDLA

Sequences:

>Translated_366_residues
MSSTEDLRLGEPHEGRFLVVKSDRLTRICAALLKAAGASEDEAQAVATGCVNANLAGHDSHGVIAIPGYIDSLKAGDIVP
GAEWTIVRESPTTAVIDGNWGFGFHVNAKAMALVIEKAKIANVAACTVFRQSHVGRLAAYPLMAVSAGMIGFAVAGSGSF
PDCVAPFGGREARLGTNPISIGVPSNLQAPFLLDMATSAAAAGKLEVAIARREKIPEGWLIDAEGRPTTNPHDYLKGGVL
LPLGGPEGYKGSGLAAIVELLCGLLPDPGFGPQPSGRENLGCFMAVFNVAAFCPLNKFKQEVAEFARYLKSATPSEGSPG
VFYPGEIGYLRAQERMANGIEIEKATWDKLRTLARNYRLAGELDLA
>Mature_365_residues
SSTEDLRLGEPHEGRFLVVKSDRLTRICAALLKAAGASEDEAQAVATGCVNANLAGHDSHGVIAIPGYIDSLKAGDIVPG
AEWTIVRESPTTAVIDGNWGFGFHVNAKAMALVIEKAKIANVAACTVFRQSHVGRLAAYPLMAVSAGMIGFAVAGSGSFP
DCVAPFGGREARLGTNPISIGVPSNLQAPFLLDMATSAAAAGKLEVAIARREKIPEGWLIDAEGRPTTNPHDYLKGGVLL
PLGGPEGYKGSGLAAIVELLCGLLPDPGFGPQPSGRENLGCFMAVFNVAAFCPLNKFKQEVAEFARYLKSATPSEGSPGV
FYPGEIGYLRAQERMANGIEIEKATWDKLRTLARNYRLAGELDLA

Specific function: Catalyzes the reduction of sulfopyruvate to (R)- sulfolactate much more efficiently than the reverse reaction. Also catalyzes the reduction of oxaloacetate, alpha-ketoglutarate, and to a much lower extent, KHTCA, but not pyruvate. Involved in the biosynth

COG id: COG2055

COG function: function code C; Malate/L-lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH2/MDH2 oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1787020, Length=344, Percent_Identity=32.5581395348837, Blast_Score=159, Evalue=2e-40,
Organism=Escherichia coli, GI1786727, Length=340, Percent_Identity=29.4117647058824, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1790000, Length=328, Percent_Identity=25.9146341463415, Blast_Score=94, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI17507179, Length=358, Percent_Identity=32.4022346368715, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17536633, Length=326, Percent_Identity=33.4355828220859, Blast_Score=130, Evalue=9e-31,
Organism=Drosophila melanogaster, GI24667908, Length=319, Percent_Identity=32.6018808777429, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24667904, Length=319, Percent_Identity=32.6018808777429, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI45553211, Length=319, Percent_Identity=32.6018808777429, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24667912, Length=319, Percent_Identity=32.6018808777429, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24658010, Length=326, Percent_Identity=28.5276073619632, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24648360, Length=350, Percent_Identity=25.4285714285714, Blast_Score=96, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003767 [H]

Pfam domain/function: PF02615 Ldh_2 [H]

EC number: =1.1.1.272 [H]

Molecular weight: Translated: 38477; Mature: 38346

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSTEDLRLGEPHEGRFLVVKSDRLTRICAALLKAAGASEDEAQAVATGCVNANLAGHDS
CCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCC
HGVIAIPGYIDSLKAGDIVPGAEWTIVRESPTTAVIDGNWGFGFHVNAKAMALVIEKAKI
CCEEEECCCHHCCCCCCCCCCCCEEEEECCCCEEEEECCCCCEEEECCCEEEEEEHHHHH
ANVAACTVFRQSHVGRLAAYPLMAVSAGMIGFAVAGSGSFPDCVAPFGGREARLGTNPIS
HHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEEEEECCCCCCHHHCCCCCCCCCCCCCCEE
IGVPSNLQAPFLLDMATSAAAAGKLEVAIARREKIPEGWLIDAEGRPTTNPHDYLKGGVL
ECCCCCCCCCEEEEHHHHHHCCCCEEEEEEHHHCCCCCCEEECCCCCCCCHHHHHCCCEE
LPLGGPEGYKGSGLAAIVELLCGLLPDPGFGPQPSGRENLGCFMAVFNVAAFCPLNKFKQ
EECCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHH
EVAEFARYLKSATPSEGSPGVFYPGEIGYLRAQERMANGIEIEKATWDKLRTLARNYRLA
HHHHHHHHHHHCCCCCCCCCEECCCCCCHHHHHHHHHCCCEEEHHHHHHHHHHHHHCCCC
GELDLA
EEECCC
>Mature Secondary Structure 
SSTEDLRLGEPHEGRFLVVKSDRLTRICAALLKAAGASEDEAQAVATGCVNANLAGHDS
CCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCC
HGVIAIPGYIDSLKAGDIVPGAEWTIVRESPTTAVIDGNWGFGFHVNAKAMALVIEKAKI
CCEEEECCCHHCCCCCCCCCCCCEEEEECCCCEEEEECCCCCEEEECCCEEEEEEHHHHH
ANVAACTVFRQSHVGRLAAYPLMAVSAGMIGFAVAGSGSFPDCVAPFGGREARLGTNPIS
HHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEEEEECCCCCCHHHCCCCCCCCCCCCCCEE
IGVPSNLQAPFLLDMATSAAAAGKLEVAIARREKIPEGWLIDAEGRPTTNPHDYLKGGVL
ECCCCCCCCCEEEEHHHHHHCCCCEEEEEEHHHCCCCCCEEECCCCCCCCHHHHHCCCEE
LPLGGPEGYKGSGLAAIVELLCGLLPDPGFGPQPSGRENLGCFMAVFNVAAFCPLNKFKQ
EECCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHH
EVAEFARYLKSATPSEGSPGVFYPGEIGYLRAQERMANGIEIEKATWDKLRTLARNYRLA
HHHHHHHHHHHCCCCCCCCCEECCCCCCHHHHHHHHHCCCEEEHHHHHHHHHHHHHCCCC
GELDLA
EEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087; 10850983 [H]