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The map label for this gene is serA [H]

Identifier: 13488239

GI number: 13488239

Start: 187199

End: 188215

Strand: Direct

Name: serA [H]

Synonym: mlr9208

Alternate gene names: 13488239

Gene position: 187199-188215 (Clockwise)

Preceding gene: 13488238

Following gene: 13488240

Centisome position: 53.19

GC content: 53.49

Gene sequence:

>1017_bases
ATGAAGATACTTGTTGGATGGCACGCGACCGATGACGAGCTGGCTCGGTTTCAAACGGCGGTTCCTGGTGCCACCGTTGT
TGGCCCCCGTCCTGAACCTCACCTTTCTCGGTTCGATCTGACACTCGAGTCGATTGCAAATGACATCAGTGACGCAGATT
GCTTCGTTGGATGGGTCATGCCCGACGGTGCACTGGACATCGCCAAGAAGCTGAAATTGATATGTTGGATGCATACGGGT
TGCGACGAGCTTGACCTAGCTCGCCTTAAAACGCTCGGTGTCCAGGTCACCAATCTACGTGGAGCCAACAGTATTCCGGT
GGCTGAGCAGGCCATGGCGATTATGCTGGGTTTGGCCAAGCGATTGCTTTTTAAGCACCAAGCTGTCGTCAACGGCGACC
CCCTGCTGGTTTTTGCCAACGAAACGCGGTCGGCCATGCTGAATGGTCGAACTGTCGGCGTGATCGGCTTGGGGCAGATC
GGGTCGGCAATCGCCAAGCGTGCCAAAGCCTTCGATATGAAGGTACTGGGGGTTCGTCTTCATCCGGAGCTTGGTGCCGG
CGTAGCGGATGAGGTGTTCGGAATCGACAAGTTGCATCATGTGCTGGCGCAGAGTGACTACGTAGTACTGTCGACGCCAA
TCACAAAAAAAACCGAGGCTTTCATTGGCGCCGCCGAGATTGCGGCGATGAAACATGGTGTTGTCTTAGTGAACGTCGCA
CGTGGCAATCTCATCCAAGAGAAACCTCTTTATGATGCGCTGCAGGCCGGCAAGATCTTTGGCTATGGTGCGGATGTCTG
GTGGAATTATAAAAATGCTTATCCTGCGACGTACCATTTTCCAGCCCCTTCAAGAACCGGGATACAGCGGCTTCCAAACG
TCATAGGGTCAGGCGATCAGGCCGTGAATGCGGACGGTGTTCTTGATGGGAACATCGATCGATGCGTGGAGAGTCTGGTT
CAGTTTTCCAACAACAAGCCACTTACTTGGAAGATAGATCTTGACCTTGGATACTAG

Upstream 100 bases:

>100_bases
GACGATACGTTTCATGTCGTCTGAAGTTTTGGCCGATTGGACGCGGTCATTTCCTCCATGATCCTGCAGCAATCAACTAA
CGACAAGCCGGGGCGTTGTA

Downstream 100 bases:

>100_bases
GCCGCACCGACAGGCGTCCGCCCCTTTGCGGACCGATGCTCACGTGGTCGTGGCGGAGCGTTCTGCGGCCCCTGGGCTGC
TTCCCAACCGCGCAGGTTCG

Product: phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MKILVGWHATDDELARFQTAVPGATVVGPRPEPHLSRFDLTLESIANDISDADCFVGWVMPDGALDIAKKLKLICWMHTG
CDELDLARLKTLGVQVTNLRGANSIPVAEQAMAIMLGLAKRLLFKHQAVVNGDPLLVFANETRSAMLNGRTVGVIGLGQI
GSAIAKRAKAFDMKVLGVRLHPELGAGVADEVFGIDKLHHVLAQSDYVVLSTPITKKTEAFIGAAEIAAMKHGVVLVNVA
RGNLIQEKPLYDALQAGKIFGYGADVWWNYKNAYPATYHFPAPSRTGIQRLPNVIGSGDQAVNADGVLDGNIDRCVESLV
QFSNNKPLTWKIDLDLGY

Sequences:

>Translated_338_residues
MKILVGWHATDDELARFQTAVPGATVVGPRPEPHLSRFDLTLESIANDISDADCFVGWVMPDGALDIAKKLKLICWMHTG
CDELDLARLKTLGVQVTNLRGANSIPVAEQAMAIMLGLAKRLLFKHQAVVNGDPLLVFANETRSAMLNGRTVGVIGLGQI
GSAIAKRAKAFDMKVLGVRLHPELGAGVADEVFGIDKLHHVLAQSDYVVLSTPITKKTEAFIGAAEIAAMKHGVVLVNVA
RGNLIQEKPLYDALQAGKIFGYGADVWWNYKNAYPATYHFPAPSRTGIQRLPNVIGSGDQAVNADGVLDGNIDRCVESLV
QFSNNKPLTWKIDLDLGY
>Mature_338_residues
MKILVGWHATDDELARFQTAVPGATVVGPRPEPHLSRFDLTLESIANDISDADCFVGWVMPDGALDIAKKLKLICWMHTG
CDELDLARLKTLGVQVTNLRGANSIPVAEQAMAIMLGLAKRLLFKHQAVVNGDPLLVFANETRSAMLNGRTVGVIGLGQI
GSAIAKRAKAFDMKVLGVRLHPELGAGVADEVFGIDKLHHVLAQSDYVVLSTPITKKTEAFIGAAEIAAMKHGVVLVNVA
RGNLIQEKPLYDALQAGKIFGYGADVWWNYKNAYPATYHFPAPSRTGIQRLPNVIGSGDQAVNADGVLDGNIDRCVESLV
QFSNNKPLTWKIDLDLGY

Specific function: Fermentative Lactate Dehydrogenase. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI61743967, Length=231, Percent_Identity=31.1688311688312, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI4557497, Length=231, Percent_Identity=31.1688311688312, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI23308577, Length=210, Percent_Identity=30.4761904761905, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI6912396, Length=249, Percent_Identity=30.1204819277108, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI145580578, Length=231, Percent_Identity=30.3030303030303, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI4557499, Length=231, Percent_Identity=30.3030303030303, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI145580575, Length=209, Percent_Identity=32.0574162679426, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI1787645, Length=288, Percent_Identity=29.1666666666667, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI87082289, Length=295, Percent_Identity=27.7966101694915, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1789279, Length=291, Percent_Identity=26.1168384879725, Blast_Score=72, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=201, Percent_Identity=32.8358208955224, Blast_Score=91, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI25147481, Length=209, Percent_Identity=25.8373205741627, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6324964, Length=259, Percent_Identity=30.8880308880309, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6320925, Length=266, Percent_Identity=30.8270676691729, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6322116, Length=266, Percent_Identity=30.0751879699248, Blast_Score=92, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6324055, Length=208, Percent_Identity=30.2884615384615, Blast_Score=85, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324980, Length=135, Percent_Identity=32.5925925925926, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24585514, Length=210, Percent_Identity=33.8095238095238, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI28574282, Length=210, Percent_Identity=33.8095238095238, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI28574284, Length=210, Percent_Identity=33.8095238095238, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI45551003, Length=210, Percent_Identity=33.8095238095238, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI45552429, Length=210, Percent_Identity=33.8095238095238, Blast_Score=98, Evalue=6e-21,
Organism=Drosophila melanogaster, GI62472511, Length=212, Percent_Identity=33.4905660377358, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24646446, Length=234, Percent_Identity=31.6239316239316, Blast_Score=95, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24646448, Length=234, Percent_Identity=31.6239316239316, Blast_Score=95, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24646452, Length=234, Percent_Identity=31.6239316239316, Blast_Score=95, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24646450, Length=234, Percent_Identity=31.6239316239316, Blast_Score=95, Evalue=8e-20,
Organism=Drosophila melanogaster, GI28574286, Length=199, Percent_Identity=28.643216080402, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI19921140, Length=201, Percent_Identity=31.8407960199005, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24585516, Length=236, Percent_Identity=25.8474576271186, Blast_Score=78, Evalue=9e-15,
Organism=Drosophila melanogaster, GI28571528, Length=243, Percent_Identity=27.5720164609054, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 36544; Mature: 36544

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILVGWHATDDELARFQTAVPGATVVGPRPEPHLSRFDLTLESIANDISDADCFVGWVM
CEEEEEECCCHHHHHHHHHCCCCCEEECCCCCCCCHHHHEEHHHHHCCCCCCCEEEEEEC
PDGALDIAKKLKLICWMHTGCDELDLARLKTLGVQVTNLRGANSIPVAEQAMAIMLGLAK
CCCHHHHHHHHEEEEEECCCCCHHHHHHHHHHCEEEEECCCCCCCCHHHHHHHHHHHHHH
RLLFKHQAVVNGDPLLVFANETRSAMLNGRTVGVIGLGQIGSAIAKRAKAFDMKVLGVRL
HHHHHHHHEECCCEEEEEECCCHHHHCCCCEEEEEECHHHHHHHHHHHHHCCEEEEEEEE
HPELGAGVADEVFGIDKLHHVLAQSDYVVLSTPITKKTEAFIGAAEIAAMKHGVVLVNVA
CCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHCCEEEEEEC
RGNLIQEKPLYDALQAGKIFGYGADVWWNYKNAYPATYHFPAPSRTGIQRLPNVIGSGDQ
CCCCCCCCCHHHHHHCCCEEEECCCEEECCCCCCCEEEECCCCCCHHHHHHHHHHCCCCC
AVNADGVLDGNIDRCVESLVQFSNNKPLTWKIDLDLGY
CCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEEECC
>Mature Secondary Structure
MKILVGWHATDDELARFQTAVPGATVVGPRPEPHLSRFDLTLESIANDISDADCFVGWVM
CEEEEEECCCHHHHHHHHHCCCCCEEECCCCCCCCHHHHEEHHHHHCCCCCCCEEEEEEC
PDGALDIAKKLKLICWMHTGCDELDLARLKTLGVQVTNLRGANSIPVAEQAMAIMLGLAK
CCCHHHHHHHHEEEEEECCCCCHHHHHHHHHHCEEEEECCCCCCCCHHHHHHHHHHHHHH
RLLFKHQAVVNGDPLLVFANETRSAMLNGRTVGVIGLGQIGSAIAKRAKAFDMKVLGVRL
HHHHHHHHEECCCEEEEEECCCHHHHCCCCEEEEEECHHHHHHHHHHHHHCCEEEEEEEE
HPELGAGVADEVFGIDKLHHVLAQSDYVVLSTPITKKTEAFIGAAEIAAMKHGVVLVNVA
CCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHCCEEEEEEC
RGNLIQEKPLYDALQAGKIFGYGADVWWNYKNAYPATYHFPAPSRTGIQRLPNVIGSGDQ
CCCCCCCCCHHHHHHCCCEEEECCCEEECCCCCCCEEEECCCCCCHHHHHHHHHHCCCCC
AVNADGVLDGNIDRCVESLVQFSNNKPLTWKIDLDLGY
CCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]