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The map label for this gene is lpxB

Identifier: 15603862

GI number: 15603862

Start: 2238048

End: 2239226

Strand: Direct

Name: lpxB

Synonym: PM1997

Alternate gene names: 15603862

Gene position: 2238048-2239226 (Clockwise)

Preceding gene: 15603861

Following gene: 15603863

Centisome position: 99.14

GC content: 41.82

Gene sequence:

>1179_bases
ATGAAAGAAATACATAAACAGCCGCCGACGATTGCCATTGTTGCCGGCGAAGTGTCGGGTGATATTTTGGGTGCTGGGCT
TATCCGTAGTTTGAAAGTTCAGTATCCTCATGCACGCTTTATTGGGATCGCGGGGCCTCGAATGTTGGCAGAAGGCGCGG
AAACCTTAGTAGATATGGAAGAGCTTTCAGTCATGGGATTAGCCGAAGTGGTGAAACACTTACCCCGTTTATTGAAAATC
CGTCGTCAATTAATTCACACCATGTTGCAAGAAAAGCCAGATATTTTCATTGGTATTGATGCGCCGGATTTTAATATCGA
TGTTGAATTGAAGTTAAAAGAAAATGGCATCAAAACTATACATTATGTCAGCCCTTCCGTTTGGGCTTGGCGTCAGAATC
GTATTCATAAAATTGCCAAAGCGACGCATCTCGTTTTAGCTTTTTTACCTTTTGAAAAAGCATTTTATGATCGTTTTGAG
GTGCCTTGCCGTTTTATCGGTCATACGATGGCAGATGCGATCGCATTAAAACCAAATCGTCAGGAAGCTTGTGAATATTT
AAATCTTGATGCAAGCCAGCGTTATGTGGCGATACTTGTTGGAAGTCGTGGTTCAGAAGTTACCTTTTTAGCGGAACCTT
TTTTGCAAGCGGCTAAATTGTTAAAACAACAATATCCCGATATTCAATTCTTGGTTCCACTGATTAATGCTAAGCGTCGT
GAACAATTTGAACAAATTAAAGCGCAAGTCGCGCCAGAATTAGAGCTGATCTTGTTAGACGGAAAGGCTCGCCAAGCCAT
GATAGCCGCAGAAGCAACTTTATTAGCGTCAGGGACGGCAGCGCTAGAAGCCATGTTATGTAAATCGCCGATGGTAGTGG
GTTATCGTATGAAAGCAACCACTTACTTCTTAGCAAAGCGCTTAGTGAAAACAGAGTATGTTTCCTTACCGAATTTATTG
GCGAATGAAATGTTGGTGCCAGAGCTTATCCAAGAGCAATGTACAGCAGAAAATCTTGCTGAAAAACTGGCGCTTTATTT
AAGCCAAGAAGAAAGCGCGTTACAACAACGTCATACATTAATTCAACGCTTTACGGATTTACACAAGTTGATCCAATGTG
ATGCAGATAAACAAGCGGCACAAGCTGTGATTGCATTACTCGAACAAGAGGATAAATAA

Upstream 100 bases:

>100_bases
TTCAACACGCGGAATTATTCGTTAATTAAGCGAAATTTGACTCAAATCGACCGCACTTTTTTCCTGAGAAGTGCGGTTGT
TTTTTATCTAGGATTGAGAG

Downstream 100 bases:

>100_bases
CATGGTATTTGAATATCCCAAAGGGGTTGAACTCATTGCAGGTGTGGATGAAGTCGGGCGCGGACCTTTAGTGGGCGCGG
TTGTGACGGCAGCGGTGATT

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MKEIHKQPPTIAIVAGEVSGDILGAGLIRSLKVQYPHARFIGIAGPRMLAEGAETLVDMEELSVMGLAEVVKHLPRLLKI
RRQLIHTMLQEKPDIFIGIDAPDFNIDVELKLKENGIKTIHYVSPSVWAWRQNRIHKIAKATHLVLAFLPFEKAFYDRFE
VPCRFIGHTMADAIALKPNRQEACEYLNLDASQRYVAILVGSRGSEVTFLAEPFLQAAKLLKQQYPDIQFLVPLINAKRR
EQFEQIKAQVAPELELILLDGKARQAMIAAEATLLASGTAALEAMLCKSPMVVGYRMKATTYFLAKRLVKTEYVSLPNLL
ANEMLVPELIQEQCTAENLAEKLALYLSQEESALQQRHTLIQRFTDLHKLIQCDADKQAAQAVIALLEQEDK

Sequences:

>Translated_392_residues
MKEIHKQPPTIAIVAGEVSGDILGAGLIRSLKVQYPHARFIGIAGPRMLAEGAETLVDMEELSVMGLAEVVKHLPRLLKI
RRQLIHTMLQEKPDIFIGIDAPDFNIDVELKLKENGIKTIHYVSPSVWAWRQNRIHKIAKATHLVLAFLPFEKAFYDRFE
VPCRFIGHTMADAIALKPNRQEACEYLNLDASQRYVAILVGSRGSEVTFLAEPFLQAAKLLKQQYPDIQFLVPLINAKRR
EQFEQIKAQVAPELELILLDGKARQAMIAAEATLLASGTAALEAMLCKSPMVVGYRMKATTYFLAKRLVKTEYVSLPNLL
ANEMLVPELIQEQCTAENLAEKLALYLSQEESALQQRHTLIQRFTDLHKLIQCDADKQAAQAVIALLEQEDK
>Mature_392_residues
MKEIHKQPPTIAIVAGEVSGDILGAGLIRSLKVQYPHARFIGIAGPRMLAEGAETLVDMEELSVMGLAEVVKHLPRLLKI
RRQLIHTMLQEKPDIFIGIDAPDFNIDVELKLKENGIKTIHYVSPSVWAWRQNRIHKIAKATHLVLAFLPFEKAFYDRFE
VPCRFIGHTMADAIALKPNRQEACEYLNLDASQRYVAILVGSRGSEVTFLAEPFLQAAKLLKQQYPDIQFLVPLINAKRR
EQFEQIKAQVAPELELILLDGKARQAMIAAEATLLASGTAALEAMLCKSPMVVGYRMKATTYFLAKRLVKTEYVSLPNLL
ANEMLVPELIQEQCTAENLAEKLALYLSQEESALQQRHTLIQRFTDLHKLIQCDADKQAAQAVIALLEQEDK

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family

Homologues:

Organism=Escherichia coli, GI1786379, Length=381, Percent_Identity=60.8923884514436, Blast_Score=466, Evalue=1e-132,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXB_PASMU (Q9CJK7)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_246936.1
- ProteinModelPortal:   Q9CJK7
- GeneID:   1245344
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM1997
- NMPDR:   fig|272843.1.peg.1998
- HOGENOM:   HBG584837
- OMA:   DFTHRVA
- ProtClustDB:   PRK00025
- BioCyc:   PMUL272843:PM1997-MONOMER
- BRENDA:   2.4.1.182
- HAMAP:   MF_00392
- InterPro:   IPR003835
- TIGRFAMs:   TIGR00215

Pfam domain/function: PF02684 LpxB

EC number: =2.4.1.182

Molecular weight: Translated: 44054; Mature: 44054

Theoretical pI: Translated: 7.31; Mature: 7.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEIHKQPPTIAIVAGEVSGDILGAGLIRSLKVQYPHARFIGIAGPRMLAEGAETLVDME
CCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHH
ELSVMGLAEVVKHLPRLLKIRRQLIHTMLQEKPDIFIGIDAPDFNIDVELKLKENGIKTI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEECCCCCCEE
HYVSPSVWAWRQNRIHKIAKATHLVLAFLPFEKAFYDRFEVPCRFIGHTMADAIALKPNR
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCH
QEACEYLNLDASQRYVAILVGSRGSEVTFLAEPFLQAAKLLKQQYPDIQFLVPLINAKRR
HHHHHHHCCCCCCCEEEEEEECCCCCEEEHHHHHHHHHHHHHHHCCCCEEHHHHHCCHHH
EQFEQIKAQVAPELELILLDGKARQAMIAAEATLLASGTAALEAMLCKSPMVVGYRMKAT
HHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEEHHHH
TYFLAKRLVKTEYVSLPNLLANEMLVPELIQEQCTAENLAEKLALYLSQEESALQQRHTL
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IQRFTDLHKLIQCDADKQAAQAVIALLEQEDK
HHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKEIHKQPPTIAIVAGEVSGDILGAGLIRSLKVQYPHARFIGIAGPRMLAEGAETLVDME
CCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHH
ELSVMGLAEVVKHLPRLLKIRRQLIHTMLQEKPDIFIGIDAPDFNIDVELKLKENGIKTI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEECCCCCCEE
HYVSPSVWAWRQNRIHKIAKATHLVLAFLPFEKAFYDRFEVPCRFIGHTMADAIALKPNR
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCH
QEACEYLNLDASQRYVAILVGSRGSEVTFLAEPFLQAAKLLKQQYPDIQFLVPLINAKRR
HHHHHHHCCCCCCCEEEEEEECCCCCEEEHHHHHHHHHHHHHHHCCCCEEHHHHHCCHHH
EQFEQIKAQVAPELELILLDGKARQAMIAAEATLLASGTAALEAMLCKSPMVVGYRMKAT
HHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEEHHHH
TYFLAKRLVKTEYVSLPNLLANEMLVPELIQEQCTAENLAEKLALYLSQEESALQQRHTL
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IQRFTDLHKLIQCDADKQAAQAVIALLEQEDK
HHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11248100