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The map label for this gene is lpxD

Identifier: 15603859

GI number: 15603859

Start: 2235574

End: 2236602

Strand: Direct

Name: lpxD

Synonym: PM1994

Alternate gene names: 15603859

Gene position: 2235574-2236602 (Clockwise)

Preceding gene: 15603858

Following gene: 15603860

Centisome position: 99.03

GC content: 44.12

Gene sequence:

>1029_bases
ATGCAAGTTTATTCCCTCCAAGAATTAGCACAACAGATCGGCGCTACCATTCGTGGTAACGCCGATGTTGTTGTAGAAAG
TATTGCGCCTTTAGATAAGGCGACAGAAAAACAGCTTACTTTTATTTCTAATCCTAAGTTCCGTTCCTTACTGGCACAAT
CTCATGCCGGGATTTTGGTGGTGTCAGAAGCGGATGTGGCGTTTTGTGCAGAGCAAAGTAATTTATTGATTGTAAAAGAT
CCGTACGTGGCTTATGCCGTTCTAGCACAATATATGGATAGCACGCCGAAAGCTGCGAGCGGTATTGCCGCCAGTGCGGT
GGTATCGGCTAGTGCTGTGATAGGCAAAAATGTCTCAATTGGTGCCAATGCGGTGATTGAAGACGGGGTAACGCTTGGTG
ATCATGTAGTCATTGGTGCTAACTGCTTTGTCGGCAAAAATAGCAAAATTGGTGCTTATACCCAGCTATGGGCAAATGTC
AGTGTTTATCATGAGGTTGAAATAGGGCAACATTGTTTAATTCAATCTGGTGCAGTGATTGGTAGTGATGGTTTTGGTTA
CGCCAATGATCGTGGGCGTTGGATTAAAATTCCACAAGTTGGACAAGTCATTATTGGCAATCATGTCGAAATTGGCGCTT
GCACTTGTATTGATCGAGGTGCGTTAGATCCAACGGTCATTGAAGATAATGTGATTATTGATAATCTTTGCCAAATTGCG
CATAACGTCCATATTGGGACCGGGACTGCAGTTGCTGGTGGGGTGATTATGGCTGGTAGCTTGACCGTCGGACGCTATTG
CTTAATTGGTGGTGCCAGTGTGATCAATGGACACATGGAAATCTGCGATAAAGTGACGATTACAGGCATGGGGATGGTGA
TGCGTCCAATTACTGAACCTGGCGTGTACTCTTCGGGTATCCCATTACAAACGAATAAAGAATGGCGTAAAACCGCTGCA
TTGACGTTAGGCATTGATGCGATGAATAAACGGTTAAAAGCCTTAGAAAAGAAATTCGAGAAGAAATAA

Upstream 100 bases:

>100_bases
ACACATTAGTACTGAATGAAGGTGCAGTCGTGTTTGCTGCAGATGCAAAAAATATTACTGAAGATGTTCTAAAAGTCATT
CCTGCGACACAGGCGAAATA

Downstream 100 bases:

>100_bases
GCGTGAAACGAACCGCACTTTTTTGTGGTGCGTTTTGTATTCAGCACGTAAATACCGTATAATTTTGAATGTTTTATCGT
TTTATTTTTATTGGAAGGTA

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MQVYSLQELAQQIGATIRGNADVVVESIAPLDKATEKQLTFISNPKFRSLLAQSHAGILVVSEADVAFCAEQSNLLIVKD
PYVAYAVLAQYMDSTPKAASGIAASAVVSASAVIGKNVSIGANAVIEDGVTLGDHVVIGANCFVGKNSKIGAYTQLWANV
SVYHEVEIGQHCLIQSGAVIGSDGFGYANDRGRWIKIPQVGQVIIGNHVEIGACTCIDRGALDPTVIEDNVIIDNLCQIA
HNVHIGTGTAVAGGVIMAGSLTVGRYCLIGGASVINGHMEICDKVTITGMGMVMRPITEPGVYSSGIPLQTNKEWRKTAA
LTLGIDAMNKRLKALEKKFEKK

Sequences:

>Translated_342_residues
MQVYSLQELAQQIGATIRGNADVVVESIAPLDKATEKQLTFISNPKFRSLLAQSHAGILVVSEADVAFCAEQSNLLIVKD
PYVAYAVLAQYMDSTPKAASGIAASAVVSASAVIGKNVSIGANAVIEDGVTLGDHVVIGANCFVGKNSKIGAYTQLWANV
SVYHEVEIGQHCLIQSGAVIGSDGFGYANDRGRWIKIPQVGQVIIGNHVEIGACTCIDRGALDPTVIEDNVIIDNLCQIA
HNVHIGTGTAVAGGVIMAGSLTVGRYCLIGGASVINGHMEICDKVTITGMGMVMRPITEPGVYSSGIPLQTNKEWRKTAA
LTLGIDAMNKRLKALEKKFEKK
>Mature_342_residues
MQVYSLQELAQQIGATIRGNADVVVESIAPLDKATEKQLTFISNPKFRSLLAQSHAGILVVSEADVAFCAEQSNLLIVKD
PYVAYAVLAQYMDSTPKAASGIAASAVVSASAVIGKNVSIGANAVIEDGVTLGDHVVIGANCFVGKNSKIGAYTQLWANV
SVYHEVEIGQHCLIQSGAVIGSDGFGYANDRGRWIKIPQVGQVIIGNHVEIGACTCIDRGALDPTVIEDNVIIDNLCQIA
HNVHIGTGTAVAGGVIMAGSLTVGRYCLIGGASVINGHMEICDKVTITGMGMVMRPITEPGVYSSGIPLQTNKEWRKTAA
LTLGIDAMNKRLKALEKKFEKK

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily

Homologues:

Organism=Escherichia coli, GI1786376, Length=342, Percent_Identity=64.9122807017544, Blast_Score=465, Evalue=1e-132,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXD_PASMU (Q9CJL0)

Other databases:

- EMBL:   AE004439
- EMBL:   X74357
- PIR:   S47342
- RefSeq:   NP_246933.1
- ProteinModelPortal:   Q9CJL0
- GeneID:   1245341
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM1994
- NMPDR:   fig|272843.1.peg.1995
- HOGENOM:   HBG469615
- OMA:   CFVGKNT
- ProtClustDB:   PRK00892
- BioCyc:   PMUL272843:PM1994-MONOMER
- HAMAP:   MF_00523
- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573
- TIGRFAMs:   TIGR01853

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD; SSF51161 Trimer_LpxA_like

EC number: 2.3.1.-

Molecular weight: Translated: 36049; Mature: 36049

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVYSLQELAQQIGATIRGNADVVVESIAPLDKATEKQLTFISNPKFRSLLAQSHAGILV
CCCCCHHHHHHHHCCEECCCCCEEEEHHCCCCHHCCHHEEEECCCHHHHHHHHCCCCEEE
VSEADVAFCAEQSNLLIVKDPYVAYAVLAQYMDSTPKAASGIAASAVVSASAVIGKNVSI
EECCCEEEEECCCCEEEEECCHHHHHHHHHHHCCCCCHHCCHHHHHHHHHHHHHCCCCCC
GANAVIEDGVTLGDHVVIGANCFVGKNSKIGAYTQLWANVSVYHEVEIGQHCLIQSGAVI
CCCEEEECCCEECCEEEEECEEEECCCCCCCHHHHHHCCEEEEEEECCCCEEEEECCCEE
GSDGFGYANDRGRWIKIPQVGQVIIGNHVEIGACTCIDRGALDPTVIEDNVIIDNLCQIA
CCCCCCCCCCCCCEEECCCCCEEEECCCEEEEEEEEECCCCCCCEEEECCCHHHHHHHHH
HNVHIGTGTAVAGGVIMAGSLTVGRYCLIGGASVINGHMEICDKVTITGMGMVMRPITEP
HCEECCCCCHHHCCEEEECCCCCCCEEEECCHHHHCCHHHHHCEEEEECCCEEECCCCCC
GVYSSGIPLQTNKEWRKTAALTLGIDAMNKRLKALEKKFEKK
CCCCCCCCCCCCHHHHHHEEEEECHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQVYSLQELAQQIGATIRGNADVVVESIAPLDKATEKQLTFISNPKFRSLLAQSHAGILV
CCCCCHHHHHHHHCCEECCCCCEEEEHHCCCCHHCCHHEEEECCCHHHHHHHHCCCCEEE
VSEADVAFCAEQSNLLIVKDPYVAYAVLAQYMDSTPKAASGIAASAVVSASAVIGKNVSI
EECCCEEEEECCCCEEEEECCHHHHHHHHHHHCCCCCHHCCHHHHHHHHHHHHHCCCCCC
GANAVIEDGVTLGDHVVIGANCFVGKNSKIGAYTQLWANVSVYHEVEIGQHCLIQSGAVI
CCCEEEECCCEECCEEEEECEEEECCCCCCCHHHHHHCCEEEEEEECCCCEEEEECCCEE
GSDGFGYANDRGRWIKIPQVGQVIIGNHVEIGACTCIDRGALDPTVIEDNVIIDNLCQIA
CCCCCCCCCCCCCEEECCCCCEEEECCCEEEEEEEEECCCCCCCEEEECCCHHHHHHHHH
HNVHIGTGTAVAGGVIMAGSLTVGRYCLIGGASVINGHMEICDKVTITGMGMVMRPITEP
HCEECCCCCHHHCCEEEECCCCCCCEEEECCHHHHCCHHHHHCEEEEECCCEEECCCCCC
GVYSSGIPLQTNKEWRKTAALTLGIDAMNKRLKALEKKFEKK
CCCCCCCCCCCCHHHHHHEEEEECHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100; 7642134