Click here to switch to the map view.

The map label for this gene is uppS

Identifier: 15603854

GI number: 15603854

Start: 2229521

End: 2230243

Strand: Direct

Name: uppS

Synonym: PM1989

Alternate gene names: 15603854

Gene position: 2229521-2230243 (Clockwise)

Preceding gene: 15603853

Following gene: 15603855

Centisome position: 98.76

GC content: 38.87

Gene sequence:

>723_bases
ATGGTAGAACTTGATCCAAATAATATCCCACAACATGTTGCGATTATTATGGATGGAAATGGGCGTTGGGCACAGCAAAA
GGGCAAAATGCGCATTTTTGGTCATAAAAATGGGGTGAAAGCCGTGCGAGAGGCGGTTTCTTATGCCCGAAAAGTGGGCA
TTAAAGTTTTAACACTCTATGCGTTTAGTAGTGAAAACTGGAACCGCCCAAAAAAAGAAGTGAATGCATTAATGGCGTTA
TTTATGCAAGCGTTAGATCTTGAAGTTAAAAAGTTGCATAAAAATAATATTAAATTGAATATATTAGGGGATGTAACGGG
GTTTAGTGCCAGCTTGCAGAATAAAATTCATCAGGCCGAGAAATTAACTGAAAACAATACAGCTTTAACCTTAAATATTG
CAGCGAACTATGGCGGTTGCTGGGATATCGTGCAAGCTACAAAATCGCTCGCACAACAGGTTAAAGAGGGCAAGTTAGCC
GTTGATGAGATTAATGCGCAAGTATTACAGCAAGCTTTGGTTACCAAAGAGCAGCCACAAGTCGATTTATTAATTAGAAC
GAGTGGTGAACAACGAATTAGTAACTTTTTATTATGGCAAATCGCGTATGCTGAGCTGTATTTTTCTGATGTACTTTGGC
CAGATTTTAATGAAAAGGAATTTAACGAAGCAATTATTGCTTATCAACAACGCCACCGACGCTTTGGTGGTGCAGAAGAA
TAA

Upstream 100 bases:

>100_bases
AAGGCAAGGGAATTATCTCAGTCAATCATTTTAAGTTTTTCACATCCGTAAGCCTTGTGGTATAGTGGCGAAAAAAGTGA
GGTCAGAAATTTGAGAGAAT

Downstream 100 bases:

>100_bases
TAAAGAGGATTAGATTGTGCTTAAAGAACGTGTTTTGTCAGCGATCATGTTAATTGCAATAGTATTTATTGCATTGTTTT
TCTTTTCACCCTTCTATTTT

Product: hypothetical protein

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS

Number of amino acids: Translated: 240; Mature: 240

Protein sequence:

>240_residues
MVELDPNNIPQHVAIIMDGNGRWAQQKGKMRIFGHKNGVKAVREAVSYARKVGIKVLTLYAFSSENWNRPKKEVNALMAL
FMQALDLEVKKLHKNNIKLNILGDVTGFSASLQNKIHQAEKLTENNTALTLNIAANYGGCWDIVQATKSLAQQVKEGKLA
VDEINAQVLQQALVTKEQPQVDLLIRTSGEQRISNFLLWQIAYAELYFSDVLWPDFNEKEFNEAIIAYQQRHRRFGGAEE

Sequences:

>Translated_240_residues
MVELDPNNIPQHVAIIMDGNGRWAQQKGKMRIFGHKNGVKAVREAVSYARKVGIKVLTLYAFSSENWNRPKKEVNALMAL
FMQALDLEVKKLHKNNIKLNILGDVTGFSASLQNKIHQAEKLTENNTALTLNIAANYGGCWDIVQATKSLAQQVKEGKLA
VDEINAQVLQQALVTKEQPQVDLLIRTSGEQRISNFLLWQIAYAELYFSDVLWPDFNEKEFNEAIIAYQQRHRRFGGAEE
>Mature_240_residues
MVELDPNNIPQHVAIIMDGNGRWAQQKGKMRIFGHKNGVKAVREAVSYARKVGIKVLTLYAFSSENWNRPKKEVNALMAL
FMQALDLEVKKLHKNNIKLNILGDVTGFSASLQNKIHQAEKLTENNTALTLNIAANYGGCWDIVQATKSLAQQVKEGKLA
VDEINAQVLQQALVTKEQPQVDLLIRTSGEQRISNFLLWQIAYAELYFSDVLWPDFNEKEFNEAIIAYQQRHRRFGGAEE

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family

Homologues:

Organism=Homo sapiens, GI45580738, Length=227, Percent_Identity=37.8854625550661, Blast_Score=156, Evalue=1e-38,
Organism=Homo sapiens, GI45580742, Length=227, Percent_Identity=37.8854625550661, Blast_Score=156, Evalue=2e-38,
Organism=Escherichia coli, GI1786371, Length=234, Percent_Identity=61.1111111111111, Blast_Score=306, Evalue=1e-84,
Organism=Caenorhabditis elegans, GI71993029, Length=227, Percent_Identity=37.4449339207048, Blast_Score=147, Evalue=6e-36,
Organism=Saccharomyces cerevisiae, GI6323748, Length=216, Percent_Identity=34.2592592592593, Blast_Score=122, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6319474, Length=215, Percent_Identity=35.3488372093023, Blast_Score=119, Evalue=4e-28,
Organism=Drosophila melanogaster, GI18857969, Length=226, Percent_Identity=35.3982300884956, Blast_Score=151, Evalue=3e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UPPS_PASMU (Q9CJL4)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_246928.1
- ProteinModelPortal:   Q9CJL4
- SMR:   Q9CJL4
- GeneID:   1245336
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM1989
- NMPDR:   fig|272843.1.peg.1990
- HOGENOM:   HBG627837
- OMA:   RVRWAGR
- ProtClustDB:   CLSK870686
- BioCyc:   PMUL272843:PM1989-MONOMER
- BRENDA:   2.5.1.31
- HAMAP:   MF_01139
- InterPro:   IPR001441
- InterPro:   IPR018520
- Gene3D:   G3DSA:3.40.1180.10
- PANTHER:   PTHR10291
- TIGRFAMs:   TIGR00055

Pfam domain/function: PF01255 Prenyltransf; SSF64005 UPP_synth

EC number: =2.5.1.31

Molecular weight: Translated: 27195; Mature: 27195

Theoretical pI: Translated: 9.27; Mature: 9.27

Prosite motif: PS01066 UPP_SYNTHASE

Important sites: ACT_SITE 18-18

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVELDPNNIPQHVAIIMDGNGRWAQQKGKMRIFGHKNGVKAVREAVSYARKVGIKVLTLY
CCEECCCCCCCEEEEEECCCCCCHHCCCCEEEEECCCCHHHHHHHHHHHHHCCEEEEEEE
AFSSENWNRPKKEVNALMALFMQALDLEVKKLHKNNIKLNILGDVTGFSASLQNKIHQAE
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHH
KLTENNTALTLNIAANYGGCWDIVQATKSLAQQVKEGKLAVDEINAQVLQQALVTKEQPQ
HHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCC
VDLLIRTSGEQRISNFLLWQIAYAELYFSDVLWPDFNEKEFNEAIIAYQQRHRRFGGAEE
EEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MVELDPNNIPQHVAIIMDGNGRWAQQKGKMRIFGHKNGVKAVREAVSYARKVGIKVLTLY
CCEECCCCCCCEEEEEECCCCCCHHCCCCEEEEECCCCHHHHHHHHHHHHHCCEEEEEEE
AFSSENWNRPKKEVNALMALFMQALDLEVKKLHKNNIKLNILGDVTGFSASLQNKIHQAE
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHH
KLTENNTALTLNIAANYGGCWDIVQATKSLAQQVKEGKLAVDEINAQVLQQALVTKEQPQ
HHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCC
VDLLIRTSGEQRISNFLLWQIAYAELYFSDVLWPDFNEKEFNEAIIAYQQRHRRFGGAEE
EEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100