Click here to switch to the map view.

The map label for this gene is dxr

Identifier: 15603853

GI number: 15603853

Start: 2228254

End: 2229471

Strand: Direct

Name: dxr

Synonym: PM1988

Alternate gene names: 15603853

Gene position: 2228254-2229471 (Clockwise)

Preceding gene: 15603852

Following gene: 15603854

Centisome position: 98.71

GC content: 41.87

Gene sequence:

>1218_bases
ATGAGTATTAGTTATTTTATGAAAAAGATCGTTATTTTAGGTTCAACTGGATCGATTGGTACCAGTACTTTATCCGTGAT
TACACATAATCCTGATAAGTACCAAGTGTTTGCGTTAGTTGGTGGACGTAATGTAGAGCTAATGTTTCAACAATGTTTGA
CATTCCAACCGTCGTTTGCTGCGTTAGATGACGATGTCGCAGCCAAAATGTTGGCAGAGAAACTGAAAGCCCACCAAAGC
CAAACAACAGTCTTAGCAGGACAGCAAGCCATTTGTGAGTTAGCGGCACATCCTGAAGCAGATATGGTAATGGCTGCGAT
TGTGGGGGCGGCGGGATTATTGCCTACTTTGTCTGCGGTGAAAGCTGGAAAACGTGTACTATTAGCAAATAAAGAAGCCT
TGGTAACTTGCGGGCAATTATTTATTGATGCAGTGCGTGAATCTCAAGCACAATTGTTACCAGTAGATAGTGAACATAAT
GCGATTTTCCAATCCCTTCCGCCTGAAGCGCAAAGACAAATTGGGTTTTGCCCGCTTTCTGAATTAGGGATCAGTAAGAT
TGTGTTAACGGGATCCGGTGGTCCATTCCGTTATACCCCTCTGGAGCAATTTGAACAGATCACCCCAGCACAAGCAGTTG
CGCATCCTAATTGGTCAATGGGGAAAAAGATCTCTGTCGATTCCGCTACCATGATGAATAAAGGGTTGGAATATATTGAA
GCACGCTGGTTATTTAATGCCTCGGCAGAAGAAATGGAAGTTATTATTCATCCTCAATCCATTATTCATTCTATGGTACG
TTACATCGATGGGTCCGTGATTGCTCAAATGGGGAATCCTGATATGCGTACACCGATTGCGGAAACCATGGCATATCCAA
GTCGGACCGTTGCTGGCGTTGAGCCCTTGGATTTTTACCAACTGAATGGATTAACCTTTATTGAGCCAGACTATCAACGT
TATCCTTGTTTAAAATTAGCTATTGACGCATTTTCAGCCGGACAATATGCCACGACAGCAATGAATGCAGCGAATGAAAT
CGCGGTAGCGTCTTTCTTAGACAATAAGATTAAATTCACAGATATTGCGCGACTAAATCAGTTAGTCGTGAGCAAATTGC
AACCACAAAAAATTCATTGCATAGAAGATGTACTTGAGGTAGATAAAAAGGCAAGGGAATTATCTCAGTCAATCATTTTA
AGTTTTTCACATCCGTAA

Upstream 100 bases:

>100_bases
TGGTCTATCTAATCATTACATCCATTCAGATATTAAGAGGGCGCTTTATTGAATACATAAAACGGTTTATTTCAAGTGTG
AAGTAAATCGTTTTTTATTA

Downstream 100 bases:

>100_bases
GCCTTGTGGTATAGTGGCGAAAAAAGTGAGGTCAGAAATTTGAGAGAATATGGTAGAACTTGATCCAAATAATATCCCAC
AACATGTTGCGATTATTATG

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 405; Mature: 404

Protein sequence:

>405_residues
MSISYFMKKIVILGSTGSIGTSTLSVITHNPDKYQVFALVGGRNVELMFQQCLTFQPSFAALDDDVAAKMLAEKLKAHQS
QTTVLAGQQAICELAAHPEADMVMAAIVGAAGLLPTLSAVKAGKRVLLANKEALVTCGQLFIDAVRESQAQLLPVDSEHN
AIFQSLPPEAQRQIGFCPLSELGISKIVLTGSGGPFRYTPLEQFEQITPAQAVAHPNWSMGKKISVDSATMMNKGLEYIE
ARWLFNASAEEMEVIIHPQSIIHSMVRYIDGSVIAQMGNPDMRTPIAETMAYPSRTVAGVEPLDFYQLNGLTFIEPDYQR
YPCLKLAIDAFSAGQYATTAMNAANEIAVASFLDNKIKFTDIARLNQLVVSKLQPQKIHCIEDVLEVDKKARELSQSIIL
SFSHP

Sequences:

>Translated_405_residues
MSISYFMKKIVILGSTGSIGTSTLSVITHNPDKYQVFALVGGRNVELMFQQCLTFQPSFAALDDDVAAKMLAEKLKAHQS
QTTVLAGQQAICELAAHPEADMVMAAIVGAAGLLPTLSAVKAGKRVLLANKEALVTCGQLFIDAVRESQAQLLPVDSEHN
AIFQSLPPEAQRQIGFCPLSELGISKIVLTGSGGPFRYTPLEQFEQITPAQAVAHPNWSMGKKISVDSATMMNKGLEYIE
ARWLFNASAEEMEVIIHPQSIIHSMVRYIDGSVIAQMGNPDMRTPIAETMAYPSRTVAGVEPLDFYQLNGLTFIEPDYQR
YPCLKLAIDAFSAGQYATTAMNAANEIAVASFLDNKIKFTDIARLNQLVVSKLQPQKIHCIEDVLEVDKKARELSQSIIL
SFSHP
>Mature_404_residues
SISYFMKKIVILGSTGSIGTSTLSVITHNPDKYQVFALVGGRNVELMFQQCLTFQPSFAALDDDVAAKMLAEKLKAHQSQ
TTVLAGQQAICELAAHPEADMVMAAIVGAAGLLPTLSAVKAGKRVLLANKEALVTCGQLFIDAVRESQAQLLPVDSEHNA
IFQSLPPEAQRQIGFCPLSELGISKIVLTGSGGPFRYTPLEQFEQITPAQAVAHPNWSMGKKISVDSATMMNKGLEYIEA
RWLFNASAEEMEVIIHPQSIIHSMVRYIDGSVIAQMGNPDMRTPIAETMAYPSRTVAGVEPLDFYQLNGLTFIEPDYQRY
PCLKLAIDAFSAGQYATTAMNAANEIAVASFLDNKIKFTDIARLNQLVVSKLQPQKIHCIEDVLEVDKKARELSQSIILS
FSHP

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=397, Percent_Identity=63.4760705289673, Blast_Score=525, Evalue=1e-150,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_PASMU (P57985)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_246927.1
- ProteinModelPortal:   P57985
- SMR:   P57985
- GeneID:   1245335
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM1988
- NMPDR:   fig|272843.1.peg.1989
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- ProtClustDB:   PRK05447
- BioCyc:   PMUL272843:PM1988-MONOMER
- BRENDA:   1.1.1.267
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 44208; Mature: 44076

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: NA

Important sites: BINDING 131-131 BINDING 158-158 BINDING 192-192 BINDING 215-215 BINDING 237-237

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSISYFMKKIVILGSTGSIGTSTLSVITHNPDKYQVFALVGGRNVELMFQQCLTFQPSFA
CCHHHHHHHHEEECCCCCCCCCEEEEEEECCCCEEEEEEECCCCHHHHHHHHHCCCCCHH
ALDDDVAAKMLAEKLKAHQSQTTVLAGQQAICELAAHPEADMVMAAIVGAAGLLPTLSAV
HCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
KAGKRVLLANKEALVTCGQLFIDAVRESQAQLLPVDSEHNAIFQSLPPEAQRQIGFCPLS
HCCCEEEEECCHHHHHHHHHHHHHHHHCCCCEECCCCCCCHHHHCCCCHHHHHCCCCCHH
ELGISKIVLTGSGGPFRYTPLEQFEQITPAQAVAHPNWSMGKKISVDSATMMNKGLEYIE
HCCCEEEEEECCCCCEECCCHHHHHHCCCHHHHCCCCCCCCCEECCCHHHHHHHHHHHHH
ARWLFNASAEEMEVIIHPQSIIHSMVRYIDGSVIAQMGNPDMRTPIAETMAYPSRTVAGV
HHHEECCCCCCEEEEECCHHHHHHHHHHHCCHHEEECCCCCCCCCHHHHHCCCCCCCCCC
EPLDFYQLNGLTFIEPDYQRYPCLKLAIDAFSAGQYATTAMNAANEIAVASFLDNKIKFT
CCCCEEEECCEEEECCCCCCCCHHHHHHHHHCCCCHHHHHHHCHHHHHHHHHHCCCCCHH
DIARLNQLVVSKLQPQKIHCIEDVLEVDKKARELSQSIILSFSHP
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHEEECCC
>Mature Secondary Structure 
SISYFMKKIVILGSTGSIGTSTLSVITHNPDKYQVFALVGGRNVELMFQQCLTFQPSFA
CHHHHHHHHEEECCCCCCCCCEEEEEEECCCCEEEEEEECCCCHHHHHHHHHCCCCCHH
ALDDDVAAKMLAEKLKAHQSQTTVLAGQQAICELAAHPEADMVMAAIVGAAGLLPTLSAV
HCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
KAGKRVLLANKEALVTCGQLFIDAVRESQAQLLPVDSEHNAIFQSLPPEAQRQIGFCPLS
HCCCEEEEECCHHHHHHHHHHHHHHHHCCCCEECCCCCCCHHHHCCCCHHHHHCCCCCHH
ELGISKIVLTGSGGPFRYTPLEQFEQITPAQAVAHPNWSMGKKISVDSATMMNKGLEYIE
HCCCEEEEEECCCCCEECCCHHHHHHCCCHHHHCCCCCCCCCEECCCHHHHHHHHHHHHH
ARWLFNASAEEMEVIIHPQSIIHSMVRYIDGSVIAQMGNPDMRTPIAETMAYPSRTVAGV
HHHEECCCCCCEEEEECCHHHHHHHHHHHCCHHEEECCCCCCCCCHHHHHCCCCCCCCCC
EPLDFYQLNGLTFIEPDYQRYPCLKLAIDAFSAGQYATTAMNAANEIAVASFLDNKIKFT
CCCCEEEECCEEEECCCCCCCCHHHHHHHHHCCCCHHHHHHHCHHHHHHHHHHCCCCCHH
DIARLNQLVVSKLQPQKIHCIEDVLEVDKKARELSQSIILSFSHP
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11248100