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The map label for this gene is frr [H]

Identifier: 15603852

GI number: 15603852

Start: 2227549

End: 2228106

Strand: Direct

Name: frr [H]

Synonym: PM1987

Alternate gene names: 15603852

Gene position: 2227549-2228106 (Clockwise)

Preceding gene: 15603851

Following gene: 15603853

Centisome position: 98.67

GC content: 40.32

Gene sequence:

>558_bases
GTGATTAATGAAATTAAAAAAGATACGCAATTGCGTATGGAAAAAAGCTTAGAAACCTTTAAAAACCACATTGCTAAAGT
GCGTACAGGTCGTGCTCAACCAAGTTTACTTGATGGTATTCAAGTGGAATACTATGGTTCACCAACCCCATTACGTCAGT
TAGCCAACGTGGTTGCAGAAGATGCGCGTACACTTGCGGTCACTGTGTTTGATCGTAGCTTAATTAGTGCGGTAGAAAAA
GCGATTTTGACCTCAGATTTAGGGTTAAACCCGTCTTCTGCCGGGACAACGATTCGTGTACCGTTACCGCCATTAACAGA
AGAACGCCGTCGTGATTTAATTAAAATTGTGAAAGGTGAAGCTGAGCAAGGGAAAATTGCTGTACGTAATGTGCGTCGTG
ATGCCAATGATCAAATTAAAGCTTTGCTGAAAGACAAAGAAATCAGTGAAGACGAAGAGCGTAAAGCACAAGACGAAATC
CAAAAAATCACGGATACTTTCGTGAAAAAAGTGGATGAAGTATTGGCAGATAAAGAGAAAGAATTGCTCGATTTCTAA

Upstream 100 bases:

>100_bases
GATTTGTGACCAAAAGTTGTCGTGATTTTTCACCAGAATTAGATTAAACTTACAGGCAGCCGATTAACTAAGACTTATTG
ACTATAAAGAAGGACTTCTT

Downstream 100 bases:

>100_bases
TTCATGAGCCTCTCTTTATGGACGGATATGTCAAGCATAGTATTGATTGGTCTATCTAATCATTACATCCATTCAGATAT
TAAGAGGGCGCTTTATTGAA

Product: ribosome recycling factor

Products: NA

Alternate protein names: RRF; Ribosome-releasing factor [H]

Number of amino acids: Translated: 185; Mature: 185

Protein sequence:

>185_residues
MINEIKKDTQLRMEKSLETFKNHIAKVRTGRAQPSLLDGIQVEYYGSPTPLRQLANVVAEDARTLAVTVFDRSLISAVEK
AILTSDLGLNPSSAGTTIRVPLPPLTEERRRDLIKIVKGEAEQGKIAVRNVRRDANDQIKALLKDKEISEDEERKAQDEI
QKITDTFVKKVDEVLADKEKELLDF

Sequences:

>Translated_185_residues
MINEIKKDTQLRMEKSLETFKNHIAKVRTGRAQPSLLDGIQVEYYGSPTPLRQLANVVAEDARTLAVTVFDRSLISAVEK
AILTSDLGLNPSSAGTTIRVPLPPLTEERRRDLIKIVKGEAEQGKIAVRNVRRDANDQIKALLKDKEISEDEERKAQDEI
QKITDTFVKKVDEVLADKEKELLDF
>Mature_185_residues
MINEIKKDTQLRMEKSLETFKNHIAKVRTGRAQPSLLDGIQVEYYGSPTPLRQLANVVAEDARTLAVTVFDRSLISAVEK
AILTSDLGLNPSSAGTTIRVPLPPLTEERRRDLIKIVKGEAEQGKIAVRNVRRDANDQIKALLKDKEISEDEERKAQDEI
QKITDTFVKKVDEVLADKEKELLDF

Specific function: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another [H]

COG id: COG0233

COG function: function code J; Ribosome recycling factor

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RRF family [H]

Homologues:

Organism=Homo sapiens, GI20270317, Length=174, Percent_Identity=32.7586206896552, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI291042689, Length=150, Percent_Identity=34, Blast_Score=68, Evalue=4e-12,
Organism=Escherichia coli, GI1786368, Length=185, Percent_Identity=69.1891891891892, Blast_Score=278, Evalue=2e-76,
Organism=Drosophila melanogaster, GI24661488, Length=174, Percent_Identity=32.183908045977, Blast_Score=84, Evalue=6e-17,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002661
- InterPro:   IPR015998 [H]

Pfam domain/function: PF01765 RRF [H]

EC number: NA

Molecular weight: Translated: 20851; Mature: 20851

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINEIKKDTQLRMEKSLETFKNHIAKVRTGRAQPSLLDGIQVEYYGSPTPLRQLANVVAE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCEEEEECCCHHHHHHHHHHHH
DARTLAVTVFDRSLISAVEKAILTSDLGLNPSSAGTTIRVPLPPLTEERRRDLIKIVKGE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCC
AEQGKIAVRNVRRDANDQIKALLKDKEISEDEERKAQDEIQKITDTFVKKVDEVLADKEK
CCCCHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
ELLDF
HHCCC
>Mature Secondary Structure
MINEIKKDTQLRMEKSLETFKNHIAKVRTGRAQPSLLDGIQVEYYGSPTPLRQLANVVAE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCEEEEECCCHHHHHHHHHHHH
DARTLAVTVFDRSLISAVEKAILTSDLGLNPSSAGTTIRVPLPPLTEERRRDLIKIVKGE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCC
AEQGKIAVRNVRRDANDQIKALLKDKEISEDEERKAQDEIQKITDTFVKKVDEVLADKEK
CCCCHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
ELLDF
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA