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The map label for this gene is pyrH

Identifier: 15603851

GI number: 15603851

Start: 2226745

End: 2227473

Strand: Direct

Name: pyrH

Synonym: PM1986

Alternate gene names: 15603851

Gene position: 2226745-2227473 (Clockwise)

Preceding gene: 15603850

Following gene: 15603852

Centisome position: 98.64

GC content: 43.62

Gene sequence:

>729_bases
ATGAGCCAACCAATTTATAAACGAATTTTATTAAAACTAAGCGGTGAAGCATTACAAGGTGACGAGGGATTTGGTATTGA
CCCGTCTATCTTAGACAGAATGGCGCTCGAGATTAAAGAATTAGTAGCAATGGGCGTCGAAGTTGGTGTTGTACTGGGTG
GTGGTAATTTGTTCCGTGGTGCCAAATTAGCAAAAGCAGGGATGAACCGTGTAGTTGGTGATCACATGGGGATGCTCGCA
ACCGTCATGAATGGTCTTGCCATGCGCGATGCACTACATCGTGCTGATGTGAATGCCAAACTGATGTCAGCCTTTCAATT
AAATGGTATTTGTGATACCTATAACTGGTCTGAAGCAATAAAAATGTTGCGTGAAAAACGCGTAGTGATTTTCTCTGCGG
GGACAGGAAGCCCATTTTTTACAACGGACTCTGCGGCTTGTTTACGTGGAATTGAAATTGAAGCGGATGTGGTGTTAAAA
GCGACGAAAGTCGATGGTGTGTATAATTGCGATCCCGCAAAAAATGCAGATGCGGTGCTTTATCATCAGCTGAATTATGC
TGATGTTATTGAGCATGAATTGCAAGTGATGGATTTAGCCGCCTTTACCTTAGCACGTGATCATCATATGCCAATTCGGG
TCTTTAATATGGGTAAGCCGGGAGCATTACGTCGAGTGATTTTGGGTGAAGTCGAAGGGACACTGATTTGTGACCAAAAG
TTGTCGTGA

Upstream 100 bases:

>100_bases
GAGATGGATAGCGGCACTCGCCTCTCTTTGTGTATAAGATGTCAGAGTGCAGCGGAATAAAAGATAATTTGTTGCTTACA
GAATCAAAAGAGGTACAAAA

Downstream 100 bases:

>100_bases
TTTTTCACCAGAATTAGATTAAACTTACAGGCAGCCGATTAACTAAGACTTATTGACTATAAAGAAGGACTTCTTGTGAT
TAATGAAATTAAAAAAGATA

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 242; Mature: 241

Protein sequence:

>242_residues
MSQPIYKRILLKLSGEALQGDEGFGIDPSILDRMALEIKELVAMGVEVGVVLGGGNLFRGAKLAKAGMNRVVGDHMGMLA
TVMNGLAMRDALHRADVNAKLMSAFQLNGICDTYNWSEAIKMLREKRVVIFSAGTGSPFFTTDSAACLRGIEIEADVVLK
ATKVDGVYNCDPAKNADAVLYHQLNYADVIEHELQVMDLAAFTLARDHHMPIRVFNMGKPGALRRVILGEVEGTLICDQK
LS

Sequences:

>Translated_242_residues
MSQPIYKRILLKLSGEALQGDEGFGIDPSILDRMALEIKELVAMGVEVGVVLGGGNLFRGAKLAKAGMNRVVGDHMGMLA
TVMNGLAMRDALHRADVNAKLMSAFQLNGICDTYNWSEAIKMLREKRVVIFSAGTGSPFFTTDSAACLRGIEIEADVVLK
ATKVDGVYNCDPAKNADAVLYHQLNYADVIEHELQVMDLAAFTLARDHHMPIRVFNMGKPGALRRVILGEVEGTLICDQK
LS
>Mature_241_residues
SQPIYKRILLKLSGEALQGDEGFGIDPSILDRMALEIKELVAMGVEVGVVLGGGNLFRGAKLAKAGMNRVVGDHMGMLAT
VMNGLAMRDALHRADVNAKLMSAFQLNGICDTYNWSEAIKMLREKRVVIFSAGTGSPFFTTDSAACLRGIEIEADVVLKA
TKVDGVYNCDPAKNADAVLYHQLNYADVIEHELQVMDLAAFTLARDHHMPIRVFNMGKPGALRRVILGEVEGTLICDQKL
S

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=237, Percent_Identity=79.3248945147679, Blast_Score=397, Evalue=1e-112,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_PASMU (Q9CJL5)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_246925.1
- ProteinModelPortal:   Q9CJL5
- SMR:   Q9CJL5
- PRIDE:   Q9CJL5
- GeneID:   1245333
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM1986
- NMPDR:   fig|272843.1.peg.1987
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- ProtClustDB:   PRK00358
- BioCyc:   PMUL272843:PM1986-MONOMER
- BRENDA:   2.7.4.22
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 26322; Mature: 26191

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: BINDING 54-54 BINDING 55-55 BINDING 59-59 BINDING 74-74 BINDING 162-162 BINDING 168-168 BINDING 171-171

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQPIYKRILLKLSGEALQGDEGFGIDPSILDRMALEIKELVAMGVEVGVVLGGGNLFRG
CCCHHHHHHHHHHCCCEECCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCC
AKLAKAGMNRVVGDHMGMLATVMNGLAMRDALHRADVNAKLMSAFQLNGICDTYNWSEAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHH
KMLREKRVVIFSAGTGSPFFTTDSAACLRGIEIEADVVLKATKVDGVYNCDPAKNADAVL
HHHHHCEEEEEECCCCCCCEECCHHHHHHCCEEEEEEEEEEEECCCEEECCCCCCCCEEE
YHQLNYADVIEHELQVMDLAAFTLARDHHMPIRVFNMGKPGALRRVILGEVEGTLICDQK
EEECCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHCCCCEEEECCC
LS
CC
>Mature Secondary Structure 
SQPIYKRILLKLSGEALQGDEGFGIDPSILDRMALEIKELVAMGVEVGVVLGGGNLFRG
CCHHHHHHHHHHCCCEECCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCC
AKLAKAGMNRVVGDHMGMLATVMNGLAMRDALHRADVNAKLMSAFQLNGICDTYNWSEAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHH
KMLREKRVVIFSAGTGSPFFTTDSAACLRGIEIEADVVLKATKVDGVYNCDPAKNADAVL
HHHHHCEEEEEECCCCCCCEECCHHHHHHCCEEEEEEEEEEEECCCEEECCCCCCCCEEE
YHQLNYADVIEHELQVMDLAAFTLARDHHMPIRVFNMGKPGALRRVILGEVEGTLICDQK
EEECCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHCCCCEEEECCC
LS
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100