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The map label for this gene is lon [H]

Identifier: 15603843

GI number: 15603843

Start: 2213893

End: 2216307

Strand: Direct

Name: lon [H]

Synonym: PM1978

Alternate gene names: 15603843

Gene position: 2213893-2216307 (Clockwise)

Preceding gene: 15603842

Following gene: 15603844

Centisome position: 98.07

GC content: 42.48

Gene sequence:

>2415_bases
ATGAGCGCAAAAAAAACACAGCAACAGAGCATTCCAGTATTACCATTGCGTGATGTCGTCGTATTTCCTTATATGGTGAT
GCCATTATTTGTAGGGAGACCGAAGTCAATTCGTAGTCTCGATGAAGCAATGGAAACTGGTAAACAGCTATTATTAGTGT
CTCAAAAACAAGCTGATTTAGAAGAACCAACGGTGGATGATGTGTATCGCGTTGGTACGGTCGCTAATATTATTCAATTA
TTAAAATTGCCCGATGGGACAGTAAAAGTCCTCGTCGAAGGGCAACAACGTGCCACTATTGAGCAGTTAGACGATAATGG
TGAGTATTTTTCTGCCCAAATTCGCTTAATTGAAACAGAATTTGGTGATGATAAAGAACTTGAAGTCGTCAAAAAAGCGA
CCCTTGCAGAATTTGAAAAATACGCAAAATTAAATAAGAAAGTGCAACCAGATGTGCATGCAGCTCTTGAACGTATTGAA
GAATTTGATCGTTTAAGTGATACCTTAGCTGCGCATATGCCTGTGGCAGTCAAACACAAACAAAAAGTCCTTGAAATTGC
CAAAGTGGTCGCCCGTTTTGAATATTTGCTCGGTTTAATGGAATCAGAAACGGATTTATTGCAAATTGAAAAACGCATTC
GTGGACGTGTCAAAGAGCAAATGGAAAAAACACAGCGCGATTATTATTTAAATGAGCAAATCAAAGCCATTCAAAAAGAG
TTAGGCGAAGGGGATAGTGCGGATGAAATTGAGCAACTTCGCCAAAAAATTGAAGAGGCGAAAATGCCTGCAGAGGCGAA
AAGTAAAGCCGAAGCAGAATTACAAAAATTAAAAATGATGTCGCCGATGTCGGCGGAAGCCACAGTCGTACGTAGTTACA
TTGATTGGATGATTCAAGTGCCTTGGCATAAACGCACCAAAGTGAAGAAAGATCTGACCAAAGCACAACAAGTGTTGGAT
GCAGATCATTACGGACTTGAGCGCGTAAAAGAGCGTATTTTAGAGTATTTAGCGGTACAAACCCGTTTGAATCAAATCAA
AGGACCTATCCTGTGTCTAGTTGGTCCACCGGGAGTGGGAAAAACCTCGTTAGGTCAGTCGATTGCCCAAGCAACGGGAC
GTAAATATGTGCGGATGGCATTAGGTGGCGTGCGTGATGAAGCGGAAATTCGTGGTCACCGTAAAACCTATATTGGAGCA
TTGCCGGGTAAATTGATTCAGAAAATGGCAAAAGTAGGGGTAAAAAACCCGTTATTCTTGCTTGATGAAATCGACAAAAT
GAGTTCAGATATGCGTGGAGATCCGGCATCAGCGTTATTAGAAGTGCTGGATCCTGAGCAAAATACCTCATTTAACGATC
ATTATTTAGAAGTCGACTACGATCTGTCTGATGTGATGTTTGTGGCCACCTCAAACTCAATGCGTATTCCTGCGCCATTA
TTGGATCGTATGGAAGTGATTCGTCTGTCAGGTTATACCGAAGATGAAAAACTCAATATTGCTACACGTCATTTGATTGC
AAAACAAATGGAGCGTAATGGCTTAAAAGCGGGTGAGTTGACCATTGAAGACAGTGCGATTTTAGATATTATCCGTTACT
ACACCCGTGAAGCCGGCGTGCGTAGCCTTGAACGTGAAATTTCGAAAATCTGTCGTAAAGCGGTGAAAAACTTATTACTC
GATAAAAAAGTGAAATCGTTGAAAGTGAATGCGACAAATTTACACGATTATTTAGGCGTGAAACGCTTTGAATTTGGGCG
TGCGGATACGCAAAACCGTGTTGGTGAAGTCACAGGCTTAGCTTGGACCGAAGTGGGTGGTGATTTACTAACCATTGAAA
CCGCGTCAGTCTTGGGTAAGGGCAAATTAACTTATACAGGCTCTCTAGGTGATGTGATGAAAGAATCGATTCAAGCGGCG
ATGACTGTAGTGCGTTCGCGAGCAGAGAAATTGGGGATTGCGTCTGACTTCCATGAAAAACGCGATATCCATATTCATGT
GCCAGAGGGAGCAACGCCTAAAGATGGACCAAGTGCGGGGATTGCGATGTGTACAGCATTAGTTTCTTGCTTGACGGGGA
ACCCTGTTAAAGCGGATGTGGCAATGACTGGTGAGATCACCTTGCGTGGTAAAGTGTTGCCAATTGGTGGCTTGAAAGAG
AAATTATTGGCGGCACACCGTGGTGGTATTAAAACGGTGATTATTCCGAAAGAAAACGTGAAAGATTTGGAAGAGATTCC
AGATAACGCGAAAAGTAATTTGACGATTCATGCTGTTGAAACGATTGATGAAGTCTTAACGATTGCGTTAGAAAATGCAC
CAACGGGGGTTGAATTCATGAAATTGACACCGGTTAGTGCGGCGAAAACGGTCCGCAAAGGGCGATCTACTTCACGTAAA
AGTGCGGTCAATTAA

Upstream 100 bases:

>100_bases
GGTATTTTTTACCGCACTTTTTTGCCCTCAAGCTTGATTTATGATTATTTACCCTCATATTTGAGCGAAGTAGCCTAATT
TTTAACTAAGAGAGAACGGA

Downstream 100 bases:

>100_bases
TTAATACTTTTATAAATAAAGCCAAATTGTTATGATTTGGCTTATTTTATTTTGCCAGTGCGAAAATCAGTACTTTTGAT
TATAATCGTACACATTTTCG

Product: hypothetical protein

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 804; Mature: 803

Protein sequence:

>804_residues
MSAKKTQQQSIPVLPLRDVVVFPYMVMPLFVGRPKSIRSLDEAMETGKQLLLVSQKQADLEEPTVDDVYRVGTVANIIQL
LKLPDGTVKVLVEGQQRATIEQLDDNGEYFSAQIRLIETEFGDDKELEVVKKATLAEFEKYAKLNKKVQPDVHAALERIE
EFDRLSDTLAAHMPVAVKHKQKVLEIAKVVARFEYLLGLMESETDLLQIEKRIRGRVKEQMEKTQRDYYLNEQIKAIQKE
LGEGDSADEIEQLRQKIEEAKMPAEAKSKAEAELQKLKMMSPMSAEATVVRSYIDWMIQVPWHKRTKVKKDLTKAQQVLD
ADHYGLERVKERILEYLAVQTRLNQIKGPILCLVGPPGVGKTSLGQSIAQATGRKYVRMALGGVRDEAEIRGHRKTYIGA
LPGKLIQKMAKVGVKNPLFLLDEIDKMSSDMRGDPASALLEVLDPEQNTSFNDHYLEVDYDLSDVMFVATSNSMRIPAPL
LDRMEVIRLSGYTEDEKLNIATRHLIAKQMERNGLKAGELTIEDSAILDIIRYYTREAGVRSLEREISKICRKAVKNLLL
DKKVKSLKVNATNLHDYLGVKRFEFGRADTQNRVGEVTGLAWTEVGGDLLTIETASVLGKGKLTYTGSLGDVMKESIQAA
MTVVRSRAEKLGIASDFHEKRDIHIHVPEGATPKDGPSAGIAMCTALVSCLTGNPVKADVAMTGEITLRGKVLPIGGLKE
KLLAAHRGGIKTVIIPKENVKDLEEIPDNAKSNLTIHAVETIDEVLTIALENAPTGVEFMKLTPVSAAKTVRKGRSTSRK
SAVN

Sequences:

>Translated_804_residues
MSAKKTQQQSIPVLPLRDVVVFPYMVMPLFVGRPKSIRSLDEAMETGKQLLLVSQKQADLEEPTVDDVYRVGTVANIIQL
LKLPDGTVKVLVEGQQRATIEQLDDNGEYFSAQIRLIETEFGDDKELEVVKKATLAEFEKYAKLNKKVQPDVHAALERIE
EFDRLSDTLAAHMPVAVKHKQKVLEIAKVVARFEYLLGLMESETDLLQIEKRIRGRVKEQMEKTQRDYYLNEQIKAIQKE
LGEGDSADEIEQLRQKIEEAKMPAEAKSKAEAELQKLKMMSPMSAEATVVRSYIDWMIQVPWHKRTKVKKDLTKAQQVLD
ADHYGLERVKERILEYLAVQTRLNQIKGPILCLVGPPGVGKTSLGQSIAQATGRKYVRMALGGVRDEAEIRGHRKTYIGA
LPGKLIQKMAKVGVKNPLFLLDEIDKMSSDMRGDPASALLEVLDPEQNTSFNDHYLEVDYDLSDVMFVATSNSMRIPAPL
LDRMEVIRLSGYTEDEKLNIATRHLIAKQMERNGLKAGELTIEDSAILDIIRYYTREAGVRSLEREISKICRKAVKNLLL
DKKVKSLKVNATNLHDYLGVKRFEFGRADTQNRVGEVTGLAWTEVGGDLLTIETASVLGKGKLTYTGSLGDVMKESIQAA
MTVVRSRAEKLGIASDFHEKRDIHIHVPEGATPKDGPSAGIAMCTALVSCLTGNPVKADVAMTGEITLRGKVLPIGGLKE
KLLAAHRGGIKTVIIPKENVKDLEEIPDNAKSNLTIHAVETIDEVLTIALENAPTGVEFMKLTPVSAAKTVRKGRSTSRK
SAVN
>Mature_803_residues
SAKKTQQQSIPVLPLRDVVVFPYMVMPLFVGRPKSIRSLDEAMETGKQLLLVSQKQADLEEPTVDDVYRVGTVANIIQLL
KLPDGTVKVLVEGQQRATIEQLDDNGEYFSAQIRLIETEFGDDKELEVVKKATLAEFEKYAKLNKKVQPDVHAALERIEE
FDRLSDTLAAHMPVAVKHKQKVLEIAKVVARFEYLLGLMESETDLLQIEKRIRGRVKEQMEKTQRDYYLNEQIKAIQKEL
GEGDSADEIEQLRQKIEEAKMPAEAKSKAEAELQKLKMMSPMSAEATVVRSYIDWMIQVPWHKRTKVKKDLTKAQQVLDA
DHYGLERVKERILEYLAVQTRLNQIKGPILCLVGPPGVGKTSLGQSIAQATGRKYVRMALGGVRDEAEIRGHRKTYIGAL
PGKLIQKMAKVGVKNPLFLLDEIDKMSSDMRGDPASALLEVLDPEQNTSFNDHYLEVDYDLSDVMFVATSNSMRIPAPLL
DRMEVIRLSGYTEDEKLNIATRHLIAKQMERNGLKAGELTIEDSAILDIIRYYTREAGVRSLEREISKICRKAVKNLLLD
KKVKSLKVNATNLHDYLGVKRFEFGRADTQNRVGEVTGLAWTEVGGDLLTIETASVLGKGKLTYTGSLGDVMKESIQAAM
TVVRSRAEKLGIASDFHEKRDIHIHVPEGATPKDGPSAGIAMCTALVSCLTGNPVKADVAMTGEITLRGKVLPIGGLKEK
LLAAHRGGIKTVIIPKENVKDLEEIPDNAKSNLTIHAVETIDEVLTIALENAPTGVEFMKLTPVSAAKTVRKGRSTSRKS
AVN

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=769, Percent_Identity=39.7919375812744, Blast_Score=534, Evalue=1e-151,
Organism=Homo sapiens, GI21396489, Length=620, Percent_Identity=43.2258064516129, Blast_Score=510, Evalue=1e-144,
Organism=Escherichia coli, GI1786643, Length=781, Percent_Identity=75.416133162612, Blast_Score=1216, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=662, Percent_Identity=40.9365558912387, Blast_Score=483, Evalue=1e-136,
Organism=Caenorhabditis elegans, GI17556486, Length=732, Percent_Identity=34.4262295081967, Blast_Score=435, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6319449, Length=671, Percent_Identity=40.9836065573771, Blast_Score=489, Evalue=1e-138,
Organism=Drosophila melanogaster, GI221513036, Length=648, Percent_Identity=44.5987654320988, Blast_Score=522, Evalue=1e-148,
Organism=Drosophila melanogaster, GI24666867, Length=648, Percent_Identity=44.5987654320988, Blast_Score=522, Evalue=1e-148,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 89443; Mature: 89312

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAKKTQQQSIPVLPLRDVVVFPYMVMPLFVGRPKSIRSLDEAMETGKQLLLVSQKQADL
CCCCCCHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHEEEEECHHCCC
EEPTVDDVYRVGTVANIIQLLKLPDGTVKVLVEGQQRATIEQLDDNGEYFSAQIRLIETE
CCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHCCCCCEEEEEEEEEEEC
FGDDKELEVVKKATLAEFEKYAKLNKKVQPDVHAALERIEEFDRLSDTLAAHMPVAVKHK
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
QKVLEIAKVVARFEYLLGLMESETDLLQIEKRIRGRVKEQMEKTQRDYYLNEQIKAIQKE
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGEGDSADEIEQLRQKIEEAKMPAEAKSKAEAELQKLKMMSPMSAEATVVRSYIDWMIQV
HCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHEEC
PWHKRTKVKKDLTKAQQVLDADHYGLERVKERILEYLAVQTRLNQIKGPILCLVGPPGVG
CCCHHHHHHHHHHHHHHHHCCHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCC
KTSLGQSIAQATGRKYVRMALGGVRDEAEIRGHRKTYIGALPGKLIQKMAKVGVKNPLFL
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHCCCHHHHHHHHHCCCCCCHHH
LDEIDKMSSDMRGDPASALLEVLDPEQNTSFNDHYLEVDYDLSDVMFVATSNSMRIPAPL
HHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEEEEEECCCCCCCHHH
LDRMEVIRLSGYTEDEKLNIATRHLIAKQMERNGLKAGELTIEDSAILDIIRYYTREAGV
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEECHHHHHHHHHHHHHHHHH
RSLEREISKICRKAVKNLLLDKKVKSLKVNATNLHDYLGVKRFEFGRADTQNRVGEVTGL
HHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHCCHHCCCCCCCCHHHHHHHCCC
AWTEVGGDLLTIETASVLGKGKLTYTGSLGDVMKESIQAAMTVVRSRAEKLGIASDFHEK
CHHHCCCCEEEEEHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCC
RDIHIHVPEGATPKDGPSAGIAMCTALVSCLTGNPVKADVAMTGEITLRGKVLPIGGLKE
CCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECEEEEEEEEEECCCHHH
KLLAAHRGGIKTVIIPKENVKDLEEIPDNAKSNLTIHAVETIDEVLTIALENAPTGVEFM
HHHHHHCCCCEEEEECCCCHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHCCCCCCCEEE
KLTPVSAAKTVRKGRSTSRKSAVN
EECCHHHHHHHHHCCCCCHHCCCC
>Mature Secondary Structure 
SAKKTQQQSIPVLPLRDVVVFPYMVMPLFVGRPKSIRSLDEAMETGKQLLLVSQKQADL
CCCCCHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHEEEEECHHCCC
EEPTVDDVYRVGTVANIIQLLKLPDGTVKVLVEGQQRATIEQLDDNGEYFSAQIRLIETE
CCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHCCCCCEEEEEEEEEEEC
FGDDKELEVVKKATLAEFEKYAKLNKKVQPDVHAALERIEEFDRLSDTLAAHMPVAVKHK
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
QKVLEIAKVVARFEYLLGLMESETDLLQIEKRIRGRVKEQMEKTQRDYYLNEQIKAIQKE
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGEGDSADEIEQLRQKIEEAKMPAEAKSKAEAELQKLKMMSPMSAEATVVRSYIDWMIQV
HCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHEEC
PWHKRTKVKKDLTKAQQVLDADHYGLERVKERILEYLAVQTRLNQIKGPILCLVGPPGVG
CCCHHHHHHHHHHHHHHHHCCHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCC
KTSLGQSIAQATGRKYVRMALGGVRDEAEIRGHRKTYIGALPGKLIQKMAKVGVKNPLFL
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHCCCHHHHHHHHHCCCCCCHHH
LDEIDKMSSDMRGDPASALLEVLDPEQNTSFNDHYLEVDYDLSDVMFVATSNSMRIPAPL
HHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEEEEEECCCCCCCHHH
LDRMEVIRLSGYTEDEKLNIATRHLIAKQMERNGLKAGELTIEDSAILDIIRYYTREAGV
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEECHHHHHHHHHHHHHHHHH
RSLEREISKICRKAVKNLLLDKKVKSLKVNATNLHDYLGVKRFEFGRADTQNRVGEVTGL
HHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHCCHHCCCCCCCCHHHHHHHCCC
AWTEVGGDLLTIETASVLGKGKLTYTGSLGDVMKESIQAAMTVVRSRAEKLGIASDFHEK
CHHHCCCCEEEEEHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCC
RDIHIHVPEGATPKDGPSAGIAMCTALVSCLTGNPVKADVAMTGEITLRGKVLPIGGLKE
CCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECEEEEEEEEEECCCHHH
KLLAAHRGGIKTVIIPKENVKDLEEIPDNAKSNLTIHAVETIDEVLTIALENAPTGVEFM
HHHHHHCCCCEEEEECCCCHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHCCCCCCCEEE
KLTPVSAAKTVRKGRSTSRKSAVN
EECCHHHHHHHHHCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]