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The map label for this gene is clpX

Identifier: 15603842

GI number: 15603842

Start: 2212533

End: 2213768

Strand: Direct

Name: clpX

Synonym: PM1977

Alternate gene names: 15603842

Gene position: 2212533-2213768 (Clockwise)

Preceding gene: 15603841

Following gene: 15603843

Centisome position: 98.01

GC content: 39.89

Gene sequence:

>1236_bases
ATGGAAAAAGACACTGAATTACATTGTTCTTTTTGTGGTAAAGAACAGAAACACGTCAGCAAGTTAATTGCGGGTACATC
AGGTTATATTTGTAATGAATGTATCGAATTATGTCATGATATGTTGTTATCGGATGCCGTAGAAACGCCAGAAGTCGAAA
GTACAGAACAACAAAAATTACCCACACCACATGAAATTCGTGCACATTTAGATGATTATGTTATCGGGCAAGATTATGCG
AAGAAAGTGTTGTCTGTCGCCGTTTATAATCACTATAAACGTTTACGTTCTGATAAACAGATTACCGATGTGGAATTAGG
TAAAAGTAATATTTTGCTTATTGGTCCAACTGGAAGCGGGAAAACGTTATTAGCGGAAACCATGGCACGTATGTTGAATG
TGCCCTTTGCTATGGCTGATGCCACTACGTTGACTGAAGCCGGTTACGTGGGGGAAGACGTGGAGAATGTACTACAAAAA
TTAGTGCAAAGTTGCGACTATGATGTAGAACGTGCAGAGCAAGGGATTATTTATATTGATGAGATCGATAAAATTACCCG
TAAGTCTGAAAATCCGTCGATTACTCGCGATGTTTCTGGCGAAGGGGTACAACAAGCGTTACTTAAATTAATTGAAGGGA
CGGTTGCCTCAATTCCACCACAAGGTGGACGCAAACATCCACAACAAGAAATGTTACGTGTTGATACCTCGAAAATTCTG
TTTATTTGTGGTGGTGCATTTGCCGGCTTAGATAAAGTGATCGAAAAACGTGTGCATGTGGGATCAGGTATTGGTTTTAG
TGCAGAAGTGAAAAGTAAGCAAGATAAAGCCACTCTGAGCCAATTATTTGAGCAAGTCGAACCAGATGATTTAATGAAAT
TTGGTTTAATTCCAGAATTTATTGGTCGTTTACCTGTGGTAGCACCACTGGCTGAACTCGATGAAGAAGCGTTAGTTAAA
ATTTTAACTGAACCAAAAAATGCGCTGATTAAACAATATCAAGCGTTATTTAGTTTAGAAGATGTTGCCTTGGAATTTAG
CCCAGAGGCGCTTACTGCGATGGCGAAGAAAGCCTTAGCGCGTAAAACCGGTGCGCGTGGTTTACGTTCGATTGTGGAAG
CCATTTTATTGGATACTATGTATGACTTGCCTTCATTACAGCATCTTGAAAAAGTGATTGTAGAAGCCAGCACCATTACA
GACAATCAACCGCCAACACTCGTGTATAAAGCATAA

Upstream 100 bases:

>100_bases
GCGTGACACGGATCGGGATAATTTTATGTCTGCAGAAGAGGCAAAAGCTTATGGCTTGGTCGATGAAGTGTTAGCAAGTC
GATAAGTATTAGGATAAGAA

Downstream 100 bases:

>100_bases
TTTCTGCATGTCATCTAAAAGTGCGGTATTTTTTACCGCACTTTTTTGCCCTCAAGCTTGATTTATGATTATTTACCCTC
ATATTTGAGCGAAGTAGCCT

Product: ATP-dependent protease ATP-binding subunit ClpX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 411; Mature: 411

Protein sequence:

>411_residues
MEKDTELHCSFCGKEQKHVSKLIAGTSGYICNECIELCHDMLLSDAVETPEVESTEQQKLPTPHEIRAHLDDYVIGQDYA
KKVLSVAVYNHYKRLRSDKQITDVELGKSNILLIGPTGSGKTLLAETMARMLNVPFAMADATTLTEAGYVGEDVENVLQK
LVQSCDYDVERAEQGIIYIDEIDKITRKSENPSITRDVSGEGVQQALLKLIEGTVASIPPQGGRKHPQQEMLRVDTSKIL
FICGGAFAGLDKVIEKRVHVGSGIGFSAEVKSKQDKATLSQLFEQVEPDDLMKFGLIPEFIGRLPVVAPLAELDEEALVK
ILTEPKNALIKQYQALFSLEDVALEFSPEALTAMAKKALARKTGARGLRSIVEAILLDTMYDLPSLQHLEKVIVEASTIT
DNQPPTLVYKA

Sequences:

>Translated_411_residues
MEKDTELHCSFCGKEQKHVSKLIAGTSGYICNECIELCHDMLLSDAVETPEVESTEQQKLPTPHEIRAHLDDYVIGQDYA
KKVLSVAVYNHYKRLRSDKQITDVELGKSNILLIGPTGSGKTLLAETMARMLNVPFAMADATTLTEAGYVGEDVENVLQK
LVQSCDYDVERAEQGIIYIDEIDKITRKSENPSITRDVSGEGVQQALLKLIEGTVASIPPQGGRKHPQQEMLRVDTSKIL
FICGGAFAGLDKVIEKRVHVGSGIGFSAEVKSKQDKATLSQLFEQVEPDDLMKFGLIPEFIGRLPVVAPLAELDEEALVK
ILTEPKNALIKQYQALFSLEDVALEFSPEALTAMAKKALARKTGARGLRSIVEAILLDTMYDLPSLQHLEKVIVEASTIT
DNQPPTLVYKA
>Mature_411_residues
MEKDTELHCSFCGKEQKHVSKLIAGTSGYICNECIELCHDMLLSDAVETPEVESTEQQKLPTPHEIRAHLDDYVIGQDYA
KKVLSVAVYNHYKRLRSDKQITDVELGKSNILLIGPTGSGKTLLAETMARMLNVPFAMADATTLTEAGYVGEDVENVLQK
LVQSCDYDVERAEQGIIYIDEIDKITRKSENPSITRDVSGEGVQQALLKLIEGTVASIPPQGGRKHPQQEMLRVDTSKIL
FICGGAFAGLDKVIEKRVHVGSGIGFSAEVKSKQDKATLSQLFEQVEPDDLMKFGLIPEFIGRLPVVAPLAELDEEALVK
ILTEPKNALIKQYQALFSLEDVALEFSPEALTAMAKKALARKTGARGLRSIVEAILLDTMYDLPSLQHLEKVIVEASTIT
DNQPPTLVYKA

Specific function: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP

COG id: COG1219

COG function: function code O; ATP-dependent protease Clp, ATPase subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family

Homologues:

Organism=Homo sapiens, GI7242140, Length=310, Percent_Identity=51.6129032258064, Blast_Score=308, Evalue=9e-84,
Organism=Escherichia coli, GI1786642, Length=403, Percent_Identity=73.697270471464, Blast_Score=612, Evalue=1e-176,
Organism=Escherichia coli, GI1790366, Length=122, Percent_Identity=38.5245901639344, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71982908, Length=298, Percent_Identity=46.9798657718121, Blast_Score=271, Evalue=3e-73,
Organism=Caenorhabditis elegans, GI71982905, Length=298, Percent_Identity=46.9798657718121, Blast_Score=271, Evalue=5e-73,
Organism=Caenorhabditis elegans, GI71988663, Length=398, Percent_Identity=36.4321608040201, Blast_Score=247, Evalue=8e-66,
Organism=Caenorhabditis elegans, GI71988660, Length=255, Percent_Identity=36.078431372549, Blast_Score=166, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6319704, Length=425, Percent_Identity=40.4705882352941, Blast_Score=276, Evalue=5e-75,
Organism=Drosophila melanogaster, GI24648291, Length=302, Percent_Identity=48.3443708609272, Blast_Score=292, Evalue=4e-79,
Organism=Drosophila melanogaster, GI24648289, Length=302, Percent_Identity=48.3443708609272, Blast_Score=291, Evalue=5e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPX_PASMU (P57981)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_246916.1
- ProteinModelPortal:   P57981
- PRIDE:   P57981
- GeneID:   1245324
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM1977
- NMPDR:   fig|272843.1.peg.1978
- HOGENOM:   HBG745965
- OMA:   CGKSQEQ
- ProtClustDB:   PRK05342
- BioCyc:   PMUL272843:PM1977-MONOMER
- HAMAP:   MF_00175
- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR019489
- InterPro:   IPR004487
- InterPro:   IPR010603
- PANTHER:   PTHR11262:SF4
- SMART:   SM00382
- TIGRFAMs:   TIGR00382

Pfam domain/function: PF07724 AAA_2; PF10431 ClpB_D2-small; PF06689 zf-C4_ClpX

EC number: NA

Molecular weight: Translated: 45253; Mature: 45253

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKDTELHCSFCGKEQKHVSKLIAGTSGYICNECIELCHDMLLSDAVETPEVESTEQQKL
CCCCCCCHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCC
PTPHEIRAHLDDYVIGQDYAKKVLSVAVYNHYKRLRSDKQITDVELGKSNILLIGPTGSG
CCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHEECCCCEEEEECCCCC
KTLLAETMARMLNVPFAMADATTLTEAGYVGEDVENVLQKLVQSCDYDVERAEQGIIYID
CHHHHHHHHHHHCCCHHHHCHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHCCCEEEEE
EIDKITRKSENPSITRDVSGEGVQQALLKLIEGTVASIPPQGGRKHPQQEMLRVDTSKIL
HHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCHHHCCCCCCCCCCCHHHHHHHCCCCEE
FICGGAFAGLDKVIEKRVHVGSGIGFSAEVKSKQDKATLSQLFEQVEPDDLMKFGLIPEF
EEECCHHHHHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHHHCCHHHHHHHCCHHHH
IGRLPVVAPLAELDEEALVKILTEPKNALIKQYQALFSLEDVALEFSPEALTAMAKKALA
HCCCCHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
RKTGARGLRSIVEAILLDTMYDLPSLQHLEKVIVEASTITDNQPPTLVYKA
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCEEEEEC
>Mature Secondary Structure
MEKDTELHCSFCGKEQKHVSKLIAGTSGYICNECIELCHDMLLSDAVETPEVESTEQQKL
CCCCCCCHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCC
PTPHEIRAHLDDYVIGQDYAKKVLSVAVYNHYKRLRSDKQITDVELGKSNILLIGPTGSG
CCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHEECCCCEEEEECCCCC
KTLLAETMARMLNVPFAMADATTLTEAGYVGEDVENVLQKLVQSCDYDVERAEQGIIYID
CHHHHHHHHHHHCCCHHHHCHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHCCCEEEEE
EIDKITRKSENPSITRDVSGEGVQQALLKLIEGTVASIPPQGGRKHPQQEMLRVDTSKIL
HHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCHHHCCCCCCCCCCCHHHHHHHCCCCEE
FICGGAFAGLDKVIEKRVHVGSGIGFSAEVKSKQDKATLSQLFEQVEPDDLMKFGLIPEF
EEECCHHHHHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHHHCCHHHHHHHCCHHHH
IGRLPVVAPLAELDEEALVKILTEPKNALIKQYQALFSLEDVALEFSPEALTAMAKKALA
HCCCCHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
RKTGARGLRSIVEAILLDTMYDLPSLQHLEKVIVEASTITDNQPPTLVYKA
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11248100