Click here to switch to the map view.

The map label for this gene is clpP [H]

Identifier: 15603841

GI number: 15603841

Start: 2211936

End: 2212517

Strand: Direct

Name: clpP [H]

Synonym: PM1976

Alternate gene names: 15603841

Gene position: 2211936-2212517 (Clockwise)

Preceding gene: 15603840

Following gene: 15603842

Centisome position: 97.98

GC content: 42.96

Gene sequence:

>582_bases
ATGAGTGTAATTCCTATGGTTGTTGAGCAAACCGCAAGAGGGGAACGTTCTTATGATATTTATTCACGTTTATTAAAAGA
GCGCGTGATCTTCTTAGGCGGTGAAGTGGAAGATCGTATGGCAAATTTGATCGTTGCGCAATTATTATTTTTAGAATCTG
AAGATCCTGAAAAAGACATTAACATTTACATTAATTCACCGGGCGGTTCAGTAACGGCGGGAATGGCGATTTACGATACG
ATGCAATTTGTGAAACCGGATATTCGCACCCTTTGCGTAGGACAAGCTTGTTCAATGGGGGCATTTTTATTAGCGGGAGG
AACCGCGGGTAAACGCATTGCGTTACCGAGTGCACGTGTGATGATTCACCAACCCTTGGGTGGCTTCCGTGGTCAAGCCT
CTGATATTCAAATTCACGCTCAGGAAATCTTAAAAATTAAGCAAACTCTAAATGAACGTTTAGCGTTCCATACCGGTCAA
ACTATCGAACGCATTGAGCGTGACACGGATCGGGATAATTTTATGTCTGCAGAAGAGGCAAAAGCTTATGGCTTGGTCGA
TGAAGTGTTAGCAAGTCGATAA

Upstream 100 bases:

>100_bases
TTTATCTTGTGTAAATATTCAATTTAGTGAAATCGGAATTTTCAGGTAGAATAACAAAACGATTTAAAAACGGATGATTA
ATGGATTGAGAGAGGTAGAG

Downstream 100 bases:

>100_bases
GTATTAGGATAAGAAATGGAAAAAGACACTGAATTACATTGTTCTTTTTGTGGTAAAGAACAGAAACACGTCAGCAAGTT
AATTGCGGGTACATCAGGTT

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp [H]

Number of amino acids: Translated: 193; Mature: 192

Protein sequence:

>193_residues
MSVIPMVVEQTARGERSYDIYSRLLKERVIFLGGEVEDRMANLIVAQLLFLESEDPEKDINIYINSPGGSVTAGMAIYDT
MQFVKPDIRTLCVGQACSMGAFLLAGGTAGKRIALPSARVMIHQPLGGFRGQASDIQIHAQEILKIKQTLNERLAFHTGQ
TIERIERDTDRDNFMSAEEAKAYGLVDEVLASR

Sequences:

>Translated_193_residues
MSVIPMVVEQTARGERSYDIYSRLLKERVIFLGGEVEDRMANLIVAQLLFLESEDPEKDINIYINSPGGSVTAGMAIYDT
MQFVKPDIRTLCVGQACSMGAFLLAGGTAGKRIALPSARVMIHQPLGGFRGQASDIQIHAQEILKIKQTLNERLAFHTGQ
TIERIERDTDRDNFMSAEEAKAYGLVDEVLASR
>Mature_192_residues
SVIPMVVEQTARGERSYDIYSRLLKERVIFLGGEVEDRMANLIVAQLLFLESEDPEKDINIYINSPGGSVTAGMAIYDTM
QFVKPDIRTLCVGQACSMGAFLLAGGTAGKRIALPSARVMIHQPLGGFRGQASDIQIHAQEILKIKQTLNERLAFHTGQT
IERIERDTDRDNFMSAEEAKAYGLVDEVLASR

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=190, Percent_Identity=57.3684210526316, Blast_Score=234, Evalue=4e-62,
Organism=Escherichia coli, GI1786641, Length=193, Percent_Identity=70.9844559585492, Blast_Score=305, Evalue=2e-84,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=53.2258064516129, Blast_Score=213, Evalue=3e-56,
Organism=Drosophila melanogaster, GI20129427, Length=190, Percent_Identity=60.5263157894737, Blast_Score=245, Evalue=1e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 21350; Mature: 21219

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVIPMVVEQTARGERSYDIYSRLLKERVIFLGGEVEDRMANLIVAQLLFLESEDPEKDI
CCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCE
NIYINSPGGSVTAGMAIYDTMQFVKPDIRTLCVGQACSMGAFLLAGGTAGKRIALPSARV
EEEEECCCCCEEHHHHHHHHHHHHCHHHHHHHHCCHHCCCEEEEECCCCCCEEECCCCEE
MIHQPLGGFRGQASDIQIHAQEILKIKQTLNERLAFHTGQTIERIERDTDRDNFMSAEEA
EEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHCCCHHHH
KAYGLVDEVLASR
HHHHHHHHHHHCC
>Mature Secondary Structure 
SVIPMVVEQTARGERSYDIYSRLLKERVIFLGGEVEDRMANLIVAQLLFLESEDPEKDI
CCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCE
NIYINSPGGSVTAGMAIYDTMQFVKPDIRTLCVGQACSMGAFLLAGGTAGKRIALPSARV
EEEEECCCCCEEHHHHHHHHHHHHCHHHHHHHHCCHHCCCEEEEECCCCCCEEECCCCEE
MIHQPLGGFRGQASDIQIHAQEILKIKQTLNERLAFHTGQTIERIERDTDRDNFMSAEEA
EEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHCCCHHHH
KAYGLVDEVLASR
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA