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The map label for this gene is mco [H]

Identifier: 15603803

GI number: 15603803

Start: 2174564

End: 2176111

Strand: Reverse

Name: mco [H]

Synonym: PM1938

Alternate gene names: 15603803

Gene position: 2176111-2174564 (Counterclockwise)

Preceding gene: 15603804

Following gene: 15603801

Centisome position: 96.4

GC content: 42.76

Gene sequence:

>1548_bases
ATGAAACGTCGAGATTTTTTACGTTATGGAATTGGAATTAGCTTAGCCAGTAGCTCGCTTTATAGCCTTGCGAATATGAT
GAACCACGCACAACATGGCAATATGGCGATGATGCATTCAGTACCTACTGGCCTAATGCCAACTGAGGCAATGCCTTCAG
GTTTATCGCTTAATGGGATATTGCCAAAACTTGCTAATCAATCGACTCAAGCAGGGCTATTCACAGCCACTTTAAAAGCA
GAGCCAATTAAAATTCGCCTCGCAGACAATAAAGAAACGGAATTTTGGGCTTATAACGGACAACTACCAGGGCCACAAAT
TGAAGTATTTGAAGGCGACACCGTAGAAATTGAATTTATCAATCACCTACCACAACCCTCAACAGTACATTGGCACGGCT
TAGATGTACCAAATGAGGCGGATGGTAACCCGATGGATATGGTTGAACCGCAAGGGAAAAAAGTCTATCGCTTTACGCTA
CCTCAAGGCAGTGCTGGGACATATTGGTACCACCCTCATCCACATGACCATGTTTCCGAACAAGTCTATAAAGGCTTAGC
AGGCACTTTCGTTGTTAAAGCGAAAAATGATCCGCTTGCACACCTTCCTGAACAACATTGGGTGATTTCCGATCTGCGTT
TAAATGCCGATGGCACCATTCCAGCAAACACGATGTTAGATTGGATGAACGGTCGTGAGGGTGAATTTGTGTTAATCAAC
GGTCAATATCAGCCCCAGATTCAAGTGAAAACGAATGAACGAATCCGTCTTTGGAATGCCACTAGCGCTCGTTATTTTCG
TTTAAACATTCCAGGGGTGAAATGGATTGTGGTGGGTACCGAAGGTGGTTTACTTGAAAAACCTCGCGCGCCTGTTGATG
AACTGCTACTTACACCAGCCGAACGCGTTGAAGTGATTATGGTGGGTGAAACGCAAGGAACAGTCAATTTACAAAGCGGT
TATTATGATCGCCGTAAGATGATGGTTCAAGAACAGCCTAAAGATCTCACTTTAGCCACAATTCAGGTGAAATCAGAACC
TGTTCAGTTACCTGAAAGCTTAAGGTCCTTGCCTAACTGGGATGAGCCAAAGCAGGTTCGCCAAATTCGCTTTAGTGAAA
AAATGATGAACCATACGAATATGCCAATGATGAATCACGGTACACATCACGCTACTACAACACCAACGGACAACCCTATT
CCACCAATGATGAATGGTATGTTCTTAATCAACGGTCAAACCTTTGATATGAACCGTATTGATTTTGTTGCCAAATTGAA
TGAAGTGGAACAGTGGGAAATTTTCAATGAAAGCCATATGGATCATCCGTTCCATTTGCACGGCACTCAATTTGAAGTGA
TTCAACATACATTAAACGGCAAAACCTTCAAGCCAGAAGGCAGGGCGTTAAAAGATGTAGTCAATTTGCGCCCTTATGAA
AAAGTGATTATTCGCTTTAAGCAAGGACACACTGGGTTGAAAATGTACCATTGCCATATTTTGGAACATGAAAATCTCGG
TATGATGGGGATGTTTAAAGTGGAATAG

Upstream 100 bases:

>100_bases
AAGCATACGGCGGACGCAAAGATCCTTATGATGTTGTTTTAATTAAGAAAAACGGTGAAAGTGAAGTGTTCAAATCCTAT
AACCAATAGGGGGGGAAAGA

Downstream 100 bases:

>100_bases
TGGTATCTAACCATAAAAAACAGAGGGATTTTCGTGAAAATTTGTAAATCGCGAAAATCCCTCTGCTTATCACTGCCTAT
TCCAACGGTTTAACAATGCA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 515; Mature: 515

Protein sequence:

>515_residues
MKRRDFLRYGIGISLASSSLYSLANMMNHAQHGNMAMMHSVPTGLMPTEAMPSGLSLNGILPKLANQSTQAGLFTATLKA
EPIKIRLADNKETEFWAYNGQLPGPQIEVFEGDTVEIEFINHLPQPSTVHWHGLDVPNEADGNPMDMVEPQGKKVYRFTL
PQGSAGTYWYHPHPHDHVSEQVYKGLAGTFVVKAKNDPLAHLPEQHWVISDLRLNADGTIPANTMLDWMNGREGEFVLIN
GQYQPQIQVKTNERIRLWNATSARYFRLNIPGVKWIVVGTEGGLLEKPRAPVDELLLTPAERVEVIMVGETQGTVNLQSG
YYDRRKMMVQEQPKDLTLATIQVKSEPVQLPESLRSLPNWDEPKQVRQIRFSEKMMNHTNMPMMNHGTHHATTTPTDNPI
PPMMNGMFLINGQTFDMNRIDFVAKLNEVEQWEIFNESHMDHPFHLHGTQFEVIQHTLNGKTFKPEGRALKDVVNLRPYE
KVIIRFKQGHTGLKMYHCHILEHENLGMMGMFKVE

Sequences:

>Translated_515_residues
MKRRDFLRYGIGISLASSSLYSLANMMNHAQHGNMAMMHSVPTGLMPTEAMPSGLSLNGILPKLANQSTQAGLFTATLKA
EPIKIRLADNKETEFWAYNGQLPGPQIEVFEGDTVEIEFINHLPQPSTVHWHGLDVPNEADGNPMDMVEPQGKKVYRFTL
PQGSAGTYWYHPHPHDHVSEQVYKGLAGTFVVKAKNDPLAHLPEQHWVISDLRLNADGTIPANTMLDWMNGREGEFVLIN
GQYQPQIQVKTNERIRLWNATSARYFRLNIPGVKWIVVGTEGGLLEKPRAPVDELLLTPAERVEVIMVGETQGTVNLQSG
YYDRRKMMVQEQPKDLTLATIQVKSEPVQLPESLRSLPNWDEPKQVRQIRFSEKMMNHTNMPMMNHGTHHATTTPTDNPI
PPMMNGMFLINGQTFDMNRIDFVAKLNEVEQWEIFNESHMDHPFHLHGTQFEVIQHTLNGKTFKPEGRALKDVVNLRPYE
KVIIRFKQGHTGLKMYHCHILEHENLGMMGMFKVE
>Mature_515_residues
MKRRDFLRYGIGISLASSSLYSLANMMNHAQHGNMAMMHSVPTGLMPTEAMPSGLSLNGILPKLANQSTQAGLFTATLKA
EPIKIRLADNKETEFWAYNGQLPGPQIEVFEGDTVEIEFINHLPQPSTVHWHGLDVPNEADGNPMDMVEPQGKKVYRFTL
PQGSAGTYWYHPHPHDHVSEQVYKGLAGTFVVKAKNDPLAHLPEQHWVISDLRLNADGTIPANTMLDWMNGREGEFVLIN
GQYQPQIQVKTNERIRLWNATSARYFRLNIPGVKWIVVGTEGGLLEKPRAPVDELLLTPAERVEVIMVGETQGTVNLQSG
YYDRRKMMVQEQPKDLTLATIQVKSEPVQLPESLRSLPNWDEPKQVRQIRFSEKMMNHTNMPMMNHGTHHATTTPTDNPI
PPMMNGMFLINGQTFDMNRIDFVAKLNEVEQWEIFNESHMDHPFHLHGTQFEVIQHTLNGKTFKPEGRALKDVVNLRPYE
KVIIRFKQGHTGLKMYHCHILEHENLGMMGMFKVE

Specific function: May be involved in copper homeostasis and oxidative stress response [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=575, Percent_Identity=30.9565217391304, Blast_Score=191, Evalue=9e-50,
Organism=Escherichia coli, GI1789394, Length=500, Percent_Identity=25.8, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6323703, Length=473, Percent_Identity=26.215644820296, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI18859919, Length=262, Percent_Identity=28.2442748091603, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24650186, Length=232, Percent_Identity=28.448275862069, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR002355
- InterPro:   IPR008972 [H]

Pfam domain/function: PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 58573; Mature: 58573

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRRDFLRYGIGISLASSSLYSLANMMNHAQHGNMAMMHSVPTGLMPTEAMPSGLSLNGI
CCCHHHHHHCCCEEEHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCEECCC
LPKLANQSTQAGLFTATLKAEPIKIRLADNKETEFWAYNGQLPGPQIEVFEGDTVEIEFI
CHHHCCCCCCCCEEEEEEECCCEEEEEECCCCCEEEEECCCCCCCEEEEEECCEEEEEEH
NHLPQPSTVHWHGLDVPNEADGNPMDMVEPQGKKVYRFTLPQGSAGTYWYHPHPHDHVSE
HCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEECCCCCHHHHH
QVYKGLAGTFVVKAKNDPLAHLPEQHWVISDLRLNADGTIPANTMLDWMNGREGEFVLIN
HHHHCCCEEEEEEECCCCHHCCCCCCEEEEEEEECCCCCCCHHHHHHHCCCCCCCEEEEC
GQYQPQIQVKTNERIRLWNATSARYFRLNIPGVKWIVVGTEGGLLEKPRAPVDELLLTPA
CCCCCEEEEECCCEEEEEECCCEEEEEEECCCEEEEEEECCCCCCCCCCCCHHHHHCCCC
ERVEVIMVGETQGTVNLQSGYYDRRKMMVQEQPKDLTLATIQVKSEPVQLPESLRSLPNW
HHEEEEEEECCCCEEEECCCCCHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHHHCCCC
DEPKQVRQIRFSEKMMNHTNMPMMNHGTHHATTTPTDNPIPPMMNGMFLINGQTFDMNRI
CCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHCCEEEECCCEECCCHH
DFVAKLNEVEQWEIFNESHMDHPFHLHGTQFEVIQHTLNGKTFKPEGRALKDVVNLRPYE
HHHHHHCCCCEEEEECCCCCCCCEEECCCCHHHHHHHHCCCEECCCCHHHHHHHCCCCCH
KVIIRFKQGHTGLKMYHCHILEHENLGMMGMFKVE
HEEEEEECCCCCEEEEEEEEEEECCCCEEEEEEEC
>Mature Secondary Structure
MKRRDFLRYGIGISLASSSLYSLANMMNHAQHGNMAMMHSVPTGLMPTEAMPSGLSLNGI
CCCHHHHHHCCCEEEHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCEECCC
LPKLANQSTQAGLFTATLKAEPIKIRLADNKETEFWAYNGQLPGPQIEVFEGDTVEIEFI
CHHHCCCCCCCCEEEEEEECCCEEEEEECCCCCEEEEECCCCCCCEEEEEECCEEEEEEH
NHLPQPSTVHWHGLDVPNEADGNPMDMVEPQGKKVYRFTLPQGSAGTYWYHPHPHDHVSE
HCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEECCCCCHHHHH
QVYKGLAGTFVVKAKNDPLAHLPEQHWVISDLRLNADGTIPANTMLDWMNGREGEFVLIN
HHHHCCCEEEEEEECCCCHHCCCCCCEEEEEEEECCCCCCCHHHHHHHCCCCCCCEEEEC
GQYQPQIQVKTNERIRLWNATSARYFRLNIPGVKWIVVGTEGGLLEKPRAPVDELLLTPA
CCCCCEEEEECCCEEEEEECCCEEEEEEECCCEEEEEEECCCCCCCCCCCCHHHHHCCCC
ERVEVIMVGETQGTVNLQSGYYDRRKMMVQEQPKDLTLATIQVKSEPVQLPESLRSLPNW
HHEEEEEEECCCCEEEECCCCCHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHHHCCCC
DEPKQVRQIRFSEKMMNHTNMPMMNHGTHHATTTPTDNPIPPMMNGMFLINGQTFDMNRI
CCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHCCEEEECCCEECCCHH
DFVAKLNEVEQWEIFNESHMDHPFHLHGTQFEVIQHTLNGKTFKPEGRALKDVVNLRPYE
HHHHHHCCCCEEEEECCCCCCCCEEECCCCHHHHHHHHCCCEECCCCHHHHHHHCCCCCH
KVIIRFKQGHTGLKMYHCHILEHENLGMMGMFKVE
HEEEEEECCCCCEEEEEEEEEEECCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA