Click here to switch to the map view.

The map label for this gene is tpiA_2 [H]

Identifier: 15603505

GI number: 15603505

Start: 1849684

End: 1850733

Strand: Reverse

Name: tpiA_2 [H]

Synonym: PM1640

Alternate gene names: 15603505

Gene position: 1850733-1849684 (Counterclockwise)

Preceding gene: 15603506

Following gene: 15603504

Centisome position: 81.98

GC content: 37.14

Gene sequence:

>1050_bases
ATGGAAAAAAAAATTTACTTTGGTACAAATTTAAAAATGTATAAAGGTAATTGTGAAACAGTCGATTACCTTACTCAGTT
ACTTGCCCTCAGAGAAAAACTTCAATCTGATTATGATATTGAATTATTTGTCATTCCTTCTTATATCGCCTTAAAAGATG
CTGTACATGCAGCGGCATCAGAGACAACGCATAAAATTCTTATTGGTGCACAGAACATGAATGCTAAGGATAAAGGGCAG
TTTACTGGCGAAATTTCACCACTCATGTTGAAAGAGCTAGGGGTTCAGTTGGTCATGATTGGGCATTCTGAACGTCGCCA
TGTTTTGAAAGAAACCGATCAGGAAGAGAATGAGAAAGTATTGTCAGCGTTGAAGCATGGCTTTAAAACATTACTCTGTG
TTGGTGAAACGTTAGAACAGAAAAATTATCAGATTTCCGATGAAGTACTCCGGACACAATTAAAGATCGGTTTGCACGGT
GTATCAGTGAAGCAATTACCTCATTTATTCATCGCATATGAACCCGTTTGGGCAATTGGTGAAGGTGGTATTCCTGCAAC
GGCGCAATATGCAGATGAGAAACAGAAGATCATTAAACAATGTTTATTTGAAATGTTTGGTGAGGAAAGTAAAAAGATAC
CGGTATTGTATGGGGGAAGTGTGAATTTAGAAAATGCAAATGAATTAATTATGCAGCCTCATATTGACGGATTGTTTGTT
GGGCGTAGCGCCTGGGATGCACAATGTTTTTATACTTTAATAGACGGTGCGTTAAAAGCCTTGGCGGGTACAACACATCA
ATTTAGCCCTATTGCTACTCAGCTCATTAAACACTTAGGAGGAAAAGAAAATATCAGTGCGTTAACGCATTGTGCGAGTC
GGATTAGAGTGATGACGCGGAATGAAAATCATATAAATAAAGTAGCAATAGAAAAAATAAATGGGGTGAGCGGGTTATTT
TCGATCGCTAATCAATATCAAATTATTGTAGGTCCTAAATGGGTAGAAAAAATTTATAGCGAAATGAAAGCGTTATTAGA
AACAGAATAG

Upstream 100 bases:

>100_bases
AAGTCACTGTGTGGAAGGGTTAATGATACCTATTGCTATTGAACATGCAGATGGCGCGCCTTGTCGCGTTTTGGTCAAAA
ATCTTTAAAAGGTAAATGTT

Downstream 100 bases:

>100_bases
ATGATAGGGAGAAGAGCATGACACAATTAGATTCGTTACGCAGTATGACGGTTGTTGTCGCAGATACTGGTGATATTGAA
GCAATTAAGCAATATCAGCC

Product: hypothetical protein

Products: NA

Alternate protein names: TIM 2; Triose-phosphate isomerase 2 [H]

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MEKKIYFGTNLKMYKGNCETVDYLTQLLALREKLQSDYDIELFVIPSYIALKDAVHAAASETTHKILIGAQNMNAKDKGQ
FTGEISPLMLKELGVQLVMIGHSERRHVLKETDQEENEKVLSALKHGFKTLLCVGETLEQKNYQISDEVLRTQLKIGLHG
VSVKQLPHLFIAYEPVWAIGEGGIPATAQYADEKQKIIKQCLFEMFGEESKKIPVLYGGSVNLENANELIMQPHIDGLFV
GRSAWDAQCFYTLIDGALKALAGTTHQFSPIATQLIKHLGGKENISALTHCASRIRVMTRNENHINKVAIEKINGVSGLF
SIANQYQIIVGPKWVEKIYSEMKALLETE

Sequences:

>Translated_349_residues
MEKKIYFGTNLKMYKGNCETVDYLTQLLALREKLQSDYDIELFVIPSYIALKDAVHAAASETTHKILIGAQNMNAKDKGQ
FTGEISPLMLKELGVQLVMIGHSERRHVLKETDQEENEKVLSALKHGFKTLLCVGETLEQKNYQISDEVLRTQLKIGLHG
VSVKQLPHLFIAYEPVWAIGEGGIPATAQYADEKQKIIKQCLFEMFGEESKKIPVLYGGSVNLENANELIMQPHIDGLFV
GRSAWDAQCFYTLIDGALKALAGTTHQFSPIATQLIKHLGGKENISALTHCASRIRVMTRNENHINKVAIEKINGVSGLF
SIANQYQIIVGPKWVEKIYSEMKALLETE
>Mature_349_residues
MEKKIYFGTNLKMYKGNCETVDYLTQLLALREKLQSDYDIELFVIPSYIALKDAVHAAASETTHKILIGAQNMNAKDKGQ
FTGEISPLMLKELGVQLVMIGHSERRHVLKETDQEENEKVLSALKHGFKTLLCVGETLEQKNYQISDEVLRTQLKIGLHG
VSVKQLPHLFIAYEPVWAIGEGGIPATAQYADEKQKIIKQCLFEMFGEESKKIPVLYGGSVNLENANELIMQPHIDGLFV
GRSAWDAQCFYTLIDGALKALAGTTHQFSPIATQLIKHLGGKENISALTHCASRIRVMTRNENHINKVAIEKINGVSGLF
SIANQYQIIVGPKWVEKIYSEMKALLETE

Specific function: Plays an important role in several metabolic pathways. [C]

COG id: COG0149

COG function: function code G; Triosephosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the triosephosphate isomerase family [H]

Homologues:

Organism=Homo sapiens, GI4507645, Length=247, Percent_Identity=34.412955465587, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI226529917, Length=242, Percent_Identity=35.1239669421488, Blast_Score=130, Evalue=2e-30,
Organism=Escherichia coli, GI1790353, Length=200, Percent_Identity=38, Blast_Score=130, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17536593, Length=243, Percent_Identity=38.6831275720165, Blast_Score=142, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6320255, Length=245, Percent_Identity=31.8367346938775, Blast_Score=117, Evalue=2e-27,
Organism=Drosophila melanogaster, GI28572008, Length=242, Percent_Identity=35.9504132231405, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI28572006, Length=242, Percent_Identity=35.9504132231405, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI28572004, Length=242, Percent_Identity=35.9504132231405, Blast_Score=132, Evalue=4e-31,

Paralogues:

None

Copy number: 1120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR022896
- InterPro:   IPR000652
- InterPro:   IPR020861 [H]

Pfam domain/function: PF00121 TIM [H]

EC number: =5.3.1.1 [H]

Molecular weight: Translated: 39060; Mature: 39060

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS51098 PTS_EIIB_TYPE_1 ; PS00171 TIM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKKIYFGTNLKMYKGNCETVDYLTQLLALREKLQSDYDIELFVIPSYIALKDAVHAAAS
CCCEEEECCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHC
ETTHKILIGAQNMNAKDKGQFTGEISPLMLKELGVQLVMIGHSERRHVLKETDQEENEKV
CCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHCCCEEEEECCCHHHHHHHHCCCHHHHHH
LSALKHGFKTLLCVGETLEQKNYQISDEVLRTQLKIGLHGVSVKQLPHLFIAYEPVWAIG
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHCCCEEEEECCEEEEC
EGGIPATAQYADEKQKIIKQCLFEMFGEESKKIPVLYGGSVNLENANELIMQPHIDGLFV
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCEECCCCCCCEEECCCCCEEEE
GRSAWDAQCFYTLIDGALKALAGTTHQFSPIATQLIKHLGGKENISALTHCASRIRVMTR
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHEEEEC
NENHINKVAIEKINGVSGLFSIANQYQIIVGPKWVEKIYSEMKALLETE
CCCCHHHHHHHHHCCHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEKKIYFGTNLKMYKGNCETVDYLTQLLALREKLQSDYDIELFVIPSYIALKDAVHAAAS
CCCEEEECCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHC
ETTHKILIGAQNMNAKDKGQFTGEISPLMLKELGVQLVMIGHSERRHVLKETDQEENEKV
CCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHCCCEEEEECCCHHHHHHHHCCCHHHHHH
LSALKHGFKTLLCVGETLEQKNYQISDEVLRTQLKIGLHGVSVKQLPHLFIAYEPVWAIG
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHCCCEEEEECCEEEEC
EGGIPATAQYADEKQKIIKQCLFEMFGEESKKIPVLYGGSVNLENANELIMQPHIDGLFV
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCEECCCCCCCEEECCCCCEEEE
GRSAWDAQCFYTLIDGALKALAGTTHQFSPIATQLIKHLGGKENISALTHCASRIRVMTR
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHEEEEC
NENHINKVAIEKINGVSGLFSIANQYQIIVGPKWVEKIYSEMKALLETE
CCCCHHHHHHHHHCCHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA