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The map label for this gene is atpB

Identifier: 15603353

GI number: 15603353

Start: 1680682

End: 1681476

Strand: Direct

Name: atpB

Synonym: PM1488

Alternate gene names: 15603353

Gene position: 1680682-1681476 (Clockwise)

Preceding gene: 15603352

Following gene: 15603354

Centisome position: 74.45

GC content: 35.72

Gene sequence:

>795_bases
ATGGCAGCAGAGCTTACAACAGCGGGATATATTGGGCACCATTTAGCATTCTTGAAAACAGGGGATTCTTTCTGGCATGT
TCATTTAGATACCCTTCTATTTTCAATTATTTCAGGTGCAATTTTTCTTTTTGTTTTTTCAAAAGTTGCAAAAAAAGCAA
CGCCGGGTGTGCCTAGCAAGATGCAATGTTTTGTTGAGATAATGGTTGATTGGATTGATGGGATCGTAAAAGAAAATTTC
CACGGTCCTCGTCATGCTGTTGGACCATTAGCATTAACTATTTTCTGCTGGGTATTCATTATGAATGCTATCGATTTGAT
CCCGGTAGATTTCCTACCTCAATTAGCCCATTTATTTGGTATTGAATACTTAAGAGCTGTTCCAACAGCAGATATCAGTG
GAACATTAGGCTTATCAATTGGTGTCTTCTTCTTAATTATTTTCTATACAATCAAATCAAAAGGTATGAGTGGCTTTGTT
AAAGAATATACGCTTCATCCTTTTAATCATCCTTTGTTAATTCCGGTTAACTTAGCGCTTGAATCAGTCACATTATTAGC
AAAACCTGTTTCTTTGGCGTTCCGTCTTTTCGGGAATATGTATGCAGGTGAACTTATCTTTATTCTTATTGCAGTGATGT
ACATGGCAAATAATTTTGCACTTAATTCAATGGGCATTTTCATGCATTTGGCTTGGGCTATTTTCCATATTCTTGTGATT
ACCTTACAAGCATTTATTTTTATGATGCTTACAGTGGTTTATTTGAGTATGGGTTATAACAAAGCAGAACACTAA

Upstream 100 bases:

>100_bases
GGATATTTTATAACAATAGTTTTAAACAATATTCTTCCATTTTTTATAAGTAAGTACTTAAATATAAAGCATTTTCATAA
ATATCAATAAAGGATTAGTT

Downstream 100 bases:

>100_bases
TTTTTTATAAACAAAACCAGACCTTGGGTCTAAATTTCAATCTTATGGAGAACATTATGGAAACTGTAATTACTACAACA
ATCATCGCATCTGCAATTCT

Product: F0F1 ATP synthase subunit A

Products: ADP; phosphate; H+

Alternate protein names: ATP synthase F0 sector subunit a; F-ATPase subunit 6

Number of amino acids: Translated: 264; Mature: 263

Protein sequence:

>264_residues
MAAELTTAGYIGHHLAFLKTGDSFWHVHLDTLLFSIISGAIFLFVFSKVAKKATPGVPSKMQCFVEIMVDWIDGIVKENF
HGPRHAVGPLALTIFCWVFIMNAIDLIPVDFLPQLAHLFGIEYLRAVPTADISGTLGLSIGVFFLIIFYTIKSKGMSGFV
KEYTLHPFNHPLLIPVNLALESVTLLAKPVSLAFRLFGNMYAGELIFILIAVMYMANNFALNSMGIFMHLAWAIFHILVI
TLQAFIFMMLTVVYLSMGYNKAEH

Sequences:

>Translated_264_residues
MAAELTTAGYIGHHLAFLKTGDSFWHVHLDTLLFSIISGAIFLFVFSKVAKKATPGVPSKMQCFVEIMVDWIDGIVKENF
HGPRHAVGPLALTIFCWVFIMNAIDLIPVDFLPQLAHLFGIEYLRAVPTADISGTLGLSIGVFFLIIFYTIKSKGMSGFV
KEYTLHPFNHPLLIPVNLALESVTLLAKPVSLAFRLFGNMYAGELIFILIAVMYMANNFALNSMGIFMHLAWAIFHILVI
TLQAFIFMMLTVVYLSMGYNKAEH
>Mature_263_residues
AAELTTAGYIGHHLAFLKTGDSFWHVHLDTLLFSIISGAIFLFVFSKVAKKATPGVPSKMQCFVEIMVDWIDGIVKENFH
GPRHAVGPLALTIFCWVFIMNAIDLIPVDFLPQLAHLFGIEYLRAVPTADISGTLGLSIGVFFLIIFYTIKSKGMSGFVK
EYTLHPFNHPLLIPVNLALESVTLLAKPVSLAFRLFGNMYAGELIFILIAVMYMANNFALNSMGIFMHLAWAIFHILVIT
LQAFIFMMLTVVYLSMGYNKAEH

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family

Homologues:

Organism=Escherichia coli, GI1790176, Length=280, Percent_Identity=52.1428571428571, Blast_Score=258, Evalue=3e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ATP6_PASMU (Q9CKW6)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_246427.1
- ProteinModelPortal:   Q9CKW6
- SMR:   Q9CKW6
- GeneID:   1244835
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM1488
- NMPDR:   fig|272843.1.peg.1489
- HOGENOM:   HBG734175
- OMA:   AGELVFM
- ProtClustDB:   PRK05815
- BioCyc:   PMUL272843:PM1488-MONOMER
- HAMAP:   MF_01393
- InterPro:   IPR000568
- InterPro:   IPR023011
- Gene3D:   G3DSA:1.20.120.220
- PANTHER:   PTHR11410
- PRINTS:   PR00123
- TIGRFAMs:   TIGR01131

Pfam domain/function: PF00119 ATP-synt_A; SSF81336 ATPase_F0_A

EC number: 3.6.3.14

Molecular weight: Translated: 29454; Mature: 29322

Theoretical pI: Translated: 7.44; Mature: 7.44

Prosite motif: PS00449 ATPASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xd824ba8)-; HASH(0xe5a3be0)-; HASH(0xef74594)-; HASH(0xcca8260)-; HASH(0xe7685e8)-; HASH(0xe8b2c48)-;

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAELTTAGYIGHHLAFLKTGDSFWHVHLDTLLFSIISGAIFLFVFSKVAKKATPGVPSK
CCCCCCHHHHHHHHHHHEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
MQCFVEIMVDWIDGIVKENFHGPRHAVGPLALTIFCWVFIMNAIDLIPVDFLPQLAHLFG
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
IEYLRAVPTADISGTLGLSIGVFFLIIFYTIKSKGMSGFVKEYTLHPFNHPLLIPVNLAL
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCEEEEHHHHH
ESVTLLAKPVSLAFRLFGNMYAGELIFILIAVMYMANNFALNSMGIFMHLAWAIFHILVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
TLQAFIFMMLTVVYLSMGYNKAEH
HHHHHHHHHHHHHHHHHCCCCCCH
>Mature Secondary Structure 
AAELTTAGYIGHHLAFLKTGDSFWHVHLDTLLFSIISGAIFLFVFSKVAKKATPGVPSK
CCCCCHHHHHHHHHHHEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
MQCFVEIMVDWIDGIVKENFHGPRHAVGPLALTIFCWVFIMNAIDLIPVDFLPQLAHLFG
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
IEYLRAVPTADISGTLGLSIGVFFLIIFYTIKSKGMSGFVKEYTLHPFNHPLLIPVNLAL
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCEEEEHHHHH
ESVTLLAKPVSLAFRLFGNMYAGELIFILIAVMYMANNFALNSMGIFMHLAWAIFHILVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
TLQAFIFMMLTVVYLSMGYNKAEH
HHHHHHHHHHHHHHHHHCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11248100