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The map label for this gene is dnaA

Identifier: 15603026

GI number: 15603026

Start: 1357003

End: 1358358

Strand: Reverse

Name: dnaA

Synonym: PM1161

Alternate gene names: 15603026

Gene position: 1358358-1357003 (Counterclockwise)

Preceding gene: 15603032

Following gene: 15603025

Centisome position: 60.17

GC content: 39.75

Gene sequence:

>1356_bases
ATGAAACCAGACCTATCTTCTCTTTGGCAAGAATGCCTTTTACAGCTTCAAGACCAGATTTCACTAACGGATTTTAGCAC
CTGGTTACGTCCTTTACAGGCCGATTTTAGCGTACAAAATACGATTGTTTTGTATGCCTCTAATGTGTTTATTAAACAAA
AAGTGGACGAAAGTTATTTGGCACAATTGACTAAAGTTGCACAAGAGCTCAGTGGCAATGCTGAGTTAGTGGTACAGGTC
AAAGTTGGGGTGAAACCTGAACCGAAGCCCGCGCAACCTTCTGCTTTGCCAACACATCACAATAAAGAAGAAAATAAACC
GCAAACGGTTATTCGTTCTTATTTAAATCCCAAGCATGTGTTTGAAAATTTTGTGGAAGGTAAATCAAATCAACTTGCTC
GTGCTGTTGCACAAAAAGTGGCAGATAATCCTGGTGAACCGAGTTCCAATCCGCTTTTTCTGTATGGTGGTACAGGTTTA
GGGAAAACCCATTTATTGCATGCCATTGGCAATGGTATTTTATCTCGTAATACAAATGCGAGAGTCCTGTATATTCATGC
TAATAATTTTATGCAACAAATGGTGAATGCGGTACGTGATAACAAAATGGATGAATTTAAAAAATTCTACCGCTCTTTAG
ATGCGCTGTTAGTGGATGATATTCAATTCTTTGCAGAAAAAGAAAAAACCCAAGAAGAGTTTTTCCATATTTTCAATAAT
TTATTTGATACGGGACGTCAAATTATCCTGACATCGGATCGGTATCCAAAAGAAATTGAAAAACTGGAAGAGCGTCTGAA
ATCGCGTTTCGGTTGGGGATTAACCACCGCGATTGAGCCGCCTGAACTGGAAACGCGCGTAGCGATTTTATTAAAGAAAG
CCGAAGAAAAGAACATTTATTTACCTGAAGAAGTGGCATTTTTTATCGGACAAAAATTACGTACTAACGTGCGTGATCTT
GAGGGCGCACTTAATCGAGTAAGTGCGAATGCGGAGTTTATGGGGGCGGCGATTACAATTGATTTTGTACGCGAAACCTT
AAAAGACATGTTGGCATTACAGGATAAATTGGTCACAGTAGAGAATATTCAAAAAGTGGTGGCTGAATATTATCGGATTA
AAGTTTCGGATTTGAAAGGCAAGAGTCGCTCGCGATCGATTGCACGTCCACGCCAACTCGCGATGGCGTTGTCGAAAGAA
TTGACAAATCGCAGTCTGCCAGAAATCGGGAAAAACTTTGGTGATAAAGATCATACAACAGTCTTGCATGCCTGTCGTAA
AATTGCAGAATTGAGAGAACAAGAACATTCTTTAGAAGAGGATTGGTCAAATTTAATCCGTACACTCTCTGTGTAA

Upstream 100 bases:

>100_bases
TTGAAGATCTTTACGGGAGTTTATTGTAGAATTAATTTTCTTAAAGACCGCGCGTTTAGCGGAATTTTTTCAAATACCTT
AACTATAACGATAATAGAAT

Downstream 100 bases:

>100_bases
AAAGGGGAAAAATATGCAGTTTATTGTTTCAAGAGAAAATTTATTAAAGCCATTACAACAAGTGTGTGGGGTGCTAAGTA
GCCGCCCAAATATTCCCGTA

Product: chromosomal replication initiation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MKPDLSSLWQECLLQLQDQISLTDFSTWLRPLQADFSVQNTIVLYASNVFIKQKVDESYLAQLTKVAQELSGNAELVVQV
KVGVKPEPKPAQPSALPTHHNKEENKPQTVIRSYLNPKHVFENFVEGKSNQLARAVAQKVADNPGEPSSNPLFLYGGTGL
GKTHLLHAIGNGILSRNTNARVLYIHANNFMQQMVNAVRDNKMDEFKKFYRSLDALLVDDIQFFAEKEKTQEEFFHIFNN
LFDTGRQIILTSDRYPKEIEKLEERLKSRFGWGLTTAIEPPELETRVAILLKKAEEKNIYLPEEVAFFIGQKLRTNVRDL
EGALNRVSANAEFMGAAITIDFVRETLKDMLALQDKLVTVENIQKVVAEYYRIKVSDLKGKSRSRSIARPRQLAMALSKE
LTNRSLPEIGKNFGDKDHTTVLHACRKIAELREQEHSLEEDWSNLIRTLSV

Sequences:

>Translated_451_residues
MKPDLSSLWQECLLQLQDQISLTDFSTWLRPLQADFSVQNTIVLYASNVFIKQKVDESYLAQLTKVAQELSGNAELVVQV
KVGVKPEPKPAQPSALPTHHNKEENKPQTVIRSYLNPKHVFENFVEGKSNQLARAVAQKVADNPGEPSSNPLFLYGGTGL
GKTHLLHAIGNGILSRNTNARVLYIHANNFMQQMVNAVRDNKMDEFKKFYRSLDALLVDDIQFFAEKEKTQEEFFHIFNN
LFDTGRQIILTSDRYPKEIEKLEERLKSRFGWGLTTAIEPPELETRVAILLKKAEEKNIYLPEEVAFFIGQKLRTNVRDL
EGALNRVSANAEFMGAAITIDFVRETLKDMLALQDKLVTVENIQKVVAEYYRIKVSDLKGKSRSRSIARPRQLAMALSKE
LTNRSLPEIGKNFGDKDHTTVLHACRKIAELREQEHSLEEDWSNLIRTLSV
>Mature_451_residues
MKPDLSSLWQECLLQLQDQISLTDFSTWLRPLQADFSVQNTIVLYASNVFIKQKVDESYLAQLTKVAQELSGNAELVVQV
KVGVKPEPKPAQPSALPTHHNKEENKPQTVIRSYLNPKHVFENFVEGKSNQLARAVAQKVADNPGEPSSNPLFLYGGTGL
GKTHLLHAIGNGILSRNTNARVLYIHANNFMQQMVNAVRDNKMDEFKKFYRSLDALLVDDIQFFAEKEKTQEEFFHIFNN
LFDTGRQIILTSDRYPKEIEKLEERLKSRFGWGLTTAIEPPELETRVAILLKKAEEKNIYLPEEVAFFIGQKLRTNVRDL
EGALNRVSANAEFMGAAITIDFVRETLKDMLALQDKLVTVENIQKVVAEYYRIKVSDLKGKSRSRSIARPRQLAMALSKE
LTNRSLPEIGKNFGDKDHTTVLHACRKIAELREQEHSLEEDWSNLIRTLSV

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family

Homologues:

Organism=Escherichia coli, GI2367267, Length=465, Percent_Identity=61.505376344086, Blast_Score=581, Evalue=1e-167,
Organism=Escherichia coli, GI226510964, Length=249, Percent_Identity=24.8995983935743, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DNAA_PASMU (Q9CLQ4)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_246098.1
- ProteinModelPortal:   Q9CLQ4
- GeneID:   1244508
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM1161
- NMPDR:   fig|272843.1.peg.1161
- HOGENOM:   HBG695666
- OMA:   FNELHAN
- ProtClustDB:   PRK00149
- BioCyc:   PMUL272843:PM1161-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00377
- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921
- Gene3D:   G3DSA:1.10.1750.10
- PRINTS:   PR00051
- SMART:   SM00382
- SMART:   SM00760
- TIGRFAMs:   TIGR00362

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C; SSF48295 Trp_repress_rep

EC number: NA

Molecular weight: Translated: 51379; Mature: 51379

Theoretical pI: Translated: 8.22; Mature: 8.22

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPDLSSLWQECLLQLQDQISLTDFSTWLRPLQADFSVQNTIVLYASNVFIKQKVDESYL
CCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHCCHHHH
AQLTKVAQELSGNAELVVQVKVGVKPEPKPAQPSALPTHHNKEENKPQTVIRSYLNPKHV
HHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCHHHH
FENFVEGKSNQLARAVAQKVADNPGEPSSNPLFLYGGTGLGKTHLLHAIGNGILSRNTNA
HHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCC
RVLYIHANNFMQQMVNAVRDNKMDEFKKFYRSLDALLVDDIQFFAEKEKTQEEFFHIFNN
EEEEEECCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFDTGRQIILTSDRYPKEIEKLEERLKSRFGWGLTTAIEPPELETRVAILLKKAEEKNIY
HHHCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCC
LPEEVAFFIGQKLRTNVRDLEGALNRVSANAEFMGAAITIDFVRETLKDMLALQDKLVTV
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ENIQKVVAEYYRIKVSDLKGKSRSRSIARPRQLAMALSKELTNRSLPEIGKNFGDKDHTT
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCHHHH
VLHACRKIAELREQEHSLEEDWSNLIRTLSV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKPDLSSLWQECLLQLQDQISLTDFSTWLRPLQADFSVQNTIVLYASNVFIKQKVDESYL
CCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHCCHHHH
AQLTKVAQELSGNAELVVQVKVGVKPEPKPAQPSALPTHHNKEENKPQTVIRSYLNPKHV
HHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCHHHH
FENFVEGKSNQLARAVAQKVADNPGEPSSNPLFLYGGTGLGKTHLLHAIGNGILSRNTNA
HHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCC
RVLYIHANNFMQQMVNAVRDNKMDEFKKFYRSLDALLVDDIQFFAEKEKTQEEFFHIFNN
EEEEEECCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFDTGRQIILTSDRYPKEIEKLEERLKSRFGWGLTTAIEPPELETRVAILLKKAEEKNIY
HHHCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCC
LPEEVAFFIGQKLRTNVRDLEGALNRVSANAEFMGAAITIDFVRETLKDMLALQDKLVTV
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ENIQKVVAEYYRIKVSDLKGKSRSRSIARPRQLAMALSKELTNRSLPEIGKNFGDKDHTT
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCHHHH
VLHACRKIAELREQEHSLEEDWSNLIRTLSV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11248100