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The map label for this gene is dfp [H]

Identifier: 15603018

GI number: 15603018

Start: 1350705

End: 1351907

Strand: Direct

Name: dfp [H]

Synonym: PM1153

Alternate gene names: 15603018

Gene position: 1350705-1351907 (Clockwise)

Preceding gene: 15603009

Following gene: 15603019

Centisome position: 59.83

GC content: 43.81

Gene sequence:

>1203_bases
ATGCACCCCCTTCAATCAAAACGTATCGTTGTCGGTATTACTGGTGGCATTGCTGCTTATAAATCCATCGAATTAATCCG
CTTATTACGCAAAAATCAGGCTGATGTACGCGTAGTGCTCACTCCGGCTGCTGCAGAATTCGTTACTCCTTTAACGTTAC
AAGCCATCTCAGGCAATGCCGTGGCTCAGTCTCTCTTGGATCCCCAAGCTGAATTAGCGATGGGACACATTGAATTAGCC
AAATGGGCAGAAGCCATTGTGATTGCACCAGCAAGTGCAGATTTTCTCGCCCGTTTAACCGTTGGTATGGCAAATGATCT
GCTTTCTACTCTTTGTTTAGCAACCAAAGCCCCCCTTTTACTCGCTCCGGCGATGAATCAGCAAATGTTTGCTCAAGCGA
TAACGCAGAAAAATCTGAGTGCTCTAGTTCAACGTGGTTACCATGTTGTCGGTCCTAATGCAGGTGAGCAAGCTTGTGGG
GATGTTGGTTTAGGACGTATGTCTGAACCTTCTGAAATTTATACCGCACTTTGTGAGTTATTCCATACTCAACAAGATTT
AGTGGGATTAAAAGTGGCTATTACCGCAGGTCCAACGCAAGAAGCCATTGATCCAGTTCGTTATATTAGTAATCACAGTT
CTGGAAAAATGGGCTTTGCGATTGCCGAAGCCTTTGCTGAACGTGGAGCAACAGTCACGTTAATCTCAGGTCCAGTCAAT
TTAGCAACACCCGAGAAAGTCCAGCGCATCAATGTCATCTCTGCCCAAGACATGCATCAACAAGCGCTCAAAAGTGCGGT
CGAAAATCAGATATTTATTGGCTGTGCTGCCGTAGCAGATTATCGTGTTGCTGAAATCGCGACGCAAAAAATCAAAAAAG
CAGGAGATGAAATCAACCTGACGTTAGTTAAAAATCCTGACATTATTGCAGATGTTGGGCATTTAGCGGTACAACGTCCA
TTTACGGTAGGTTTCGCAGCGGAAACTCAACATGTTGAGCAGTACGCACAAGACAAACTACAACGTAAAAAGCTGGATAT
GATTTGTGCGAATGATGTATCAGGTGGACAAGTCTTCGGGCAAGACCAAAATAGCCTACATCTCTTTTGGCACAATGGCA
GCACAAAATTAGCATTAGAGAGTAAAAAAACATTAGCCAAACAATTAGTTAATCAAATTATTGCGCGTTACCGCCAATCT
TAA

Upstream 100 bases:

>100_bases
CTGGAAATAAGATCGCAAAAATACCATTCTTTCTTGGCAAAAATTACAGTAAAATAAGGCTTTTGTTGGTTTGAATAAAA
ATTAAGCGCGAGGATTCATC

Downstream 100 bases:

>100_bases
ACAATAGGACAAAGAATGAAAAAAATTGATGTCAAAATTCTCGATCAACGTATTGGAACAGAATTCCCTTTGCCAACATA
TGCAACCGAAGGGTCCGCGG

Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MHPLQSKRIVVGITGGIAAYKSIELIRLLRKNQADVRVVLTPAAAEFVTPLTLQAISGNAVAQSLLDPQAELAMGHIELA
KWAEAIVIAPASADFLARLTVGMANDLLSTLCLATKAPLLLAPAMNQQMFAQAITQKNLSALVQRGYHVVGPNAGEQACG
DVGLGRMSEPSEIYTALCELFHTQQDLVGLKVAITAGPTQEAIDPVRYISNHSSGKMGFAIAEAFAERGATVTLISGPVN
LATPEKVQRINVISAQDMHQQALKSAVENQIFIGCAAVADYRVAEIATQKIKKAGDEINLTLVKNPDIIADVGHLAVQRP
FTVGFAAETQHVEQYAQDKLQRKKLDMICANDVSGGQVFGQDQNSLHLFWHNGSTKLALESKKTLAKQLVNQIIARYRQS

Sequences:

>Translated_400_residues
MHPLQSKRIVVGITGGIAAYKSIELIRLLRKNQADVRVVLTPAAAEFVTPLTLQAISGNAVAQSLLDPQAELAMGHIELA
KWAEAIVIAPASADFLARLTVGMANDLLSTLCLATKAPLLLAPAMNQQMFAQAITQKNLSALVQRGYHVVGPNAGEQACG
DVGLGRMSEPSEIYTALCELFHTQQDLVGLKVAITAGPTQEAIDPVRYISNHSSGKMGFAIAEAFAERGATVTLISGPVN
LATPEKVQRINVISAQDMHQQALKSAVENQIFIGCAAVADYRVAEIATQKIKKAGDEINLTLVKNPDIIADVGHLAVQRP
FTVGFAAETQHVEQYAQDKLQRKKLDMICANDVSGGQVFGQDQNSLHLFWHNGSTKLALESKKTLAKQLVNQIIARYRQS
>Mature_400_residues
MHPLQSKRIVVGITGGIAAYKSIELIRLLRKNQADVRVVLTPAAAEFVTPLTLQAISGNAVAQSLLDPQAELAMGHIELA
KWAEAIVIAPASADFLARLTVGMANDLLSTLCLATKAPLLLAPAMNQQMFAQAITQKNLSALVQRGYHVVGPNAGEQACG
DVGLGRMSEPSEIYTALCELFHTQQDLVGLKVAITAGPTQEAIDPVRYISNHSSGKMGFAIAEAFAERGATVTLISGPVN
LATPEKVQRINVISAQDMHQQALKSAVENQIFIGCAAVADYRVAEIATQKIKKAGDEINLTLVKNPDIIADVGHLAVQRP
FTVGFAAETQHVEQYAQDKLQRKKLDMICANDVSGGQVFGQDQNSLHLFWHNGSTKLALESKKTLAKQLVNQIIARYRQS

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=177, Percent_Identity=33.3333333333333, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI87082301, Length=400, Percent_Identity=56.75, Blast_Score=445, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI17560194, Length=184, Percent_Identity=28.804347826087, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322762, Length=189, Percent_Identity=32.2751322751323, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24657262, Length=186, Percent_Identity=30.1075268817204, Blast_Score=82, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 43013; Mature: 43013

Theoretical pI: Translated: 7.95; Mature: 7.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHPLQSKRIVVGITGGIAAYKSIELIRLLRKNQADVRVVLTPAAAEFVTPLTLQAISGNA
CCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHCCCEEEECCCHH
VAQSLLDPQAELAMGHIELAKWAEAIVIAPASADFLARLTVGMANDLLSTLCLATKAPLL
HHHHHHCCHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEE
LAPAMNQQMFAQAITQKNLSALVQRGYHVVGPNAGEQACGDVGLGRMSEPSEIYTALCEL
EECCCCHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHCCCCCCCCCCHHHHHHHHHHH
FHTQQDLVGLKVAITAGPTQEAIDPVRYISNHSSGKMGFAIAEAFAERGATVTLISGPVN
HHCHHHHCEEEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEECCCC
LATPEKVQRINVISAQDMHQQALKSAVENQIFIGCAAVADYRVAEIATQKIKKAGDEINL
CCCHHHHHHHHEECHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCEEE
TLVKNPDIIADVGHLAVQRPFTVGFAAETQHVEQYAQDKLQRKKLDMICANDVSGGQVFG
EEEECCCHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEEC
QDQNSLHLFWHNGSTKLALESKKTLAKQLVNQIIARYRQS
CCCCCEEEEEECCCEEEEEHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MHPLQSKRIVVGITGGIAAYKSIELIRLLRKNQADVRVVLTPAAAEFVTPLTLQAISGNA
CCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHCCCEEEECCCHH
VAQSLLDPQAELAMGHIELAKWAEAIVIAPASADFLARLTVGMANDLLSTLCLATKAPLL
HHHHHHCCHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEE
LAPAMNQQMFAQAITQKNLSALVQRGYHVVGPNAGEQACGDVGLGRMSEPSEIYTALCEL
EECCCCHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHCCCCCCCCCCHHHHHHHHHHH
FHTQQDLVGLKVAITAGPTQEAIDPVRYISNHSSGKMGFAIAEAFAERGATVTLISGPVN
HHCHHHHCEEEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEECCCC
LATPEKVQRINVISAQDMHQQALKSAVENQIFIGCAAVADYRVAEIATQKIKKAGDEINL
CCCHHHHHHHHEECHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCEEE
TLVKNPDIIADVGHLAVQRPFTVGFAAETQHVEQYAQDKLQRKKLDMICANDVSGGQVFG
EEEECCCHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEEC
QDQNSLHLFWHNGSTKLALESKKTLAKQLVNQIIARYRQS
CCCCCEEEEEECCCEEEEEHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]