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The map label for this gene is argH

Identifier: 15602985

GI number: 15602985

Start: 1318496

End: 1319869

Strand: Direct

Name: argH

Synonym: PM1120

Alternate gene names: 15602985

Gene position: 1318496-1319869 (Clockwise)

Preceding gene: 15602984

Following gene: 15602986

Centisome position: 58.41

GC content: 44.69

Gene sequence:

>1374_bases
ATGGCACTTTGGGGTGGACGTTTTACACAAGCCGCAGATAAGCGTTTTAAAGATTTTAATGACTCATTACGTTTCGATTA
TCGTCTCGCAGAACAAGATATTGAAGGTTCCATTGGCTGGTCAAAAGCTTTAGTCAGCGTTGGAGTATTGACCGTGCAGG
AGCAACAACAGTTAGAAAGTGCACTGAATACTCTCTTAATTGAAGTGCGATCAAATCCACAAGCGATTTTGCAAGATGAC
GCTGAAGATATTCACAGCTGGGTCGAAAGTAAATTAATCGATAAAGTCGGGAATTTAGGTAAAAAATTACACACGGGACG
TAGCCGTAATGATCAGGTTGCACTGGACATTAAGATGTGGTGTAAACAACGTGTGATTGAACTGCAATCCTCGCTTCACG
CCTTACAATGCAAACTTGTCGAAACAGCCGAAAATAACCAACATGCGGTGATGCCGGGTTATACACACTTACAACGAGCT
CAGCCGATTACTTTTGCCCATTGGTGCATGGCTTATGTGGAAATGCTTGATCGTGATTACTCCCGTTTAACCGATGCTTA
CCAACGCATGAATAGCTGCCCACTCGGCAGTGGTGCCCTCGCTGGCACCGCTTACGCGATTGATCGTGAACAATTAGCCC
TCGATCTCGGTTTTGACGTTGCTACACGCAACAGTTTAGACAGTGTGTCAGACCGCGATCATATCGTTGAACTGCTTTCT
ACTGCCTCACTAAGCATGGCACATCTTTCACGTTTTGCGGAAGATATGATCATTTTTAACAGTGGTGAATCTAACTTCGT
GGAGCTTTCCGATCGCGTGACATCTGGTTCTTCCTTGATGCCACAGAAAAAAAACCCCGATGCTTGTGAATTAATTCGTG
GTAAAGCAGGTCGTGTAATGGGTGCTTTAACAGGCATGCTGATGACCTTAAAAGGCTTGCCGCTTGCTTATAACAAAGAT
ATGCAGGAAGACAAAGAAGGCATTTTCGACGCTCTAGATACTTGGCAAGACTGTATCGACATGGCGGCTCTTGTGTTAGA
CGGCATTCAAGTCAATGTAGAACGTACCAAAGAAGCTGCTTTAAAAGGTTATTCCAATGCCACTGAACTGGCCGACTATT
TGGTCGCCAAAGGCGTACCATTCCGTGACTCTCACCATATTGTGGGCGAAACCGTTGTTTATGCCATCCAACAGCACAAA
GCGCTTGAAGCACTCAGCGTTGCTGAATTTAAACAATTTAGTGATGTTGTCGAAGAAGATGTGTATCAGATCCTATCTCT
GCAATCTTGTTTAGATAAACGCTGTGCCAAAGGTGGCGTATCACCACTTCGTGTTGCAGAAGCCATCGCTGAAGCGAAAG
CAAGGTTGAGTTAA

Upstream 100 bases:

>100_bases
CGTCGATATCGCCAATTGGAAATATCCAGAAAAACTCACCGCACTTTTTGCTGGTGAAATCATTGGCACAAGAATTAAAC
CATAAAAATAAGAGGATGTT

Downstream 100 bases:

>100_bases
TTCTCAAATGAAACGATTTTAATCAGCCACAAAGCGCAATAATACTGTTATTTTTGTGGCTCTCATTTCGCAGTGCCCCA
ATCCAATGGGGTGTTTATGA

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 457; Mature: 456

Protein sequence:

>457_residues
MALWGGRFTQAADKRFKDFNDSLRFDYRLAEQDIEGSIGWSKALVSVGVLTVQEQQQLESALNTLLIEVRSNPQAILQDD
AEDIHSWVESKLIDKVGNLGKKLHTGRSRNDQVALDIKMWCKQRVIELQSSLHALQCKLVETAENNQHAVMPGYTHLQRA
QPITFAHWCMAYVEMLDRDYSRLTDAYQRMNSCPLGSGALAGTAYAIDREQLALDLGFDVATRNSLDSVSDRDHIVELLS
TASLSMAHLSRFAEDMIIFNSGESNFVELSDRVTSGSSLMPQKKNPDACELIRGKAGRVMGALTGMLMTLKGLPLAYNKD
MQEDKEGIFDALDTWQDCIDMAALVLDGIQVNVERTKEAALKGYSNATELADYLVAKGVPFRDSHHIVGETVVYAIQQHK
ALEALSVAEFKQFSDVVEEDVYQILSLQSCLDKRCAKGGVSPLRVAEAIAEAKARLS

Sequences:

>Translated_457_residues
MALWGGRFTQAADKRFKDFNDSLRFDYRLAEQDIEGSIGWSKALVSVGVLTVQEQQQLESALNTLLIEVRSNPQAILQDD
AEDIHSWVESKLIDKVGNLGKKLHTGRSRNDQVALDIKMWCKQRVIELQSSLHALQCKLVETAENNQHAVMPGYTHLQRA
QPITFAHWCMAYVEMLDRDYSRLTDAYQRMNSCPLGSGALAGTAYAIDREQLALDLGFDVATRNSLDSVSDRDHIVELLS
TASLSMAHLSRFAEDMIIFNSGESNFVELSDRVTSGSSLMPQKKNPDACELIRGKAGRVMGALTGMLMTLKGLPLAYNKD
MQEDKEGIFDALDTWQDCIDMAALVLDGIQVNVERTKEAALKGYSNATELADYLVAKGVPFRDSHHIVGETVVYAIQQHK
ALEALSVAEFKQFSDVVEEDVYQILSLQSCLDKRCAKGGVSPLRVAEAIAEAKARLS
>Mature_456_residues
ALWGGRFTQAADKRFKDFNDSLRFDYRLAEQDIEGSIGWSKALVSVGVLTVQEQQQLESALNTLLIEVRSNPQAILQDDA
EDIHSWVESKLIDKVGNLGKKLHTGRSRNDQVALDIKMWCKQRVIELQSSLHALQCKLVETAENNQHAVMPGYTHLQRAQ
PITFAHWCMAYVEMLDRDYSRLTDAYQRMNSCPLGSGALAGTAYAIDREQLALDLGFDVATRNSLDSVSDRDHIVELLST
ASLSMAHLSRFAEDMIIFNSGESNFVELSDRVTSGSSLMPQKKNPDACELIRGKAGRVMGALTGMLMTLKGLPLAYNKDM
QEDKEGIFDALDTWQDCIDMAALVLDGIQVNVERTKEAALKGYSNATELADYLVAKGVPFRDSHHIVGETVVYAIQQHKA
LEALSVAEFKQFSDVVEEDVYQILSLQSCLDKRCAKGGVSPLRVAEAIAEAKARLS

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=454, Percent_Identity=43.3920704845815, Blast_Score=360, Evalue=1e-99,
Organism=Homo sapiens, GI68303542, Length=454, Percent_Identity=43.3920704845815, Blast_Score=360, Evalue=1e-99,
Organism=Homo sapiens, GI68303549, Length=454, Percent_Identity=41.1894273127753, Blast_Score=327, Evalue=2e-89,
Organism=Homo sapiens, GI68303547, Length=454, Percent_Identity=40.3083700440529, Blast_Score=319, Evalue=4e-87,
Organism=Escherichia coli, GI1790398, Length=456, Percent_Identity=76.9736842105263, Blast_Score=724, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6321806, Length=458, Percent_Identity=43.4497816593886, Blast_Score=373, Evalue=1e-104,
Organism=Drosophila melanogaster, GI221473854, Length=447, Percent_Identity=40.4921700223714, Blast_Score=336, Evalue=2e-92,
Organism=Drosophila melanogaster, GI78706858, Length=447, Percent_Identity=40.4921700223714, Blast_Score=336, Evalue=2e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_PASMU (P57909)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_246057.1
- ProteinModelPortal:   P57909
- SMR:   P57909
- PRIDE:   P57909
- GeneID:   1244467
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM1120
- NMPDR:   fig|272843.1.peg.1120
- HOGENOM:   HBG539632
- OMA:   MAEDLIF
- ProtClustDB:   PRK04833
- BioCyc:   PMUL272843:PM1120-MONOMER
- BRENDA:   4.3.2.1
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 50710; Mature: 50579

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALWGGRFTQAADKRFKDFNDSLRFDYRLAEQDIEGSIGWSKALVSVGVLTVQEQQQLES
CCCCCCCHHHHHHHHHHHCCCCCEEHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
ALNTLLIEVRSNPQAILQDDAEDIHSWVESKLIDKVGNLGKKLHTGRSRNDQVALDIKMW
HHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHH
CKQRVIELQSSLHALQCKLVETAENNQHAVMPGYTHLQRAQPITFAHWCMAYVEMLDRDY
HHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHCCCCHHHHHHHHHHHHHHHHH
SRLTDAYQRMNSCPLGSGALAGTAYAIDREQLALDLGFDVATRNSLDSVSDRDHIVELLS
HHHHHHHHHHHCCCCCCCCCCCHHHEECHHHHHHHCCCCHHCCCCCCCCCHHHHHHHHHH
TASLSMAHLSRFAEDMIIFNSGESNFVELSDRVTSGSSLMPQKKNPDACELIRGKAGRVM
HHHHHHHHHHHHHHHEEEEECCCCCEEEHHHHHCCCCCCCCCCCCCCHHHHHHCCCHHHH
GALTGMLMTLKGLPLAYNKDMQEDKEGIFDALDTWQDCIDMAALVLDGIQVNVERTKEAA
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHH
LKGYSNATELADYLVAKGVPFRDSHHIVGETVVYAIQQHKALEALSVAEFKQFSDVVEED
HHCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VYQILSLQSCLDKRCAKGGVSPLRVAEAIAEAKARLS
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ALWGGRFTQAADKRFKDFNDSLRFDYRLAEQDIEGSIGWSKALVSVGVLTVQEQQQLES
CCCCCCHHHHHHHHHHHCCCCCEEHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
ALNTLLIEVRSNPQAILQDDAEDIHSWVESKLIDKVGNLGKKLHTGRSRNDQVALDIKMW
HHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHH
CKQRVIELQSSLHALQCKLVETAENNQHAVMPGYTHLQRAQPITFAHWCMAYVEMLDRDY
HHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHCCCCHHHHHHHHHHHHHHHHH
SRLTDAYQRMNSCPLGSGALAGTAYAIDREQLALDLGFDVATRNSLDSVSDRDHIVELLS
HHHHHHHHHHHCCCCCCCCCCCHHHEECHHHHHHHCCCCHHCCCCCCCCCHHHHHHHHHH
TASLSMAHLSRFAEDMIIFNSGESNFVELSDRVTSGSSLMPQKKNPDACELIRGKAGRVM
HHHHHHHHHHHHHHHEEEEECCCCCEEEHHHHHCCCCCCCCCCCCCCHHHHHHCCCHHHH
GALTGMLMTLKGLPLAYNKDMQEDKEGIFDALDTWQDCIDMAALVLDGIQVNVERTKEAA
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHH
LKGYSNATELADYLVAKGVPFRDSHHIVGETVVYAIQQHKALEALSVAEFKQFSDVVEED
HHCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VYQILSLQSCLDKRCAKGGVSPLRVAEAIAEAKARLS
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11248100