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The map label for this gene is trxM

Identifier: 15602859

GI number: 15602859

Start: 1167598

End: 1167918

Strand: Reverse

Name: trxM

Synonym: PM0994

Alternate gene names: 15602859

Gene position: 1167918-1167598 (Counterclockwise)

Preceding gene: 15602860

Following gene: 15602856

Centisome position: 51.74

GC content: 38.32

Gene sequence:

>321_bases
ATGGAAGTATTACATTCAACTGATGCAACATTTACGGCAGACGTCGTCAATTCAGATGTACCGGTCTTATTAGATTTTTG
GGCACCTTGGTGTGGTCCTTGCCGTATGATCTCTCCAATTTTAGATGAAATTGCAGCAGAATTTTCGGGTAAAGTGAAAG
TGGTGAAAATTAATATTGATGAAAACCAAGCGACACCAGCACAATTAGGTGTGCGTAGTATCCCTACTTTAGTCTTATTT
AAAAATGGTAAAGCCGTTGCGACACAAGTGGGTGCTTTACCAAAGAACCAATTAGCTAACTTTATTAATCAGAATATCTA
G

Upstream 100 bases:

>100_bases
CGGATTGATTTGCATAATGCTTATGATATTATCATTGCACTTGAAATGATAAAAAATATTCTTATTATAAAGAATGTTAT
TAACAAAAAAGGAAGAAATA

Downstream 100 bases:

>100_bases
TTAACGAATAGCATAAAAAATCCCAAACAGGTGTGTTTGGGATTTTTTTATGTTTAAAGAAATTGTGCTAAATAGTGTGG
AACCAATTCCGTCGCTTTAC

Product: TrxM

Products: NA

Alternate protein names: Trx

Number of amino acids: Translated: 106; Mature: 106

Protein sequence:

>106_residues
MEVLHSTDATFTADVVNSDVPVLLDFWAPWCGPCRMISPILDEIAAEFSGKVKVVKINIDENQATPAQLGVRSIPTLVLF
KNGKAVATQVGALPKNQLANFINQNI

Sequences:

>Translated_106_residues
MEVLHSTDATFTADVVNSDVPVLLDFWAPWCGPCRMISPILDEIAAEFSGKVKVVKINIDENQATPAQLGVRSIPTLVLF
KNGKAVATQVGALPKNQLANFINQNI
>Mature_106_residues
MEVLHSTDATFTADVVNSDVPVLLDFWAPWCGPCRMISPILDEIAAEFSGKVKVVKINIDENQATPAQLGVRSIPTLVLF
KNGKAVATQVGALPKNQLANFINQNI

Specific function: Component of the thioredoxin-thioredoxin reductase system. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain

Homologues:

Organism=Homo sapiens, GI21361403, Length=96, Percent_Identity=38.5416666666667, Blast_Score=79, Evalue=7e-16,
Organism=Homo sapiens, GI5031973, Length=88, Percent_Identity=30.6818181818182, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI87082331, Length=105, Percent_Identity=55.2380952380952, Blast_Score=136, Evalue=2e-34,
Organism=Escherichia coli, GI1788936, Length=105, Percent_Identity=42.8571428571429, Blast_Score=105, Evalue=5e-25,
Organism=Escherichia coli, GI87081747, Length=77, Percent_Identity=37.6623376623377, Blast_Score=67, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI212646193, Length=93, Percent_Identity=39.7849462365591, Blast_Score=82, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI71998175, Length=71, Percent_Identity=43.6619718309859, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI115532380, Length=102, Percent_Identity=33.3333333333333, Blast_Score=68, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17544108, Length=102, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI115532378, Length=102, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17509965, Length=63, Percent_Identity=41.2698412698413, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17507705, Length=71, Percent_Identity=38.0281690140845, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17554386, Length=85, Percent_Identity=37.6470588235294, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17556044, Length=82, Percent_Identity=32.9268292682927, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=79, Percent_Identity=40.5063291139241, Blast_Score=71, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6321648, Length=84, Percent_Identity=36.9047619047619, Blast_Score=71, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6319925, Length=88, Percent_Identity=31.8181818181818, Blast_Score=61, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24639826, Length=91, Percent_Identity=38.4615384615385, Blast_Score=81, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28573567, Length=101, Percent_Identity=34.6534653465347, Blast_Score=80, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17648013, Length=85, Percent_Identity=43.5294117647059, Blast_Score=76, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24583090, Length=85, Percent_Identity=43.5294117647059, Blast_Score=76, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24664269, Length=71, Percent_Identity=42.2535211267606, Blast_Score=72, Evalue=7e-14,
Organism=Drosophila melanogaster, GI17530795, Length=84, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=6e-13,
Organism=Drosophila melanogaster, GI21358065, Length=92, Percent_Identity=34.7826086956522, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI19921434, Length=87, Percent_Identity=35.632183908046, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): THIO_PASMU (Q9CM49)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_245931.1
- ProteinModelPortal:   Q9CM49
- SMR:   Q9CM49
- GeneID:   1244341
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM0994
- NMPDR:   fig|272843.1.peg.994
- HOGENOM:   HBG493509
- OMA:   NPGIAST
- ProtClustDB:   CLSK870324
- BioCyc:   PMUL272843:PM0994-MONOMER
- GO:   GO:0006810
- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335
- Gene3D:   G3DSA:3.40.30.10
- PANTHER:   PTHR10438
- PIRSF:   PIRSF000077
- PRINTS:   PR00421
- TIGRFAMs:   TIGR01068

Pfam domain/function: PF00085 Thioredoxin; SSF52833 Thiordxn-like_fd

EC number: NA

Molecular weight: Translated: 11476; Mature: 11476

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00194 THIOREDOXIN_1; PS51352 THIOREDOXIN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVLHSTDATFTADVVNSDVPVLLDFWAPWCGPCRMISPILDEIAAEFSGKVKVVKINID
CCCCCCCCCEEEEHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEEC
ENQATPAQLGVRSIPTLVLFKNGKAVATQVGALPKNQLANFINQNI
CCCCCHHHCCCCCCCEEEEEECCCEEEHHHCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MEVLHSTDATFTADVVNSDVPVLLDFWAPWCGPCRMISPILDEIAAEFSGKVKVVKINID
CCCCCCCCCEEEEHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEEC
ENQATPAQLGVRSIPTLVLFKNGKAVATQVGALPKNQLANFINQNI
CCCCCHHHCCCCCCCEEEEEECCCEEEHHHCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100