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The map label for this gene is ntpA [H]

Identifier: 15602846

GI number: 15602846

Start: 1151294

End: 1151812

Strand: Reverse

Name: ntpA [H]

Synonym: PM0981

Alternate gene names: 15602846

Gene position: 1151812-1151294 (Counterclockwise)

Preceding gene: 15602847

Following gene: 15602845

Centisome position: 51.02

GC content: 38.92

Gene sequence:

>519_bases
ATGTATAAGAATCCGCATAGTGTCTTAGTGGTCATCTTCTGTTATAGCACACAACGTGTTCTCATGTTACAACGACAAGA
TGATCTGACATTTTGGCAATCCGTTACCGGTTCTTTAGCCTTAAATGAGTCACCAAGAGAAACTGCGATAAGGGAAGTGA
AAGAAGAAGTCGGAATTGATATTCAGTCAGAGAGCTTAGCGCTTTTTGATTGTGAAGAAAGGATAGCGTTTGAAATTTTT
CCCCATTTCCGTTATAAATACGCACCAAATGTCACTCATTGTCTTGAACACTGGTTTTTGCTAGGGCTTGCAGAGGAAAG
AATACCCCATTTAACAGAGCATGTTGCTTTTCAATGGCTACCTGCAGATCAGGCAGCGATCTTGACTAAGTCATGGAATA
ATCGCGCATTAATCGAAAAGTATTTAGTGAAACAACCATTGGATAGTGGCATCTTACAGAGAATAACGAACGAGTATAAT
TATTTAATAAAGAAGGAAATTGAGAATGGCAGGTCATAG

Upstream 100 bases:

>100_bases
ACATTAGGTTCTTATGCAGATGGTGAAATCGATTTAGTGCTTCCTTATCGCCAGTTAAAGGACATTATTAAACCTGAATT
ACTATATTAATGGGATGAAA

Downstream 100 bases:

>100_bases
TAAGTGGGCTAACATTAAACACCGTAAAGCCGCACAAGATGCACAACGTGGCAAGATTTTTACTAAATTAATTCGTGAAT
TGGTGACAGCTGCGAAGTTA

Product: dATP pyrophosphohydrolase

Products: dAMP; pyrophosphate [C]

Alternate protein names: dATP pyrophosphohydrolase [H]

Number of amino acids: Translated: 172; Mature: 172

Protein sequence:

>172_residues
MYKNPHSVLVVIFCYSTQRVLMLQRQDDLTFWQSVTGSLALNESPRETAIREVKEEVGIDIQSESLALFDCEERIAFEIF
PHFRYKYAPNVTHCLEHWFLLGLAEERIPHLTEHVAFQWLPADQAAILTKSWNNRALIEKYLVKQPLDSGILQRITNEYN
YLIKKEIENGRS

Sequences:

>Translated_172_residues
MYKNPHSVLVVIFCYSTQRVLMLQRQDDLTFWQSVTGSLALNESPRETAIREVKEEVGIDIQSESLALFDCEERIAFEIF
PHFRYKYAPNVTHCLEHWFLLGLAEERIPHLTEHVAFQWLPADQAAILTKSWNNRALIEKYLVKQPLDSGILQRITNEYN
YLIKKEIENGRS
>Mature_172_residues
MYKNPHSVLVVIFCYSTQRVLMLQRQDDLTFWQSVTGSLALNESPRETAIREVKEEVGIDIQSESLALFDCEERIAFEIF
PHFRYKYAPNVTHCLEHWFLLGLAEERIPHLTEHVAFQWLPADQAAILTKSWNNRALIEKYLVKQPLDSGILQRITNEYN
YLIKKEIENGRS

Specific function: Catalyzes the hydrolysis of dihydroneopterin triphosphate to dihydroneopterin monophosphate and pyrophosphate. Required for efficient folate biosynthesis. Can also hydrolyze nucleoside triphosphates with a preference for dATP [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1788172, Length=143, Percent_Identity=54.5454545454545, Blast_Score=164, Evalue=3e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003564
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 20168; Mature: 20168

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKNPHSVLVVIFCYSTQRVLMLQRQDDLTFWQSVTGSLALNESPRETAIREVKEEVGID
CCCCCCEEEEEEEECCCCEEEEEECCCCHHHHHHHCCCEEECCCHHHHHHHHHHHHHCCE
IQSESLALFDCEERIAFEIFPHFRYKYAPNVTHCLEHWFLLGLAEERIPHLTEHVAFQWL
ECCCCEEEEEHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEC
PADQAAILTKSWNNRALIEKYLVKQPLDSGILQRITNEYNYLIKKEIENGRS
CCCCCEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MYKNPHSVLVVIFCYSTQRVLMLQRQDDLTFWQSVTGSLALNESPRETAIREVKEEVGID
CCCCCCEEEEEEEECCCCEEEEEECCCCHHHHHHHCCCEEECCCHHHHHHHHHHHHHCCE
IQSESLALFDCEERIAFEIFPHFRYKYAPNVTHCLEHWFLLGLAEERIPHLTEHVAFQWL
ECCCCEEEEEHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEC
PADQAAILTKSWNNRALIEKYLVKQPLDSGILQRITNEYNYLIKKEIENGRS
CCCCCEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: deoxy-ATP; H2O [C]

Specific reaction: deoxy-ATP + H2O = dAMP + pyrophosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]