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The map label for this gene is ppiB [H]

Identifier: 15602809

GI number: 15602809

Start: 1114825

End: 1115334

Strand: Reverse

Name: ppiB [H]

Synonym: PM0944

Alternate gene names: 15602809

Gene position: 1115334-1114825 (Counterclockwise)

Preceding gene: 15602811

Following gene: 15602808

Centisome position: 49.41

GC content: 39.41

Gene sequence:

>510_bases
ATGATTACATTACACACTAACTTGGGTAACATTAAAATTCAATTAGATCATGAAAAAGCACCGAACACAGCGCAAAACTT
TGTAAATTACTGTAAAAGTGGATTCTATGATAACACAATTTTTCATCGTGTTATTGATGGATTTATGATCCAAGGTGGTG
GTATGGATGAGGCGATGCGTGAGAAAAAGACGAATGCGCCGATCCAAAATGAAGCCAACAATGGTTTAAGTAACAAACGT
GGCACAATTGCGATGGCGCGAACATCGGATCCTCATTCTGCGACCGCACAATTTTTTATTAATGTAGCAGATAATACTTT
TTTAGATCACCGTTCAAAAGAGTTATTTGGTAAAAAGGTGGTACAAGAGTGGGGCTATGCCGTCTTTGGTGAAGTGGTTG
AGGGCATGGATGTAGTAGATAAGATCAAAGGCGTGAAAACCGGAAATAAAGGGTTTCACCAAGATGTACCACAAGAAGCC
ATCGTGATTACTGCAGTGACCGTTGAATAA

Upstream 100 bases:

>100_bases
TTAGCATAGCGTAATTTGCCATAAACAAAGTTACTTTATAGCATTTAATGCGCTTTTATGAAATAATCGAATGATATAAA
ACTATTAGAGGAAAACAGAT

Downstream 100 bases:

>100_bases
TCAGTCTCTCCCCTCGTAATTGAGGGGATTCTTTTAGGAGAAGAGAAAATGTTAAGAATAATTACCGCACTTTTGCTTGC
TGGTGTTGTTTGTGTTGCTC

Product: PpiB

Products: NA

Alternate protein names: PPIase B; Rotamase B [H]

Number of amino acids: Translated: 169; Mature: 169

Protein sequence:

>169_residues
MITLHTNLGNIKIQLDHEKAPNTAQNFVNYCKSGFYDNTIFHRVIDGFMIQGGGMDEAMREKKTNAPIQNEANNGLSNKR
GTIAMARTSDPHSATAQFFINVADNTFLDHRSKELFGKKVVQEWGYAVFGEVVEGMDVVDKIKGVKTGNKGFHQDVPQEA
IVITAVTVE

Sequences:

>Translated_169_residues
MITLHTNLGNIKIQLDHEKAPNTAQNFVNYCKSGFYDNTIFHRVIDGFMIQGGGMDEAMREKKTNAPIQNEANNGLSNKR
GTIAMARTSDPHSATAQFFINVADNTFLDHRSKELFGKKVVQEWGYAVFGEVVEGMDVVDKIKGVKTGNKGFHQDVPQEA
IVITAVTVE
>Mature_169_residues
MITLHTNLGNIKIQLDHEKAPNTAQNFVNYCKSGFYDNTIFHRVIDGFMIQGGGMDEAMREKKTNAPIQNEANNGLSNKR
GTIAMARTSDPHSATAQFFINVADNTFLDHRSKELFGKKVVQEWGYAVFGEVVEGMDVVDKIKGVKTGNKGFHQDVPQEA
IVITAVTVE

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI22547212, Length=170, Percent_Identity=34.1176470588235, Blast_Score=91, Evalue=7e-19,
Organism=Homo sapiens, GI7657473, Length=170, Percent_Identity=34.1176470588235, Blast_Score=91, Evalue=7e-19,
Organism=Homo sapiens, GI22547215, Length=170, Percent_Identity=34.7058823529412, Blast_Score=87, Evalue=5e-18,
Organism=Homo sapiens, GI19557636, Length=170, Percent_Identity=30.5882352941176, Blast_Score=85, Evalue=3e-17,
Organism=Homo sapiens, GI24308049, Length=172, Percent_Identity=31.9767441860465, Blast_Score=77, Evalue=5e-15,
Organism=Homo sapiens, GI64276486, Length=120, Percent_Identity=36.6666666666667, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI7706339, Length=165, Percent_Identity=29.0909090909091, Blast_Score=70, Evalue=8e-13,
Organism=Escherichia coli, GI1786736, Length=168, Percent_Identity=63.0952380952381, Blast_Score=223, Evalue=4e-60,
Organism=Escherichia coli, GI1789763, Length=167, Percent_Identity=58.6826347305389, Blast_Score=201, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI71980590, Length=152, Percent_Identity=34.2105263157895, Blast_Score=89, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI71980594, Length=152, Percent_Identity=34.2105263157895, Blast_Score=89, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17532641, Length=175, Percent_Identity=29.7142857142857, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17506311, Length=171, Percent_Identity=29.8245614035088, Blast_Score=73, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17539496, Length=164, Percent_Identity=30.4878048780488, Blast_Score=69, Evalue=8e-13,
Organism=Drosophila melanogaster, GI17986117, Length=170, Percent_Identity=31.1764705882353, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI19922376, Length=174, Percent_Identity=29.8850574712644, Blast_Score=80, Evalue=6e-16,
Organism=Drosophila melanogaster, GI19922912, Length=168, Percent_Identity=32.1428571428571, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24652460, Length=170, Percent_Identity=27.0588235294118, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21357249, Length=120, Percent_Identity=34.1666666666667, Blast_Score=67, Evalue=7e-12,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 18731; Mature: 18731

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITLHTNLGNIKIQLDHEKAPNTAQNFVNYCKSGFYDNTIFHRVIDGFMIQGGGMDEAMR
CEEEEECCCEEEEEECCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHEECCCCCCHHHH
EKKTNAPIQNEANNGLSNKRGTIAMARTSDPHSATAQFFINVADNTFLDHRSKELFGKKV
HHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHH
VQEWGYAVFGEVVEGMDVVDKIKGVKTGNKGFHQDVPQEAIVITAVTVE
HHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEEC
>Mature Secondary Structure
MITLHTNLGNIKIQLDHEKAPNTAQNFVNYCKSGFYDNTIFHRVIDGFMIQGGGMDEAMR
CEEEEECCCEEEEEECCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHEECCCCCCHHHH
EKKTNAPIQNEANNGLSNKRGTIAMARTSDPHSATAQFFINVADNTFLDHRSKELFGKKV
HHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHH
VQEWGYAVFGEVVEGMDVVDKIKGVKTGNKGFHQDVPQEAIVITAVTVE
HHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]