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The map label for this gene is fadD_2 [C]

Identifier: 15602790

GI number: 15602790

Start: 1091068

End: 1092888

Strand: Direct

Name: fadD_2 [C]

Synonym: PM0925

Alternate gene names: 15602790

Gene position: 1091068-1092888 (Clockwise)

Preceding gene: 15602789

Following gene: 15602795

Centisome position: 48.33

GC content: 38.93

Gene sequence:

>1821_bases
ATGACTAATTTGAACTTACACTTTGTTAATCGCATCCGCGAACAAGCCAAGCTCTTATTAAATGAAACTGCCCTACGTTA
CCACACGCCTTCAGGTTGGGAAAATATCTCTTGGCACCAATTTCAACAGGATCTCGACACCTTTTCTTATGCGCTCTTAG
CCAATCATATTGGGGTACAAGATAAAATTGCCATTTTTGCACATAATATGCCACGTTGGACTATCGCTGACATAGGGACA
ATGCAAGTACGCGCTGTTGTTGTGCCAATCTATGCGACAAGTGCCGCCAAACAAGTCGAATATATCCTTAACAACGCAGA
TGTCAAAATCCTCTTTGTTGGTGATCAAGAAGAGTACAACTGTACGCTAGAAATCATCGATGCTTGTCCACAAATACAAA
AAATTGTCGCCATGAAAGACAATTTGGACTTAAAAAATCATCCTAAAGCTTGTGATTGGCAAACTTTTTTGCTCGAGGGA
AGCCCACTCCAACAAACAGCTCTGCAAGAGCGTCTTGAACAAAAACAACTGACAGACTTATTTACTTTAATCTATACCTC
GGGCACGACGGGAGAACCGAAGGGCGTGATGTTGGATTACGCTAATCTTGCTCACCAATTAAAAGCGCATGACGAAGCAT
TTACTACACTCAATGTCAGCCAATATGATAGCTCGCTTTCTTTCTTACCGTTATCCCATATCTTTGAACGAGCCTGGGTT
GCTTATGTTTTACACCGTGGTGCAGTCAATTGTTATCTTGAAGATACCAACAGAGTACGTGAAGCTCTTAGCGAAATTCG
CCCAACCCTGATGTGTGCCGTGCCACGTTTTTATGAAAAAATTTACACCGCCGTTTGGGATAAAGTACAAAAAGCACCTC
TCTTCCGTCGTATGATCTTCAATTGGGCAATTGCAGTTGGACAAAAACGTTTTCAGTTTATTTCACAAAAGAAACCTATC
CCTTTTGTACTACGGCAACAATATGCGCTAGCCGATAAGTTAGTGTTATCTAAATTACGTCAATTACTCGGTGGTCGCAT
CCGCATGATGCCTTGTGGCGGTGCAAAATTAGAGCCTAACATTGGTCTGTTTTTCCACAGTATTGGTATTAATGTCAAGC
TCGGCTACGGTATGACAGAAACCACGGCTACCGTATCTTGCTGGGAAGAAGGGCATTTTGAACCAAATTCTATTGGTACA
TTGATGCCTGGTGCAGAAGTCAAAATTGGGGAAAATAATGAAATCTTAGTGCGTGGTGGGATGGTCATGCGTGGTTATTA
TAAAAAACCACAAGAAACTGCTGACAGTTTTACAGAAGACGGATTCTTAAAAACTGGTGATGCTGGAGAATTTGATCCAC
AAGGTAATTTATATATTACAGATCGTATCAAAGAGTTAATGAAAACCTCCAATGGAAAATATATTGCTCCACAATATATT
GAAACCAAAGTGGGTAAAGATAAATTTATTGAACAAATTGCAGTCATTGCGGATGCCAAAAAATATGTCTCAGCGCTTAT
TGTACCTTGCTTCAATAGTCTTGAAGAATACGCCAAACAATTAAATATAAAATATCACGATCGTTTAGAACTCATTAAAC
ATTCTGATATTCTTCAAATGTTTGAACAGCGTATTAATGATTTACAAAAAGAATTGCCTAGCTTTGAGCAAATTAAAAAA
TTCACTTTATTACCTCAGGCATTTACCACAAAAATGGAAGAAATTACTCCGACATTGAAACTCCGTCGTAAAGTGATTTT
GGAACGCTATAAAGCACAAATTGAAGCGATGTATAAAGAATACACTCATAAAAAAGACTAA

Upstream 100 bases:

>100_bases
CGGTATTTTTAATCAAATTTCGAGAAAAATAACTAGTTTATTTTAGCTAACAAGTGTAAGCTAAAGCGGTTAAATTCCAT
TCTAATTAATTAAGGACACC

Downstream 100 bases:

>100_bases
CTTGCAATACACAAAGGGCTTCCAAACAGAAGCCCTTTATTTTTGCTAAAAATGACCGCACTTTTTACTTGCTTAAGCAA
GCAAAGTAGCTGTCCGCCGT

Product: FadD

Products: NA

Alternate protein names: Long-chain acyl-CoA synthetase; LACS [H]

Number of amino acids: Translated: 606; Mature: 605

Protein sequence:

>606_residues
MTNLNLHFVNRIREQAKLLLNETALRYHTPSGWENISWHQFQQDLDTFSYALLANHIGVQDKIAIFAHNMPRWTIADIGT
MQVRAVVVPIYATSAAKQVEYILNNADVKILFVGDQEEYNCTLEIIDACPQIQKIVAMKDNLDLKNHPKACDWQTFLLEG
SPLQQTALQERLEQKQLTDLFTLIYTSGTTGEPKGVMLDYANLAHQLKAHDEAFTTLNVSQYDSSLSFLPLSHIFERAWV
AYVLHRGAVNCYLEDTNRVREALSEIRPTLMCAVPRFYEKIYTAVWDKVQKAPLFRRMIFNWAIAVGQKRFQFISQKKPI
PFVLRQQYALADKLVLSKLRQLLGGRIRMMPCGGAKLEPNIGLFFHSIGINVKLGYGMTETTATVSCWEEGHFEPNSIGT
LMPGAEVKIGENNEILVRGGMVMRGYYKKPQETADSFTEDGFLKTGDAGEFDPQGNLYITDRIKELMKTSNGKYIAPQYI
ETKVGKDKFIEQIAVIADAKKYVSALIVPCFNSLEEYAKQLNIKYHDRLELIKHSDILQMFEQRINDLQKELPSFEQIKK
FTLLPQAFTTKMEEITPTLKLRRKVILERYKAQIEAMYKEYTHKKD

Sequences:

>Translated_606_residues
MTNLNLHFVNRIREQAKLLLNETALRYHTPSGWENISWHQFQQDLDTFSYALLANHIGVQDKIAIFAHNMPRWTIADIGT
MQVRAVVVPIYATSAAKQVEYILNNADVKILFVGDQEEYNCTLEIIDACPQIQKIVAMKDNLDLKNHPKACDWQTFLLEG
SPLQQTALQERLEQKQLTDLFTLIYTSGTTGEPKGVMLDYANLAHQLKAHDEAFTTLNVSQYDSSLSFLPLSHIFERAWV
AYVLHRGAVNCYLEDTNRVREALSEIRPTLMCAVPRFYEKIYTAVWDKVQKAPLFRRMIFNWAIAVGQKRFQFISQKKPI
PFVLRQQYALADKLVLSKLRQLLGGRIRMMPCGGAKLEPNIGLFFHSIGINVKLGYGMTETTATVSCWEEGHFEPNSIGT
LMPGAEVKIGENNEILVRGGMVMRGYYKKPQETADSFTEDGFLKTGDAGEFDPQGNLYITDRIKELMKTSNGKYIAPQYI
ETKVGKDKFIEQIAVIADAKKYVSALIVPCFNSLEEYAKQLNIKYHDRLELIKHSDILQMFEQRINDLQKELPSFEQIKK
FTLLPQAFTTKMEEITPTLKLRRKVILERYKAQIEAMYKEYTHKKD
>Mature_605_residues
TNLNLHFVNRIREQAKLLLNETALRYHTPSGWENISWHQFQQDLDTFSYALLANHIGVQDKIAIFAHNMPRWTIADIGTM
QVRAVVVPIYATSAAKQVEYILNNADVKILFVGDQEEYNCTLEIIDACPQIQKIVAMKDNLDLKNHPKACDWQTFLLEGS
PLQQTALQERLEQKQLTDLFTLIYTSGTTGEPKGVMLDYANLAHQLKAHDEAFTTLNVSQYDSSLSFLPLSHIFERAWVA
YVLHRGAVNCYLEDTNRVREALSEIRPTLMCAVPRFYEKIYTAVWDKVQKAPLFRRMIFNWAIAVGQKRFQFISQKKPIP
FVLRQQYALADKLVLSKLRQLLGGRIRMMPCGGAKLEPNIGLFFHSIGINVKLGYGMTETTATVSCWEEGHFEPNSIGTL
MPGAEVKIGENNEILVRGGMVMRGYYKKPQETADSFTEDGFLKTGDAGEFDPQGNLYITDRIKELMKTSNGKYIAPQYIE
TKVGKDKFIEQIAVIADAKKYVSALIVPCFNSLEEYAKQLNIKYHDRLELIKHSDILQMFEQRINDLQKELPSFEQIKKF
TLLPQAFTTKMEEITPTLKLRRKVILERYKAQIEAMYKEYTHKKD

Specific function: Esterification, Concomitant With Transport, Of Exogenous Long-Chain Fatty Acids Into Metabolically Active CoA Thioesters For Subsequent Degradation Or Incorporation Into Phospholipids. [C]

COG id: COG1022

COG function: function code I; Long-chain acyl-CoA synthetases (AMP-forming)

Gene ontology:

Cell location: Partially Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI40807491, Length=589, Percent_Identity=27.8438030560272, Blast_Score=232, Evalue=6e-61,
Organism=Homo sapiens, GI57165410, Length=567, Percent_Identity=30.1587301587302, Blast_Score=227, Evalue=3e-59,
Organism=Homo sapiens, GI57165412, Length=563, Percent_Identity=30.0177619893428, Blast_Score=226, Evalue=5e-59,
Organism=Homo sapiens, GI27477105, Length=606, Percent_Identity=28.5478547854785, Blast_Score=225, Evalue=1e-58,
Organism=Homo sapiens, GI42794760, Length=616, Percent_Identity=28.5714285714286, Blast_Score=223, Evalue=6e-58,
Organism=Homo sapiens, GI42794758, Length=616, Percent_Identity=28.5714285714286, Blast_Score=223, Evalue=6e-58,
Organism=Homo sapiens, GI42794756, Length=616, Percent_Identity=28.5714285714286, Blast_Score=222, Evalue=7e-58,
Organism=Homo sapiens, GI83745141, Length=614, Percent_Identity=26.0586319218241, Blast_Score=214, Evalue=2e-55,
Organism=Homo sapiens, GI42794754, Length=576, Percent_Identity=26.9097222222222, Blast_Score=194, Evalue=3e-49,
Organism=Homo sapiens, GI42794752, Length=576, Percent_Identity=26.9097222222222, Blast_Score=194, Evalue=3e-49,
Organism=Homo sapiens, GI12669909, Length=607, Percent_Identity=25.3706754530478, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI4758332, Length=607, Percent_Identity=25.3706754530478, Blast_Score=168, Evalue=1e-41,
Organism=Escherichia coli, GI1788107, Length=134, Percent_Identity=32.089552238806, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17510401, Length=597, Percent_Identity=30.4857621440536, Blast_Score=246, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI17541856, Length=591, Percent_Identity=30.7952622673435, Blast_Score=243, Evalue=3e-64,
Organism=Caenorhabditis elegans, GI17556552, Length=562, Percent_Identity=27.9359430604982, Blast_Score=229, Evalue=4e-60,
Organism=Caenorhabditis elegans, GI193204819, Length=626, Percent_Identity=28.594249201278, Blast_Score=210, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17564090, Length=543, Percent_Identity=26.8876611418048, Blast_Score=177, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17553312, Length=574, Percent_Identity=25.7839721254355, Blast_Score=176, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI25147511, Length=603, Percent_Identity=24.212271973466, Blast_Score=170, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17559526, Length=508, Percent_Identity=24.8031496062992, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17531443, Length=342, Percent_Identity=26.6081871345029, Blast_Score=100, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI32563687, Length=400, Percent_Identity=26.75, Blast_Score=100, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17558820, Length=169, Percent_Identity=33.7278106508876, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI133901848, Length=222, Percent_Identity=30.1801801801802, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71985884, Length=167, Percent_Identity=31.7365269461078, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17557194, Length=137, Percent_Identity=37.2262773722628, Blast_Score=73, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17538037, Length=137, Percent_Identity=38.6861313868613, Blast_Score=69, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6322182, Length=454, Percent_Identity=29.7356828193833, Blast_Score=181, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6324893, Length=456, Percent_Identity=30.2631578947368, Blast_Score=178, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6320852, Length=581, Percent_Identity=25.8175559380379, Blast_Score=172, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6323903, Length=449, Percent_Identity=27.6169265033408, Blast_Score=168, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6319699, Length=427, Percent_Identity=24.3559718969555, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI281366413, Length=609, Percent_Identity=29.7208538587849, Blast_Score=239, Evalue=4e-63,
Organism=Drosophila melanogaster, GI24666501, Length=609, Percent_Identity=29.8850574712644, Blast_Score=239, Evalue=4e-63,
Organism=Drosophila melanogaster, GI24666497, Length=609, Percent_Identity=29.8850574712644, Blast_Score=239, Evalue=4e-63,
Organism=Drosophila melanogaster, GI17933690, Length=599, Percent_Identity=25.2086811352254, Blast_Score=221, Evalue=1e-57,
Organism=Drosophila melanogaster, GI19921316, Length=641, Percent_Identity=26.5210608424337, Blast_Score=211, Evalue=1e-54,
Organism=Drosophila melanogaster, GI62471681, Length=582, Percent_Identity=26.6323024054983, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI62471687, Length=582, Percent_Identity=26.6323024054983, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24586634, Length=582, Percent_Identity=26.6323024054983, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI22026970, Length=582, Percent_Identity=26.6323024054983, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI62471679, Length=582, Percent_Identity=26.6323024054983, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI62471683, Length=582, Percent_Identity=26.6323024054983, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI62471685, Length=582, Percent_Identity=26.6323024054983, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24586636, Length=582, Percent_Identity=26.6323024054983, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI62471689, Length=582, Percent_Identity=26.6323024054983, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI21355181, Length=460, Percent_Identity=23.9130434782609, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24648260, Length=120, Percent_Identity=35, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21356947, Length=132, Percent_Identity=32.5757575757576, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI20130357, Length=136, Percent_Identity=33.8235294117647, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI161076582, Length=231, Percent_Identity=29.8701298701299, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24653035, Length=134, Percent_Identity=36.5671641791045, Blast_Score=66, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.3 [H]

Molecular weight: Translated: 69595; Mature: 69464

Theoretical pI: Translated: 8.19; Mature: 8.19

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNLNLHFVNRIREQAKLLLNETALRYHTPSGWENISWHQFQQDLDTFSYALLANHIGVQ
CCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
DKIAIFAHNMPRWTIADIGTMQVRAVVVPIYATSAAKQVEYILNNADVKILFVGDQEEYN
CCEEEEECCCCCEEEECCCCEEEEEEEEEEEHHHHHHHHHHHHCCCCEEEEEEECCCCCC
CTLEIIDACPQIQKIVAMKDNLDLKNHPKACDWQTFLLEGSPLQQTALQERLEQKQLTDL
HHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHH
FTLIYTSGTTGEPKGVMLDYANLAHQLKAHDEAFTTLNVSQYDSSLSFLPLSHIFERAWV
HHHHEECCCCCCCCCEEEEHHHHHHHHHHCCHHHEEEEHHHHCCCCCCCCHHHHHHHHHH
AYVLHRGAVNCYLEDTNRVREALSEIRPTLMCAVPRFYEKIYTAVWDKVQKAPLFRRMIF
HHHHHCCCEEEEECCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NWAIAVGQKRFQFISQKKPIPFVLRQQYALADKLVLSKLRQLLGGRIRMMPCGGAKLEPN
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCC
IGLFFHSIGINVKLGYGMTETTATVSCWEEGHFEPNSIGTLMPGAEVKIGENNEILVRGG
CEEEEEEECEEEEECCCCCCCCCEEEHHHCCCCCCCCCCCCCCCCEEEECCCCEEEEECC
MVMRGYYKKPQETADSFTEDGFLKTGDAGEFDPQGNLYITDRIKELMKTSNGKYIAPQYI
EEEECCCCCCHHHHHHHCCCCCEECCCCCCCCCCCCEEEHHHHHHHHHCCCCCEECCHHH
ETKVGKDKFIEQIAVIADAKKYVSALIVPCFNSLEEYAKQLNIKYHDRLELIKHSDILQM
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
FEQRINDLQKELPSFEQIKKFTLLPQAFTTKMEEITPTLKLRRKVILERYKAQIEAMYKE
HHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YTHKKD
HCCCCC
>Mature Secondary Structure 
TNLNLHFVNRIREQAKLLLNETALRYHTPSGWENISWHQFQQDLDTFSYALLANHIGVQ
CCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
DKIAIFAHNMPRWTIADIGTMQVRAVVVPIYATSAAKQVEYILNNADVKILFVGDQEEYN
CCEEEEECCCCCEEEECCCCEEEEEEEEEEEHHHHHHHHHHHHCCCCEEEEEEECCCCCC
CTLEIIDACPQIQKIVAMKDNLDLKNHPKACDWQTFLLEGSPLQQTALQERLEQKQLTDL
HHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHH
FTLIYTSGTTGEPKGVMLDYANLAHQLKAHDEAFTTLNVSQYDSSLSFLPLSHIFERAWV
HHHHEECCCCCCCCCEEEEHHHHHHHHHHCCHHHEEEEHHHHCCCCCCCCHHHHHHHHHH
AYVLHRGAVNCYLEDTNRVREALSEIRPTLMCAVPRFYEKIYTAVWDKVQKAPLFRRMIF
HHHHHCCCEEEEECCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NWAIAVGQKRFQFISQKKPIPFVLRQQYALADKLVLSKLRQLLGGRIRMMPCGGAKLEPN
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCC
IGLFFHSIGINVKLGYGMTETTATVSCWEEGHFEPNSIGTLMPGAEVKIGENNEILVRGG
CEEEEEEECEEEEECCCCCCCCCEEEHHHCCCCCCCCCCCCCCCCEEEECCCCEEEEECC
MVMRGYYKKPQETADSFTEDGFLKTGDAGEFDPQGNLYITDRIKELMKTSNGKYIAPQYI
EEEECCCCCCHHHHHHHCCCCCEECCCCCCCCCCCCEEEHHHHHHHHHCCCCCEECCHHH
ETKVGKDKFIEQIAVIADAKKYVSALIVPCFNSLEEYAKQLNIKYHDRLELIKHSDILQM
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
FEQRINDLQKELPSFEQIKKFTLLPQAFTTKMEEITPTLKLRRKVILERYKAQIEAMYKE
HHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YTHKKD
HCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]