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The map label for this gene is msrB

Identifier: 15602788

GI number: 15602788

Start: 1088861

End: 1089253

Strand: Reverse

Name: msrB

Synonym: PM0923

Alternate gene names: 15602788

Gene position: 1089253-1088861 (Counterclockwise)

Preceding gene: 15602791

Following gene: 15602787

Centisome position: 48.25

GC content: 42.24

Gene sequence:

>393_bases
ATGAAAAAAAGAGAAGATATGACGGAAATGCAAGTGCATGTTTGTTTAAATCAAGGTACGGAATATCCGTTTACGGGGAA
ATTATTAGATCAACAAAAGAAAGGATTGTACCGTTGTGTAGTGTGCCATTCACCGTTATTTGTGTCTGATACAAAATTTG
ATGCGGGCTGCGGGTGGCCTAGCTTTTTTCAAGCGATTTCACCTGAAGCAATACGTTATTTAGATGACTACACATTATCA
CGCCCTCGCACTGAAATTCGTTGTGGTCAATGTGATGCCCATTTGGGACATGTGTTTGAAGACGGTCCCCCGCCGACAGG
ATTACGTTATTGTGTTAATTCAGTGTCCATGGCATTTGAAGATAGCGAAACGGGCGAGCTCATTGAAGGCTAA

Upstream 100 bases:

>100_bases
CTTTTTGTGATCTATGTCAAAATAATAAAATGTCGGGCTTGTTTAATCTTTTTCTATTTTTTAAAACAGAAGATGAGCTC
GTTTTTTATGAGGAAATGAC

Downstream 100 bases:

>100_bases
ATTTTTTTAAAATCTACCGCACTTTTTTATTTTTAGCTGATTTTCCGTGGATTTATCGGCATAATAGTCATTATCATTCA
TTATAAAGGAAGACGTTATG

Product: methionine sulfoxide reductase B

Products: NA

Alternate protein names: Peptide-methionine (R)-S-oxide reductase

Number of amino acids: Translated: 130; Mature: 130

Protein sequence:

>130_residues
MKKREDMTEMQVHVCLNQGTEYPFTGKLLDQQKKGLYRCVVCHSPLFVSDTKFDAGCGWPSFFQAISPEAIRYLDDYTLS
RPRTEIRCGQCDAHLGHVFEDGPPPTGLRYCVNSVSMAFEDSETGELIEG

Sequences:

>Translated_130_residues
MKKREDMTEMQVHVCLNQGTEYPFTGKLLDQQKKGLYRCVVCHSPLFVSDTKFDAGCGWPSFFQAISPEAIRYLDDYTLS
RPRTEIRCGQCDAHLGHVFEDGPPPTGLRYCVNSVSMAFEDSETGELIEG
>Mature_130_residues
MKKREDMTEMQVHVCLNQGTEYPFTGKLLDQQKKGLYRCVVCHSPLFVSDTKFDAGCGWPSFFQAISPEAIRYLDDYTLS
RPRTEIRCGQCDAHLGHVFEDGPPPTGLRYCVNSVSMAFEDSETGELIEG

Specific function: Unknown

COG id: COG0229

COG function: function code O; Conserved domain frequently associated with peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrB Met sulfoxide reductase family

Homologues:

Organism=Homo sapiens, GI301336164, Length=127, Percent_Identity=48.0314960629921, Blast_Score=141, Evalue=2e-34,
Organism=Homo sapiens, GI301336162, Length=127, Percent_Identity=48.0314960629921, Blast_Score=141, Evalue=2e-34,
Organism=Homo sapiens, GI73089054, Length=127, Percent_Identity=48.0314960629921, Blast_Score=141, Evalue=2e-34,
Organism=Homo sapiens, GI37620216, Length=127, Percent_Identity=48.0314960629921, Blast_Score=140, Evalue=2e-34,
Organism=Homo sapiens, GI117606353, Length=124, Percent_Identity=45.1612903225806, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1788077, Length=127, Percent_Identity=57.4803149606299, Blast_Score=167, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17553450, Length=112, Percent_Identity=52.6785714285714, Blast_Score=114, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI115532676, Length=112, Percent_Identity=52.6785714285714, Blast_Score=114, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6319816, Length=126, Percent_Identity=42.0634920634921, Blast_Score=105, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24645799, Length=121, Percent_Identity=47.1074380165289, Blast_Score=128, Evalue=1e-30,
Organism=Drosophila melanogaster, GI45553335, Length=121, Percent_Identity=47.1074380165289, Blast_Score=127, Evalue=1e-30,
Organism=Drosophila melanogaster, GI21356369, Length=121, Percent_Identity=47.1074380165289, Blast_Score=127, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24645801, Length=132, Percent_Identity=43.1818181818182, Blast_Score=123, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24645804, Length=132, Percent_Identity=43.1818181818182, Blast_Score=123, Evalue=3e-29,
Organism=Drosophila melanogaster, GI221378664, Length=122, Percent_Identity=45.9016393442623, Blast_Score=123, Evalue=3e-29,
Organism=Drosophila melanogaster, GI221378662, Length=129, Percent_Identity=44.9612403100775, Blast_Score=123, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MSRB_PASMU (Q9CMB1)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_245860.1
- ProteinModelPortal:   Q9CMB1
- SMR:   Q9CMB1
- GeneID:   1244270
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM0923
- NMPDR:   fig|272843.1.peg.923
- HOGENOM:   HBG715255
- OMA:   CCETPLF
- ProtClustDB:   PRK00222
- BioCyc:   PMUL272843:PM0923-MONOMER
- BRENDA:   1.8.4.12
- HAMAP:   MF_01400
- InterPro:   IPR002579
- InterPro:   IPR011057
- Gene3D:   G3DSA:2.170.150.20
- TIGRFAMs:   TIGR00357

Pfam domain/function: PF01641 SelR; SSF51316 Mss4_like

EC number: =1.8.4.12

Molecular weight: Translated: 14675; Mature: 14675

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: NA

Important sites: ACT_SITE 111-111

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
8.5 %Cys+Met (Translated Protein)
5.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
8.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKREDMTEMQVHVCLNQGTEYPFTGKLLDQQKKGLYRCVVCHSPLFVSDTKFDAGCGWP
CCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCEEEEEECCCEEEECCCCCCCCCCH
SFFQAISPEAIRYLDDYTLSRPRTEIRCGQCDAHLGHVFEDGPPPTGLRYCVNSVSMAFE
HHHHHCCHHHHHHHHHHCCCCCCCCEECCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHCC
DSETGELIEG
CCCCCCCCCC
>Mature Secondary Structure
MKKREDMTEMQVHVCLNQGTEYPFTGKLLDQQKKGLYRCVVCHSPLFVSDTKFDAGCGWP
CCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCEEEEEECCCEEEECCCCCCCCCCH
SFFQAISPEAIRYLDDYTLSRPRTEIRCGQCDAHLGHVFEDGPPPTGLRYCVNSVSMAFE
HHHHHCCHHHHHHHHHHCCCCCCCCEECCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHCC
DSETGELIEG
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100