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The map label for this gene is gmk

Identifier: 15602787

GI number: 15602787

Start: 1088137

End: 1088763

Strand: Reverse

Name: gmk

Synonym: PM0922

Alternate gene names: 15602787

Gene position: 1088763-1088137 (Counterclockwise)

Preceding gene: 15602788

Following gene: 15602786

Centisome position: 48.23

GC content: 37.96

Gene sequence:

>627_bases
ATGGCACAAGGTAATTTATATATTCTTTCGGCACCCAGTGGCGCGGGGAAATCCTCATTAATTTCCGCATTATTAAATCA
GCAACAAGACAATAAAATGATGGTTTCTGTTTCACATACAACAAGACAACCCCGTCCCGGTGAGCAAGAGGGAGTGCATT
ATTATTTTGTATCAGTTGAAGCCTTTGAATCATTGATTGAGCAAGATTTATTTCTTGAGTATGCCAAGGTTTTTGGCGGA
AATTATTACGGCACTTCATTACCTGCTATCGAAGAAAATTTAGCCAAAGGTATTGATGTTTTTTTAGATATTGATTGGCA
GGGTGCGCAGCAAATTCGTCAAAAAGTGCCGAATGTCAAAAGTATTTTTATTTTACCCCCGTCTTTAGCTGAATTAGAAC
GTCGTTTAATTGGACGTGGGCAAGATAGTACGGAAGTGATTGCCGCACGTATGTCGAAAGCAATCGATGAAATTTCTCAT
TATAATGAATACGATTATGTGATTGTAAATGATGTCTTTGAACAAGCATTAGCTGATTTTCAAGCGATTCTACGTGCCGA
ACGTTTAACGTTAACGCATCAGCAAAAACAAAATCAGGCGTTGATTGAACAATTGCTAGCAAAATAG

Upstream 100 bases:

>100_bases
TAAATTTTTTTAAAATCTACCGCACTTTTTTATTTTTAGCTGATTTTCCGTGGATTTATCGGCATAATAGTCATTATCAT
TCATTATAAAGGAAGACGTT

Downstream 100 bases:

>100_bases
ACCTCACTTTAGTATCATATGACCCCTTTTTAACATTTTTTTGACTAATAAGAGATGGAGTAATATATGGCTCGTGTCAC
AGTACAAGGTGCGGTAGAAA

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 208; Mature: 207

Protein sequence:

>208_residues
MAQGNLYILSAPSGAGKSSLISALLNQQQDNKMMVSVSHTTRQPRPGEQEGVHYYFVSVEAFESLIEQDLFLEYAKVFGG
NYYGTSLPAIEENLAKGIDVFLDIDWQGAQQIRQKVPNVKSIFILPPSLAELERRLIGRGQDSTEVIAARMSKAIDEISH
YNEYDYVIVNDVFEQALADFQAILRAERLTLTHQQKQNQALIEQLLAK

Sequences:

>Translated_208_residues
MAQGNLYILSAPSGAGKSSLISALLNQQQDNKMMVSVSHTTRQPRPGEQEGVHYYFVSVEAFESLIEQDLFLEYAKVFGG
NYYGTSLPAIEENLAKGIDVFLDIDWQGAQQIRQKVPNVKSIFILPPSLAELERRLIGRGQDSTEVIAARMSKAIDEISH
YNEYDYVIVNDVFEQALADFQAILRAERLTLTHQQKQNQALIEQLLAK
>Mature_207_residues
AQGNLYILSAPSGAGKSSLISALLNQQQDNKMMVSVSHTTRQPRPGEQEGVHYYFVSVEAFESLIEQDLFLEYAKVFGGN
YYGTSLPAIEENLAKGIDVFLDIDWQGAQQIRQKVPNVKSIFILPPSLAELERRLIGRGQDSTEVIAARMSKAIDEISHY
NEYDYVIVNDVFEQALADFQAILRAERLTLTHQQKQNQALIEQLLAK

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874831, Length=185, Percent_Identity=41.0810810810811, Blast_Score=122, Evalue=2e-28,
Organism=Homo sapiens, GI226874833, Length=185, Percent_Identity=41.0810810810811, Blast_Score=122, Evalue=2e-28,
Organism=Homo sapiens, GI4504221, Length=185, Percent_Identity=41.0810810810811, Blast_Score=122, Evalue=2e-28,
Organism=Homo sapiens, GI38570142, Length=180, Percent_Identity=30.5555555555556, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI14780902, Length=198, Percent_Identity=29.7979797979798, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI111154074, Length=163, Percent_Identity=30.6748466257669, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI21361598, Length=197, Percent_Identity=27.4111675126904, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI21536464, Length=159, Percent_Identity=31.4465408805031, Blast_Score=67, Evalue=8e-12,
Organism=Homo sapiens, GI52630447, Length=193, Percent_Identity=27.4611398963731, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1790080, Length=207, Percent_Identity=66.1835748792271, Blast_Score=281, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI193203132, Length=182, Percent_Identity=39.5604395604396, Blast_Score=131, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17508835, Length=182, Percent_Identity=39.5604395604396, Blast_Score=130, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI71984092, Length=134, Percent_Identity=34.3283582089552, Blast_Score=64, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6320662, Length=185, Percent_Identity=39.4594594594595, Blast_Score=134, Evalue=7e-33,
Organism=Drosophila melanogaster, GI21356141, Length=193, Percent_Identity=39.8963730569948, Blast_Score=122, Evalue=1e-28,
Organism=Drosophila melanogaster, GI85724806, Length=184, Percent_Identity=27.7173913043478, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI116007136, Length=184, Percent_Identity=27.7173913043478, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24640542, Length=184, Percent_Identity=27.7173913043478, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI45554489, Length=184, Percent_Identity=27.7173913043478, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI45554481, Length=184, Percent_Identity=27.7173913043478, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI161077626, Length=184, Percent_Identity=27.7173913043478, Blast_Score=68, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_PASMU (P57888)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_245859.1
- ProteinModelPortal:   P57888
- SMR:   P57888
- GeneID:   1244269
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM0922
- NMPDR:   fig|272843.1.peg.922
- HOGENOM:   HBG671982
- OMA:   DIDWQGT
- ProtClustDB:   PRK00300
- BioCyc:   PMUL272843:PM0922-MONOMER
- BRENDA:   2.7.4.8
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 23378; Mature: 23247

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQGNLYILSAPSGAGKSSLISALLNQQQDNKMMVSVSHTTRQPRPGEQEGVHYYFVSVE
CCCCCEEEEECCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCEEEEEEEHH
AFESLIEQDLFLEYAKVFGGNYYGTSLPAIEENLAKGIDVFLDIDWQGAQQIRQKVPNVK
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCEEEEECCCCCHHHHHHHCCCCC
SIFILPPSLAELERRLIGRGQDSTEVIAARMSKAIDEISHYNEYDYVIVNDVFEQALADF
EEEEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHH
QAILRAERLTLTHQQKQNQALIEQLLAK
HHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AQGNLYILSAPSGAGKSSLISALLNQQQDNKMMVSVSHTTRQPRPGEQEGVHYYFVSVE
CCCCEEEEECCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCEEEEEEEHH
AFESLIEQDLFLEYAKVFGGNYYGTSLPAIEENLAKGIDVFLDIDWQGAQQIRQKVPNVK
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCEEEEECCCCCHHHHHHHCCCCC
SIFILPPSLAELERRLIGRGQDSTEVIAARMSKAIDEISHYNEYDYVIVNDVFEQALADF
EEEEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHH
QAILRAERLTLTHQQKQNQALIEQLLAK
HHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100