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The map label for this gene is aceE [H]

Identifier: 15602760

GI number: 15602760

Start: 1051649

End: 1054312

Strand: Reverse

Name: aceE [H]

Synonym: PM0895

Alternate gene names: 15602760

Gene position: 1054312-1051649 (Counterclockwise)

Preceding gene: 15602761

Following gene: 15602759

Centisome position: 46.7

GC content: 41.89

Gene sequence:

>2664_bases
ATGTCAGATATGTTAAAGAATGACGTAGATCCAGTCGAAACTAATGATTGGTTGTTAGCTATTGATGCGGTCATTCGCGA
AGAAGGTGTTGAACGCGCACAATATATTATTGAGCAATTAATGCAACACGCTCGAGCCAACAATGTTTCTTTACCAACAG
GTATCACCACTGACTACATCAATACCATTCCAGCTTCAGAAGAACCAAACTATCCAGGCAATTTAGACTTAGAAAGACGT
ATCCGCGGTGCAATTCGTTGGAATGCGATTATGATGGTATTGCGTGCTTCGAAAAAAGATTTGGAATTAGGTGGACATAT
GTCTTCTTTCCAATCTTCTGCAACTATTTATGAAGTCTGTTTTAACCACTTCTTTAAAGCGCGCTCCGCGAAAAATGGTG
GTGACTTAGTTTTCTTCCAAGGTCATATCTCACCAGGCATTTATGCCCGTGCATTCTTAGAAGGTCGTTTAACTGAAGAA
CAAATGGATAACTTCCGTCAAGAAGTTCACGGTAAAGGGCTTTCTTCCTATCCGCATCCGAAATTAATGCCTGAATTCTG
GCAGTTCCCAACCGTGTCCATGGGTCTAGGACCATTGAATGCCATTTACCAAGCGCGTTTCTTAAAATATTTACACAACC
GTGGCTTAAAAGATACTGCTGATCAAACTGTTTATGCCTTCTTAGGTGATGGTGAAATGGATGAAGTGGAATCGCGTGGT
GCGATTTCTGTGGCAGCGCGTGAGAAGTTAGACAACCTTGTGTTTGTGATTAACTGTAACTTACAACGTTTAGACGGTCC
AGTAACAGGTAACGGCAAAATCATCCAAGAATTAGAAGGTTTATTCAACGGCGCAGGCTGGGAAGTGATTAAAGTGATTT
GGGGCCGTCGTTGGGATCGTTTATTACAACGTGATACCTCAGGTAAATTATTACAATTAATGATGGAAGTGGTTGATGGT
GACTACCAAACCATGAAAGCAAAAGATGGTGCTTACGTTCGTAAACACTTCTTTGGTCGTTACCCAGAAACAGAAGCCTT
AGTGGCTGAAATGACAGATGATGAAATCTGGGCATTAAATCGTGGTGGTCACGATCCATTAAAAATATTCGCTGCCTTCA
ATAAAGCAAAACAAGTGAAAGGGAAACCTGTTGTTTTACTTGTGAAAACCATTAAAGGTTATGGTATGGGTGAAGCTGCT
GAAGGGAAAAACATTGCTCACCAAGTGAAGAAAATGGATATGTCAGGCGTGAAACACGTTCGTGATCGCTTTAATATTGA
TATTGCAGATGCTGACATTGAAAATTTACCATACATTAAATTTGCAGAAGGTTCTGAAGAGTACAAATACCTTCACGAAC
GTCGTCAAGCGTTACAAGGTTATTTACCAACCCGTTTACCACGTTTCACGGAACAATTAGAGGTGCCGGAATTAGAGGAG
TTTGCACAATTATTTGAAGCTCAAGCCCGTCCAATTTCAACAACGATGGCATTTGTACGTTCACTAAACGTATTATTGAA
AAACAAATCTGTGGGTAAACGTATCGTGCCAATTCTGGCAGACGAAGCACGTACATTTGGTATGGAAGGCTTATTCCGTC
AAATCGGTATTTACAACCCGTATGGTCAAAACTATACCCCGCAAGATCGCGAGCAAGTATCTTACTACCGTGAAGCCATT
GATGGTCAAGTGTTACAAGAAGGGATCAATGAGCAAGGTGCAACCGCCTCTTGGTTAGCTGCGGCTACTTCTTACTCAAC
AAATGATTTCCCAATGATTCCATTCTATGTGTACTACTCCATGTTTGGTTTCCAACGTATTGGCGACTTAATGTGGGCCG
CGGGTGACCAACAAGCACGTGGTTTCATGATTGGTGGAACATCGGGTCGTACAACATTAAACGGCGAAGGTTTACAACAT
GAAGATGGTCACAGCCATATTCAATCATTAACTATCCCTAACTGTATCTCTTATGACCCAGCATTTGCTTTTGAGGTTGC
GGTTATCATGCAAGACGGCGTACGTCGTATGTATGGACCAGAACAAGAGAACATTTACTACTATATCACTACATTGAACG
AAACTTATGACCAACCGGCTATGCCAAAAGGTGCGGAAGAAGGTATCCGTAAAGGTATCTATAAGTTTGAAACCGTAACC
GGTCAAGGTAAAGGTAAAGTTCAGTTATTAGGTTCTGGTGCAATCTTACGTCATGTTCGCGAAGCAGCACAGTTGTTAGC
CAATGACTTTGGTGTCACTTCAGATGTGTATAGTGTACCGTCATTCACAGAAGTAGCACGTGAAGGTGCTGATGCAGATC
GTTGGAACTTATTACATCCAGAAGCCAAAGCACGTGTACCTTACATTGCACAAGTAATGAATGATGCGCCTGCTGTTGCT
GCAACAGACTACATGAAATTATTTGCAGAACAAGTTCGTGCTTATGTGCCAGCAGCAAGCTATCGTGTATTAGGTACAGA
TGGTTTTGGTCGTTCAGATAGCCGTGAAAACCTACGTGAGCACTTTGAAGTGGATGCTCGTTATGTGGCAATCGCAGCAT
TATCTGAATTGGCGAAACAAGGTACTATCGATAAGAAAGTGGTTGCAGACGCTATTCAAAAATACGGTATTGATGCAGAT
AAAGTGAACCCACTTTACGCCTAA

Upstream 100 bases:

>100_bases
TGTAAATTATATTCAATTTTACATATTTCGTGATTAATTCATTGTTTAATCTTAACTTAAGATTAAGCTTACTTTTAACT
TAACAAATAAGGAAAAGACT

Downstream 100 bases:

>100_bases
GTAAATAGGATTAACATTCCAGCTCCCTGATATCAGGGAGCATGTTATGGAATGATTGGAGGATAAAAAAACATGTCAAA
ACAAATTCAAGTACCAGATA

Product: pyruvate dehydrogenase subunit E1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 887; Mature: 886

Protein sequence:

>887_residues
MSDMLKNDVDPVETNDWLLAIDAVIREEGVERAQYIIEQLMQHARANNVSLPTGITTDYINTIPASEEPNYPGNLDLERR
IRGAIRWNAIMMVLRASKKDLELGGHMSSFQSSATIYEVCFNHFFKARSAKNGGDLVFFQGHISPGIYARAFLEGRLTEE
QMDNFRQEVHGKGLSSYPHPKLMPEFWQFPTVSMGLGPLNAIYQARFLKYLHNRGLKDTADQTVYAFLGDGEMDEVESRG
AISVAAREKLDNLVFVINCNLQRLDGPVTGNGKIIQELEGLFNGAGWEVIKVIWGRRWDRLLQRDTSGKLLQLMMEVVDG
DYQTMKAKDGAYVRKHFFGRYPETEALVAEMTDDEIWALNRGGHDPLKIFAAFNKAKQVKGKPVVLLVKTIKGYGMGEAA
EGKNIAHQVKKMDMSGVKHVRDRFNIDIADADIENLPYIKFAEGSEEYKYLHERRQALQGYLPTRLPRFTEQLEVPELEE
FAQLFEAQARPISTTMAFVRSLNVLLKNKSVGKRIVPILADEARTFGMEGLFRQIGIYNPYGQNYTPQDREQVSYYREAI
DGQVLQEGINEQGATASWLAAATSYSTNDFPMIPFYVYYSMFGFQRIGDLMWAAGDQQARGFMIGGTSGRTTLNGEGLQH
EDGHSHIQSLTIPNCISYDPAFAFEVAVIMQDGVRRMYGPEQENIYYYITTLNETYDQPAMPKGAEEGIRKGIYKFETVT
GQGKGKVQLLGSGAILRHVREAAQLLANDFGVTSDVYSVPSFTEVAREGADADRWNLLHPEAKARVPYIAQVMNDAPAVA
ATDYMKLFAEQVRAYVPAASYRVLGTDGFGRSDSRENLREHFEVDARYVAIAALSELAKQGTIDKKVVADAIQKYGIDAD
KVNPLYA

Sequences:

>Translated_887_residues
MSDMLKNDVDPVETNDWLLAIDAVIREEGVERAQYIIEQLMQHARANNVSLPTGITTDYINTIPASEEPNYPGNLDLERR
IRGAIRWNAIMMVLRASKKDLELGGHMSSFQSSATIYEVCFNHFFKARSAKNGGDLVFFQGHISPGIYARAFLEGRLTEE
QMDNFRQEVHGKGLSSYPHPKLMPEFWQFPTVSMGLGPLNAIYQARFLKYLHNRGLKDTADQTVYAFLGDGEMDEVESRG
AISVAAREKLDNLVFVINCNLQRLDGPVTGNGKIIQELEGLFNGAGWEVIKVIWGRRWDRLLQRDTSGKLLQLMMEVVDG
DYQTMKAKDGAYVRKHFFGRYPETEALVAEMTDDEIWALNRGGHDPLKIFAAFNKAKQVKGKPVVLLVKTIKGYGMGEAA
EGKNIAHQVKKMDMSGVKHVRDRFNIDIADADIENLPYIKFAEGSEEYKYLHERRQALQGYLPTRLPRFTEQLEVPELEE
FAQLFEAQARPISTTMAFVRSLNVLLKNKSVGKRIVPILADEARTFGMEGLFRQIGIYNPYGQNYTPQDREQVSYYREAI
DGQVLQEGINEQGATASWLAAATSYSTNDFPMIPFYVYYSMFGFQRIGDLMWAAGDQQARGFMIGGTSGRTTLNGEGLQH
EDGHSHIQSLTIPNCISYDPAFAFEVAVIMQDGVRRMYGPEQENIYYYITTLNETYDQPAMPKGAEEGIRKGIYKFETVT
GQGKGKVQLLGSGAILRHVREAAQLLANDFGVTSDVYSVPSFTEVAREGADADRWNLLHPEAKARVPYIAQVMNDAPAVA
ATDYMKLFAEQVRAYVPAASYRVLGTDGFGRSDSRENLREHFEVDARYVAIAALSELAKQGTIDKKVVADAIQKYGIDAD
KVNPLYA
>Mature_886_residues
SDMLKNDVDPVETNDWLLAIDAVIREEGVERAQYIIEQLMQHARANNVSLPTGITTDYINTIPASEEPNYPGNLDLERRI
RGAIRWNAIMMVLRASKKDLELGGHMSSFQSSATIYEVCFNHFFKARSAKNGGDLVFFQGHISPGIYARAFLEGRLTEEQ
MDNFRQEVHGKGLSSYPHPKLMPEFWQFPTVSMGLGPLNAIYQARFLKYLHNRGLKDTADQTVYAFLGDGEMDEVESRGA
ISVAAREKLDNLVFVINCNLQRLDGPVTGNGKIIQELEGLFNGAGWEVIKVIWGRRWDRLLQRDTSGKLLQLMMEVVDGD
YQTMKAKDGAYVRKHFFGRYPETEALVAEMTDDEIWALNRGGHDPLKIFAAFNKAKQVKGKPVVLLVKTIKGYGMGEAAE
GKNIAHQVKKMDMSGVKHVRDRFNIDIADADIENLPYIKFAEGSEEYKYLHERRQALQGYLPTRLPRFTEQLEVPELEEF
AQLFEAQARPISTTMAFVRSLNVLLKNKSVGKRIVPILADEARTFGMEGLFRQIGIYNPYGQNYTPQDREQVSYYREAID
GQVLQEGINEQGATASWLAAATSYSTNDFPMIPFYVYYSMFGFQRIGDLMWAAGDQQARGFMIGGTSGRTTLNGEGLQHE
DGHSHIQSLTIPNCISYDPAFAFEVAVIMQDGVRRMYGPEQENIYYYITTLNETYDQPAMPKGAEEGIRKGIYKFETVTG
QGKGKVQLLGSGAILRHVREAAQLLANDFGVTSDVYSVPSFTEVAREGADADRWNLLHPEAKARVPYIAQVMNDAPAVAA
TDYMKLFAEQVRAYVPAASYRVLGTDGFGRSDSRENLREHFEVDARYVAIAALSELAKQGTIDKKVVADAIQKYGIDADK
VNPLYA

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG2609

COG function: function code C; Pyruvate dehydrogenase complex, dehydrogenase (E1) component

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786304, Length=889, Percent_Identity=78.0652418447694, Blast_Score=1479, Evalue=0.0,

Paralogues:

None

Copy number: 1140 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 400 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004660
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 99611; Mature: 99480

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDMLKNDVDPVETNDWLLAIDAVIREEGVERAQYIIEQLMQHARANNVSLPTGITTDYI
CCCCHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
NTIPASEEPNYPGNLDLERRIRGAIRWNAIMMVLRASKKDLELGGHMSSFQSSATIYEVC
HCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCHHHHHCCHHHHHHH
FNHFFKARSAKNGGDLVFFQGHISPGIYARAFLEGRLTEEQMDNFRQEVHGKGLSSYPHP
HHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCC
KLMPEFWQFPTVSMGLGPLNAIYQARFLKYLHNRGLKDTADQTVYAFLGDGEMDEVESRG
CCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHCCC
AISVAAREKLDNLVFVINCNLQRLDGPVTGNGKIIQELEGLFNGAGWEVIKVIWGRRWDR
CEEHHHHHHHCCEEEEEECCHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHH
LLQRDTSGKLLQLMMEVVDGDYQTMKAKDGAYVRKHFFGRYPETEALVAEMTDDEIWALN
HHHCCCCHHHHHHHHHHHCCCHHEEECCCCHHHHHHHCCCCCCHHHHHHHCCCCCEEEEC
RGGHDPLKIFAAFNKAKQVKGKPVVLLVKTIKGYGMGEAAEGKNIAHQVKKMDMSGVKHV
CCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
RDRFNIDIADADIENLPYIKFAEGSEEYKYLHERRQALQGYLPTRLPRFTEQLEVPELEE
HHHCCEEEECCCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCHHH
FAQLFEAQARPISTTMAFVRSLNVLLKNKSVGKRIVPILADEARTFGMEGLFRQIGIYNP
HHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCHHHHHHHHCCCCC
YGQNYTPQDREQVSYYREAIDGQVLQEGINEQGATASWLAAATSYSTNDFPMIPFYVYYS
CCCCCCCCHHHHHHHHHHHHCHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHH
MFGFQRIGDLMWAAGDQQARGFMIGGTSGRTTLNGEGLQHEDGHSHIQSLTIPNCISYDP
HHHHHHHHHHHHCCCCCCCCCEEEECCCCCCEECCCCCCCCCCHHHHHHCCCCCCCCCCC
AFAFEVAVIMQDGVRRMYGPEQENIYYYITTLNETYDQPAMPKGAEEGIRKGIYKFETVT
HHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHCCHHEEEEC
GQGKGKVQLLGSGAILRHVREAAQLLANDFGVTSDVYSVPSFTEVAREGADADRWNLLHP
CCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCHHHCCCCHHHHHHCCCCCCCCCCCCC
EAKARVPYIAQVMNDAPAVAATDYMKLFAEQVRAYVPAASYRVLGTDGFGRSDSRENLRE
HHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHH
HFEVDARYVAIAALSELAKQGTIDKKVVADAIQKYGIDADKVNPLYA
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHCCCCCCC
>Mature Secondary Structure 
SDMLKNDVDPVETNDWLLAIDAVIREEGVERAQYIIEQLMQHARANNVSLPTGITTDYI
CCCHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
NTIPASEEPNYPGNLDLERRIRGAIRWNAIMMVLRASKKDLELGGHMSSFQSSATIYEVC
HCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCHHHHHCCHHHHHHH
FNHFFKARSAKNGGDLVFFQGHISPGIYARAFLEGRLTEEQMDNFRQEVHGKGLSSYPHP
HHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCC
KLMPEFWQFPTVSMGLGPLNAIYQARFLKYLHNRGLKDTADQTVYAFLGDGEMDEVESRG
CCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHCCC
AISVAAREKLDNLVFVINCNLQRLDGPVTGNGKIIQELEGLFNGAGWEVIKVIWGRRWDR
CEEHHHHHHHCCEEEEEECCHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHH
LLQRDTSGKLLQLMMEVVDGDYQTMKAKDGAYVRKHFFGRYPETEALVAEMTDDEIWALN
HHHCCCCHHHHHHHHHHHCCCHHEEECCCCHHHHHHHCCCCCCHHHHHHHCCCCCEEEEC
RGGHDPLKIFAAFNKAKQVKGKPVVLLVKTIKGYGMGEAAEGKNIAHQVKKMDMSGVKHV
CCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
RDRFNIDIADADIENLPYIKFAEGSEEYKYLHERRQALQGYLPTRLPRFTEQLEVPELEE
HHHCCEEEECCCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCHHH
FAQLFEAQARPISTTMAFVRSLNVLLKNKSVGKRIVPILADEARTFGMEGLFRQIGIYNP
HHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCHHHHHHHHCCCCC
YGQNYTPQDREQVSYYREAIDGQVLQEGINEQGATASWLAAATSYSTNDFPMIPFYVYYS
CCCCCCCCHHHHHHHHHHHHCHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHH
MFGFQRIGDLMWAAGDQQARGFMIGGTSGRTTLNGEGLQHEDGHSHIQSLTIPNCISYDP
HHHHHHHHHHHHCCCCCCCCCEEEECCCCCCEECCCCCCCCCCHHHHHHCCCCCCCCCCC
AFAFEVAVIMQDGVRRMYGPEQENIYYYITTLNETYDQPAMPKGAEEGIRKGIYKFETVT
HHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHCCHHEEEEC
GQGKGKVQLLGSGAILRHVREAAQLLANDFGVTSDVYSVPSFTEVAREGADADRWNLLHP
CCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCHHHCCCCHHHHHHCCCCCCCCCCCCC
EAKARVPYIAQVMNDAPAVAATDYMKLFAEQVRAYVPAASYRVLGTDGFGRSDSRENLRE
HHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHH
HFEVDARYVAIAALSELAKQGTIDKKVVADAIQKYGIDADKVNPLYA
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]