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The map label for this gene is folK [H]

Identifier: 15602730

GI number: 15602730

Start: 1018576

End: 1019073

Strand: Direct

Name: folK [H]

Synonym: PM0865

Alternate gene names: 15602730

Gene position: 1018576-1019073 (Clockwise)

Preceding gene: 15602729

Following gene: 15602732

Centisome position: 45.12

GC content: 42.57

Gene sequence:

>498_bases
ATGAAGTCTGTCTATATTGCATTAGGAAGCAATTTACAAACACCAATTGCGCAGTTAGAGGCGGCTCTGGCGGCATTAGC
TAACTTACCTACAACTCAGTTAATCCATGTCAGTTCTTTTTACCAAAGCAAGCCACTTGGTCCACAAGATCAGCCAGACT
ACGTAAATGCGGTAGCGCATTTACGAACTACGTTACCGCCCTTAACGCTCCTTGATCATTTACAGCAGATTGAAAATACA
CAAGGTAGAGTGCGCCTTCGCCGTTGGGGTGAACGCACTTTAGATCTGGATATTTTGCTTTATGATAATGTTGTCTGTCA
GACTGAACGCTTAACCCTTCCCCACTACGATATGACCAATCGAGAATTTGTGATCATCCCTCTGTTTGAAATTGCCCCTG
ATTTATGTTTACCGAGTGGACAACCTCTGCTGGAATTAAGGAAAAAATTCGAAGATCACCAAATGCAGAAAATACGTACA
GAACCTAGTCTTGATTAG

Upstream 100 bases:

>100_bases
AAGAGCAACAACGTTTACACCCTAAGCCGAAGAAAAAATATTATCGTGCGAGAAAGCGTCGTAAGCCTAAAGCCATCTCG
TCCTCATAGGGTAACTTAAT

Downstream 100 bases:

>100_bases
CCAGAGCTAATCGAATTTTCTTCTCAAAAAAAGCATAATCAACTAAAAATGCATCGTGTCCATAATCGGAAGAAAATTGA
TAATATACTAAATCGACGCC

Product: hypothetical protein

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 165; Mature: 165

Protein sequence:

>165_residues
MKSVYIALGSNLQTPIAQLEAALAALANLPTTQLIHVSSFYQSKPLGPQDQPDYVNAVAHLRTTLPPLTLLDHLQQIENT
QGRVRLRRWGERTLDLDILLYDNVVCQTERLTLPHYDMTNREFVIIPLFEIAPDLCLPSGQPLLELRKKFEDHQMQKIRT
EPSLD

Sequences:

>Translated_165_residues
MKSVYIALGSNLQTPIAQLEAALAALANLPTTQLIHVSSFYQSKPLGPQDQPDYVNAVAHLRTTLPPLTLLDHLQQIENT
QGRVRLRRWGERTLDLDILLYDNVVCQTERLTLPHYDMTNREFVIIPLFEIAPDLCLPSGQPLLELRKKFEDHQMQKIRT
EPSLD
>Mature_165_residues
MKSVYIALGSNLQTPIAQLEAALAALANLPTTQLIHVSSFYQSKPLGPQDQPDYVNAVAHLRTTLPPLTLLDHLQQIENT
QGRVRLRRWGERTLDLDILLYDNVVCQTERLTLPHYDMTNREFVIIPLFEIAPDLCLPSGQPLLELRKKFEDHQMQKIRT
EPSLD

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=147, Percent_Identity=57.8231292517007, Blast_Score=177, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6324073, Length=161, Percent_Identity=31.055900621118, Blast_Score=77, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 18822; Mature: 18822

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSVYIALGSNLQTPIAQLEAALAALANLPTTQLIHVSSFYQSKPLGPQDQPDYVNAVAH
CCEEEEEECCCCCCHHHHHHHHHHHHHCCCCHHEEEHHHHHHCCCCCCCCCCHHHHHHHH
LRTTLPPLTLLDHLQQIENTQGRVRLRRWGERTLDLDILLYDNVVCQTERLTLPHYDMTN
HHHCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCEEEEEEEECCEEECCCCCCCCCCCCCC
REFVIIPLFEIAPDLCLPSGQPLLELRKKFEDHQMQKIRTEPSLD
CCEEEEEHHHHCCHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKSVYIALGSNLQTPIAQLEAALAALANLPTTQLIHVSSFYQSKPLGPQDQPDYVNAVAH
CCEEEEEECCCCCCHHHHHHHHHHHHHCCCCHHEEEHHHHHHCCCCCCCCCCHHHHHHHH
LRTTLPPLTLLDHLQQIENTQGRVRLRRWGERTLDLDILLYDNVVCQTERLTLPHYDMTN
HHHCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCEEEEEEEECCEEECCCCCCCCCCCCCC
REFVIIPLFEIAPDLCLPSGQPLLELRKKFEDHQMQKIRTEPSLD
CCEEEEEHHHHCCHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 10080886 [H]