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The map label for this gene is uvrC [H]

Identifier: 15602722

GI number: 15602722

Start: 1008201

End: 1010036

Strand: Reverse

Name: uvrC [H]

Synonym: PM0857

Alternate gene names: 15602722

Gene position: 1010036-1008201 (Counterclockwise)

Preceding gene: 15602723

Following gene: 15602721

Centisome position: 44.74

GC content: 41.01

Gene sequence:

>1836_bases
ATGCTGTTTATGTTTGATGCCAAATCCTTTTTAGCCAATGTTTCCCACGATGCGGGTGTTTATCGTATGTATGACGAGAA
AGACACCGTCATTTATGTGGGAAAAGCGAAGGATCTGAAAAAGCGCCTCTCAAGTTATTTTCGCACTCATCTTAGCAGTA
AAAAAACAGAGGCGCTGGTTAGTGCGATTGCACGAATTGACACCACGATTACATCGTCGGAAACAGAAGCCTTATTGCTT
GAGCATAACTACATTAAGACCTATCAGCCGCGTTATAATGTTTTATTACGCGATGATAAATCCTATCCCTATATTTTATT
AACCGCAGAGCGCCATCCTCGTATTAGTGCATATCGAGGAAGTAAAAAAATTAAAGGCGAATATTTTGGACCTTATCCGC
ATGCTAGTGCGGTCAGAGAAACCCTTTCTTTACTGCAAAAACTCTTCCCAATCCGCCAGTGTGAAAATGCCGTTTATAAC
AACCGTTCTCGCCCTTGTTTACAATATCAGATTGGACGATGTGCAGCCCCTTGTGTTGCAGGTTATGTGACGGATGAGGC
TTATTTACAACAAGTTGAGTTAGCTCGTCTTTTTTTACAAGGCAAAGACCAGCAAGTGCTTGAACATTTGATACATAAAA
TGGAACAAGCCAGCCTAGCACTGGATTTTGAAGAGGCTGCTCGCATCCGTGATCAAATTCAAGCCGTCCGTGCCGTCATG
GAAAAACAATTTGTGTCCACTGAACGTCTGGATGATATGGATATTCTCTCGATTGCTTATCAATTAGGTATTGCTTGTGT
TCAGGTCTTGTTTATCCGACAAGGTAAAATGTTAGGGAATCGGAGCTATTTCCCTAAAGTACCGGCAAATACAACGTTGT
CTGAGTTAACGGCAACCTTTGTGGGGCAATTTTATTTACAGGCACACCAAGGACGCAGTATTCCACACCGTATTATTGTT
GATCATAAGTTATCGGAAAAGACCGAGTTAGAAGAATTACTGACTCAGCAAGCGGGGCGAAAAGTTCATATTCAAGACAA
TACAAAAGGTGAGAAGAGTAAATACTTGCAACTAGCCAAAATGAATGCTCAATCAGCATTAGTCACTCAGCTTAAACAAA
GTACGTTACTCAAAGAACGCTATCAAGCGCTGCAAGCCATTTTACAGTTAGGTGAAATTCGACGTATGGAATGTTTTGAT
ATTAGTCATACAATGGGTGAACAAACCATTGCATCTTGTGTGGTTTTTAATCAAGATGGACCATTAAAGTCGGACTATCG
TCGATTTAATATTACCGGAATTACCGCTGGGGATGATTATGCAGCCATGGAGCAAGCCTTGCTAAAACGTTATGATAAGC
CACTTGAGCAAGAAAAAATCCCAGACGTGATTTTTATTGATGGTGGTAAGGGACAACTTAATCGCGCGTTACAGACATTT
TCTAAGCTAAACGTGAAATGGGATAAAAATCAACCGCACTTAATTGGTGTGGCGAAAGGCATTGATCGGAAAGCAGGGTT
AGAAACCTTAATTCTAAGCAAACAGGGAAAAATACTTCATTTACCTTCTGATCATTTAGCCTTACATCTGATTCAACATA
TTCGTGATGAAAGCCATCAGCATGCGATTAGTGGACATCGTAAAAAACGCCAACAAGCCTTTTTACAGAGTGGCTTAGAA
TCGGTAGAAGGTGTTGGTGCAAAACGCCGTCAAACATTGTTGAAATATTTAGGTGGGATGCAAGGGGTCAAAAAGGCTAC
GCTAGATGAAATCGCCTCTGTTCCAGGCATTTCTAAAGCCCTTGCCGAACGAATTTATGATGCTTTGCGAGATTAA

Upstream 100 bases:

>100_bases
AGCGCGAGAAGTGCCGCCGGTTGGCGTGGATACCGCTGAAGATTTAGAAAAAGTGCGGTCAATTTTAGAAAAATAAAGGG
CAGGCGTTTAGCGACGCCTG

Downstream 100 bases:

>100_bases
TACATGAATCTTATTAGGATATGAAAATTCCATTTTCAAATAAAACAGATATGTTTTAGAATAATTAGACTATAAAAACG
GACCTGACTCTTTCTATGAA

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 611; Mature: 611

Protein sequence:

>611_residues
MLFMFDAKSFLANVSHDAGVYRMYDEKDTVIYVGKAKDLKKRLSSYFRTHLSSKKTEALVSAIARIDTTITSSETEALLL
EHNYIKTYQPRYNVLLRDDKSYPYILLTAERHPRISAYRGSKKIKGEYFGPYPHASAVRETLSLLQKLFPIRQCENAVYN
NRSRPCLQYQIGRCAAPCVAGYVTDEAYLQQVELARLFLQGKDQQVLEHLIHKMEQASLALDFEEAARIRDQIQAVRAVM
EKQFVSTERLDDMDILSIAYQLGIACVQVLFIRQGKMLGNRSYFPKVPANTTLSELTATFVGQFYLQAHQGRSIPHRIIV
DHKLSEKTELEELLTQQAGRKVHIQDNTKGEKSKYLQLAKMNAQSALVTQLKQSTLLKERYQALQAILQLGEIRRMECFD
ISHTMGEQTIASCVVFNQDGPLKSDYRRFNITGITAGDDYAAMEQALLKRYDKPLEQEKIPDVIFIDGGKGQLNRALQTF
SKLNVKWDKNQPHLIGVAKGIDRKAGLETLILSKQGKILHLPSDHLALHLIQHIRDESHQHAISGHRKKRQQAFLQSGLE
SVEGVGAKRRQTLLKYLGGMQGVKKATLDEIASVPGISKALAERIYDALRD

Sequences:

>Translated_611_residues
MLFMFDAKSFLANVSHDAGVYRMYDEKDTVIYVGKAKDLKKRLSSYFRTHLSSKKTEALVSAIARIDTTITSSETEALLL
EHNYIKTYQPRYNVLLRDDKSYPYILLTAERHPRISAYRGSKKIKGEYFGPYPHASAVRETLSLLQKLFPIRQCENAVYN
NRSRPCLQYQIGRCAAPCVAGYVTDEAYLQQVELARLFLQGKDQQVLEHLIHKMEQASLALDFEEAARIRDQIQAVRAVM
EKQFVSTERLDDMDILSIAYQLGIACVQVLFIRQGKMLGNRSYFPKVPANTTLSELTATFVGQFYLQAHQGRSIPHRIIV
DHKLSEKTELEELLTQQAGRKVHIQDNTKGEKSKYLQLAKMNAQSALVTQLKQSTLLKERYQALQAILQLGEIRRMECFD
ISHTMGEQTIASCVVFNQDGPLKSDYRRFNITGITAGDDYAAMEQALLKRYDKPLEQEKIPDVIFIDGGKGQLNRALQTF
SKLNVKWDKNQPHLIGVAKGIDRKAGLETLILSKQGKILHLPSDHLALHLIQHIRDESHQHAISGHRKKRQQAFLQSGLE
SVEGVGAKRRQTLLKYLGGMQGVKKATLDEIASVPGISKALAERIYDALRD
>Mature_611_residues
MLFMFDAKSFLANVSHDAGVYRMYDEKDTVIYVGKAKDLKKRLSSYFRTHLSSKKTEALVSAIARIDTTITSSETEALLL
EHNYIKTYQPRYNVLLRDDKSYPYILLTAERHPRISAYRGSKKIKGEYFGPYPHASAVRETLSLLQKLFPIRQCENAVYN
NRSRPCLQYQIGRCAAPCVAGYVTDEAYLQQVELARLFLQGKDQQVLEHLIHKMEQASLALDFEEAARIRDQIQAVRAVM
EKQFVSTERLDDMDILSIAYQLGIACVQVLFIRQGKMLGNRSYFPKVPANTTLSELTATFVGQFYLQAHQGRSIPHRIIV
DHKLSEKTELEELLTQQAGRKVHIQDNTKGEKSKYLQLAKMNAQSALVTQLKQSTLLKERYQALQAILQLGEIRRMECFD
ISHTMGEQTIASCVVFNQDGPLKSDYRRFNITGITAGDDYAAMEQALLKRYDKPLEQEKIPDVIFIDGGKGQLNRALQTF
SKLNVKWDKNQPHLIGVAKGIDRKAGLETLILSKQGKILHLPSDHLALHLIQHIRDESHQHAISGHRKKRQQAFLQSGLE
SVEGVGAKRRQTLLKYLGGMQGVKKATLDEIASVPGISKALAERIYDALRD

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=606, Percent_Identity=64.1914191419142, Blast_Score=835, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF00633 HHH; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 69339; Mature: 69339

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFMFDAKSFLANVSHDAGVYRMYDEKDTVIYVGKAKDLKKRLSSYFRTHLSSKKTEALV
CEEEEEHHHHHHHCCCCCCEEEEECCCCCEEEEECHHHHHHHHHHHHHHHHCCHHHHHHH
SAIARIDTTITSSETEALLLEHNYIKTYQPRYNVLLRDDKSYPYILLTAERHPRISAYRG
HHHHHHHHHCCCCCCCEEEEECCCCEECCCCCCEEEECCCCCCEEEEECCCCCCCCHHCC
SKKIKGEYFGPYPHASAVRETLSLLQKLFPIRQCENAVYNNRSRPCLQYQIGRCAAPCVA
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
GYVTDEAYLQQVELARLFLQGKDQQVLEHLIHKMEQASLALDFEEAARIRDQIQAVRAVM
HHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
EKQFVSTERLDDMDILSIAYQLGIACVQVLFIRQGKMLGNRSYFPKVPANTTLSELTATF
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHH
VGQFYLQAHQGRSIPHRIIVDHKLSEKTELEELLTQQAGRKVHIQDNTKGEKSKYLQLAK
HHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHH
MNAQSALVTQLKQSTLLKERYQALQAILQLGEIRRMECFDISHTMGEQTIASCVVFNQDG
HCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHEEEECCCC
PLKSDYRRFNITGITAGDDYAAMEQALLKRYDKPLEQEKIPDVIFIDGGKGQLNRALQTF
CCCCCCCEEEEEEEECCCCHHHHHHHHHHHHCCCCHHHCCCCEEEEECCCHHHHHHHHHH
SKLNVKWDKNQPHLIGVAKGIDRKAGLETLILSKQGKILHLPSDHLALHLIQHIRDESHQ
HHCCCEECCCCCCEEEEECCCCCCCCCCEEEECCCCCEEECCCHHHHHHHHHHHHHHHHH
HAISGHRKKRQQAFLQSGLESVEGVGAKRRQTLLKYLGGMQGVKKATLDEIASVPGISKA
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHH
LAERIYDALRD
HHHHHHHHHCC
>Mature Secondary Structure
MLFMFDAKSFLANVSHDAGVYRMYDEKDTVIYVGKAKDLKKRLSSYFRTHLSSKKTEALV
CEEEEEHHHHHHHCCCCCCEEEEECCCCCEEEEECHHHHHHHHHHHHHHHHCCHHHHHHH
SAIARIDTTITSSETEALLLEHNYIKTYQPRYNVLLRDDKSYPYILLTAERHPRISAYRG
HHHHHHHHHCCCCCCCEEEEECCCCEECCCCCCEEEECCCCCCEEEEECCCCCCCCHHCC
SKKIKGEYFGPYPHASAVRETLSLLQKLFPIRQCENAVYNNRSRPCLQYQIGRCAAPCVA
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
GYVTDEAYLQQVELARLFLQGKDQQVLEHLIHKMEQASLALDFEEAARIRDQIQAVRAVM
HHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
EKQFVSTERLDDMDILSIAYQLGIACVQVLFIRQGKMLGNRSYFPKVPANTTLSELTATF
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHH
VGQFYLQAHQGRSIPHRIIVDHKLSEKTELEELLTQQAGRKVHIQDNTKGEKSKYLQLAK
HHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHH
MNAQSALVTQLKQSTLLKERYQALQAILQLGEIRRMECFDISHTMGEQTIASCVVFNQDG
HCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHEEEECCCC
PLKSDYRRFNITGITAGDDYAAMEQALLKRYDKPLEQEKIPDVIFIDGGKGQLNRALQTF
CCCCCCCEEEEEEEECCCCHHHHHHHHHHHHCCCCHHHCCCCEEEEECCCHHHHHHHHHH
SKLNVKWDKNQPHLIGVAKGIDRKAGLETLILSKQGKILHLPSDHLALHLIQHIRDESHQ
HHCCCEECCCCCCEEEEECCCCCCCCCCEEEECCCCCEEECCCHHHHHHHHHHHHHHHHH
HAISGHRKKRQQAFLQSGLESVEGVGAKRRQTLLKYLGGMQGVKKATLDEIASVPGISKA
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHH
LAERIYDALRD
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]