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The map label for this gene is hisH_1

Identifier: 15602703

GI number: 15602703

Start: 987822

End: 988919

Strand: Direct

Name: hisH_1

Synonym: PM0838

Alternate gene names: 15602703

Gene position: 987822-988919 (Clockwise)

Preceding gene: 15602702

Following gene: 15602704

Centisome position: 43.76

GC content: 39.71

Gene sequence:

>1098_bases
ATGCAATACATCAACATCGTTAACGAAGGGGTGAAACAGCTTCACCCTTATCAAGCTGGAAAACCGATTGAAGAGTTAGA
ACGAGAGCTAGGAATTACCAATATCATTAAGTTAGCATCCAATGAAAATCCATTTGGTTTGCCTGACAGTGCTAAACAAG
CGATTTTAGCGGAATTGGATAATCTGACTCGCTACCCTGACAGTAATGGCTTTTACTTTAAACAAACGGTCGCAAAAAAA
TTTGGCTTATCTCCTGAACAAATTACCTTAGGCAATGGTTCAAATGATTTATTAGAGTTAGTCGCGCATACCTTTGCTAA
CGAACAAGATGAAATTCTCTTTTCACAATATGCCTTTATTGTGTATCCCCTTGTTACACAAGCTATCAATGCCAAAAAAG
TGGAAATTCCAGCGAAAAATTATGGGGCTGATTTAGACGGTTTTTTACAGGCAATAAGTGATAAAACCAAATTAATTTAT
CTCGCGAATCCCAATAATCCGACAGGCACTTTTTTAAGTGCGGGTGAAATTTCCCAATTTTTAAATCAAGTGCCCGCGCA
TGTCATCGTGGTATTAGATGAGGCTTATACTGAATTTACCTTGCCGGAAGAGCGAGTAGATTCCTTTACGTTACTCAAAA
AACACTCTAATCTTGTGATTTGTCGTACCCTTTCTAAAGCCTATGGTTTAGCGGGTTTGCGCATTGGTTACGCGGTTTCT
TCTGCCGAGATTGCTGACCTCTTTAATCGCGTTCGCCAACCGTTTAACTGTAATAGTCTGGCATTAGCCGCTGCTACCGC
GGTGCTGCATGATGATGCATTTATTGCGAAAGTGGCTGAAAACAACCGACAAGGGTTGAAGTTATTGGAAGACTTCTTTA
CAGCCAAAGGTTTGAACTATATTCCTTCAAAAGGCAATTTTGTCATGTTAGATGTCAATCAACCAGCCTTACCAATTTAT
CAGGCATTATTACAAAAAGGCGTGATTGTGCGTCCGATTGCAGGTTATGGCTTACCAAATCATTTACGGATTAGCATCGG
TTTACCAGAAGAAAACCAACGTTTCTTACTCGCATTAAACGAAGTATTAGGGCTTTAA

Upstream 100 bases:

>100_bases
TGCCTTCATGAAACAATTTGAAGCTGAAAACCGTTAAAAGTGCGGTTTGTTTTCGCCAAATTTTACAATACAGTAAATAT
AAAAATAATAAAGGAACACT

Downstream 100 bases:

>100_bases
GCCAAACTTATCCAGTGTATAGGAAATATAAATCGTGATAAAAGATGCGACCGCTATTACTCTCAATCCCATCAGCTATA
TTGAAGGCGAGGTGCGTTTA

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase 2

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MQYINIVNEGVKQLHPYQAGKPIEELERELGITNIIKLASNENPFGLPDSAKQAILAELDNLTRYPDSNGFYFKQTVAKK
FGLSPEQITLGNGSNDLLELVAHTFANEQDEILFSQYAFIVYPLVTQAINAKKVEIPAKNYGADLDGFLQAISDKTKLIY
LANPNNPTGTFLSAGEISQFLNQVPAHVIVVLDEAYTEFTLPEERVDSFTLLKKHSNLVICRTLSKAYGLAGLRIGYAVS
SAEIADLFNRVRQPFNCNSLALAAATAVLHDDAFIAKVAENNRQGLKLLEDFFTAKGLNYIPSKGNFVMLDVNQPALPIY
QALLQKGVIVRPIAGYGLPNHLRISIGLPEENQRFLLALNEVLGL

Sequences:

>Translated_365_residues
MQYINIVNEGVKQLHPYQAGKPIEELERELGITNIIKLASNENPFGLPDSAKQAILAELDNLTRYPDSNGFYFKQTVAKK
FGLSPEQITLGNGSNDLLELVAHTFANEQDEILFSQYAFIVYPLVTQAINAKKVEIPAKNYGADLDGFLQAISDKTKLIY
LANPNNPTGTFLSAGEISQFLNQVPAHVIVVLDEAYTEFTLPEERVDSFTLLKKHSNLVICRTLSKAYGLAGLRIGYAVS
SAEIADLFNRVRQPFNCNSLALAAATAVLHDDAFIAKVAENNRQGLKLLEDFFTAKGLNYIPSKGNFVMLDVNQPALPIY
QALLQKGVIVRPIAGYGLPNHLRISIGLPEENQRFLLALNEVLGL
>Mature_365_residues
MQYINIVNEGVKQLHPYQAGKPIEELERELGITNIIKLASNENPFGLPDSAKQAILAELDNLTRYPDSNGFYFKQTVAKK
FGLSPEQITLGNGSNDLLELVAHTFANEQDEILFSQYAFIVYPLVTQAINAKKVEIPAKNYGADLDGFLQAISDKTKLIY
LANPNNPTGTFLSAGEISQFLNQVPAHVIVVLDEAYTEFTLPEERVDSFTLLKKHSNLVICRTLSKAYGLAGLRIGYAVS
SAEIADLFNRVRQPFNCNSLALAAATAVLHDDAFIAKVAENNRQGLKLLEDFFTAKGLNYIPSKGNFVMLDVNQPALPIY
QALLQKGVIVRPIAGYGLPNHLRISIGLPEENQRFLLALNEVLGL

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=369, Percent_Identity=28.4552845528455, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1788627, Length=215, Percent_Identity=27.4418604651163, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322075, Length=393, Percent_Identity=25.9541984732824, Blast_Score=107, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS82_PASMU (Q9CMI7)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_245775.1
- ProteinModelPortal:   Q9CMI7
- SMR:   Q9CMI7
- GeneID:   1244185
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM0838
- NMPDR:   fig|272843.1.peg.838
- HOGENOM:   HBG646350
- OMA:   KLIYIAN
- ProtClustDB:   PRK02731
- BioCyc:   PMUL272843:PM0838-MONOMER
- BRENDA:   2.6.1.9
- HAMAP:   MF_01023
- InterPro:   IPR001176
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PRINTS:   PR00753
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 40251; Mature: 40251

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQYINIVNEGVKQLHPYQAGKPIEELERELGITNIIKLASNENPFGLPDSAKQAILAELD
CCCHHHHHHHHHHHCCCCCCCCHHHHHHHHCHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
NLTRYPDSNGFYFKQTVAKKFGLSPEQITLGNGSNDLLELVAHTFANEQDEILFSQYAFI
HHHCCCCCCCCCHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHH
VYPLVTQAINAKKVEIPAKNYGADLDGFLQAISDKTKLIYLANPNNPTGTFLSAGEISQF
HHHHHHHHCCCCEEECCCHHCCCCHHHHHHHHCCCCEEEEEECCCCCCCCEEEHHHHHHH
LNQVPAHVIVVLDEAYTEFTLPEERVDSFTLLKKHSNLVICRTLSKAYGLAGLRIGYAVS
HHHCCCEEEEEEECCHHHCCCCHHHHHHHHHHHCCCCEEEEEEHHHHHCCCCEEEHHEEC
SAEIADLFNRVRQPFNCNSLALAAATAVLHDDAFIAKVAENNRQGLKLLEDFFTAKGLNY
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHCCCCC
IPSKGNFVMLDVNQPALPIYQALLQKGVIVRPIAGYGLPNHLRISIGLPEENQRFLLALN
CCCCCCEEEEECCCCCHHHHHHHHHCCCEEEEHHCCCCCCCEEEEEECCCCCCHHHEEHH
EVLGL
HHHCC
>Mature Secondary Structure
MQYINIVNEGVKQLHPYQAGKPIEELERELGITNIIKLASNENPFGLPDSAKQAILAELD
CCCHHHHHHHHHHHCCCCCCCCHHHHHHHHCHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
NLTRYPDSNGFYFKQTVAKKFGLSPEQITLGNGSNDLLELVAHTFANEQDEILFSQYAFI
HHHCCCCCCCCCHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHH
VYPLVTQAINAKKVEIPAKNYGADLDGFLQAISDKTKLIYLANPNNPTGTFLSAGEISQF
HHHHHHHHCCCCEEECCCHHCCCCHHHHHHHHCCCCEEEEEECCCCCCCCEEEHHHHHHH
LNQVPAHVIVVLDEAYTEFTLPEERVDSFTLLKKHSNLVICRTLSKAYGLAGLRIGYAVS
HHHCCCEEEEEEECCHHHCCCCHHHHHHHHHHHCCCCEEEEEEHHHHHCCCCEEEHHEEC
SAEIADLFNRVRQPFNCNSLALAAATAVLHDDAFIAKVAENNRQGLKLLEDFFTAKGLNY
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHCCCCC
IPSKGNFVMLDVNQPALPIYQALLQKGVIVRPIAGYGLPNHLRISIGLPEENQRFLLALN
CCCCCCEEEEECCCCCHHHHHHHHHCCCEEEEHHCCCCCCCEEEEEECCCCCCHHHEEHH
EVLGL
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11248100