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The map label for this gene is serC

Identifier: 15602702

GI number: 15602702

Start: 986676

End: 987758

Strand: Direct

Name: serC

Synonym: PM0837

Alternate gene names: 15602702

Gene position: 986676-987758 (Clockwise)

Preceding gene: 15602700

Following gene: 15602703

Centisome position: 43.71

GC content: 42.57

Gene sequence:

>1083_bases
ATGTCAAAGGTTTTTAATTTTAGCGCCGGCCCTGCCATGATGCCTGAAGCAGTCTTAGCGCAAGCACAAGCGGAGCTTTT
AAACTGGCAAGAACAACAGACTTCTGTCATGGAAGTCAGCCATCGTGGTAAATTATTTATGGCATTAGCAAGCCAATCTG
AGTTAGATTTACGCCAGCTTTATCAGATCCCAGACAATTACCGCATCCTTTTCTTACAAGGTGGTGCTCGCGGGCAATTT
GCTGCGATTCCAATGAATTTATTAAAAGAAAAAGGCAAAGCCTTATATTTGACCAGTGGGCATTGGTCTGCCACCGCTGC
CAAAGAAGCGCGCTTATTTGGTGACATTGATGAAGTCAATATTCTGGAAGAAGGCAACGAACTCAAGATCGGTCAGTTAG
ATTTTAGTCATATTGCCGACCAATATGATTATGTTCACTACTGCCCAAATGAAACGATCAGTGGCGTAGAAATTTTTGAT
CTGCCAAAAGTGGGGAACGCGGTCTTAGTGGCAGATATGTCTTCCAATATTCTCTCACGCAAAATTGATATCAGCCAATT
CGGCTTAATTTATGCGGGCGCACAGAAAAATCTTGGTCCAGCAGGAATTACTCTAGTCATTGTACGCGAAGATTTAATTG
GTCATGCACGCCAAACTACACCAACAATTTGGAATTACGAAATACAAAGTAAAGCTGACTCAATGATTAATACGCCACCC
ACCTTTGCTTGGTATTTATGTGCTTTAGTCTTCAAGCATCTTTTATCCCTTGGCGGGATCGAGGAAATCGAAAAACGGAA
TCAGGCAAAAGCACAACTGCTTTACGACTATTTAGAGAGTACACCGTTTTACCGTAATCCTGTTGCCAAAGTAAACCGCT
CACGCATGAATGTGACCTTTACTACCGATAATGATGAACTGAATGCAAAATTTGTTGCTGAAGCAACGGCTGCGGGATTG
CATGCCTTAAAAGGACATAAAGTGCTAGGTGGCATGCGCGCGTCAATCTATAACGCAATGCCGATGGAAGGAGTGCAAGC
TTTAATTGCCTTCATGAAACAATTTGAAGCTGAAAACCGTTAA

Upstream 100 bases:

>100_bases
TAAACAAAAAAATCCGCTTATTTCAGCCTTCCCCCATTGCCTAGAATGGGTTGAGGTGATAAAACTAGTCAATTATTTTG
AGTAAAAAAAGGAAGTGACT

Downstream 100 bases:

>100_bases
AAGTGCGGTTTGTTTTCGCCAAATTTTACAATACAGTAAATATAAAAATAATAAAGGAACACTATGCAATACATCAACAT
CGTTAACGAAGGGGTGAAAC

Product: phosphoserine aminotransferase

Products: NA

Alternate protein names: Phosphohydroxythreonine aminotransferase; PSAT

Number of amino acids: Translated: 360; Mature: 359

Protein sequence:

>360_residues
MSKVFNFSAGPAMMPEAVLAQAQAELLNWQEQQTSVMEVSHRGKLFMALASQSELDLRQLYQIPDNYRILFLQGGARGQF
AAIPMNLLKEKGKALYLTSGHWSATAAKEARLFGDIDEVNILEEGNELKIGQLDFSHIADQYDYVHYCPNETISGVEIFD
LPKVGNAVLVADMSSNILSRKIDISQFGLIYAGAQKNLGPAGITLVIVREDLIGHARQTTPTIWNYEIQSKADSMINTPP
TFAWYLCALVFKHLLSLGGIEEIEKRNQAKAQLLYDYLESTPFYRNPVAKVNRSRMNVTFTTDNDELNAKFVAEATAAGL
HALKGHKVLGGMRASIYNAMPMEGVQALIAFMKQFEAENR

Sequences:

>Translated_360_residues
MSKVFNFSAGPAMMPEAVLAQAQAELLNWQEQQTSVMEVSHRGKLFMALASQSELDLRQLYQIPDNYRILFLQGGARGQF
AAIPMNLLKEKGKALYLTSGHWSATAAKEARLFGDIDEVNILEEGNELKIGQLDFSHIADQYDYVHYCPNETISGVEIFD
LPKVGNAVLVADMSSNILSRKIDISQFGLIYAGAQKNLGPAGITLVIVREDLIGHARQTTPTIWNYEIQSKADSMINTPP
TFAWYLCALVFKHLLSLGGIEEIEKRNQAKAQLLYDYLESTPFYRNPVAKVNRSRMNVTFTTDNDELNAKFVAEATAAGL
HALKGHKVLGGMRASIYNAMPMEGVQALIAFMKQFEAENR
>Mature_359_residues
SKVFNFSAGPAMMPEAVLAQAQAELLNWQEQQTSVMEVSHRGKLFMALASQSELDLRQLYQIPDNYRILFLQGGARGQFA
AIPMNLLKEKGKALYLTSGHWSATAAKEARLFGDIDEVNILEEGNELKIGQLDFSHIADQYDYVHYCPNETISGVEIFDL
PKVGNAVLVADMSSNILSRKIDISQFGLIYAGAQKNLGPAGITLVIVREDLIGHARQTTPTIWNYEIQSKADSMINTPPT
FAWYLCALVFKHLLSLGGIEEIEKRNQAKAQLLYDYLESTPFYRNPVAKVNRSRMNVTFTTDNDELNAKFVAEATAAGLH
ALKGHKVLGGMRASIYNAMPMEGVQALIAFMKQFEAENR

Specific function: Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine

COG id: COG1932

COG function: function code HE; Phosphoserine aminotransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily

Homologues:

Organism=Homo sapiens, GI17402893, Length=360, Percent_Identity=44.4444444444444, Blast_Score=308, Evalue=4e-84,
Organism=Homo sapiens, GI10863955, Length=356, Percent_Identity=40.1685393258427, Blast_Score=261, Evalue=6e-70,
Organism=Escherichia coli, GI1787136, Length=359, Percent_Identity=53.7604456824513, Blast_Score=399, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI17506897, Length=357, Percent_Identity=41.7366946778711, Blast_Score=272, Evalue=2e-73,
Organism=Saccharomyces cerevisiae, GI6324758, Length=385, Percent_Identity=39.7402597402597, Blast_Score=254, Evalue=1e-68,
Organism=Drosophila melanogaster, GI21356589, Length=363, Percent_Identity=44.9035812672176, Blast_Score=308, Evalue=4e-84,

Paralogues:

None

Copy number: 2500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): SERC_PASMU (P57881)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_245774.1
- ProteinModelPortal:   P57881
- SMR:   P57881
- GeneID:   1244184
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM0837
- NMPDR:   fig|272843.1.peg.837
- HOGENOM:   HBG289982
- OMA:   TFAWYLA
- ProtClustDB:   PRK05355
- BioCyc:   PMUL272843:PM0837-MONOMER
- BRENDA:   2.6.1.52
- GO:   GO:0005737
- HAMAP:   MF_00160
- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR022278
- InterPro:   IPR003248
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PIRSF:   PIRSF000525
- TIGRFAMs:   TIGR01364

Pfam domain/function: PF00266 Aminotran_5; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.52

Molecular weight: Translated: 40059; Mature: 39928

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: BINDING 42-42 BINDING 102-102 BINDING 152-152 BINDING 172-172 BINDING 195-195

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKVFNFSAGPAMMPEAVLAQAQAELLNWQEQQTSVMEVSHRGKLFMALASQSELDLRQL
CCCEECCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEECCCCCCCHHHH
YQIPDNYRILFLQGGARGQFAAIPMNLLKEKGKALYLTSGHWSATAAKEARLFGDIDEVN
HCCCCCCEEEEEECCCCCCEEECCHHHHHCCCCEEEEECCCCCCHHHHHHHHHCCCCHHH
ILEEGNELKIGQLDFSHIADQYDYVHYCPNETISGVEIFDLPKVGNAVLVADMSSNILSR
EEECCCEEEEECCCHHHHHHHCCEEEECCCCCCCCEEEEECCCCCCEEEEEECCCCHHHH
KIDISQFGLIYAGAQKNLGPAGITLVIVREDLIGHARQTTPTIWNYEIQSKADSMINTPP
CCCHHHCCEEEECCCCCCCCCCEEEEEEECHHHCCCCCCCCCEEEEEHHHHHCHHCCCCC
TFAWYLCALVFKHLLSLGGIEEIEKRNQAKAQLLYDYLESTPFYRNPVAKVNRSRMNVTF
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCEEEEEE
TTDNDELNAKFVAEATAAGLHALKGHKVLGGMRASIYNAMPMEGVQALIAFMKQFEAENR
ECCCCCCCCEEEHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SKVFNFSAGPAMMPEAVLAQAQAELLNWQEQQTSVMEVSHRGKLFMALASQSELDLRQL
CCEECCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEECCCCCCCHHHH
YQIPDNYRILFLQGGARGQFAAIPMNLLKEKGKALYLTSGHWSATAAKEARLFGDIDEVN
HCCCCCCEEEEEECCCCCCEEECCHHHHHCCCCEEEEECCCCCCHHHHHHHHHCCCCHHH
ILEEGNELKIGQLDFSHIADQYDYVHYCPNETISGVEIFDLPKVGNAVLVADMSSNILSR
EEECCCEEEEECCCHHHHHHHCCEEEECCCCCCCCEEEEECCCCCCEEEEEECCCCHHHH
KIDISQFGLIYAGAQKNLGPAGITLVIVREDLIGHARQTTPTIWNYEIQSKADSMINTPP
CCCHHHCCEEEECCCCCCCCCCEEEEEEECHHHCCCCCCCCCEEEEEHHHHHCHHCCCCC
TFAWYLCALVFKHLLSLGGIEEIEKRNQAKAQLLYDYLESTPFYRNPVAKVNRSRMNVTF
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCEEEEEE
TTDNDELNAKFVAEATAAGLHALKGHKVLGGMRASIYNAMPMEGVQALIAFMKQFEAENR
ECCCCCCCCEEEHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11248100