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The map label for this gene is ptnC [H]

Identifier: 15602698

GI number: 15602698

Start: 982686

End: 983489

Strand: Reverse

Name: ptnC [H]

Synonym: PM0833

Alternate gene names: 15602698

Gene position: 983489-982686 (Counterclockwise)

Preceding gene: 15602699

Following gene: 15602697

Centisome position: 43.57

GC content: 43.53

Gene sequence:

>804_bases
ATGGAAATTTCAACTTTACAAATTGTACTTGTCTTTCTCGTTGCTTGTGTATCAGGAATGGGATCGATTTTGGATGAATG
GCAAACACACCGTCCGTTGATTGCTTGTACGTTAATTGGTCTTGTCTTAGGTGACATTAAGACGGGTATCATTGTTGGTG
GTACGCTTGAATTGTTAGCCTTAGGCTGGATGAATATCGGAGCAGCATTAGCGCCAGATGCGGCGTTGGCTTCTGTTGTA
TCGACTATTCTGGTTATTGTCGGTGGTCAAGATATTTCAACTGGTATTGCGATTGCGATTCCATTGGCGGCAGCCGGTCA
AGTCTTAACTTATGTTGTCCGTGCGATTACGGTTGGTTTCCAACATGCCGCGGATAATGTTGTTGAGAGCGGTGATCTGA
ATAAATTAGATTGGATTCACCGTTCCGCTTTGTTATTACAAGCTATGCGTATTGCAATCCCTGCATTAATTGTTGCCATG
ACGGCGGGAACAGATACGGTTCAAACTATGTTAAGTGCGATTCCTGATGTGGTGACGACCGGGCTTAAAATAGCGGGTGG
ATTCATTGCTGTCGTGGGTTACGCAATGGTGATCAATATGATGCGTGCAGGGCATTTAATGCCATTCTTCTATGCAGGTT
TTGTGATTGCTGCCTTTACGGAATTTAACTTAGTGGCATTAGGGGTATTAGGCGCGATCATGGCGGTGCTTTATATTCAG
CTTCACCCGAAATACAACCAAAGTAAGCAAGTGGTACAAGTGGTGAGCAATGGTAACAATGATCTTGATAACAGATTAGA
TTAA

Upstream 100 bases:

>100_bases
GCTTGATGTGCGTAAAGTCTCAAATGATAGCCGTCAGTATATGATGGATTTATTAAAGAAAAATAATCTCATCTAATGAT
ATTAAGAAAAGGAAATTAGA

Downstream 100 bases:

>100_bases
TAGGAATTACAACAATGACAACTGAAATGAAAAAAGTAACGCAAAGCGATTTAAATGCAGTAGTACGTCGTTCTAATCTT
TTCCAAGGGTCTTGGAACTT

Product: PtnC

Products: protein histidine; sugar phosphate; D-glucosamine-6-phosphate [Cytoplasm]; pyruvate; glucose-6-phosphate [Cytoplasm]; N-acetyl-D-glucosamine-6-phosphate [Cytoplasm]; mannose-6-phosphate [Cytoplasm]; fructose-6-phosphate [Cytoplasm] [C]

Alternate protein names: EII-P-Man; EIIC-Man; PTS system mannose-specific EIIC component [H]

Number of amino acids: Translated: 267; Mature: 267

Protein sequence:

>267_residues
MEISTLQIVLVFLVACVSGMGSILDEWQTHRPLIACTLIGLVLGDIKTGIIVGGTLELLALGWMNIGAALAPDAALASVV
STILVIVGGQDISTGIAIAIPLAAAGQVLTYVVRAITVGFQHAADNVVESGDLNKLDWIHRSALLLQAMRIAIPALIVAM
TAGTDTVQTMLSAIPDVVTTGLKIAGGFIAVVGYAMVINMMRAGHLMPFFYAGFVIAAFTEFNLVALGVLGAIMAVLYIQ
LHPKYNQSKQVVQVVSNGNNDLDNRLD

Sequences:

>Translated_267_residues
MEISTLQIVLVFLVACVSGMGSILDEWQTHRPLIACTLIGLVLGDIKTGIIVGGTLELLALGWMNIGAALAPDAALASVV
STILVIVGGQDISTGIAIAIPLAAAGQVLTYVVRAITVGFQHAADNVVESGDLNKLDWIHRSALLLQAMRIAIPALIVAM
TAGTDTVQTMLSAIPDVVTTGLKIAGGFIAVVGYAMVINMMRAGHLMPFFYAGFVIAAFTEFNLVALGVLGAIMAVLYIQ
LHPKYNQSKQVVQVVSNGNNDLDNRLD
>Mature_267_residues
MEISTLQIVLVFLVACVSGMGSILDEWQTHRPLIACTLIGLVLGDIKTGIIVGGTLELLALGWMNIGAALAPDAALASVV
STILVIVGGQDISTGIAIAIPLAAAGQVLTYVVRAITVGFQHAADNVVESGDLNKLDWIHRSALLLQAMRIAIPALIVAM
TAGTDTVQTMLSAIPDVVTTGLKIAGGFIAVVGYAMVINMMRAGHLMPFFYAGFVIAAFTEFNLVALGVLGAIMAVLYIQ
LHPKYNQSKQVVQVVSNGNNDLDNRLD

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system i

COG id: COG3715

COG function: function code G; Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-4 domain [H]

Homologues:

Organism=Escherichia coli, GI1788121, Length=267, Percent_Identity=73.0337078651685, Blast_Score=355, Evalue=1e-99,
Organism=Escherichia coli, GI1789528, Length=266, Percent_Identity=29.6992481203008, Blast_Score=107, Evalue=8e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004700
- InterPro:   IPR018404 [H]

Pfam domain/function: PF03609 EII-Sor [H]

EC number: NA

Molecular weight: Translated: 28022; Mature: 28022

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS51106 PTS_EIIC_TYPE_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEISTLQIVLVFLVACVSGMGSILDEWQTHRPLIACTLIGLVLGDIKTGIIVGGTLELLA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCEEECCHHHHHH
LGWMNIGAALAPDAALASVVSTILVIVGGQDISTGIAIAIPLAAAGQVLTYVVRAITVGF
HHHHHCCCHHCCHHHHHHHHHHHHHHCCCCCCCCCHHEEEHHHHHHHHHHHHHHHHHHHH
QHAADNVVESGDLNKLDWIHRSALLLQAMRIAIPALIVAMTAGTDTVQTMLSAIPDVVTT
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
GLKIAGGFIAVVGYAMVINMMRAGHLMPFFYAGFVIAAFTEFNLVALGVLGAIMAVLYIQ
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LHPKYNQSKQVVQVVSNGNNDLDNRLD
CCCCCCHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MEISTLQIVLVFLVACVSGMGSILDEWQTHRPLIACTLIGLVLGDIKTGIIVGGTLELLA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCEEECCHHHHHH
LGWMNIGAALAPDAALASVVSTILVIVGGQDISTGIAIAIPLAAAGQVLTYVVRAITVGF
HHHHHCCCHHCCHHHHHHHHHHHHHHCCCCCCCCCHHEEEHHHHHHHHHHHHHHHHHHHH
QHAADNVVESGDLNKLDWIHRSALLLQAMRIAIPALIVAMTAGTDTVQTMLSAIPDVVTT
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
GLKIAGGFIAVVGYAMVINMMRAGHLMPFFYAGFVIAAFTEFNLVALGVLGAIMAVLYIQ
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LHPKYNQSKQVVQVVSNGNNDLDNRLD
CCCCCCHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: protein N p -phosphohistidine; sugar; phosphoenolpyruvate; glucosamine [Periplasm]; phosphoenolpyruvate; beta-D-glucose [Periplasm]; N-acetyl-D-glucosamine [Periplasm]; mannose [Periplasm]; fructose [Periplasm] [C]

Specific reaction: protein N p -phosphohistidine + sugar = protein histidine + sugar phosphate phosphoenolpyruvate + glucosamine [Periplasm] = D-glucosamine-6-phosphate [Cytoplasm] + pyruvate phosphoenolpyruvate + beta-D-glucose [Periplasm] = glucose-6-phosphate [Cytoplasm]

General reaction: Transferring phosphorus-containing groups; Phosphotransferases with an alcohol group as acceptor [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]