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The map label for this gene is pmi [H]

Identifier: 15602694

GI number: 15602694

Start: 978551

End: 979753

Strand: Reverse

Name: pmi [H]

Synonym: PM0829

Alternate gene names: 15602694

Gene position: 979753-978551 (Counterclockwise)

Preceding gene: 15602695

Following gene: 15602691

Centisome position: 43.4

GC content: 40.57

Gene sequence:

>1203_bases
ATGGGAATTTATCAATTAACAGGTCGTTTACAGCATTACGTTTGGGGTGGGAAAGACTATTTACCTGCCTTACTTGGGAT
GAAAAAAGAAACAGAACAGTATTATGCAGAGTGGTGGTTAGGTGCACATGTGTCAGCACCGTCCATGCTTGATGTTGAGG
GCAAAGAAACGTCGTTAGCTACATTTTTAGCTCAAAAACCAACCGCACTTGGCGACAAGAGCCTGTCCCAGTTTGGTTCA
GAATTGCCTTATTTATTAAAGATTTTAGATGTGGCAAAACCCTTGTCTATTCAATTACATCCGACAAAAAAACAGGCAGA
GATCGGATTTGCGCAAGAGAATGCGCAAGGCATTGCCTTAACAAGTCCCATTCGTACTTATAAAGACAATAATCACAAGC
CAGAAATGATGATTGCATTATCCGATTTTTGGTTATTACATGGGTTTAAAACGAAACAGACTATGCTTGCAACCTTAAAT
GCACGTCCTTCTTTACAAGGACTGGCAACGAAGCTTGTACAACAAGATATGCATGCTTTTTATGCTGACATTATGCAAGC
AGATCAAGAACAGTTATCTCAATGGTTATTGCCGATTATAGAAGAAAATAAAGCGAAATATGCCGCGAATCAACTTGAGC
TGAGCAATCCAGATTATTGGGTTCTTTATACGATGGAGGCGATGGGGATTGCACCGTCAAAATTGGATGCAGGTCTTGTT
TGCTTTTATTTATTTAATATTGTGCACTTACGCGAAGGCGAGGGCATTTTCCAAGATGCGGGTATTCCTCATGCGTATTT
ACGTGGACAAAATATTGAATTAATGGCGTGTTCAGATAATGTGATTCGCGGTGGGTTAACCCCAAAACATGTGGATATCC
AAGCCTTGCTAGCGATTATTGATTGTCGTGAAGTGGTACCTGAGATTATTCCAGTGGCACCAGCACAACAGGCTTATTTT
ACTTACCATACTCCTGCTAAAGATTTTGCGCTTACTCGATTTAACTATTGTCAAGGACAAACACAGTCCTGCCAGGCACA
AAGTGCACAAATTTTGTTAGTGATGAAAGGAAAGCTTACCCTGTCTCAAGGCACGCAGGTACTTGAATTAAAACAGGGTG
AATCAGCTTTTATTGAAAGTGAAACTAGCTATCAAATCACAGGTTTGGAAGAGGGCTATTGTGTCATTTCTGCACTGCCT
TAA

Upstream 100 bases:

>100_bases
ACATGAAAAATGGGAAACGTTTGTTAGTGCATTTGTTGACAGATCAAGATCGTGAACAGGTTATTCAATTTTTTGGTGGT
TATAAATAACAGGGGAATAT

Downstream 100 bases:

>100_bases
GTAAAAAAGCGAAAAGAGAAAAAGGCTAACGTAGTTAGCCTTTTTTATTTTGTAGCGCTTGAATCAAGATTTTGGAACGA
CGTTGATAATTATAGTGTTG

Product: Pmi

Products: NA

Alternate protein names: Phosphohexomutase; Phosphomannose isomerase; PMI [H]

Number of amino acids: Translated: 400; Mature: 399

Protein sequence:

>400_residues
MGIYQLTGRLQHYVWGGKDYLPALLGMKKETEQYYAEWWLGAHVSAPSMLDVEGKETSLATFLAQKPTALGDKSLSQFGS
ELPYLLKILDVAKPLSIQLHPTKKQAEIGFAQENAQGIALTSPIRTYKDNNHKPEMMIALSDFWLLHGFKTKQTMLATLN
ARPSLQGLATKLVQQDMHAFYADIMQADQEQLSQWLLPIIEENKAKYAANQLELSNPDYWVLYTMEAMGIAPSKLDAGLV
CFYLFNIVHLREGEGIFQDAGIPHAYLRGQNIELMACSDNVIRGGLTPKHVDIQALLAIIDCREVVPEIIPVAPAQQAYF
TYHTPAKDFALTRFNYCQGQTQSCQAQSAQILLVMKGKLTLSQGTQVLELKQGESAFIESETSYQITGLEEGYCVISALP

Sequences:

>Translated_400_residues
MGIYQLTGRLQHYVWGGKDYLPALLGMKKETEQYYAEWWLGAHVSAPSMLDVEGKETSLATFLAQKPTALGDKSLSQFGS
ELPYLLKILDVAKPLSIQLHPTKKQAEIGFAQENAQGIALTSPIRTYKDNNHKPEMMIALSDFWLLHGFKTKQTMLATLN
ARPSLQGLATKLVQQDMHAFYADIMQADQEQLSQWLLPIIEENKAKYAANQLELSNPDYWVLYTMEAMGIAPSKLDAGLV
CFYLFNIVHLREGEGIFQDAGIPHAYLRGQNIELMACSDNVIRGGLTPKHVDIQALLAIIDCREVVPEIIPVAPAQQAYF
TYHTPAKDFALTRFNYCQGQTQSCQAQSAQILLVMKGKLTLSQGTQVLELKQGESAFIESETSYQITGLEEGYCVISALP
>Mature_399_residues
GIYQLTGRLQHYVWGGKDYLPALLGMKKETEQYYAEWWLGAHVSAPSMLDVEGKETSLATFLAQKPTALGDKSLSQFGSE
LPYLLKILDVAKPLSIQLHPTKKQAEIGFAQENAQGIALTSPIRTYKDNNHKPEMMIALSDFWLLHGFKTKQTMLATLNA
RPSLQGLATKLVQQDMHAFYADIMQADQEQLSQWLLPIIEENKAKYAANQLELSNPDYWVLYTMEAMGIAPSKLDAGLVC
FYLFNIVHLREGEGIFQDAGIPHAYLRGQNIELMACSDNVIRGGLTPKHVDIQALLAIIDCREVVPEIIPVAPAQQAYFT
YHTPAKDFALTRFNYCQGQTQSCQAQSAQILLVMKGKLTLSQGTQVLELKQGESAFIESETSYQITGLEEGYCVISALP

Specific function: Involved in the conversion of glucose to GDP-L-fucose, which can be converted to L-fucose, a capsular polysaccharide [H]

COG id: COG1482

COG function: function code G; Phosphomannose isomerase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 1 family [H]

Homologues:

Organism=Homo sapiens, GI4505235, Length=417, Percent_Identity=29.2565947242206, Blast_Score=157, Evalue=2e-38,
Organism=Escherichia coli, GI1787899, Length=386, Percent_Identity=36.5284974093264, Blast_Score=213, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI71997620, Length=400, Percent_Identity=28, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17557650, Length=430, Percent_Identity=26.7441860465116, Blast_Score=126, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6320839, Length=440, Percent_Identity=27.2727272727273, Blast_Score=144, Evalue=2e-35,
Organism=Drosophila melanogaster, GI21356061, Length=413, Percent_Identity=29.7820823244552, Blast_Score=144, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR001250
- InterPro:   IPR016305
- InterPro:   IPR018050
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01238 PMI_typeI [H]

EC number: =5.3.1.8 [H]

Molecular weight: Translated: 44585; Mature: 44454

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS00965 PMI_I_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIYQLTGRLQHYVWGGKDYLPALLGMKKETEQYYAEWWLGAHVSAPSMLDVEGKETSLA
CCHHHHHHHHHHEECCCCHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCEEECCCCCHHHH
TFLAQKPTALGDKSLSQFGSELPYLLKILDVAKPLSIQLHPTKKQAEIGFAQENAQGIAL
HHHHCCCCCCCHHHHHHHCCCCHHHHHHHHHCCCCEEEECCCCCHHHCCEECCCCCCEEE
TSPIRTYKDNNHKPEMMIALSDFWLLHGFKTKQTMLATLNARPSLQGLATKLVQQDMHAF
ECCHHHHCCCCCCCEEEEEEEHHHHHCCCCCHHEEEEEECCCCCHHHHHHHHHHHHHHHH
YADIMQADQEQLSQWLLPIIEENKAKYAANQLELSNPDYWVLYTMEAMGIAPSKLDAGLV
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHCEEECCCCCEEEEEEEEHHCCCCCHHCHHHH
CFYLFNIVHLREGEGIFQDAGIPHAYLRGQNIELMACSDNVIRGGLTPKHVDIQALLAII
HHHHHHHHEEECCCCCCCCCCCCHHHCCCCCEEEEEECCCEEECCCCCCCCHHHHHHHHH
DCREVVPEIIPVAPAQQAYFTYHTPAKDFALTRFNYCQGQTQSCQAQSAQILLVMKGKLT
HHHHHHHHHHCCCCCCCCEEEEECCCHHHHEEEEHHCCCCCCCCCCCCCEEEEEEECEEE
LSQGTQVLELKQGESAFIESETSYQITGLEEGYCVISALP
ECCCCEEEEECCCCCEEEECCCCEEEEECCCCEEEEEECC
>Mature Secondary Structure 
GIYQLTGRLQHYVWGGKDYLPALLGMKKETEQYYAEWWLGAHVSAPSMLDVEGKETSLA
CHHHHHHHHHHEECCCCHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCEEECCCCCHHHH
TFLAQKPTALGDKSLSQFGSELPYLLKILDVAKPLSIQLHPTKKQAEIGFAQENAQGIAL
HHHHCCCCCCCHHHHHHHCCCCHHHHHHHHHCCCCEEEECCCCCHHHCCEECCCCCCEEE
TSPIRTYKDNNHKPEMMIALSDFWLLHGFKTKQTMLATLNARPSLQGLATKLVQQDMHAF
ECCHHHHCCCCCCCEEEEEEEHHHHHCCCCCHHEEEEEECCCCCHHHHHHHHHHHHHHHH
YADIMQADQEQLSQWLLPIIEENKAKYAANQLELSNPDYWVLYTMEAMGIAPSKLDAGLV
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHCEEECCCCCEEEEEEEEHHCCCCCHHCHHHH
CFYLFNIVHLREGEGIFQDAGIPHAYLRGQNIELMACSDNVIRGGLTPKHVDIQALLAII
HHHHHHHHEEECCCCCCCCCCCCHHHCCCCCEEEEEECCCEEECCCCCCCCHHHHHHHHH
DCREVVPEIIPVAPAQQAYFTYHTPAKDFALTRFNYCQGQTQSCQAQSAQILLVMKGKLT
HHHHHHHHHHCCCCCCCCEEEEECCCHHHHEEEEHHCCCCCCCCCCCCCEEEEEEECEEE
LSQGTQVLELKQGESAFIESETSYQITGLEEGYCVISALP
ECCCCEEEEECCCCCEEEECCCCEEEEECCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6397402; 9097039; 9278503 [H]