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The map label for this gene is grxA [H]

Identifier: 15602692

GI number: 15602692

Start: 976808

End: 977071

Strand: Direct

Name: grxA [H]

Synonym: PM0827

Alternate gene names: 15602692

Gene position: 976808-977071 (Clockwise)

Preceding gene: 15602689

Following gene: 15602693

Centisome position: 43.27

GC content: 40.15

Gene sequence:

>264_bases
ATGTTCGTCGTCATCTTTGGGCGCGCAGGTTGCCCGTATTGTGTACGTGCTAAAAACTTAGCCGACAAATTAAAACAAAG
CTTACCAGATTTCGATTATCGCTATGTCGATATCGTTGCAGAAGGCATTTCTAAAGCGGATTTATCCAAATCAGTTGGGA
AACCCGTTGAAACCGTACCACAAATTTTTATTGATGAAAAACCGATTGGTGGCTGTACAGATTTTGAAGCCTTAATGAAG
GCACAATTCAATATTGTTGCGTAA

Upstream 100 bases:

>100_bases
AGGCTGAAAAATACTTTATTCTTTTTCTTTGTATGAGGTAAAATGTGTTCCGTTTTGATCGCTATCAGATCATTTTTTTC
ATTCAAACAAGGAAATATGT

Downstream 100 bases:

>100_bases
TGCAACGCCAAAAATGCGATGAACACCTCATCGCATTTTTTATTGCACCAAAATTCTGCTTGCATAAGATAATAAATGAA
TATAAATTCAGTAAAAATGA

Product: glutaredoxin 1

Products: deoxyribonucleotides [C]

Alternate protein names: NA

Number of amino acids: Translated: 87; Mature: 87

Protein sequence:

>87_residues
MFVVIFGRAGCPYCVRAKNLADKLKQSLPDFDYRYVDIVAEGISKADLSKSVGKPVETVPQIFIDEKPIGGCTDFEALMK
AQFNIVA

Sequences:

>Translated_87_residues
MFVVIFGRAGCPYCVRAKNLADKLKQSLPDFDYRYVDIVAEGISKADLSKSVGKPVETVPQIFIDEKPIGGCTDFEALMK
AQFNIVA
>Mature_87_residues
MFVVIFGRAGCPYCVRAKNLADKLKQSLPDFDYRYVDIVAEGISKADLSKSVGKPVETVPQIFIDEKPIGGCTDFEALMK
AQFNIVA

Specific function: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins [H]

COG id: COG0695

COG function: function code O; Glutaredoxin and related proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutaredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1787073, Length=84, Percent_Identity=63.0952380952381, Blast_Score=116, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011767
- InterPro:   IPR002109
- InterPro:   IPR014025
- InterPro:   IPR011902
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00462 Glutaredoxin [H]

EC number: NA

Molecular weight: Translated: 9588; Mature: 9588

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: PS00195 GLUTAREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFVVIFGRAGCPYCVRAKNLADKLKQSLPDFDYRYVDIVAEGISKADLSKSVGKPVETVP
CEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHCCCCHHHHH
QIFIDEKPIGGCTDFEALMKAQFNIVA
HHHCCCCCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MFVVIFGRAGCPYCVRAKNLADKLKQSLPDFDYRYVDIVAEGISKADLSKSVGKPVETVP
CEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHCCCCHHHHH
QIFIDEKPIGGCTDFEALMKAQFNIVA
HHHCCCCCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ribonucleotides [C]

Specific reaction: ribonucleotides = deoxyribonucleotides [C]

General reaction: deoxyribonucleotide biosynthesis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]