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The map label for this gene is fumC [H]

Identifier: 15602688

GI number: 15602688

Start: 973036

End: 974430

Strand: Direct

Name: fumC [H]

Synonym: PM0823

Alternate gene names: 15602688

Gene position: 973036-974430 (Clockwise)

Preceding gene: 15602682

Following gene: 15602689

Centisome position: 43.1

GC content: 40.93

Gene sequence:

>1395_bases
ATGACATTTCGTATCGAAAAAGACACTATGGGTGAAGTACAAGTTCCTGCCGATAAATATTGGGCAGCACAGACTGAACG
CTCACGCAATAATTTCAAAATTGGACCTGAAGCCTCTATGCCAAAAGAGATTATTGAAGCCTTTGGTTATTTAAAAAAAG
CAGCCGCTTATGCTAACCATGATTTAGGTGTATTACCAGTGGAAAAACGGGATTTAATTGCACAGGCTTGTGATGAGATC
CTCGCTAATAAATTAGATGATCAATTTCCTCTCGTCATTTGGCAAACCGGTTCCGGTACACAATCCAATATGAACCTTAA
CGAAGTCATTTCAAACCGTGCCCATGTTTTAAATGGTGGTAAATTAGGTGAAAAATCCATTATCCATCCAAATGACGATG
TGAACAAATCTCAATCTTCAAACGATACTTACCCAACAGCAATGCACATCGCGGCGTATAAAAAAGTCGTTGAAGTCACT
ATTCCTTGTGTAGAACGTTTACAAAAAACCTTAGCGCAAAAAGCAGACGCCTTTAAAGATGTGGTGAAAATTGGGCGTAC
TCACTTAATGGATGCGACACCATTAACCTTAGGTCAAGAATTCTCTGCTTATGCTGCCCAATTAGATTTTGGCTTACGCG
CATTGAAAAACACGCTGCCACATTTAGCACAATTAGCGCTAGGCGGTACTGCAGTGGGTACAGGTTTAAATACACCGAAA
GGTTATGATGTGAAAGTGGCAGACTACATTGCAAAATTTACAGGCTTGCCATTTATCACCGCTGAAAATAAATTTGAAGC
GTTAGCCACCCATGATGCCGTTGTGGAAACGCACGGCGCATTAAAACAATTAGCGGTATCCTTATACAAAATCGCAAATG
ATATCCGTTTATTAGCCTCTGGACCACGTTCTGGTATTGGTGAAATTTTAATTCCTGAAAATGAGCCGGGCTCTTCTATC
ATGCCAGGTAAAGTTAACCCAACCCAATGTGAAGCCATGACGATGGTATGCGCGCAAGTACTCGGTAATGACACCACCAT
TTCCTTTGCAGGTACACAAGGTCATTTCCAATTGAACGTATTTAAACCAGTGATGGCGGCTAACTTCTTACAATCTGCTC
AATTATTGGCGGATGCTTGTGTGTCCTTCGATGAACATTGTGCAGTCGGTATTGAACCAAACTTCCCTCGCATCAAAAAA
CAACTTGATGACTCATTAATGTTAGTGACCGCCTTAAATACACATATCGGTTACGAAAATGCGGCGAAAATCGCGAAAAC
CGCACACAAAAATGGGACAACATTAAAAGAAGAAGCAATCAACTTAGGCTTAGTTACAGCTGAACAATTTGATGAATGGG
TACGTCCAGAAGATATGGTCGGTAGCTTAAAGTAA

Upstream 100 bases:

>100_bases
AAAACTCAGTTTTGCTTCTTGGGATTGATTCCACATCTAACCCGCAAGTGTTAGAATCTTCCCATTCATTTTCTTCATAT
TTAAACAAAGAGGTAACACT

Downstream 100 bases:

>100_bases
TTTAAGTAAAACACAGCAAGGCGAACGTAAAGTTCGCCTTTTTTTTCTTTGTTTTGTTATAATCAGCCCCATCAACTTTT
TGTAATAGGTTTATGATGAA

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MTFRIEKDTMGEVQVPADKYWAAQTERSRNNFKIGPEASMPKEIIEAFGYLKKAAAYANHDLGVLPVEKRDLIAQACDEI
LANKLDDQFPLVIWQTGSGTQSNMNLNEVISNRAHVLNGGKLGEKSIIHPNDDVNKSQSSNDTYPTAMHIAAYKKVVEVT
IPCVERLQKTLAQKADAFKDVVKIGRTHLMDATPLTLGQEFSAYAAQLDFGLRALKNTLPHLAQLALGGTAVGTGLNTPK
GYDVKVADYIAKFTGLPFITAENKFEALATHDAVVETHGALKQLAVSLYKIANDIRLLASGPRSGIGEILIPENEPGSSI
MPGKVNPTQCEAMTMVCAQVLGNDTTISFAGTQGHFQLNVFKPVMAANFLQSAQLLADACVSFDEHCAVGIEPNFPRIKK
QLDDSLMLVTALNTHIGYENAAKIAKTAHKNGTTLKEEAINLGLVTAEQFDEWVRPEDMVGSLK

Sequences:

>Translated_464_residues
MTFRIEKDTMGEVQVPADKYWAAQTERSRNNFKIGPEASMPKEIIEAFGYLKKAAAYANHDLGVLPVEKRDLIAQACDEI
LANKLDDQFPLVIWQTGSGTQSNMNLNEVISNRAHVLNGGKLGEKSIIHPNDDVNKSQSSNDTYPTAMHIAAYKKVVEVT
IPCVERLQKTLAQKADAFKDVVKIGRTHLMDATPLTLGQEFSAYAAQLDFGLRALKNTLPHLAQLALGGTAVGTGLNTPK
GYDVKVADYIAKFTGLPFITAENKFEALATHDAVVETHGALKQLAVSLYKIANDIRLLASGPRSGIGEILIPENEPGSSI
MPGKVNPTQCEAMTMVCAQVLGNDTTISFAGTQGHFQLNVFKPVMAANFLQSAQLLADACVSFDEHCAVGIEPNFPRIKK
QLDDSLMLVTALNTHIGYENAAKIAKTAHKNGTTLKEEAINLGLVTAEQFDEWVRPEDMVGSLK
>Mature_463_residues
TFRIEKDTMGEVQVPADKYWAAQTERSRNNFKIGPEASMPKEIIEAFGYLKKAAAYANHDLGVLPVEKRDLIAQACDEIL
ANKLDDQFPLVIWQTGSGTQSNMNLNEVISNRAHVLNGGKLGEKSIIHPNDDVNKSQSSNDTYPTAMHIAAYKKVVEVTI
PCVERLQKTLAQKADAFKDVVKIGRTHLMDATPLTLGQEFSAYAAQLDFGLRALKNTLPHLAQLALGGTAVGTGLNTPKG
YDVKVADYIAKFTGLPFITAENKFEALATHDAVVETHGALKQLAVSLYKIANDIRLLASGPRSGIGEILIPENEPGSSIM
PGKVNPTQCEAMTMVCAQVLGNDTTISFAGTQGHFQLNVFKPVMAANFLQSAQLLADACVSFDEHCAVGIEPNFPRIKKQ
LDDSLMLVTALNTHIGYENAAKIAKTAHKNGTTLKEEAINLGLVTAEQFDEWVRPEDMVGSLK

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=461, Percent_Identity=62.6898047722343, Blast_Score=585, Evalue=1e-167,
Organism=Homo sapiens, GI266458395, Length=87, Percent_Identity=47.1264367816092, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1787896, Length=463, Percent_Identity=62.8509719222462, Blast_Score=587, Evalue=1e-169,
Organism=Escherichia coli, GI87082375, Length=461, Percent_Identity=41.2147505422993, Blast_Score=349, Evalue=2e-97,
Organism=Caenorhabditis elegans, GI17553882, Length=460, Percent_Identity=63.4782608695652, Blast_Score=602, Evalue=1e-172,
Organism=Caenorhabditis elegans, GI32565146, Length=325, Percent_Identity=64.3076923076923, Blast_Score=441, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6324993, Length=461, Percent_Identity=60.3036876355748, Blast_Score=558, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24640177, Length=461, Percent_Identity=60.7375271149675, Blast_Score=575, Evalue=1e-164,
Organism=Drosophila melanogaster, GI24640179, Length=461, Percent_Identity=60.7375271149675, Blast_Score=574, Evalue=1e-164,
Organism=Drosophila melanogaster, GI78710009, Length=462, Percent_Identity=60.6060606060606, Blast_Score=570, Evalue=1e-162,
Organism=Drosophila melanogaster, GI24662684, Length=461, Percent_Identity=58.7852494577007, Blast_Score=554, Evalue=1e-158,
Organism=Drosophila melanogaster, GI24583245, Length=461, Percent_Identity=50.7592190889371, Blast_Score=464, Evalue=1e-131,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 50419; Mature: 50288

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFRIEKDTMGEVQVPADKYWAAQTERSRNNFKIGPEASMPKEIIEAFGYLKKAAAYANH
CCEEECCCCCCCEECCHHHHHHHHHHCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHCCC
DLGVLPVEKRDLIAQACDEILANKLDDQFPLVIWQTGSGTQSNMNLNEVISNRAHVLNGG
CCCEECCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHCCCCEEECCC
KLGEKSIIHPNDDVNKSQSSNDTYPTAMHIAAYKKVVEVTIPCVERLQKTLAQKADAFKD
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVKIGRTHLMDATPLTLGQEFSAYAAQLDFGLRALKNTLPHLAQLALGGTAVGTGLNTPK
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCC
GYDVKVADYIAKFTGLPFITAENKFEALATHDAVVETHGALKQLAVSLYKIANDIRLLAS
CCCCHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEC
GPRSGIGEILIPENEPGSSIMPGKVNPTQCEAMTMVCAQVLGNDTTISFAGTQGHFQLNV
CCCCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEE
FKPVMAANFLQSAQLLADACVSFDEHCAVGIEPNFPRIKKQLDDSLMLVTALNTHIGYEN
HHHHHHHHHHHHHHHHHHHHHCCHHCEEECCCCCCHHHHHHCCCCEEEEEHHHHHCCCHH
AAKIAKTAHKNGTTLKEEAINLGLVTAEQFDEWVRPEDMVGSLK
HHHHHHHHCCCCCCHHHHHHHCCEEEHHHHHHHCCCHHHHCCCC
>Mature Secondary Structure 
TFRIEKDTMGEVQVPADKYWAAQTERSRNNFKIGPEASMPKEIIEAFGYLKKAAAYANH
CEEECCCCCCCEECCHHHHHHHHHHCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHCCC
DLGVLPVEKRDLIAQACDEILANKLDDQFPLVIWQTGSGTQSNMNLNEVISNRAHVLNGG
CCCEECCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHCCCCEEECCC
KLGEKSIIHPNDDVNKSQSSNDTYPTAMHIAAYKKVVEVTIPCVERLQKTLAQKADAFKD
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVKIGRTHLMDATPLTLGQEFSAYAAQLDFGLRALKNTLPHLAQLALGGTAVGTGLNTPK
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCC
GYDVKVADYIAKFTGLPFITAENKFEALATHDAVVETHGALKQLAVSLYKIANDIRLLAS
CCCCHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEC
GPRSGIGEILIPENEPGSSIMPGKVNPTQCEAMTMVCAQVLGNDTTISFAGTQGHFQLNV
CCCCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEE
FKPVMAANFLQSAQLLADACVSFDEHCAVGIEPNFPRIKKQLDDSLMLVTALNTHIGYEN
HHHHHHHHHHHHHHHHHHHHHCCHHCEEECCCCCCHHHHHHCCCCEEEEEHHHHHCCCHH
AAKIAKTAHKNGTTLKEEAINLGLVTAEQFDEWVRPEDMVGSLK
HHHHHHHHCCCCCCHHHHHHHCCEEEHHHHHHHCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]