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The map label for this gene is hemH

Identifier: 15602680

GI number: 15602680

Start: 964167

End: 965027

Strand: Reverse

Name: hemH

Synonym: PM0815

Alternate gene names: 15602680

Gene position: 965027-964167 (Counterclockwise)

Preceding gene: 15602683

Following gene: 15602679

Centisome position: 42.75

GC content: 39.61

Gene sequence:

>861_bases
ATGACACAGCTTAGTCTTAAAAAAATCTACTCAGGTAAAGTGCGTGATCTTTATGAAATTGATGATAAACGTATGCTCAT
GGTGGCGACTGATCGTTTATCAGCCTTTGATGTGATTTTGGACGATCCGATTCCTCGTAAAGGGGAAATTTTGACGCAAA
TTTCGAATTTTTGGTTTAATCAACTCGCCCATATTATGCCGAATCATTTTACTGGTGACACCGTGTATGATGTGTTACCA
AAAGAAGAGGCGGATAAGGTAAAAGATCGGGCTGTTGTCTGCAAACGTTTGACCCCAATTAAAATTGAATCTATTGTACG
CGGTTATTTAACTGGTAGTGGTTTAAAAGATTATCAAAAAACAGGCACAATTTGTGGTTTAGCATTACCAGAAGGGCTAG
TCGAAGCCAGCAAATTACCAGAACCTATTTTTACGCCTTCCAGTAAAGCTGAGGTCGGCGATCATGATGTGAATATTAGT
TATGCCGAATGTGAGCAATTAATTGGTCCAGAACTAGCGGCACAAGTGAAAGAAAAAGCGATCGCGCTTTATCAAGCCGC
TGCAGAATATGCACTAAGCAAGGGCATTATTATTTGTGATACGAAATTTGAGTTTGGTTTAGATGAAAATGGTACACTCA
CCTTAATGGATGAAGTGTTGACGCCAGATTCAAGCCGTTTTTGGTCTGTTGAGACGTATCGAGAAGGCATTAATCCACCG
TCGTTTGATAAACAATTTATTCGTGATTGGTTAGAAACGAGCGGTTGGAATAAACAACCTCCCGCACCGAAAGTGCCTGC
GGAGGTGATTGAAAAAACCGTTAATAAATACCAAGAGGCTTTGGATTTATTAACAAAATAA

Upstream 100 bases:

>100_bases
TAGATGCAACAAAAAATGCAAACGTTTGCTTATCTTTCTACATAAAGTGCGGTACAATATGAACCGATTTTTATAATACA
AAATATAAAGGTGCAAACAG

Downstream 100 bases:

>100_bases
AGTGAAAATGGGCTTTCTTCCCTTGGCGGGGAGAAAGCTTTTTTTCAACAGCAACATTCATGAGGAGAATTATGAAATCG
GTTTCAATTGTGGGATTAGG

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase

Number of amino acids: Translated: 286; Mature: 285

Protein sequence:

>286_residues
MTQLSLKKIYSGKVRDLYEIDDKRMLMVATDRLSAFDVILDDPIPRKGEILTQISNFWFNQLAHIMPNHFTGDTVYDVLP
KEEADKVKDRAVVCKRLTPIKIESIVRGYLTGSGLKDYQKTGTICGLALPEGLVEASKLPEPIFTPSSKAEVGDHDVNIS
YAECEQLIGPELAAQVKEKAIALYQAAAEYALSKGIIICDTKFEFGLDENGTLTLMDEVLTPDSSRFWSVETYREGINPP
SFDKQFIRDWLETSGWNKQPPAPKVPAEVIEKTVNKYQEALDLLTK

Sequences:

>Translated_286_residues
MTQLSLKKIYSGKVRDLYEIDDKRMLMVATDRLSAFDVILDDPIPRKGEILTQISNFWFNQLAHIMPNHFTGDTVYDVLP
KEEADKVKDRAVVCKRLTPIKIESIVRGYLTGSGLKDYQKTGTICGLALPEGLVEASKLPEPIFTPSSKAEVGDHDVNIS
YAECEQLIGPELAAQVKEKAIALYQAAAEYALSKGIIICDTKFEFGLDENGTLTLMDEVLTPDSSRFWSVETYREGINPP
SFDKQFIRDWLETSGWNKQPPAPKVPAEVIEKTVNKYQEALDLLTK
>Mature_285_residues
TQLSLKKIYSGKVRDLYEIDDKRMLMVATDRLSAFDVILDDPIPRKGEILTQISNFWFNQLAHIMPNHFTGDTVYDVLPK
EEADKVKDRAVVCKRLTPIKIESIVRGYLTGSGLKDYQKTGTICGLALPEGLVEASKLPEPIFTPSSKAEVGDHDVNISY
AECEQLIGPELAAQVKEKAIALYQAAAEYALSKGIIICDTKFEFGLDENGTLTLMDEVLTPDSSRFWSVETYREGINPPS
FDKQFIRDWLETSGWNKQPPAPKVPAEVIEKTVNKYQEALDLLTK

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family

Homologues:

Organism=Saccharomyces cerevisiae, GI6319326, Length=287, Percent_Identity=47.7351916376307, Blast_Score=270, Evalue=3e-73,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): PUR7_PASMU (P57878)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_245752.1
- ProteinModelPortal:   P57878
- SMR:   P57878
- GeneID:   1244162
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM0815
- NMPDR:   fig|272843.1.peg.815
- HOGENOM:   HBG555040
- OMA:   LTLMDEV
- ProtClustDB:   PRK13961
- BioCyc:   PMUL272843:PM0815-MONOMER
- BRENDA:   6.3.2.6
- HAMAP:   MF_00137
- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236
- Gene3D:   G3DSA:3.30.470.20
- PANTHER:   PTHR11609
- TIGRFAMs:   TIGR00081

Pfam domain/function: PF01259 SAICAR_synt

EC number: =6.3.2.6

Molecular weight: Translated: 32093; Mature: 31962

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS01057 SAICAR_SYNTHETASE_1; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQLSLKKIYSGKVRDLYEIDDKRMLMVATDRLSAFDVILDDPIPRKGEILTQISNFWFN
CCCCHHHHHHCCCHHHHHHCCCCEEEEEECCCHHHHHHEECCCCCCCHHHHHHHHHHHHH
QLAHIMPNHFTGDTVYDVLPKEEADKVKDRAVVCKRLTPIKIESIVRGYLTGSGLKDYQK
HHHHHCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHH
TGTICGLALPEGLVEASKLPEPIFTPSSKAEVGDHDVNISYAECEQLIGPELAAQVKEKA
CCCEEEECCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCHHHHHHHHHHH
IALYQAAAEYALSKGIIICDTKFEFGLDENGTLTLMDEVLTPDSSRFWSVETYREGINPP
HHHHHHHHHHHHHCCEEEEECCEECCCCCCCCEEEEHHHHCCCCCCEEEHHHHHHCCCCC
SFDKQFIRDWLETSGWNKQPPAPKVPAEVIEKTVNKYQEALDLLTK
CCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TQLSLKKIYSGKVRDLYEIDDKRMLMVATDRLSAFDVILDDPIPRKGEILTQISNFWFN
CCCHHHHHHCCCHHHHHHCCCCEEEEEECCCHHHHHHEECCCCCCCHHHHHHHHHHHHH
QLAHIMPNHFTGDTVYDVLPKEEADKVKDRAVVCKRLTPIKIESIVRGYLTGSGLKDYQK
HHHHHCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHH
TGTICGLALPEGLVEASKLPEPIFTPSSKAEVGDHDVNISYAECEQLIGPELAAQVKEKA
CCCEEEECCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCHHHHHHHHHHH
IALYQAAAEYALSKGIIICDTKFEFGLDENGTLTLMDEVLTPDSSRFWSVETYREGINPP
HHHHHHHHHHHHHCCEEEEECCEECCCCCCCCEEEEHHHHCCCCCCEEEHHHHHHCCCCC
SFDKQFIRDWLETSGWNKQPPAPKVPAEVIEKTVNKYQEALDLLTK
CCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100