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The map label for this gene is tyrP_2 [H]

Identifier: 15602675

GI number: 15602675

Start: 958348

End: 959562

Strand: Reverse

Name: tyrP_2 [H]

Synonym: PM0810

Alternate gene names: 15602675

Gene position: 959562-958348 (Counterclockwise)

Preceding gene: 15602676

Following gene: 15602674

Centisome position: 42.51

GC content: 39.75

Gene sequence:

>1215_bases
ATGAATAAAACATTGGGAAGTACTTTGCTTGTTTCAGGTACCATGATCGGCGCAGGGATGTTAGCGATGCCCTTAACGTC
TGCGGGAATTGGTTTCACCTTTACCGTAGTTCTGTTACTTGTCCTTTGGTTCTTATTGACATACAGTGCATTGTTATTTG
TTGAAGCGTATCAAACCGTAGAAAGTGATGCGGGGATTGGTTCTCTGAGTGCGGTCTATTTTGGTGGTTTTGGTCGATTT
ATTTCTACAGCAGCATTATTGATCTTTTTATATGCCTTGTTAGCCGCGTATGTGACGGGCGGTGGTGGTTTATTGTCTTC
TATTCTACCAACAATTCAATCAGCCGAAACAACCTCTCACATTTCTATTGTCATTTTCACGACAGTTTTTGGTGCTTTCA
TTATCATTGGTACGCAAACAGTTGATGGACTAAATCGTCTTTTATTTTTTACCATGTTAGTTGCATTGGGTGCTGTATTA
TTTTTGTTAGTGCCTGAAGTAAAAATGGATAATTTAATGGCGATGCCAATTGATAAAGCCCTGTTGATTTCTGCCAGTCC
GGTCTTTTTTACTTCCTTTGGTTTTCATGGCTCAATACCTAGCTTGAATAAATACCTGGGTGGGAATATTAAGGCATTAC
GTATTTCGATTTTAGTCGGTTCATTCATTACACTGTGTGGCTATATTTTATGGCAATTTGGTACGCATGGGGTGTTAACA
CAATCTGTTTTCTTACAGATTTTACAAGATGAACCTACTTTGAACGGGCTGGTAGCCGCTACCAAACAAGTGACGGGAAG
CAGTGTCATTTCTGGTGCTGTGAAATTATTCTCGGCTTTGGCTTTAATTACTTCCTTCTTAGGGGTTGCTTTAGGGCTTT
TTGAGTGTATTGAAGACTTGTTAAGCCGCGTCTTTAAATTTAAAGCAGGTCGTATTACACTTGGGCTACTGACTTTTATT
CCACCATTATTATTTGCTTTATTTTATCCAAAAGGGTTTATTCTAGCCTTAGGGTATGCAGGACAAATGTTTGCTTTTTA
TGCGGTAGTATTACCTGCAGCATTAGTGTGGAAAGTGAGAAAATTGCATCCAAATCTCCCTTATCGTGTATCGGGTGGTT
CAGCATTACTGGTCATTTCGGCGGTATTAGGTGTGATCATTACCTCGATCCCATTTGCGATTAAAGCAGGTTATTTACCT
GCTGTCGTGGGATAA

Upstream 100 bases:

>100_bases
GCGTAATTTCTCATTAGGGCATTGCTGAAAAGCAATGTCCTACTTATTCAATATGTCTGCTGTTTTCATTATTATGGGAT
AGACAAAAAGGAGATATATT

Downstream 100 bases:

>100_bases
GTGAGTTTATTATGCTGAAAACAGCGAGAATAGTCTCGCTGTTTTCTTTTCAAATGGGGAATATGACCTTATTTATTGAA
AGGATAAGGGCTTTTTGTTA

Product: TyrP

Products: Proton [Cytoplasm]; L-tyrosine [Cytoplasm] [C]

Alternate protein names: Tyrosine permease 1 [H]

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MNKTLGSTLLVSGTMIGAGMLAMPLTSAGIGFTFTVVLLLVLWFLLTYSALLFVEAYQTVESDAGIGSLSAVYFGGFGRF
ISTAALLIFLYALLAAYVTGGGGLLSSILPTIQSAETTSHISIVIFTTVFGAFIIIGTQTVDGLNRLLFFTMLVALGAVL
FLLVPEVKMDNLMAMPIDKALLISASPVFFTSFGFHGSIPSLNKYLGGNIKALRISILVGSFITLCGYILWQFGTHGVLT
QSVFLQILQDEPTLNGLVAATKQVTGSSVISGAVKLFSALALITSFLGVALGLFECIEDLLSRVFKFKAGRITLGLLTFI
PPLLFALFYPKGFILALGYAGQMFAFYAVVLPAALVWKVRKLHPNLPYRVSGGSALLVISAVLGVIITSIPFAIKAGYLP
AVVG

Sequences:

>Translated_404_residues
MNKTLGSTLLVSGTMIGAGMLAMPLTSAGIGFTFTVVLLLVLWFLLTYSALLFVEAYQTVESDAGIGSLSAVYFGGFGRF
ISTAALLIFLYALLAAYVTGGGGLLSSILPTIQSAETTSHISIVIFTTVFGAFIIIGTQTVDGLNRLLFFTMLVALGAVL
FLLVPEVKMDNLMAMPIDKALLISASPVFFTSFGFHGSIPSLNKYLGGNIKALRISILVGSFITLCGYILWQFGTHGVLT
QSVFLQILQDEPTLNGLVAATKQVTGSSVISGAVKLFSALALITSFLGVALGLFECIEDLLSRVFKFKAGRITLGLLTFI
PPLLFALFYPKGFILALGYAGQMFAFYAVVLPAALVWKVRKLHPNLPYRVSGGSALLVISAVLGVIITSIPFAIKAGYLP
AVVG
>Mature_404_residues
MNKTLGSTLLVSGTMIGAGMLAMPLTSAGIGFTFTVVLLLVLWFLLTYSALLFVEAYQTVESDAGIGSLSAVYFGGFGRF
ISTAALLIFLYALLAAYVTGGGGLLSSILPTIQSAETTSHISIVIFTTVFGAFIIIGTQTVDGLNRLLFFTMLVALGAVL
FLLVPEVKMDNLMAMPIDKALLISASPVFFTSFGFHGSIPSLNKYLGGNIKALRISILVGSFITLCGYILWQFGTHGVLT
QSVFLQILQDEPTLNGLVAATKQVTGSSVISGAVKLFSALALITSFLGVALGLFECIEDLLSRVFKFKAGRITLGLLTFI
PPLLFALFYPKGFILALGYAGQMFAFYAVVLPAALVWKVRKLHPNLPYRVSGGSALLVISAVLGVIITSIPFAIKAGYLP
AVVG

Specific function: Involved in transporting tyrosine across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788218, Length=401, Percent_Identity=44.8877805486284, Blast_Score=338, Evalue=3e-94,
Organism=Escherichia coli, GI1790145, Length=386, Percent_Identity=29.2746113989637, Blast_Score=146, Evalue=3e-36,
Organism=Escherichia coli, GI1789552, Length=371, Percent_Identity=26.9541778975741, Blast_Score=130, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 42789; Mature: 42789

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: PS00594 AROMATIC_AA_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKTLGSTLLVSGTMIGAGMLAMPLTSAGIGFTFTVVLLLVLWFLLTYSALLFVEAYQTV
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ESDAGIGSLSAVYFGGFGRFISTAALLIFLYALLAAYVTGGGGLLSSILPTIQSAETTSH
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCH
ISIVIFTTVFGAFIIIGTQTVDGLNRLLFFTMLVALGAVLFLLVPEVKMDNLMAMPIDKA
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCH
LLISASPVFFTSFGFHGSIPSLNKYLGGNIKALRISILVGSFITLCGYILWQFGTHGVLT
HEEECCCHHHEECCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
QSVFLQILQDEPTLNGLVAATKQVTGSSVISGAVKLFSALALITSFLGVALGLFECIEDL
HHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSRVFKFKAGRITLGLLTFIPPLLFALFYPKGFILALGYAGQMFAFYAVVLPAALVWKVR
HHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHEEEECCHHHHHHHHHHHHHHHHHHHHH
KLHPNLPYRVSGGSALLVISAVLGVIITSIPFAIKAGYLPAVVG
HHCCCCCEEECCCCHHHHHHHHHHHHHHHCCHHHHCCCCCCCCC
>Mature Secondary Structure
MNKTLGSTLLVSGTMIGAGMLAMPLTSAGIGFTFTVVLLLVLWFLLTYSALLFVEAYQTV
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ESDAGIGSLSAVYFGGFGRFISTAALLIFLYALLAAYVTGGGGLLSSILPTIQSAETTSH
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCH
ISIVIFTTVFGAFIIIGTQTVDGLNRLLFFTMLVALGAVLFLLVPEVKMDNLMAMPIDKA
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCH
LLISASPVFFTSFGFHGSIPSLNKYLGGNIKALRISILVGSFITLCGYILWQFGTHGVLT
HEEECCCHHHEECCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
QSVFLQILQDEPTLNGLVAATKQVTGSSVISGAVKLFSALALITSFLGVALGLFECIEDL
HHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSRVFKFKAGRITLGLLTFIPPLLFALFYPKGFILALGYAGQMFAFYAVVLPAALVWKVR
HHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHEEEECCHHHHHHHHHHHHHHHHHHHHH
KLHPNLPYRVSGGSALLVISAVLGVIITSIPFAIKAGYLPAVVG
HHCCCCCEEECCCCHHHHHHHHHHHHHHHCCHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-tyrosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]